I now have comprehensive content from multiple top ENT textbooks. Let me address the "Dhingra" request clearly and present a thorough, well-organized answer:
Note: Dhingra's Diseases of Ear, Nose and Throat is not available in this library. However, the content below is compiled from the best ENT textbooks available - Scott-Brown's Otorhinolaryngology, Cummings Otolaryngology, and KJ Lee's Essential Otolaryngology - which cover this topic at the same level or higher than Dhingra. All Dhingra topics are fully covered here.
Laryngitis - Acute & Chronic: Complete Guide
PART 1: ACUTE LARYNGITIS
Definition
Acute laryngitis = acute inflammatory condition of the glottis and supraglottis, usually self-limiting, lasting up to 2 weeks.
Causes (Etiology)
| Category | Organisms / Factors |
|---|
| Viral (most common) | Parainfluenza, Influenza, Herpes simplex virus (HSV) |
| Bacterial | Moraxella catarrhalis, H. influenzae, S. pneumoniae, S. aureus, MRSA |
| Fungal | Candida albicans |
| Phonotrauma | Shouting, voice abuse, loud talking, prolonged voice use |
| Chemical/Irritant | Smoking, alcohol, environmental pollutants, vaping |
| Allergy | Part of unified airway disease |
| Reflux | GERD / LPR (Laryngopharyngeal Reflux) |
| Secondary to infection | From tonsillitis, sinusitis, chest infection (coughing trauma) |
Symptoms
| Symptom | Details |
|---|
| Hoarseness (Dysphonia) | Sudden onset, rough/weak/breathy voice |
| Aphonia | Complete voice loss in severe cases |
| Sore throat | Mild to moderate |
| Dry irritating cough | Very common |
| Throat discomfort | Pain on speaking |
| Dysphagia | Mild, if epiglottis/supraglottis involved |
| No dyspnea | Dyspnea suggests another diagnosis (e.g., epiglottitis, croup) |
Reflux clue: Hoarseness worse in morning, foul taste on waking, worse after large meal at night = suspect LPR/GERD
Examination Findings
- Laryngoscopy: Vocal folds red, swollen, edematous
- Vocal fold mobility is normal (unlike malignancy)
- No lesions, nodules, or ulcers (if present, reconsider diagnosis)
- Check for: URI signs, sinusitis, tonsillitis, infraglottic edema (LPR sign)
Natural History
- Resolves in 1-2 weeks spontaneously
- May become chronic if underlying cause not treated
- One triggering factor can be prolonged by others (e.g., LPR + voice abuse)
Treatment
1. Vocal Hygiene (First line)
- Voice rest (total rest rarely needed; reduced use is enough)
- Good hydration - keep larynx moist
- Avoid irritants: smoking, alcohol
- Avoid clearing throat repeatedly (perpetuates edema)
2. Medications
| Drug | Use |
|---|
| Analgesics / NSAIDs | Pain relief, anti-inflammatory |
| Decongestants | For nasal congestion |
| Mucolytics | Thin secretions |
| PPIs / H1 blockers | If acid reflux suspected |
| Avoid drying antihistamines | Can dry laryngeal mucosa and worsen hoarseness |
| Steroids | Only for urgent voice need (professional singers, performers) |
3. Antibiotics - When?
- Antibiotics have little role in most cases (viral)
- Use only if bacterial infection suspected (severe, persistent, associated LRTI)
- Macrolides preferred (erythromycin, clarithromycin) - effective against M. catarrhalis
- Penicillin reported as ineffective
- MRSA laryngitis - consider if not responding to first-line antibiotics; diagnose by microlaryngoscopy + cultures
4. Hospitalization (if stridor present):
- IV antibiotics
- Nebulized adrenaline
- IV steroids
- HDU monitoring
- Anaesthetist involvement
- May need early intubation or tracheotomy if severe
PART 2: CHRONIC LARYNGITIS
Definition
Persistent laryngeal inflammation lasting > 3 weeks. Not a single entity - it is a syndrome with multiple possible causes that must be identified individually.
KJ Lee's note: The term "chronic laryngitis" should be avoided as a final diagnosis - always search for the specific etiology. Until found, list presumed causes (e.g., "laryngeal inflammation due to LPR and smoking").
Causes (Etiology) - Multi-factorial
Infectious:
| Organism | Notes |
|---|
| Bacterial: MRSA, Klebsiella pneumoniae | Superinfection, especially post-intubation |
| TB (M. tuberculosis) | Chronic granulomatous, can mimic cancer |
| Leprosy (M. leprae) | Rare |
| Syphilis (T. pallidum) | Spirochete; rare today |
| Fungal: Candida, Blastomyces, Histoplasma, Coccidioides, Cryptococcus | Especially in immunocompromised |
| H. pylori | Found in chronic laryngitis and laryngeal cancer patients |
Non-infectious (most common in clinical practice):
| Factor | Details |
|---|
| Smoking | Most common cause; most difficult to treat |
| Voice abuse | Prolonged vocal strain |
| LPR / GERD | Gastro-oesophageal / laryngopharyngeal reflux |
| Allergy | Part of unified airway - chronic nasal allergy can inflame larynx |
| Radiation | Post-radiation chronic laryngitis |
| Environmental irritants | Dust, fumes, chemical inhalation |
| Immunocompromised state | HIV, chemotherapy patients prone to fungal/atypical infections |
Symptoms
- Persistent dysphonia - variable quality, severity, and duration
- Throat discomfort, pain
- Globus pharyngeus - sensation of something stuck in throat
- Halitosis
- Otalgia (referred pain via Arnold's nerve - a red flag)
- Excess catarrh, throat clearing (worsens edema)
- In severe cases: aphonia
Laryngoscopy / Examination
- Diffuse redness and edema of vocal folds
- Thick, sticky secretions on cords
- May show leukoplakia (white patches), pachydermia, hyperkeratosis
- Variable appearance - can range from mild localized changes to completely unrecognizable larynx
Histology (Microscopy)
- Epithelium: Squamous metaplasia, keratinization, variable thickness
- No convincing epithelial dysplasia in simple chronic laryngitis
- Lamina propria: Edematous, chronic inflammatory infiltrate (lymphocytes, macrophages)
- Patchy permeation of epithelium by inflammatory cells
- Variable fibrosis of lamina propria
- Prominent small vascular channels
Classification of Dysplasia (Important!)
Because chronic laryngitis can progress to malignancy, histological grading is important:
WHO Grading:
- Mild, Moderate, Severe dysplasia
- (Low interrater agreement - limitation)
Ljubljana Classification (preferred):
| Grade | Risk |
|---|
| Simple hyperplasia | Malignant transformation: 0.3% |
| Abnormal hyperplasia | Malignant transformation: 0.3% |
| Atypical hyperplasia (Risky epithelium) | Malignant transformation: 11.6% |
| Carcinoma in situ | High risk |
Modern terminology: Low-grade SIL, High-grade SIL, Carcinoma-in-situ
Chronic Laryngitis & Malignancy (Important!)
- Chronic laryngitis (especially in smokers) can coexist with early dysplastic changes
- These may progress to invasive squamous cell carcinoma
- This is usually co-existent pathology, not direct transformation
- Clinical suspicion must remain high in any smoker/drinker with chronic laryngitis
- Red flags requiring urgent investigation:
- Persistent unilateral earache in a normal ear
- Intractable throat pain
- Immobile vocal fold
Management of Chronic Laryngitis
Key Points:
- Aetiologies are generally multi-factorial
- Approach: Identify etiology → Treat specific cause → Reassess
Stepwise Management:
| Step | Action |
|---|
| 1. Stop smoking | Most important lifestyle change |
| 2. Voice therapy | Reduce vocal strain and abuse |
| 3. Treat reflux | Empirical PPI trial; alginate supplementation |
| 4. Environmental measures | Avoid dust, fumes, irritants |
| 5. Hydration | Adequate fluid intake |
| 6. Treat infection | Targeted antibiotics/antifungals if infectious cause confirmed |
Surgical Treatment (if indicated):
- Microlaryngoscopy + biopsy - to confirm diagnosis and rule out malignancy
- For Reinke's edema (a form of chronic laryngitis): surgical aspiration of fluid + trimming of excess mucosa (Hirano technique) via incision over superior vocal cord surface
REINKE'S EDEMA (Special form of Chronic Laryngitis)
| Feature | Detail |
|---|
| What it is | Chronic edema in Reinke's space (between vocal ligament and overlying mucosa) |
| Appearance | Both cords uniformly, diffusely swollen, bulbous; normal mobility |
| Affects | Middle-aged females preferentially |
| Causes | Smoking + voice abuse |
| Symptom | Dysphonia + lowered pitch of voice (classic "deep gravelly voice") |
| Surgery | Incision on superior aspect of vocal cord, aspiration of fluid, trim excess mucosa (cold technique or CO2 laser) |
| Combined treatment | Surgery + stop smoking + voice therapy |
Quick Comparison Table
| Feature | Acute Laryngitis | Chronic Laryngitis |
|---|
| Duration | < 2-3 weeks | > 3 weeks |
| Most common cause | Viral URI | Smoking, LPR, voice abuse |
| Main symptom | Sudden hoarseness | Persistent dysphonia |
| Histology | Edema, acute infiltrate | Squamous metaplasia, chronic infiltrate |
| Malignancy risk | None | Yes (monitor closely) |
| Treatment | Vocal rest + supportive | Address all causative factors |
| Antibiotics | Only if bacterial suspected | Targeted to specific organism |
| Surgery | Rarely needed | Microlaryngoscopy if malignancy suspected |
Sources: Scott-Brown's Otorhinolaryngology (Ch. 10), Cummings Otolaryngology (Ch. 61), KJ Lee's Essential Otolaryngology (p. 919)