I now have comprehensive material from multiple anesthesia textbooks. Let me compile the complete, PG-level answer.
Brachial Plexus Block - Complete Guide for Anesthesia PG
1. Anatomy of the Brachial Plexus
The brachial plexus is formed by the ventral rami (anterior primary divisions) of C5, C6, C7, C8, and T1. Minor contributions from C4 and T2 may occur. The organization follows the mnemonic RTDCB: Roots → Trunks → Divisions → Cords → Branches (terminal nerves).
Organization
| Level | Components | Location |
|---|
| Roots | C5, C6, C7, C8, T1 | Exit intervertebral foramina |
| Trunks | Superior (C5+C6), Middle (C7), Inferior (C8+T1) | Between anterior & middle scalene muscles |
| Divisions | Anterior & posterior from each trunk (6 total) | Over lateral border of 1st rib, under clavicle |
| Cords | Lateral, Medial, Posterior | Named relative to axillary artery; below clavicle |
| Terminal nerves | Median, Ulnar, Radial, Musculocutaneous, Axillary | Lateral border of pectoralis minor |
Cord-to-Terminal Nerve Formation
- Lateral cord → lateral head of median nerve + musculocutaneous nerve
- Medial cord → medial head of median nerve + ulnar nerve + medial brachial cutaneous + medial antebrachial cutaneous nerves
- Posterior cord → axillary nerve + radial nerve
Brachial plexus organization showing roots C4-T1, upper/middle/lower trunks, cords, and the interscalene location - Morgan & Mikhail's Clinical Anesthesiology, 7e
Pre-terminal Branches (Important - often missed)
- Dorsal scapular nerve (C5) - rhomboids
- Long thoracic nerve (C5, C6, C7) - serratus anterior
- Suprascapular nerve (C5, C6) - supraspinatus, infraspinatus, glenohumeral joint - branches from upper trunk, must be blocked for complete shoulder analgesia
- Nerve to subclavius (C5, C6)
Nerve Sensory Distribution
Cutaneous nerve distribution of the upper limb - anterior (palmar) and posterior (dorsal) views - Morgan & Mikhail's Clinical Anesthesiology, 7e
2. Approaches to Brachial Plexus Block
The key principle is: where you inject determines what you block. Proximal blocks intercept roots/trunks (shoulder and above). Distal blocks intercept cords/terminal nerves (elbow and below).
| Approach | Anatomical Level Targeted | Surgical Indication |
|---|
| Interscalene | Roots / upper & middle trunks | Shoulder, proximal humerus |
| Supraclavicular | Distal trunks / proximal divisions | Elbow, forearm, hand ("spinal of the arm") |
| Infraclavicular | Cords | Elbow, forearm, hand; best for catheters |
| Axillary | Terminal nerves | Hand, wrist, forearm distal to elbow |
3. Interscalene Block
Anatomy
The brachial plexus trunks lie between the anterior scalene and middle scalene muscles in the neck, visualized at the C6 level. The phrenic nerve (C3-C5) lies directly on the anterior scalene muscle just medial to the interscalene groove.
Indication
Shoulder surgery, proximal humerus fractures, AC joint procedures. Not suitable for hand/wrist surgery because C8-T1 (inferior trunk, ulnar distribution) is frequently spared.
US-Guided Technique
- Patient supine, head turned 30-45° away from the side to be blocked
- High-frequency linear probe placed at the level of the cricoid cartilage (C6)
- Trace the plexus cephalad from a supraclavicular view until the trunks appear as hypoechoic structures between the scalene muscles - the "stoplight" sign (three trunks stacked vertically)
- In-plane or out-of-plane needle approach; out-of-plane avoids the long thoracic and dorsal scapular nerves inside the middle scalene
- Local anesthetic volume: 10-20 mL surrounds the trunks
Key Point for Shoulder Coverage
The supraclavicular nerve (C3-C4, from cervical plexus) covers the "cape" area of the shoulder. A separate cervical plexus block or subcutaneous infiltration along the clavicle is needed for complete shoulder anesthesia.
Complications
- Ipsilateral phrenic nerve block - near 100% incidence with conventional volumes; causes hemidiaphragmatic paralysis. Contraindicated in contralateral phrenic nerve palsy, severe COPD/restrictive disease (FEV1 or FVC <50%)
- Recurrent laryngeal nerve block (hoarseness)
- Horner syndrome (ptosis, miosis, anhidrosis)
- Cervical sympathetic chain block
- Vertebral artery injection (risk of CNS toxicity)
- Intrathecal/epidural injection
- Spinal cord injury with high-volume injection
4. Supraclavicular Block
Anatomy
At the lateral border of the first rib, all six divisions of the brachial plexus are compact in a space <1 cm, making this the most efficient location for complete upper extremity anesthesia. The subclavian artery lies medial/deep, the first rib is deep (bony backstop), and the pleura is just beyond the rib.
Indication
Operations on elbow, forearm, and hand. Sometimes called the "spinal of the arm" due to rapid onset and dense block.
Not ideal for: shoulder surgery (suprascapular nerve, which is a proximal branch of upper trunk, is not reliably blocked).
US-Guided Technique
- Patient supine, head turned 30° away
- High-frequency linear probe placed in the supraclavicular fossa, angled slightly toward thorax
- Subclavian artery identified as pulsatile structure; brachial plexus appears as "cluster of grapes" - multiple hypoechoic nodules, just superficial and posterolateral to the artery
- First rib is a hyperechoic line deep to the artery; pleura lies just beyond and moves with respiration
- Needle inserted posterolateral in-plane toward subclavian artery; aim for the "corner pocket" between artery, plexus, and first rib - this ensures inferior trunk (ulnar nerve distribution) is adequately blocked
- Local anesthetic: 20-30 mL, injected in multiple locations to encircle plexus
Supraclavicular US showing subclavian artery (red), divisions of the brachial plexus (yellow - SA/SP/MA/MP/IA/IP = superior/middle/inferior anterior and posterior divisions), first rib, and pleura - Morgan & Mikhail's, 7e
Complications
- Pneumothorax (most feared; risk ~0.5-1%, reduced but not eliminated by US)
- Phrenic nerve palsy (~50% incidence - less than interscalene but still significant)
- Subclavian artery puncture
- Horner syndrome
- Ulnar sparing (if "corner pocket" injection is missed)
5. Infraclavicular Block
Anatomy
Below the clavicle, the brachial plexus is now organized as three cords arranged around the axillary artery:
- Lateral cord - lateral/cephalad to artery
- Medial cord - medial/caudad to artery
- Posterior cord - posterior to artery
All three cords lie deep to the pectoralis major and pectoralis minor muscles. The subclavian artery becomes the axillary artery at the lateral border of the first rib.
Indication
Surgery at or distal to the elbow. Preferred approach for perineural catheter placement (superior to supraclavicular and axillary catheters due to muscle and fascial layers securing it).
US-Guided Technique
- Patient supine; arm abducted 90° (dramatically improves visualization)
- High-frequency linear or small curvilinear probe placed parasagittal, 2 cm medial and 2 cm caudad to coracoid process
- Axillary artery and vein seen in cross-section; cords appear as hyperechoic bundles:
- Lateral cord - cephalad to artery
- Medial cord - caudad to artery
- Posterior cord - posterior (deep) to artery
- A long (10-cm) needle inserted 1-3 cm cephalad to probe tip, angled steeply
- Optimal injection: between artery and posterior cord ("U" of local anesthetic wrapping around artery); a single 30-mL injection at this location is equivalent to individual cord injections
- Catheter tip placed posterior to artery for continuous infusion
Complications
- Vascular puncture (axillary artery or vein)
- Pneumothorax (less common than supraclavicular)
- Hematoma
- Contraindicated: ipsilateral subclavian vascular catheter, transvenous pacemaker
6. Axillary Block
Anatomy
At the lateral border of pectoralis minor, the cords have divided into terminal branches surrounding the axillary artery in fascial compartments:
- Median nerve - anterior/medial to artery
- Radial nerve - posterior to artery
- Ulnar nerve - medial to artery
- Musculocutaneous nerve - already departed and lies within the coracobrachialis muscle (must be separately targeted)
- Axillary nerve - already branched proximally (not blocked by axillary approach)
- Medial brachial & antebrachial cutaneous nerves - branch proximally (spared)
Because the nerves are separated by fascial compartments at this level, multiple injections are usually required.
Indication
Surgery on hand, wrist, and forearm distal to elbow. Most superficial and safe approach.
Not suitable for: arm tourniquet at the upper arm (intercostobrachial nerve, T2, is spared and must be blocked separately with subcutaneous infiltration along the axilla).
US-Guided Technique
- Patient supine, arm abducted 90°, elbow flexed, forearm externally rotated (supinated)
- High-frequency linear probe placed in axilla, perpendicular to arm
- Axillary artery pulsates in center; veins are compressible; nerves are hyperechoic
- Individual injections around each nerve (5-10 mL per nerve)
- Musculocutaneous nerve located as oval hyperechoic structure within coracobrachialis muscle - requires separate injection
- Total volume: 25-40 mL
Complications
- Axillary artery/vein puncture (most common; hematoma formation)
- Nerve injury
- Local anesthetic systemic toxicity (LAST) - highly vascular area
7. Phrenic Nerve-Sparing Approaches for Shoulder Surgery
Patients with significant pulmonary disease cannot tolerate interscalene block (phrenic nerve palsy). Alternatives:
- Superior trunk block - targets C5-C6 at the level where suprascapular nerve branches; 5-15 mL deep to omohyoid muscle; significantly less phrenic nerve involvement
- Anterior suprascapular nerve block - blocks the suprascapular nerve proximal to suprascapular notch; combined with infraclavicular block for complete shoulder coverage
8. Local Anesthetics Used
| Drug | Concentration | Duration | Onset |
|---|
| Ropivacaine | 0.375-0.5% (surgical), 0.2% (analgesia) | 8-12 h | Moderate |
| Bupivacaine | 0.25-0.5% | 8-16 h | Moderate |
| Lidocaine | 1-1.5% (±epi) | 2-4 h | Rapid |
| Mepivacaine | 1-1.5% | 4-6 h | Rapid |
Adding epinephrine (1:200,000) prolongs duration and serves as an intravascular injection marker. Dexamethasone 4-8 mg (IV or perineural) reliably extends block duration by 6-8 hours.
9. Contraindications (General)
- Patient refusal
- Local infection at injection site
- Severe coagulopathy (relative; varies by approach depth)
- True local anesthetic allergy
- Pre-existing severe neurological deficit (relative)
- Bilateral blocks (combined phrenic nerve palsy risk)
10. Complications Overview
| Complication | Most Common Approach |
|---|
| Phrenic nerve palsy | Interscalene (>95%), Supraclavicular (~50%) |
| Pneumothorax | Supraclavicular > Infraclavicular |
| Horner syndrome | Interscalene, Supraclavicular |
| Recurrent laryngeal nerve | Interscalene |
| Vascular puncture | Axillary, Infraclavicular |
| LAST | All (especially axillary - high vascularity) |
| Nerve injury | All approaches |
| Spinal/epidural injection | Interscalene |
Summary - "Which Block for Which Surgery?" (Exam Table)
| Surgery | Best Approach | Why |
|---|
| Shoulder arthroplasty / RCR | Interscalene | Targets C5-C6 roots + upper trunk |
| Clavicle ORIF | Interscalene + cervical plexus | Supraclavicular nerve (C3-C4) supplementation needed |
| Shoulder (high-risk lung) | Superior trunk / suprascapular + infraclavicular | Phrenic-sparing |
| Elbow / forearm | Supraclavicular or infraclavicular | Dense block at division/cord level |
| Wrist / hand | Infraclavicular or axillary | Cord / terminal nerve level |
| Catheter for prolonged analgesia | Infraclavicular | Best catheter stability |
| Pediatric or obese arm | Axillary | Superficial, safe |
Sources: Miller's Anesthesia 10e, Morgan & Mikhail's Clinical Anesthesiology 7e, Barash Clinical Anesthesia 9e