Pharmacology comprehensive notes on Autocoids pptx

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Autocoids Pharmacology Notes

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#	Section	Slides
Title & Contents	Overview of all 10 modules	2 slides
01	Introduction to Autocoids	2
02	Histamine – synthesis, receptor table (H1-H4), organ effects	4
03	Antihistamines – 1st gen, 2nd gen, comparison two-column layout, H2 blockers	4
04	Serotonin – synthesis, full receptor classification table, agonists, antagonists	4
05	Eicosanoids – AA pathway, prostaglandins/TXA2, leukotrienes/lipoxins, NSAIDs & COX	4
06	Kinins – bradykinin synthesis, B1/B2 receptors, HAE, ACE inhibitor connection	2
07	Neuropeptides – Substance P/NK1, CGRP/gepants/anti-CGRP MAbs, PAF, adenosine	2
08	Clinical Summary – drug-receptor reference table (15 drugs), exam high-yields, disease chart	3
Closing	Thank You	1

Key exam highlights covered:

H1/H2/H3/H4 receptor coupling & locations
1st vs 2nd generation antihistamines (50% vs 7% sedation)
Triptan mechanism & contraindications; lasmiditan (CV-safe 5-HT1F)
Serotonin syndrome recognition & management
COX-1 vs COX-2 (constitutive vs inducible); aspirin irreversible COX-1 acetylation
ACE inhibitor cough = bradykinin accumulation (not renin)
HAE = bradykinin-mediated (antihistamines ineffective - icatibant is the treatment)
CysLTs as SRS-A; montelukast in aspirin-exacerbated asthma

Source: Katzung's Basic & Clinical Pharmacology, 16th Edition

Amine derived autocoids , peptide and lipids derived??

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