Create a comprehensive, structured Global Drug & Medicine Reference Database for educational and professional reference. GOAL: Build an extensive database covering medicines used in human healthcare across major therapeutic areas and diseases worldwide. Organize medicines by therapeutic class, pharmacological class, drug group, generic name, dosage form, indication, and manufacturer/brand information. IMPORTANT: Do NOT claim that the database contains literally every medicine ever made. Include medicines that are approved/recognized in major countries and clearly state the country/region and approval status when relevant. Drug information changes over time, so use the most current reliable sources available. FOR EACH DISEASE/CONDITION, PROVIDE: 1. Disease/condition name 2. Therapeutic area 3. First-line treatment options where established 4. Drug class/group 5. Pharmacological subclass 6. Generic/INN name 7. Common brand/trade names 8. Manufacturer/company 9. Country/market where the brand is available 10. Dosage form (tablet, capsule, injection, syrup, cream, inhaler, etc.) 11. Common strengths 12. Route of administration 13. Basic mechanism of action (MOA) 14. Main therapeutic uses 15. Important adverse effects 16. Major contraindications/warnings 17. Important drug interactions 18. Prescription/OTC status where applicable 19. Special populations/cautions (children, pregnancy, elderly, renal/hepatic impairment) when relevant 20. Whether the medicine is generic, branded, biosimilar, vaccine, biologic, or other category 21. Reliable references/sources and the date checked ORGANIZE THE DATABASE INTO MAJOR THERAPEUTIC AREAS: A. Cardiovascular system - Hypertension - Heart failure - Angina - Arrhythmias - Hyperlipidemia - Thrombosis - Anticoagulants - Antiplatelets - Fibrinolytics - Peripheral vascular diseases B. Endocrine & metabolic diseases - Diabetes mellitus - Thyroid disorders - Adrenal disorders - Osteoporosis - Obesity - Gout - Electrolyte disorders C. CNS & psychiatric disorders - Epilepsy - Parkinson's disease - Alzheimer's disease - Migraine - Depression - Anxiety disorders - Psychotic disorders - Sleep disorders - ADHD - Multiple sclerosis D. Respiratory diseases - Asthma - COPD - Allergic respiratory diseases - Cough - Respiratory infections E. Gastrointestinal diseases - GERD - Peptic ulcer disease - Nausea/vomiting - Diarrhea - Constipation - Inflammatory bowel disease - Liver diseases F. Anti-infective drugs - Antibacterial drugs - Antiviral drugs - Antifungal drugs - Antiprotozoal drugs - Anthelmintics - Antitubercular drugs - Antimalarial drugs - Antiretroviral drugs G. Oncology - Alkylating agents - Antimetabolites - Antitumor antibiotics - Plant-derived anticancer drugs - Hormonal anticancer drugs - Targeted therapies - Immunotherapies - Supportive cancer medicines H. Musculoskeletal & rheumatology - NSAIDs - DMARDs - Corticosteroids - Rheumatoid arthritis - Osteoarthritis - Muscle relaxants - Osteoporosis I. Dermatology - Acne - Eczema - Psoriasis - Fungal skin infections - Bacterial skin infections - Viral skin infections - Scabies - Hair disorders J. Allergy & immunology - H1 antihistamines - H2 antihistamines - Leukotriene modifiers - Immunosuppressants - Biologic therapies K. Hematology - Hematinics - Anticoagulants - Antiplatelets - Fibrinolytics - Hemostatics - Drugs affecting red/white blood cells L. Ophthalmology - Glaucoma - Dry eye - Eye infections - Allergic eye diseases - Anti-inflammatory ophthalmic drugs M. ENT - Rhinitis - Sinusitis - Otitis - Vertigo N. Obstetrics & gynecology - Contraceptives - Fertility medicines - Menstrual disorders - Menopause - Pregnancy-related medicines O. Urology/nephrology - Diuretics - Urinary tract disorders - Benign prostatic hyperplasia - Erectile dysfunction - Kidney diseases P. Anesthesia & pain management - Local anesthetics - General anesthetics - Analgesics - Opioids - Adjuvant analgesics Q. Emergency & critical care - Shock - Anaphylaxis - Cardiac arrest - Acute poisoning - Emergency cardiovascular medicines R. Vaccines & immunological products - Vaccines by disease - Immunoglobulins - Monoclonal antibodies - Other biologics ALSO INCLUDE: 1. A complete classification of major drug classes. 2. Important examples for every class. 3. Generic name vs brand name. 4. Major pharmaceutical companies/manufacturers. 5. Separate international generic names from country-specific brand names. 6. Include Indian brands/manufacturers separately when Indian information is requested. 7. Mention when the same generic drug is sold under multiple brand names. 8. Avoid treating a brand name as a different active drug when the active ingredient is identical. 9. Distinguish combination products from single-ingredient products. 10. Identify discontinued, withdrawn, investigational, or country-restricted medicines where reliable evidence exists. DATABASE FORMAT: Use tables wherever practical: | Disease | Drug Class | Generic Drug | Brand Name | Manufacturer | Dosage Form | Main Use | MOA | Important Adverse Effects | For each major drug class, additionally provide: CLASS → SUBCLASS → GENERIC DRUGS → COMMON BRANDS → MANUFACTURERS → MAIN USES → MOA → IMPORTANT SAFETY INFORMATION SOURCE REQUIREMENTS: Use authoritative and current sources such as: - WHO - FDA - EMA - MHRA - CDSCO - National formularies - Official product labels - Official regulatory databases - Recognized pharmacopoeias - Peer-reviewed medical/pharmacology literature For manufacturer and brand information, prioritize official manufacturer/regulatory sources rather than unreliable medicine-selling websites. SAFETY: This database is for education and reference, NOT personal prescribing. Never tell a person which medicine they personally should take, change, stop, or combine based only on symptoms. Do not provide individualized prescriptions or dosages without appropriate clinical context. Clearly distinguish educational information from medical advice. When information differs between countries, explicitly label the country/region. When information cannot be verified, write: "Not reliably verified — do not assume." Keep the database organized, searchable, and expandable. If the complete database is too large for one response, divide it into logical sections and continue systematically without omitting major therapeutic areas.