Cefpodoxime dosage
Reading Document
Medical Text Search
cefpodoxime dosage indications adult pediatric
GradeResponse
The retrieval didn't return specific cefpodoxime data. Here is a comprehensive answer from established pharmacological knowledge:
Cefpodoxime Dosage
Cefpodoxime proxetil is a third-generation oral cephalosporin used for respiratory, urinary, skin, and ENT infections.
Adults & Adolescents (≥13 years)
| Indication | Dose | Frequency | Duration |
|---|---|---|---|
| Community-acquired pneumonia | 200 mg | Every 12 h | 14 days |
| Acute exacerbation of chronic bronchitis | 200 mg | Every 12 h | 10 days |
| Acute maxillary sinusitis | 200 mg | Every 12 h | 10 days |
| Pharyngitis / Tonsillitis | 100 mg | Every 12 h | 5–10 days |
| Uncomplicated UTI (cystitis) | 100 mg | Every 12 h | 7 days |
| Uncomplicated gonorrhea | 200 mg | Single dose | — |
| Uncomplicated skin & soft tissue infections | 400 mg | Every 12 h | 7–14 days |
Pediatric Dosing (2 months – 12 years)
| Indication | Dose | Frequency | Duration |
|---|---|---|---|
| Acute otitis media | 10 mg/kg/day (max 400 mg/day) | Every 12 h OR once daily | 5–10 days |
| Pharyngitis / Tonsillitis | 5 mg/kg/dose (max 100 mg/dose) | Every 12 h | 5–10 days |
| Acute maxillary sinusitis | 5 mg/kg/dose (max 200 mg/dose) | Every 12 h | 10 days |
Note: Oral suspension is available (50 mg/5 mL or 100 mg/5 mL) for children.
Renal Dose Adjustment
| CrCl | Adjustment |
|---|---|
| ≥30 mL/min | No adjustment needed |
| <30 mL/min | Increase interval to every 24 h |
| Hemodialysis | Dose 3× per week after dialysis |
Key Points
- Take with food to enhance absorption (bioavailability increases ~30%)
- Avoid in patients with cephalosporin/penicillin allergy (cross-reactivity ~1–2%)
- Pregnancy category B — generally considered safe
- Common adverse effects: diarrhea, nausea, vaginal candidiasis, rash
- Maximum single dose: 400 mg; maximum daily dose: 800 mg in adults
Syp polypod
Medical Text Search
Polypod syrup cefpodoxime oral suspension dosage
GradeResponse
Polypod is a brand of Cefpodoxime Proxetil oral suspension, commonly available in India.
Syrup Polypod — Brand Details
| Parameter | Details |
|---|---|
| Generic name | Cefpodoxime Proxetil |
| Available strengths | 50 mg/5 mL and 100 mg/5 mL (dry syrup) |
| Class | 3rd generation oral cephalosporin |
Dosing (Weight-based)
| Age / Weight | Dose | Frequency |
|---|---|---|
| Infants & children (2 months–12 yrs) | 4–5 mg/kg/dose | Every 12 hours |
| Max single dose | 100–200 mg depending on indication | — |
Indication-wise Dosing
| Indication | Dose | Duration |
|---|---|---|
| Acute Otitis Media | 10 mg/kg/day ÷ 2 doses (max 400 mg/day) | 5–10 days |
| Pharyngitis / Tonsillitis | 5 mg/kg/dose (max 100 mg) BD | 5–10 days |
| Sinusitis | 5 mg/kg/dose (max 200 mg) BD | 10 days |
| URTI / LRTI | 5 mg/kg/dose BD | 7–10 days |
Quick Dose Reference (50 mg/5 mL strength)
| Weight | Dose (5 mg/kg) | Volume (50 mg/5 mL) |
|---|---|---|
| 5 kg | 25 mg | 2.5 mL BD |
| 8 kg | 40 mg | 4 mL BD |
| 10 kg | 50 mg | 5 mL BD |
| 15 kg | 75 mg | 7.5 mL BD |
| 20 kg | 100 mg | 10 mL BD |
Key Instructions
- Reconstitute with the specified amount of water before dispensing
- Shake well before each use
- Store in a cool, dry place after reconstitution; use within 14 days
- Give with food to improve absorption and reduce GI upset
- Complete the full course even if the child feels better
Syp o2m
Medical Text Search
O2M syrup oral suspension composition dosage
GradeResponse
Syrup O2M is a combination oral suspension commonly used in pediatric practice in India.
Syrup O2M — Composition
| Component | Strength (per 5 mL) |
|---|---|
| Ofloxacin | 50 mg |
| Metronidazole (Ornidazole in some formulations) | 125 mg |
Some variants may contain Ofloxacin + Ornidazole instead of Metronidazole — confirm from the label.
Indications
- Acute diarrhea / Traveler's diarrhea
- Amoebic dysentery
- Giardiasis
- Mixed bacterial + protozoal GI infections
- Enteric fever (supportive)
Dosage
Pediatric
| Weight | Dose | Frequency | Duration |
|---|---|---|---|
| Ofloxacin component: 7.5 mg/kg/day | ÷ 2 doses | BD | 5–7 days |
| General guideline | 5 mL (1 tsp) per 10 kg | BD | 5–7 days |
| Weight | Volume | Frequency |
|---|---|---|
| 10 kg | 5 mL | BD |
| 15 kg | 7.5 mL | BD |
| 20 kg | 10 mL | BD |
Adult
- 10 mL (2 tsp) twice daily for 5–7 days
Key Points
- Avoid in children under 1 year (fluoroquinolone caution)
- Use with caution in patients with seizure disorders (Metronidazole/Ornidazole lowers seizure threshold)
- Avoid alcohol during and 48 hours after course (Metronidazole/Ornidazole — disulfiram-like reaction)
- Give with or after food to reduce nausea
- Not recommended in pregnancy (especially 1st trimester) — Ofloxacin and Metronidazole both have restrictions
⚠️ Fluoroquinolones (Ofloxacin) are generally avoided in children due to concerns about cartilage development — use only when clearly indicated and alternatives are unavailable.
Oflaxacin dosage
Medical Text Search
ofloxacin dosage indications adult pediatric
GradeResponse
Ofloxacin Dosage
Ofloxacin is a second-generation fluoroquinolone antibiotic with broad-spectrum activity against gram-negative, some gram-positive, and atypical organisms.
Adults
| Indication | Dose | Frequency | Duration |
|---|---|---|---|
| Urinary Tract Infection (uncomplicated) | 200 mg | Every 12 h | 3–7 days |
| UTI (complicated) | 200 mg | Every 12 h | 10 days |
| Acute pyelonephritis | 200–400 mg | Every 12 h | 10–14 days |
| Community-acquired pneumonia | 400 mg | Every 12 h | 10 days |
| Acute exacerbation of chronic bronchitis | 400 mg | Every 12 h | 10 days |
| Acute sinusitis | 400 mg | Every 12 h | 10 days |
| Skin & soft tissue infections | 400 mg | Every 12 h | 10 days |
| Pelvic Inflammatory Disease (PID) | 400 mg | Every 12 h | 14 days |
| Gonorrhea (uncomplicated) | 400 mg | Single dose | — |
| Typhoid / Enteric fever | 200–400 mg | Every 12 h | 7–14 days |
| Traveler's diarrhea | 200 mg | Every 12 h | 3–5 days |
| Tuberculosis (second-line) | 600–800 mg | Once daily | As per regimen |
Pediatric
⚠️ Fluoroquinolones are generally avoided in children (<18 years) due to risk of arthropathy and cartilage damage. Use only when benefit outweighs risk and no suitable alternative exists.
| Indication | Dose | Frequency |
|---|---|---|
| Acute otitis media (ear drops) | Topical only | BD |
| Typhoid (when alternatives fail) | 7.5 mg/kg/dose (max 400 mg) | Every 12 h |
| Complicated UTI (selected cases) | 7.5 mg/kg/dose | Every 12 h |
Renal Dose Adjustment
| CrCl | Adjustment |
|---|---|
| >50 mL/min | No adjustment |
| 20–50 mL/min | 200–400 mg every 24 h |
| <20 mL/min | 100–200 mg every 24 h |
| Hemodialysis | Dose after dialysis, every 24 h |
Available Formulations
| Form | Strengths |
|---|---|
| Tablets | 200 mg, 400 mg |
| Oral suspension | 50 mg/5 mL |
| IV infusion | 200 mg/100 mL, 400 mg/200 mL |
| Eye / Ear drops | 0.3% solution |
Key Points
- Take on an empty stomach (1 hr before or 2 hrs after food) for best absorption
- Avoid antacids, iron, zinc, calcium within 2 hours — reduce absorption significantly
- Avoid in pregnancy and lactation
- QT prolongation risk — avoid with other QT-prolonging drugs
- May cause tendinitis/tendon rupture — especially in elderly and those on corticosteroids
- Photosensitivity — advise sun protection during treatment
Ibugesic plus syp
Medical Text Search
Ibugesic Plus syrup ibuprofen paracetamol combination dosage pediatric
GradeResponse
Syrup Ibugesic Plus
Ibugesic Plus is a popular pediatric combination suspension manufactured by Cipla (India).
Composition (per 5 mL)
| Component | Strength |
|---|---|
| Ibuprofen | 100 mg |
| Paracetamol (Acetaminophen) | 162.5 mg |
Indications
- Fever (especially when unresponsive to single agent)
- Pain with fever — post-vaccination, otitis media, pharyngitis, dental pain
- Post-operative pain and fever in children
Dosage
Weight-based (recommended)
| Component | Dose |
|---|---|
| Ibuprofen | 5–10 mg/kg/dose |
| Paracetamol | 10–15 mg/kg/dose |
| Frequency | Every 6–8 hours |
| Max doses/day | 3–4 times |
Age/Weight Quick Reference (per dose)
| Age | Weight | Volume |
|---|---|---|
| 3–6 months | 5–7 kg | 2.5 mL |
| 6–12 months | 7–10 kg | 5 mL |
| 1–2 years | 10–14 kg | 5–7.5 mL |
| 2–3 years | 14–16 kg | 7.5 mL |
| 3–5 years | 16–20 kg | 7.5–10 mL |
| 5–8 years | 20–25 kg | 10–12.5 mL |
| 8–12 years | 25–35 kg | 12.5–15 mL |
Key Points
- Give with food or milk to minimize GI upset (ibuprofen component)
- Do not exceed 4 doses in 24 hours
- Minimum interval between doses: 6 hours
- Avoid in children under 3 months
- Avoid in dehydration, renal impairment, or active GI bleed (ibuprofen risk)
- Shake well before use
- Use the measuring cup/dropper provided — do not estimate
Contraindications
- Age < 3 months
- Known hypersensitivity to NSAIDs or paracetamol
- Active peptic ulcer / GI bleeding
- Severe hepatic or renal impairment
- Dengue fever — avoid ibuprofen (bleeding risk); use paracetamol alone
This is a shared conversation. Sign in to Orris to start your own chat.