Role of immunotherapy in carcinoma ovary, in upfront and recurrent settings, rationale of combining immunotherapy with parp inhibitors , detailed overview using all the evidences, in detail, include all latest evidences also. Describe Using tables/ flowchart s wherever applicable. Also mention about latest guidelines for immunotherapy in ovarian cancer.
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Quick Orientation
Key Takeaways at a Glance
| Setting | ICI Role | Evidence Level | Guideline Status |
|---|---|---|---|
| 1st Line (upfront) | Investigational only | Multiple negative Phase III trials | NOT standard (NCCN/ESMO 2026) |
| Platinum-sensitive recurrence | Not effective | Negative trials (JAVELIN, others) | NOT recommended |
| Platinum-resistant recurrence (PD-L1 CPS ≥1) | APPROVED | KEYNOTE-B96 Phase III (Lancet 2026) | FDA/EMA approved Feb-Apr 2026 |
| PARPi + ICI combination | Modest benefit in selected biomarker groups | Phase III trials + 2026 meta-analyses | Not standard; active trial area |