You are a medical pharmacology expert. Search the medical textbook library database and retrieve comprehensive content on the following 4 topics. Use query_library_db with FTS searches, then read_file to get full content. TOPICS TO RESEARCH: 1. **5-HT (Serotonin) receptor agonists and antagonists** - classification of 5-HT receptors, agonists (with examples and therapeutic uses), antagonists (with examples and therapeutic uses) 2. **Drug therapy of migraine including prophylaxis** - acute/abortive treatment (triptans, ergotamine, NSAIDs, etc.) and prophylactic treatment (beta-blockers, valproate, topiramate, amitriptyline, etc.) 3. **Prostaglandin analogues** - classification, pharmacological actions, therapeutic uses, adverse effects, contraindications 4. **Leukotrienes and leukotriene antagonists** - role of leukotrienes, leukotriene receptor antagonists (montelukast, zafirlukast), 5-lipoxygenase inhibitors (zileuton), therapeutic uses SEARCH STRATEGY: - Use headings_fts to find relevant sections - Use paragraphs_fts for specific drug details - Read actual file content using read_file with appropriate offsets - Search queries to try: '5-HT receptor', 'serotonin receptor agonist', 'migraine treatment', 'triptans', 'prostaglandin analogue', 'leukotriene antagonist', 'montelukast' For each topic, provide: - Full classification - Mechanisms of action - Specific drug examples with doses where available - Therapeutic uses - Adverse effects - Any contraindications Return a detailed, structured report covering all 4 topics with as much pharmacological detail as possible from the textbooks.

You are a medical pharmacology expert. Search the medical textbook library database and retrieve comprehensive content on the following 4 topics. Use query_library_db with FTS searches, then read_file to get full content. TOPICS TO RESEARCH: 1. **Aspirin pharmacology** - mechanism of action, pharmacological actions, therapeutic uses, adverse effects, contraindications, aspirin poisoning (salicylate toxicity) and treatment 2. **Paracetamol (acetaminophen) pharmacology** - mechanism of action (including recent understanding), adverse effects, acute poisoning (hepatotoxicity), treatment of paracetamol overdose (N-acetylcysteine), clinical uses 3. **Rheumatoid Arthritis pharmacological management** - DMARDs (methotrexate, hydroxychloroquine, sulfasalazine, leflunomide), biologics (TNF inhibitors, IL-6 inhibitors, B-cell depletion, T-cell costimulation blockers), NSAIDs, corticosteroids, step-up therapy 4. **Drugs used in gout** - classification, management of acute gout (NSAIDs, colchicine, corticosteroids), management of chronic/interval gout (allopurinol, febuxostat, probenecid, benzbromarone), uricosuric drugs, xanthine oxidase inhibitors SEARCH STRATEGY: - Use headings_fts to find relevant sections - Use paragraphs_fts for specific drug details - Read actual file content using read_file with appropriate offsets - Search queries to try: 'aspirin mechanism', 'salicylate poisoning', 'paracetamol acetaminophen toxicity', 'rheumatoid arthritis DMARD', 'gout colchicine allopurinol', 'methotrexate rheumatoid' For each topic, provide: - Full classification where applicable - Mechanisms of action - Specific drug examples with doses where available - Therapeutic uses - Adverse effects - Contraindications - Poisoning/overdose management where applicable Return a detailed, structured report covering all 4 topics with as much pharmacological detail as possible from the textbooks.