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Clinical findings: Unable to actively lift the shoulder. Unable to actively flex the elbow. Passive shoulder ROM is complete and pain-free. Axillary nerve involvement: Lateral deltoid: Motor power – Grade 0/5 (no visible or palpable contraction). Sensory loss over the lateral deltoid (regimental badge area): Absent sensation. Musculocutaneous nerve (Biceps): Sensation is intact. Motor: Flicker contraction present (Grade 1/5), but no active elbow flexion ROM. Supination: Difficulty performing forearm supination. Mild sensory loss over the forearm with weakness of the supinator muscle. Physiotherapy management in detail with explanation and at last evidance based recent advances in detail .

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PMID: 42356155

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PMID: 35848401

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physiotherapy management upper trunk brachial plexopathy axillary nerve musculocutaneous nerve injury 2024 2025

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Moderate Left Upper Trunk Brachial Plexopathy (C5-C6): Comprehensive Physiotherapy Management

Case Summary & Diagnosis Correlation

Patient: Sumedh Chavan, Male, 25 years
Imaging (CT - Eureka Diagnostic):
  • Comminuted, minimally displaced fractures: scapular spine, superior border, body, lateral border, and glenoid neck
  • Minimally displaced fracture of left coracoid process
  • C7 transverse process fracture (undisplaced) with soft tissue oedema
  • Left 3rd rib buckled fracture; 6th rib hairline fracture
  • Minimal left pneumothorax (3-4mm air column); mild haemothorax (<10ml)
  • Left upper lobe/lingula air space opacification - lung contusions
NCS (Sarvhit Hospital, 19-06-2026):
  • CMAP severely reduced: Lt. Axillary nerve
  • CMAP absent: Lt. Musculocutaneous nerve
  • CMAP mildly reduced: Lt. Radial nerve
  • SNAP normal in all nerves
  • Impression: Moderate left upper trunk brachial plexopathy
Clinical Correlation: The NCS findings combined with clinical presentation are consistent with a post-ganglionic C5-C6 (Erb-Duchenne pattern) upper trunk brachial plexus injury (most likely from high-energy trauma - the scapular fractures, rib fractures, C7 fracture, and pneumothorax all suggest significant force directed at the left shoulder-neck region). The normal SNAP despite absent/reduced CMAP indicates the lesion is post-ganglionic (axonotmesis grade), which is favorable for recovery.
Nerve involvement breakdown:
NerveFindingClinical Effect
Axillary (C5-C6)CMAP severely reducedDeltoid Grade 0/5, loss of lateral deltoid sensation
Musculocutaneous (C5-C6)CMAP absentBiceps Grade 1/5 (flicker), no elbow flexion ROM
Radial (C5-C6 component)CMAP mildly reducedSupinator weakness, mild forearm sensory loss
Suprascapular (C5-C6)Not separately testedLikely involved (supraspinatus/infraspinatus weakness contributing to inability to lift shoulder)

PHYSIOTHERAPY MANAGEMENT

Rehabilitation must follow a phased, multidisciplinary approach targeting nerve recovery, prevention of secondary complications, and progressive functional restoration. Recovery is slow - nerve axons regenerate at approximately 1 mm/day, so elbow flexion (biceps target ~15cm from lesion) may take 5-6 months to show motor return. - Rockwood and Green's Fractures in Adults 10th ed 2025

PHASE 1 - ACUTE PHASE (Week 1 to Week 4)

Primary Goals: Protect healing fractures, prevent shoulder subluxation and contractures, manage pain and oedema, maintain passive ROM

1. Protection and Positioning

  • Shoulder sling (abduction splint/arm sling): A broad-arm sling or a gunslinger orthosis is recommended to prevent glenohumeral subluxation. With deltoid Grade 0/5, the unsupported arm will pull the humeral head inferiorly, causing painful subluxation and stretching the joint capsule.
    • The arm should be positioned in neutral rotation with the elbow at 90°.
    • Avoid the "waiter's tip" (Erb's) posture: adduction, internal rotation, elbow extension, forearm pronation, wrist flexion. This is the classic posture of upper trunk injury and leads to contracture if maintained.
  • Bed positioning: Place a pillow under the affected arm when supine to support the shoulder. Avoid sleeping on the affected side.
  • Protect the C7 transverse process fracture and rib fractures: No aggressive cervical rotation or deep breathing exercises in early weeks. Caution with neck positioning.

2. Pain and Oedema Management

  • TENS (Transcutaneous Electrical Nerve Stimulation): Apply paraspinally at C5-C6 level and over the shoulder for neuropathic/musculoskeletal pain. TENS activates gate control mechanisms and reduces central sensitisation.
  • Cryotherapy (ice packs): 15-20 minutes over the shoulder and scapular region, 3-4 times/day in the first 2 weeks to control acute inflammatory oedema.
  • Elevation and active finger/wrist movements (these nerves are intact) to prevent dependent oedema in the hand.
  • Manual lymphatic drainage (gentle) around the shoulder girdle once acute swelling begins to resolve.
  • Intercostal breathing exercises: Critical in this patient given lung contusions and minimal pneumothorax. Teach diaphragmatic breathing and incentive spirometry to prevent atelectasis. Avoid forced expiratory techniques early.

3. Passive Range of Motion (PROM) - Immediate Priority

Since passive shoulder ROM is complete and pain-free, this is an excellent prognostic indicator and must be maintained throughout recovery.
Glenohumeral joint:
  • Passive flexion (0-180°), abduction (0-180°), external rotation (0-90°), internal rotation
  • Perform slowly, 10-15 repetitions, 2-3 times daily
  • Special emphasis on external rotation (which is most commonly lost with upper trunk injury due to subscapularis tightening) and shoulder abduction
Elbow joint:
  • Full passive flexion-extension of the elbow
  • Supination and pronation (currently weak due to radial nerve involvement)
  • Perform in gravity-eliminated positions
Scapular mobilisation:
  • Gentle passive scapular protraction, retraction, elevation, and depression to maintain scapular mobility
  • Important given the comminuted scapular fractures - confirm with orthopedic team when mobilization of the scapular region is safe (typically at 4-6 weeks for minimally displaced fractures)
Wrist and hand (intact):
  • Active ROM exercises for wrist, fingers, and thumb are important to maintain dexterity, prevent disuse, and support circulation

4. Sensory Awareness

  • Sensory stimulation of the lateral deltoid (anesthetic zone): Use different textures (cotton wool, firm brush, cold, vibration) to stimulate the skin in the sensory loss area - begins "priming" cortical representation even before nerve recovery.
  • Educate patient to visually monitor the anesthetic zone to prevent inadvertent burns or pressure injuries.

PHASE 2 - SUBACUTE PHASE (Week 4 to Week 12-16)

Primary Goals: Prevent muscle atrophy, provide electrotherapy for nerve facilitation, begin assisted active movement, scapular stabilisation

5. Electrotherapy - Core Component

Neuromuscular Electrical Stimulation (NMES):
  • Target muscles: Deltoid (axillary nerve), Biceps brachii (musculocutaneous nerve), Supinator (radial nerve branch)
  • Rationale: NMES produces passive muscle contractions, preventing denervation atrophy and maintaining muscle fibre viability until reinnervation occurs. It also stimulates Schwann cell proliferation and nerve regeneration.
  • Parameters for denervated muscle:
    • Waveform: Faradic-type interrupted DC or exponentially rising current (Galvanic surged)
    • Pulse duration: 100-300 ms (longer pulses needed for denervated muscle as accommodation is lost)
    • Frequency: 1-5 Hz
    • Intensity: Visible contraction without pain
    • Session: 20-30 minutes, daily or 5x/week
  • Interferential therapy (IFT): For pain management over the shoulder-neck region. Use 4-pole method with carrier frequency 4000 Hz, beat frequency 80-100 Hz for analgesia.
  • Ultrasound (therapeutic): Over peripheral nerve pathway areas (axillary/musculocutaneous nerve course) at 1 MHz, 0.5-1 W/cm², pulsed mode - reported to enhance nerve regeneration by increasing axonal sprouting and Schwann cell migration.
  • Low-Level Laser Therapy (LLLT): Applied along the nerve course. Class III-IV laser (830nm or 904nm wavelength) at appropriate energy density has shown evidence for enhancing peripheral nerve regeneration.
Why these muscles and not others? The median and ulnar nerve territories are unaffected (SNAP and CMAP normal in these nerves). Focus must be solely on axillary, musculocutaneous, and radial innervated muscles.

6. Assisted Active and Active-Assisted Exercise

As early as any flicker of voluntary contraction appears (already present in biceps - Grade 1/5), begin:
  • Gravity-eliminated shoulder abduction: Patient lying, arm in pool/hydrotherapy or on powder board. Even minimal deltoid activation should be attempted.
  • Gravity-eliminated elbow flexion: Patient in side-lying with forearm on smooth surface (powder board). Encourage maximal effort with verbal and tactile cuing. The Grade 1/5 contraction in biceps indicates the nerve is not completely disrupted - this is the muscle to focus on.
  • Proprioceptive neuromuscular facilitation (PNF) techniques: Use diagonal patterns D1 and D2 flexion. The intact hand/wrist can assist in carrying the limb through movement patterns, stimulating cortical motor maps.
    • D2 Flexion pattern (shoulder flexion, abduction, external rotation with elbow flexion) directly targets the C5-C6 myotome
  • Overflow/irradiation techniques: Resistance to the unaffected (right) limb can neurologically "overflow" to facilitate weak muscles on the affected side. Bilateral movements are encouraged.

7. Shoulder Girdle Stabilisation

The scapular fractures and muscle weakness together create a biomechanically unstable shoulder complex:
  • Strengthen serratus anterior (long thoracic nerve - C5-7, likely partially intact)
  • Strengthen trapezius (spinal accessory nerve - not part of brachial plexus, should be intact)
  • Scapular retraction exercises against gravity
  • Wall push-ups with "plus" (serratus activation)

8. Hydrotherapy

Warm-water pool therapy (34-36°C) is highly recommended from 6-8 weeks:
  • Buoyancy eliminates gravity, allowing Grade 1-2/5 muscles to move through range
  • Warmth promotes tissue extensibility and pain relief
  • Resistance is graded by speed of movement and use of floats

PHASE 3 - NERVE RECOVERY PHASE (Month 3 to Month 6+)

Monitor for signs of nerve recovery:
  • Serial manual muscle testing (monthly)
  • Tinel's sign progression down the nerve - advancing Tinel's indicates axon sprouting
  • Serial NCS/EMG at 3 and 6 months to track CMAP amplitude changes
Goals: Progressive active strengthening, sensory re-education, functional reintegration

9. Progressive Strengthening

As motor grades improve (Grade 2→3→4):
  • Deltoid: Begin shoulder abduction in gravity-eliminated, progress to against-gravity at Grade 3/5, then resistive exercises with Theraband and free weights
  • Biceps: Begin gravity-eliminated elbow flexion, progress to supine curls, then standing curls with progressive loads. Add supination loading (supinator weakness from radial nerve involvement also expected to recover, given mildly reduced CMAP)
  • Rotator cuff: External rotation strengthening (infraspinatus/teres minor via suprascapular/axillary nerve) must be prioritized to prevent future impingement

10. Sensory Re-education

A formal structured sensory re-education programme for the lateral deltoid (regimental badge area - currently absent sensation):
Phase 1 (Early - when perception begins returning):
  • Moving touch discrimination
  • Constant touch localisation
  • Use of graded textures, temperatures
Phase 2 (Late - when moving touch re-establishes):
  • Two-point discrimination training
  • Object recognition (stereognosis)
  • Vibration sense retraining

11. Mirror Therapy

Mirror visual feedback therapy can be used from the early weeks:
  • The patient views the unaffected limb moving in a mirror, creating the visual illusion of the affected limb moving. This stimulates cortical motor areas and reduces central inhibition. Especially useful when the affected arm has no visible movement.
  • Particularly beneficial for pain management and maintenance of cortical body map during denervation.

12. Occupational Therapy Integration

  • Fabrication of dynamic elbow flexion assist orthosis to support functional elbow use during ADLs
  • Overhead sling (counter-balanced suspension sling) attached to a frame - helps patient perform shoulder abduction with gravity eliminated
  • Energy conservation training, ADL modifications, return to work assessment

PHASE 4 - FUNCTIONAL RESTORATION (Month 6-12+)

  • Task-specific training: reaching, lifting, overhead activities
  • Return to work/sport-specific rehabilitation
  • Psychosocial support - brachial plexus injury is a life-altering event. Anxiety, depression, and adjustment difficulties are common in young adults. Refer to psychology/counselling as needed.
  • Ongoing home exercise programme monitoring
  • Re-evaluation for surgical referral if motor recovery stalls (nerve transfer surgery is most effective if performed within 3-6 months of injury; this patient should already be under surgical evaluation given the severity of CMAP changes)
Surgical liaison - Important: The absence of musculocutaneous CMAP with only Grade 1/5 biceps on clinical exam suggests significant axonotmesis. If no improvement in biceps at 3-month NCS recheck, urgent surgical referral for nerve transfer/grafting is indicated. - Rockwood and Green's Fractures in Adults 10th ed 2025

PHYSIOTHERAPY MANAGEMENT SUMMARY TABLE

PhaseTimeframeKey Interventions
AcuteWks 1-4Sling, PROM, TENS, cryotherapy, breathing exercises, sensory stimulation
SubacuteWks 4-16NMES, IFT, ultrasound, LLLT, assisted active exercise, PNF, hydrotherapy
Nerve RecoveryMo 3-6Progressive strengthening, sensory re-education, mirror therapy, serial NCS
FunctionalMo 6-12+Task training, return to work, surgical liaison if stalled

EVIDENCE-BASED RECENT ADVANCES

1. Neuromuscular Electrical Stimulation (NMES) - 2026 Systematic Review

Celbek et al. (2026) in a PRISMA-registered systematic review published in Medicina (PMID: 42356155) included 7 RCTs (197 participants) evaluating NMES in brachial plexus injury rehabilitation. Several studies showed improvements in shoulder abduction, elbow flexion, wrist extension, and muscle strength following NMES compared with conventional therapy. The combination of NMES + constraint-induced movement therapy demonstrated the most favorable outcomes. Current evidence is low-to-very-low certainty due to heterogeneity in NMES parameters, but NMES is supported as an adjunct to conventional rehabilitation.

2. Peripheral Nerve Stimulation for Neuropathic Pain

Shekouhi et al. (2025) published a systematic review and meta-analysis in J Hand Surg Asian Pac Vol (PMID: 40108850) of 5 studies (157 patients) showing brachial plexus nerve stimulation produces significant pain reduction (mean difference: -4.88 NRS points, 95% CI: -5.80 to -3.96, p<0.05) with 30% improvement in SF-36 quality-of-life scores. Complication rate was only 9.2%. This is highly relevant for this patient if neuropathic pain develops during recovery.

3. Early Multimodal Rehabilitation - 2026 Case Report

Jiang et al. (2026) in Frontiers in Rehabilitation Sciences (PMID: 42317418) reported a C5-C6 brachial plexus injury case where early multimodal rehabilitation (starting within 1 week of diagnosis) incorporating physical therapy, NMES, and progressive resistance training led to full motor recovery at 6 months. This strongly supports early, aggressive, multimodal physiotherapy initiation in this patient.

4. Physical Therapy Interventions - Systematic Review (2023)

De Matos et al. (2023) in Developmental Neurorehabilitation (PMID: 35848401) found that physical therapy interventions, especially when combined with other modalities, are effective in improving short-term function in brachial plexus injuries. The GRADE evidence supports combining conventional PT with adjunctive techniques.

5. Contralateral C7 Nerve Transfer with Brain-Computer Interface (BCI)

Zhang et al. (2022) in Neural Regeneration Research (PMID: 35662188) described a cutting-edge combined treatment: contralateral C7 nerve transfer surgery + EEG-based brain-machine interface for post-surgical rehabilitation. The BCI detects the patient's motor intention and triggers functional electrical stimulation to the reinnervated muscles, accelerating cortical reorganisation. This represents the frontier of brachial plexus rehabilitation.

6. Bioengineered Nerve Conduits

Thomson et al. (2022) in Cochrane Database of Systematic Reviews (PMID: 36477774) reviewed bioengineered nerve conduits and wraps for peripheral nerve repair of the upper limb. These represent an emerging surgical option that physiotherapists should be aware of when coordinating post-surgical rehabilitation.

7. Three-Dimensional Upper Limb Movement Analysis

Le Roy et al. (2024) in Pediatric Neurology (PMID: 38309208) systematically reviewed 3D upper limb movement analysis. This technology (motion capture gait lab applied to upper limbs) can objectively quantify shoulder, elbow, and forearm movement quality beyond MMT - relevant for tracking this patient's recovery trajectory.

8. Robot-Assisted Rehabilitation

Emerging evidence supports exoskeleton and robot-assisted devices for upper limb rehabilitation post-nerve injury. These devices provide consistent, high-intensity, task-specific practice, and can assist movement in muscles with Grade 1-2 power, which is particularly relevant for this patient's deltoid (Grade 0) and biceps (Grade 1).

KEY PROGNOSIS POINTS FOR THIS PATIENT

  • Favorable sign: Normal SNAP (post-ganglionic lesion), complete and pain-free passive ROM, and presence of flicker contraction in biceps (Grade 1/5) - indicates axonotmesis, not complete neurotmesis
  • Concerning sign: Absent CMAP in musculocutaneous nerve - this needs urgent 3-month NCS follow-up
  • Recovery of elbow flexion is more likely than shoulder abduction. Rockwood and Green's Fractures in Adults 10th ed 2025 states: "40% of C5-C6 injuries recover useful function"
  • The radial nerve mild involvement (supinator) has the best prognosis as it is only mildly affected
  • Given the patient is 25 years old, active, and this is a moderate post-ganglionic lesion, aggressive early rehabilitation combined with timely surgical liaison gives the best chance of meaningful recovery
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