A one-page medical study note / visual chart on AMYLOIDOSIS for NEET PG exam preparation. Dense but clear layout. Dark navy blue background with white and bright colored text. Organized into clearly labeled sections with icons, arrows, tables, and memory tricks. TITLE: AMYLOIDOSIS (big, bold, yellow, top center) Subtitle: "Extracellular deposition of misfolded proteins in β-pleated sheet conformation" --- SECTION 1: STRUCTURE (left top, light blue box) --- • β-pleated sheet conformation → resistant to proteolysis • Components: Fibril protein (95%) + P-component + GAGs • Staining: Congo Red → Apple-green birefringence under POLARIZED LIGHT ✨ • Also: PAS+, Thioflavin T (fluorescence), Crystal violet (metachromasia) • EM: non-branching fibrils, 7.5–10 nm diameter --- SECTION 2: CLASSIFICATION TABLE (center, bright white table) --- 3-column table: TYPE | PRECURSOR PROTEIN | CLINICAL SETTING AL (Primary) | Ig Light chains (λ > κ) | MM / Plasma cell dyscrasia → Heart, GIT, Tongue, Skin, Nerves AA (Secondary/Reactive) | SAA (liver) → stimulated by IL-1, IL-6 | RA (MC), TB, Crohn's, Osteomyelitis → Kidney, Liver, Spleen ATTR | Transthyretin | Familial (mutant TTR) / Senile (wild-type) → Heart, Nerves Aβ | APP (Chr 21) | Alzheimer's disease → Brain plaques Aβ2M | β2-microglobulin | Long-term hemodialysis → Joints AA-FMF | AA type | Familial Mediterranean Fever (Auto-inflammatory) --- SECTION 3: ORGANS AFFECTED (right top, organ icons) --- KIDNEY (MC serious): Nephrotic syndrome → progresses to CRF HEART: Restrictive cardiomyopathy, arrhythmias ("sparkling" on echo) LIVER: Hepatomegaly, grey-waxy appearance SPLEEN: Sago spleen (periarteriolar) or Lardaceous spleen (sinusoidal) TONGUE: Macroglossia (AL type) NERVES: Peripheral neuropathy ADRENALS: Adrenal insufficiency --- SECTION 4: DIAGNOSIS (bottom left, green box) --- GOLD STANDARD: Biopsy + Congo Red stain → Apple-green birefringence Sites: Rectal biopsy (MC used), Abdominal fat pad aspirate (safest), Gingival, Kidney, Bone marrow Other: Serum/urine immunofixation, Echo, Cardiac MRI, Scintigraphy (SAP scan) Specific typing: Immunohistochemistry (AA, TTR) / Mass spectrometry (AL) --- SECTION 5: MNEMONICS (bottom center, yellow sticky note style) --- 🧠 "A MATT" = Types: AL, AA, ATTR, Aβ, ATTR-TTR 🧠 AL → "A Lot" → Heart, Liver, Tongue (BIG organs) 🧠 AA → "After Anything chronic" → Kidney MC involved 🧠 Congo Red = CR = "Classic Red" → Green birefringence (trick!) 🧠 Sago spleen = periARTERIOlar = Small white nodules like sago grains --- SECTION 6: HIGH-YIELD NEET POINTS (bottom right, red alert box) --- ★ MC type worldwide: AL ★ MC organ involved: KIDNEY ★ MC cause of AA: Rheumatoid Arthritis ★ MC cause of death: Renal failure / Cardiac ★ Macroglossia: AL type ★ Dialysis amyloid: β2-microglobulin (Aβ2M) ★ Alzheimer's: APP → Aβ (Chr 21) → also why Down syndrome gets Alzheimer's early ★ Gross appearance: Grey, waxy, firm ★ H&E: Amorphous eosinophilic hyaline deposits (extracellular) Use small readable fonts, color-coded boxes, a clean grid layout, and ensure ALL content is clearly visible and legible. Medical textbook style but visually engaging for students.

One-page NEET PG medical study chart on AMYLOIDOSIS. Dark navy background, colorful text boxes, compact dense layout like a handwritten revision sheet but digital and crisp. All text must be clearly legible. TOP BANNER (yellow): 🔬 AMYLOIDOSIS — NEET PG ONE-PAGE REVISION Subtitle (white): Extracellular deposition of misfolded proteins in β-pleated sheet conformation ROW 1 — Two side by side boxes: LEFT BOX (light blue, title: STRUCTURE & STAINING): • β-pleated sheet → resistant to proteolysis • Fibril protein 95% + P-component + GAGs • H&E: Amorphous eosinophilic hyaline (extracellular) • CONGO RED stain → Apple-green birefringence under POLARIZED LIGHT ★ • Thioflavin T → Fluorescence • Crystal violet → Metachromasia (purple) • PAS positive, diastase resistant • EM: Non-branching fibrils, 7.5–10 nm RIGHT BOX (orange, title: TYPES — QUICK TABLE): Small 4-column table: TYPE | PRECURSOR | CAUSE | ORGANS AL (Primary) | Ig Light chain (λ>κ) | Myeloma / MGUS | Heart, Tongue, Nerves, Skin AA (Secondary) | SAA protein | RA★, TB, Crohn's, Osteomyelitis | Kidney★, Liver, Spleen ATTR | Transthyretin | Familial (mutant) / Senile (wild) | Heart, Nerves Aβ | APP (Chr 21) | Alzheimer's / Down syndrome | Brain senile plaques Aβ2M | β2-microglobulin | Long-term hemodialysis | Joints (CTS) AA-FMF | AA type | Familial Mediterranean Fever | Kidney ROW 2 — Three side by side boxes: LEFT BOX (green, title: ORGANS INVOLVED): KIDNEY (MC serious): Nephrotic syndrome → CRF SPLEEN: Sago (periarteriolar, small) or Lardaceous (sinusoidal, large) HEART: Restrictive CMP, "sparkling" echo LIVER: Grey-waxy, enlarged TONGUE: Macroglossia (AL only) ADRENAL: Insufficiency GIT: Malabsorption, bleeding CENTER BOX (purple, title: DIAGNOSIS): ★ GOLD STANDARD: Biopsy + Congo Red Biopsy Sites: • Rectal mucosa (MC used) • Abdominal fat pad aspirate (safest, easiest) • Gingival / Kidney / Bone marrow • SAP (Serum Amyloid P) scintigraphy Typing: IHC (AA, TTR) / Mass spec (AL) RIGHT BOX (red, title: HIGH-YIELD NEET ★★★): ★ MC type worldwide = AL ★ MC organ = KIDNEY ★ MC cause of AA = Rheumatoid Arthritis ★ Macroglossia = AL type ★ Dialysis amyloid = β2M (joints/CTS) ★ Alzheimer's + Down syndrome = Aβ (App Ch21) ★ Sago spleen = periarteriolar ★ Lardaceous spleen = red pulp sinusoids ★ MC cause of death = Renal / Cardiac failure ★ Gross: Grey, waxy, firm consistency BOTTOM ROW — Full width yellow sticky note style box (title: 🧠 MNEMONICS & TRICKS): • "COAL" = Congo red → Orange (light) → Apple-green (polarized) • AL = "A Lot" → affects Heart, Tongue, Nerves (non-renal predominant) • AA = "After Anything chronic" → Kidney MC organ • Sago spleen looks like tiny white grains = small & periarteriolar • APP on Chr 21 → Down syndrome (trisomy 21) gets Alzheimer's early → same Aβ • FMF = AA type + autosomal recessive + Armenian/Sephardic Jewish/Arab populations • Biopsy: "Rectal is Routine, Fat is Fast" (rectal = MC used, fat pad = safest) Make all text crisp, small but readable, use icons/stars/arrows, keep it very dense yet organized in a grid. Style: medical infographic poster for students.

One-page NEET PG medical revision chart titled AMYLOIDOSIS. Dark navy blue background. Compact grid layout with colorful labeled sections. All text clearly readable. Title bar (bold yellow): AMYLOIDOSIS — NEET PG ONE-PAGE REVISION Subtitle (white small): Extracellular deposition of misfolded proteins in beta-pleated sheet conformation Section 1 (top left, light blue box) titled STRUCTURE AND STAINING: - beta-pleated sheet, resistant to proteolysis - H and E: amorphous eosinophilic hyaline extracellular deposits - Congo Red stain: apple-green birefringence under polarized light (KEY FACT) - Thioflavin T: fluorescence; Crystal violet: metachromasia - EM: non-branching fibrils 7.5 to 10 nm Section 2 (top right, orange box) titled CLASSIFICATION TABLE: Small table with columns TYPE, PRECURSOR, CAUSE, ORGANS: AL Primary — Ig light chain lambda greater than kappa — Myeloma or MGUS — Heart Tongue Nerves Skin AA Secondary — SAA protein — RA (MC) TB Crohns Osteomyelitis — Kidney Liver Spleen ATTR — Transthyretin — Familial mutant or Senile wild type — Heart Nerves A-beta — APP chromosome 21 — Alzheimers Down syndrome — Brain plaques Beta2M — beta2-microglobulin — Long-term hemodialysis — Joints CTS FMF — AA type — Autosomal recessive Armenian Jewish Arab — Kidney Section 3 (middle left, green box) titled ORGANS INVOLVED: Kidney (MC serious): nephrotic syndrome progresses to CRF Spleen: Sago spleen = periarteriolar white nodules; Lardaceous = sinusoidal Heart: restrictive cardiomyopathy sparkling on echo Liver: grey waxy enlarged hepatomegaly Tongue: macroglossia in AL type only GIT: malabsorption bleeding Section 4 (middle right, purple box) titled DIAGNOSIS: Gold standard: Biopsy plus Congo Red stain Biopsy sites: Rectal mucosa (MC used), Abdominal fat pad aspirate (safest), Gingival, Kidney, Bone marrow SAP scintigraphy for distribution Typing: Immunohistochemistry for AA and TTR; Mass spectrometry for AL Section 5 (bottom left, red box) titled HIGH YIELD NEET STARS: MC type worldwide = AL MC organ involved = Kidney MC cause of AA type = Rheumatoid Arthritis Macroglossia = AL type only Dialysis amyloid = beta2M affects joints and carpal tunnel Alzheimer plus Down syndrome = A-beta from APP on chromosome 21 MC cause of death = Renal failure or Cardiac failure Gross appearance: grey waxy firm Section 6 (bottom right, yellow box) titled MNEMONICS: Congo Red to Apple Green = polarized light trick AL = Heart Tongue Nerves (non-renal dominant) AA = After Anything chronic, Kidney is MC organ Sago spleen = small white grains = periarteriolar Rectal is Routine Fat is Fast for biopsy sites FMF = Armenian Sephardic Jewish Arabic populations