mkdir -p /home/daytona/workspace/lung-nonresp-ppt && ls /home/daytona/workspace/…

~/lung-nonresp-ppt/create_ppt.js

const pptxgen = require("pptxgenjs");

let pres = new pptxgen();
pres.layout = 'LAYOUT_16x9';
pres.title = 'Non-Respiratory Functions of the Lungs';

// ─── COLOR PALETTE ────────────────────────────────────────────────
const BG_DARK    = "0D2B45";   // deep navy — title, section covers
const BG_LIGHT   = "F0F6FC";   // pale blue — content slides
const ACCENT     = "1B8FD8";   // mid-blue
const ACCENT2    = "E8A020";   // amber — icons/highlights
const WHITE      = "FFFFFF";
const DARK_TEXT  = "0D2B45";
const BODY_TEXT  = "1A3550";
const DIVIDER    = "1B8FD8";

// ─── HELPERS ──────────────────────────────────────────────────────
function addTitleSlide(pres, title, subtitle) {
  let slide = pres.addSlide();
  // Background
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:5.625, fill:{color: BG_DARK} });
  // Decorative accent bar
  slide.addShape(pres.ShapeType.rect, { x:0, y:4.4, w:10, h:0.18, fill:{color: ACCENT2} });
  // Blue vertical stripe left
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:0.22, h:5.625, fill:{color: ACCENT} });
  // Title
  slide.addText(title, {
    x:0.45, y:1.5, w:9.1, h:1.5,
    fontSize:40, bold:true, color:WHITE,
    fontFace:"Calibri", align:"center", valign:"middle", margin:0
  });
  // Subtitle
  slide.addText(subtitle, {
    x:0.45, y:3.2, w:9.1, h:0.8,
    fontSize:20, color:"B8D4F0",
    fontFace:"Calibri", align:"center", valign:"middle", margin:0
  });
  // Bottom caption
  slide.addText("Medical Physiology | Morgan & Mikhail's Clinical Anesthesiology", {
    x:0.45, y:4.9, w:9.1, h:0.5,
    fontSize:11, color:"7AAFD4",
    fontFace:"Calibri", align:"center", valign:"middle", margin:0
  });
  return slide;
}

function addSectionDivider(pres, sectionNum, sectionTitle, tagline) {
  let slide = pres.addSlide();
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:5.625, fill:{color: BG_DARK} });
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:0.5, h:5.625, fill:{color: ACCENT} });
  slide.addShape(pres.ShapeType.rect, { x:0.5, y:2.6, w:9.5, h:0.06, fill:{color: ACCENT2} });
  slide.addText(`0${sectionNum}`, {
    x:0.7, y:0.4, w:2, h:1.2,
    fontSize:64, bold:true, color:ACCENT2,
    fontFace:"Calibri", margin:0
  });
  slide.addText(sectionTitle, {
    x:0.7, y:1.7, w:8.8, h:1.1,
    fontSize:32, bold:true, color:WHITE,
    fontFace:"Calibri", margin:0
  });
  slide.addText(tagline, {
    x:0.7, y:3.0, w:8.8, h:0.8,
    fontSize:17, color:"A0C8E8",
    fontFace:"Calibri", margin:0
  });
  return slide;
}

function addContentSlide(pres, title, bullets, footnote) {
  let slide = pres.addSlide();
  // Light background
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:5.625, fill:{color: BG_LIGHT} });
  // Top bar
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:0.9, fill:{color: BG_DARK} });
  // Accent underline for title
  slide.addShape(pres.ShapeType.rect, { x:0, y:0.9, w:10, h:0.07, fill:{color: ACCENT2} });
  // Title
  slide.addText(title, {
    x:0.4, y:0.08, w:9.2, h:0.74,
    fontSize:22, bold:true, color:WHITE,
    fontFace:"Calibri", valign:"middle", margin:0
  });
  // Bullet list
  let bulletItems = bullets.map((b, i) => {
    if (b.startsWith("  ")) {
      return { text: b.trim(), options: { bullet:{indent:30}, breakLine: true, fontSize:16, color:BODY_TEXT, indentLevel:1 } };
    }
    return { text: b, options: { bullet:{indent:20}, breakLine: true, fontSize:17, color:DARK_TEXT, bold: false } };
  });
  // Remove breakLine from last item
  bulletItems[bulletItems.length-1].options.breakLine = false;

  slide.addText(bulletItems, {
    x:0.45, y:1.1, w:9.1, h:4.1,
    fontFace:"Calibri", valign:"top", margin:4
  });
  if (footnote) {
    slide.addText(footnote, {
      x:0.4, y:5.2, w:9.2, h:0.38,
      fontSize:10, color:"5580A0", fontFace:"Calibri", italic:true, margin:0
    });
  }
  return slide;
}

function addTwoColumnSlide(pres, title, leftTitle, leftPoints, rightTitle, rightPoints, footnote) {
  let slide = pres.addSlide();
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:5.625, fill:{color: BG_LIGHT} });
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:0.9, fill:{color: BG_DARK} });
  slide.addShape(pres.ShapeType.rect, { x:0, y:0.9, w:10, h:0.07, fill:{color: ACCENT2} });
  slide.addText(title, {
    x:0.4, y:0.08, w:9.2, h:0.74,
    fontSize:22, bold:true, color:WHITE,
    fontFace:"Calibri", valign:"middle", margin:0
  });
  // Left column header
  slide.addShape(pres.ShapeType.rect, { x:0.3, y:1.05, w:4.35, h:0.42, fill:{color: ACCENT}, line:{color:ACCENT} });
  slide.addText(leftTitle, {
    x:0.3, y:1.05, w:4.35, h:0.42,
    fontSize:15, bold:true, color:WHITE, align:"center", fontFace:"Calibri", margin:0
  });
  // Right column header
  slide.addShape(pres.ShapeType.rect, { x:5.0, y:1.05, w:4.4, h:0.42, fill:{color: ACCENT2}, line:{color:ACCENT2} });
  slide.addText(rightTitle, {
    x:5.0, y:1.05, w:4.4, h:0.42,
    fontSize:15, bold:true, color:WHITE, align:"center", fontFace:"Calibri", margin:0
  });
  // Left bullets
  let lbullets = leftPoints.map(b => ({ text: b, options: { bullet:true, breakLine:true, fontSize:15, color:DARK_TEXT } }));
  lbullets[lbullets.length-1].options.breakLine = false;
  slide.addText(lbullets, { x:0.3, y:1.55, w:4.35, h:3.7, fontFace:"Calibri", valign:"top", margin:4 });
  // Right bullets
  let rbullets = rightPoints.map(b => ({ text: b, options: { bullet:true, breakLine:true, fontSize:15, color:DARK_TEXT } }));
  rbullets[rbullets.length-1].options.breakLine = false;
  slide.addText(rbullets, { x:5.0, y:1.55, w:4.4, h:3.7, fontFace:"Calibri", valign:"top", margin:4 });
  // Divider
  slide.addShape(pres.ShapeType.rect, { x:4.78, y:1.05, w:0.06, h:4.2, fill:{color: DIVIDER} });
  if (footnote) {
    slide.addText(footnote, { x:0.4, y:5.2, w:9.2, h:0.38, fontSize:10, color:"5580A0", fontFace:"Calibri", italic:true, margin:0 });
  }
  return slide;
}

function addSummarySlide(pres, functions) {
  let slide = pres.addSlide();
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:5.625, fill:{color: BG_DARK} });
  slide.addShape(pres.ShapeType.rect, { x:0, y:0.9, w:10, h:0.07, fill:{color: ACCENT2} });
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:0.9, fill:{color:"0A2035"} });
  slide.addText("Summary: Non-Respiratory Functions", {
    x:0.4, y:0.08, w:9.2, h:0.74,
    fontSize:22, bold:true, color:WHITE,
    fontFace:"Calibri", valign:"middle", margin:0
  });
  // Draw boxes for each function
  const cols = 3;
  const boxW = 2.9, boxH = 1.5;
  const startX = 0.3, startY = 1.1, gapX = 0.22, gapY = 0.22;
  const colors = [ACCENT, "1E7BC4", ACCENT2, "D08818", "2A9D8F", "E76F51"];
  functions.forEach((fn, i) => {
    const col = i % cols;
    const row = Math.floor(i / cols);
    const x = startX + col*(boxW + gapX);
    const y = startY + row*(boxH + gapY);
    slide.addShape(pres.ShapeType.rect, { x, y, w:boxW, h:boxH, fill:{color: colors[i % colors.length]}, line:{color:WHITE, pt:1}, rounding:"8" });
    slide.addText([
      { text: fn.icon + "  ", options: { fontSize:22, color:WHITE, bold:true } },
      { text: fn.title, options: { fontSize:18, color:WHITE, bold:true, breakLine:true } },
      { text: fn.desc, options: { fontSize:12, color:"E0EEF8" } }
    ], { x, y, w:boxW, h:boxH, fontFace:"Calibri", align:"center", valign:"middle", margin:8 });
  });
  return slide;
}

// ════════════════════════════════════════════════════════════════════
// SLIDES
// ════════════════════════════════════════════════════════════════════

// 1. TITLE
addTitleSlide(pres,
  "Non-Respiratory Functions\nof the Lungs",
  "Beyond Gas Exchange — The Metabolic, Haematological & Protective Roles of the Pulmonary System"
);

// 2. OVERVIEW
addContentSlide(pres, "Overview — Why Lungs Do More Than Breathe", [
  "The lungs receive the entire cardiac output — ~5 L/min",
  "This unique position makes them ideal for:",
  "  Filtering blood before it reaches the systemic circulation",
  "  Metabolising and activating circulating substances",
  "  Serving as a blood reservoir for the left ventricle",
  "  Providing immunological and mucociliary defence",
  "  Synthesising surfactant and other lipid mediators",
  "Non-respiratory functions are clinically relevant in anaesthesia, ICU, and cardiology"
], "Source: Medical Physiology (Boron & Boulpaep); Morgan & Mikhail's Clinical Anesthesiology");

// 3. SECTION — FILTRATION
addSectionDivider(pres, 1, "Filtration of Blood", "Trapping emboli before they reach the systemic circulation");

// 4. FILTRATION content
addContentSlide(pres, "01 — Filtration of the Blood", [
  "The pulmonary capillaries are in-series with the entire venous return",
  "They trap microscopic emboli — clots, fat globules, air bubbles — from mixed-venous blood",
  "If emboli reached the systemic side, they could occlude end-arteries → infarction",
  "High heparin & plasminogen activator content in lungs aids fibrin breakdown",
  "Most small, trapped emboli are lysed locally without clinical consequence",
  "Clinical relevance: Fat embolism after long-bone fractures; paradoxical embolism via PFO",
  "Average pulmonary capillary diameter ~7 µm; larger macroglobules can still pass through"
], "Source: Morgan & Mikhail's Clinical Anesthesiology, p.977; Medical Physiology (Boron & Boulpaep)");

// 5. SECTION — RESERVOIR
addSectionDivider(pres, 2, "Blood Reservoir Function", "Buffering left ventricular filling");

// 6. RESERVOIR content
addContentSlide(pres, "02 — Blood Reservoir for the Left Ventricle", [
  "Pulmonary vessels are highly compliant and contain ~440 mL of blood in an adult",
  "Act as an immediate reserve tank for the left ventricle",
  "If pulmonary artery inflow is suddenly interrupted (experimental clamp), LV can still eject ~2 beats",
  "Compliance allows the pulmonary bed to accommodate large swings in cardiac output",
  "During exercise, recruitment & dilation of pulmonary vessels handles 3–4× resting flow",
  "Clinically important in:",
  "  Hypovolaemia — autotransfusion from pulmonary circulation helps maintain BP",
  "  Heart failure — pulmonary congestion when reservoir overloads"
], "Source: Medical Physiology (Boron & Boulpaep), Block 7");

// 7. SECTION — METABOLISM
addSectionDivider(pres, 3, "Metabolic & Biochemical Functions", "The lung as an endocrine and pharmacological organ");

// 8. ACE / Angiotensin
addContentSlide(pres, "03 — Activation of Angiotensin II (RAAS)", [
  "Angiotensin I (decapeptide) is relatively inactive",
  "Angiotensin-converting enzyme (ACE) is bound to the luminal surface of pulmonary endothelium",
  "ACE cleaves 2 amino acids → Angiotensin II (octapeptide) — potent vasoconstrictor & aldosterone stimulus",
  "~80% of Ang I is converted to Ang II in a single pass through the lungs",
  "Pharmacological importance: ACE inhibitors (e.g. enalapril, ramipril) block this reaction → antihypertensive effect",
  "Ang II also promotes sodium & water retention via aldosterone → blood pressure regulation",
  "The lung is the dominant site for Ang I → II conversion in the body"
], "Source: Morgan & Mikhail's Clinical Anesthesiology, p.978; Medical Physiology");

// 9. Inactivation of vasoactive substances
addContentSlide(pres, "03 — Inactivation of Vasoactive Substances", [
  "The pulmonary endothelium actively metabolises circulating vasoactive compounds:",
  "  Norepinephrine — up to 30% inactivated per pass",
  "  Serotonin (5-HT) — almost completely removed by monoamine oxidase in pulmonary endothelium",
  "  Bradykinin — inactivated by ACE (same enzyme that activates Ang I → II)",
  "  Prostaglandins E2, F2α — enzymatic degradation in the lung",
  "  Leukotrienes — partially metabolised by the pulmonary vasculature",
  "NOT metabolised by the lung: Epinephrine, prostacyclin (PGI2), histamine",
  "Histamine can be synthesised & released in the lung during allergic/anaphylactic reactions"
], "Source: Morgan & Mikhail's Clinical Anesthesiology, p.978; Medical Physiology");

// 10. Surfactant synthesis
addContentSlide(pres, "03 — Surfactant Synthesis", [
  "Synthesised by Type II pneumocytes (alveolar epithelial cells)",
  "Composition: ~90% lipids (mainly dipalmitoylphosphatidylcholine, DPPC) + 10% proteins (SP-A, SP-B, SP-C, SP-D)",
  "Function: Reduces alveolar surface tension → prevents collapse (atelectasis) at end-expiration",
  "LaPlace's Law: P = 2T/r — without surfactant, small alveoli would empty into large ones",
  "Surfactant also:",
  "  Contributes to host defence (SP-A, SP-D are opsonins — innate immunity)",
  "  Regulates alveolar fluid balance",
  "Deficiency states:",
  "  Neonatal Respiratory Distress Syndrome (NRDS) — premature infants, lack of mature surfactant",
  "  ARDS — surfactant destruction by inflammatory mediators"
], "Source: Medical Physiology; Fishman's Pulmonary Diseases");

// 11. SECTION — DEFENCE
addSectionDivider(pres, 4, "Immunological & Mucociliary Defence", "The lung as a front-line barrier against inhaled threats");

// 12. Mucociliary clearance
addTwoColumnSlide(pres,
  "04 — Mucociliary & Physical Defence",
  "Particle Filtration (Upper Airway)",
  [
    "Nasal hairs filter particles >15 µm",
    "Turbulence + irregular nasal topography traps >10 µm particles in mucus",
    "Right-angle turn at nasopharynx: large particles impact lymphoid tissue (Waldeyer's ring) → immune surveillance",
    "Nose breathing far more efficient than mouth breathing"
  ],
  "Mucociliary Escalator (Lower Airway)",
  [
    "Ciliated epithelium moves mucus layer upward at ~1 mm/min",
    "Particles 2–10 µm trapped by inertial impaction or gravity sedimentation",
    "Particles <0.5 µm reach alveoli as aerosols; ~80% exhaled",
    "Coughing & sneezing accelerate debris clearance",
    "Goblet cells & submucosal glands secrete mucus (IgA-rich)"
  ],
  "Source: Medical Physiology (Boron & Boulpaep)"
);

// 13. Alveolar defence
addContentSlide(pres, "04 — Alveolar Defence Mechanisms", [
  "Alveolar macrophages (AM) are the primary cellular defence at alveolar level",
  "AMs phagocytose particles, bacteria, fungi, and cellular debris",
  "Interstitial macrophages patrol the lung interstitium",
  "Enzymatic degradation — proteases, oxidases destroy organic material",
  "Lymphatic drainage carries particles & antigens to hilar nodes",
  "Neutrophils & macrophages produce reactive oxygen species (O2-derived free radicals) in response to infection",
  "Secretory IgA in airway mucus — first-line humoral defence",
  "Dendritic cells sample inhaled antigens → adaptive immune response"
], "Source: Medical Physiology; Morgan & Mikhail's Clinical Anesthesiology");

// 14. SECTION — OTHER
addSectionDivider(pres, 5, "Other Functions", "Drug metabolism, acid–base & vocal phonation");

// 15. Other functions
addTwoColumnSlide(pres,
  "05 — Additional Non-Respiratory Functions",
  "Drug & Xenobiotic Metabolism",
  [
    "Type II pneumocytes: significant extrahepatic mixed-function oxidase (CYP450) activity",
    "Nasal mucosa & lung important for first-pass metabolism of inhaled drugs",
    "Some drugs administered as aerosols exploit pulmonary absorption (e.g. inhaled insulin, β2 agonists)",
    "Lidocaine, fentanyl, propofol — partially sequestered by lung on first pass",
    "Lung is a major site of prostaglandin synthesis (PGI2 by endothelium)"
  ],
  "Acid–Base & Other Roles",
  [
    "Regulates arterial PCO2 via ventilation → controls blood pH (respiratory component of acid–base)",
    "Conversion of CO2 to H2CO3 via carbonic anhydrase in RBCs",
    "Phonation: exhaled air vibrates vocal cords → speech",
    "Thoracic bellows action aids venous return (respiratory pump)",
    "Olfaction — close anatomical link; inhaled air carries odorants to nasal epithelium",
    "Heat & water loss: ~300–400 mL water/day exhaled"
  ],
  "Source: Goodman & Gilman's Pharmacological Basis; Medical Physiology"
);

// 16. SUMMARY
addSummarySlide(pres, [
  { icon: "🔵", title: "Filtration",      desc: "Traps emboli from mixed-venous blood" },
  { icon: "🩸", title: "Reservoir",       desc: "~440 mL blood buffer for LV filling" },
  { icon: "⚗️",  title: "ACE / RAAS",     desc: "Ang I → Ang II conversion" },
  { icon: "🚫", title: "Inactivation",    desc: "NE, serotonin, bradykinin, PGs" },
  { icon: "🫧", title: "Surfactant",      desc: "Type II pneumocytes, DPPC, SP-A–D" },
  { icon: "🛡️", title: "Defence",        desc: "Mucociliary, AMs, IgA, dendritic cells" }
]);

// 17. CLOSING SLIDE
let closing = pres.addSlide();
closing.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:5.625, fill:{color: BG_DARK} });
closing.addShape(pres.ShapeType.rect, { x:0, y:4.4, w:10, h:0.18, fill:{color: ACCENT2} });
closing.addShape(pres.ShapeType.rect, { x:0, y:0, w:0.22, h:5.625, fill:{color: ACCENT} });
closing.addText("Thank You", {
  x:0.45, y:1.5, w:9.1, h:1.2,
  fontSize:44, bold:true, color:WHITE,
  fontFace:"Calibri", align:"center", margin:0
});
closing.addText("The lung — a metabolic, haematological and immunological organ\nas much as a respiratory one.", {
  x:0.45, y:2.9, w:9.1, h:1.0,
  fontSize:19, color:"A0C8E8",
  fontFace:"Calibri", align:"center", margin:0
});
closing.addText("References: Medical Physiology (Boron & Boulpaep) | Morgan & Mikhail's Clinical Anesthesiology 7e | Fishman's Pulmonary Diseases | Goodman & Gilman's Pharmacological Basis", {
  x:0.45, y:4.9, w:9.1, h:0.5,
  fontSize:10, color:"5580A0",
  fontFace:"Calibri", align:"center", margin:0
});

// ─── SAVE ────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/lung-nonresp-ppt/NonRespiratory_Functions_of_Lungs.pptx" })
  .then(() => console.log("DONE: /home/daytona/workspace/lung-nonresp-ppt/NonRespiratory_Functions_of_Lungs.pptx"))
  .catch(e => { console.error(e); process.exit(1); });

cd /home/daytona/workspace/lung-nonresp-ppt && node create_ppt.js

ls -lh /home/daytona/workspace/lung-nonresp-ppt/

~/lung-nonresp-ppt/create_ppt_fishman.js

const pptxgen = require("pptxgenjs");

let pres = new pptxgen();
pres.layout = 'LAYOUT_16x9';
pres.title = "Non-Respiratory Functions of the Lungs — Fishman's";

// ─── PALETTE (deep teal + gold accent) ──────────────────────────
const BG_DARK   = "0C2D3A";   // deep teal-navy
const BG_MID    = "134155";   // mid teal
const BG_LIGHT  = "EDF4F7";   // pale ice
const ACCENT    = "1A8C9E";   // teal
const ACCENT2   = "D4920A";   // gold
const WHITE     = "FFFFFF";
const BODY      = "0C2D3A";
const SUB       = "2A5F70";

// ─── HELPERS ────────────────────────────────────────────────────

function titleSlide(pres, title, subtitle, source) {
  let s = pres.addSlide();
  s.addShape(pres.ShapeType.rect, {x:0,y:0,w:10,h:5.625,fill:{color:BG_DARK}});
  // Top gold bar
  s.addShape(pres.ShapeType.rect, {x:0,y:0,w:10,h:0.12,fill:{color:ACCENT2}});
  // Bottom gold bar
  s.addShape(pres.ShapeType.rect, {x:0,y:5.505,w:10,h:0.12,fill:{color:ACCENT2}});
  // Decorative right side panel
  s.addShape(pres.ShapeType.rect, {x:7.8,y:0.12,w:2.2,h:5.385,fill:{color:BG_MID}});
  // Title
  s.addText(title, {
    x:0.5,y:1.3,w:7.0,h:1.8,
    fontSize:36,bold:true,color:WHITE,
    fontFace:"Calibri",valign:"middle",margin:0
  });
  // Subtitle
  s.addText(subtitle, {
    x:0.5,y:3.25,w:7.0,h:0.85,
    fontSize:18,color:"9ED4E0",
    fontFace:"Calibri",valign:"middle",margin:0
  });
  // Source badge
  s.addShape(pres.ShapeType.rect, {x:0.5,y:4.25,w:3.8,h:0.45,fill:{color:ACCENT},line:{color:ACCENT}});
  s.addText(source, {
    x:0.5,y:4.25,w:3.8,h:0.45,
    fontSize:13,color:WHITE,bold:true,align:"center",
    fontFace:"Calibri",valign:"middle",margin:0
  });
  return s;
}

function sectionSlide(pres, num, title, tagline) {
  let s = pres.addSlide();
  s.addShape(pres.ShapeType.rect, {x:0,y:0,w:10,h:5.625,fill:{color:BG_DARK}});
  s.addShape(pres.ShapeType.rect, {x:0,y:0,w:10,h:0.12,fill:{color:ACCENT2}});
  s.addShape(pres.ShapeType.rect, {x:0,y:5.505,w:10,h:0.12,fill:{color:ACCENT2}});
  // Big number
  s.addText(num, {
    x:0.5,y:0.5,w:2.0,h:1.8,
    fontSize:90,bold:true,color:ACCENT2,
    fontFace:"Calibri",margin:0
  });
  // Title
  s.addText(title, {
    x:0.5,y:2.3,w:9.0,h:1.1,
    fontSize:34,bold:true,color:WHITE,
    fontFace:"Calibri",margin:0
  });
  // Tagline
  s.addText(tagline, {
    x:0.5,y:3.5,w:9.0,h:0.8,
    fontSize:18,color:"8DCFDB",
    fontFace:"Calibri",margin:0
  });
  return s;
}

function contentSlide(pres, title, bullets, footnote) {
  let s = pres.addSlide();
  s.addShape(pres.ShapeType.rect, {x:0,y:0,w:10,h:5.625,fill:{color:BG_LIGHT}});
  // Header bar
  s.addShape(pres.ShapeType.rect, {x:0,y:0,w:10,h:1.0,fill:{color:BG_DARK}});
  // Gold accent line under header
  s.addShape(pres.ShapeType.rect, {x:0,y:1.0,w:10,h:0.07,fill:{color:ACCENT2}});
  s.addText(title, {
    x:0.45,y:0.1,w:9.1,h:0.8,
    fontSize:22,bold:true,color:WHITE,
    fontFace:"Calibri",valign:"middle",margin:0
  });
  // Bullet items
  let items = bullets.map(b => {
    const sub = b.startsWith("  ");
    return {
      text: b.trim(),
      options: {
        bullet: sub ? {indent:30} : {indent:18},
        breakLine: true,
        fontSize: sub ? 15 : 17,
        color: sub ? SUB : BODY,
        bold: false,
        indentLevel: sub ? 1 : 0
      }
    };
  });
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// ════════════════════════════════════════════════════════════════
// SLIDES
// ════════════════════════════════════════════════════════════════

// SLIDE 1 — TITLE
titleSlide(pres,
  "Non-Respiratory Functions\nof the Lungs",
  "Defence, Surfactant, Metabolic Activity, Filtration & Immunology",
  "Fishman's Pulmonary Diseases & Disorders, 2-Vol Set"
);

// SLIDE 2 — NOTE ON EGAN'S
contentSlide(pres, "Source Note — Egan's & Fishman's", [
  "Egan's Fundamentals of Respiratory Care (Stoller et al.) covers non-respiratory lung functions in Chapter 9 (\"The Lungs as a Metabolic Organ\"):",
  "  Key topics: filtration, vasoactive substance metabolism, ACE activation, eicosanoid synthesis, fluid/protein handling",
  "  Egan's perspective is clinician-focused for respiratory therapists",
  "Fishman's Pulmonary Diseases & Disorders (5e) covers the same physiology with deeper mechanistic and research-level detail:",
  "  Chapter 2: Structural aspects of lung defence",
  "  Chapter 5: Pulmonary surfactant & disorders",
  "  Chapter 6: Mucociliary clearance",
  "  Sections 3–4: Lung immunology, injury & repair",
  "This presentation is built from Fishman's textbook content available in the medical library",
  "All Fishman's content is cited by chapter and page"
], "Note: Egan's Fundamentals of Respiratory Care is not available in the institutional medical library. Content below draws on Fishman's equivalent chapters.");

// SLIDE 3 — OVERVIEW
contentSlide(pres, "Overview — Why the Lung Does More Than Exchange Gas", [
  "The lungs receive 100% of cardiac output (~5 L/min) — unique among all organs",
  "This positions the lungs to perform critical non-respiratory roles:",
  "  Act as a biological filter for the blood before it enters the systemic circulation",
  "  Metabolise, activate, and inactivate circulating vasoactive substances",
  "  Provide mechanical and immunological defence against inhaled pathogens & particles",
  "  Synthesise surfactant — essential for alveolar stability and host defence",
  "  Regulate mucociliary clearance of inhaled material",
  "  Serve as a site of eicosanoid and cytokine production",
  "Fishman's organises these into structural defence, surfactant physiology, and lung immunology"
], "Fishman's Pulmonary Diseases & Disorders — Overview (Sections 1–4)");

// SLIDE 4 — SECTION 1: DEFENCE
sectionSlide(pres, "01", "Structural Defence of the Lung", "Chapter 2 — Fishman's: The alveolar lining layer, macrophages, dendritic cells, mast cells");

// SLIDE 5 — Alveolar defence structure
contentSlide(pres, "01A — Alveolar Defence: The Primary Barrier (Fishman's Ch. 2)", [
  "The alveolar surface is vast and constantly challenged by inhaled microorganisms and particulate matter",
  "Primary defence barrier = the alveolar lining layer",
  "Alveolar macrophages (AMs) are sentinel phagocytic cells of the innate immune system",
  "The lining layer also contains antimicrobial proteins:",
  "  SP-A and SP-D — lung collectins; bind pathogens, enhance opsonisation",
  "  Lysozyme, lactoferrin — enzymatic bactericidal activity",
  "  Defensins and cathelicidins — antimicrobial peptides",
  "Second line: interstitial macrophages in connective tissue sleeves around acini",
  "  Found at junctions where lymphatics begin toward hilar lymph nodes",
  "  Replenished by blood monocytes; can become permanent storage cells for indigestible material (e.g. silicates, carbon)"
], "Fishman's Pulmonary Diseases & Disorders, Ch. 2, p. 47–50 (Structural Aspects of the Defense System)");

// SLIDE 6 — Dendritic cells, lymphocytes, mast cells
contentSlide(pres, "01B — Cellular Defence: Dendritic Cells, Lymphocytes & Mast Cells (Fishman's Ch. 2)", [
  "Dendritic cells (DCs):",
  "  Found in lung parenchyma and tracheal/bronchial epithelium — analogous to Langerhans cells in skin",
  "  Characterised by Birbeck granules (pentalaminar plate-like organelles)",
  "  Once activated, migrate to lymph nodes → stimulate antigen-specific T cells (link: innate to adaptive immunity)",
  "Lymphocytes: predominantly T cells; B cells and NK cells rare in normal lung",
  "Plasma cells around seromucous glands of bronchi → secrete antibodies (IgA) into mucus",
  "Mast cells:",
  "  Granules store heparin and histamine; contain tryptases, chymases, and lipid bodies",
  "  Site-specific heterogeneity depending on anatomical location",
  "Granulocytes (neutrophils, eosinophils, basophils) present but very rare in normal lung"
], "Fishman's Pulmonary Diseases & Disorders, Ch. 2, p. 47–52");

// SLIDE 7 — SECTION 2: MUCOCILIARY
sectionSlide(pres, "02", "Mucociliary Clearance", "Chapter 6 — Fishman's: The escalator mechanism that removes inhaled particles");

// SLIDE 8 — Mucociliary clearance
twoColSlide(pres,
  "02 — Mucociliary Clearance (Fishman's Ch. 6)",
  "The Mucus Blanket",
  [
    "Two-layer system: periciliary sol layer (low viscosity) + gel (mucus) layer on top",
    "Gel layer produced by goblet cells and submucosal glands",
    "Contains secretory IgA — humoral defence",
    "Traps particles by adhesion; properties change with hydration status",
    "Excessive or dehydrated mucus impairs clearance — key in CF, bronchiectasis"
  ],
  "Ciliary Action",
  [
    "Ciliated epithelium beats at ~10–15 Hz in coordinated metachronal waves",
    "Effective stroke propels mucus gel toward oropharynx",
    "Mucociliary transport rate ~1–20 mm/min (faster in central airways)",
    "Coughing and sneezing augment clearance when ciliary function is overwhelmed",
    "Dysfunction seen in: primary ciliary dyskinesia (Kartagener), smoking, viral infection, dry air"
  ],
  "Fishman's Pulmonary Diseases & Disorders, Ch. 6 (Mucociliary Clearance)"
);

// SLIDE 9 — SECTION 3: SURFACTANT
sectionSlide(pres, "03", "Pulmonary Surfactant Synthesis", "Chapter 5 — Fishman's: Surfactant as a non-respiratory metabolic product of the lung");

// SLIDE 10 — Surfactant composition
contentSlide(pres, "03A — Surfactant: Composition & Synthesis (Fishman's Ch. 5)", [
  "Surfactant is synthesised and secreted by alveolar Type II (AT2) cells into the alveoli",
  "Composition: 80–90% phospholipids + 10% proteins (SP-A, SP-B, SP-C, SP-D)",
  "Dominant lipid: dipalmitoylphosphatidylcholine (DPPC) — the active surface-tension reducer",
  "Forms: tubular myelin (most abundant, large aggregate) → multilayered phospholipid films at air-liquid interface",
  "Physical role: reduces alveolar surface tension to near zero → prevents collapse at end-expiration",
  "LaPlace: P = 2T/r — without surfactant, small alveoli collapse into large ones",
  "Small aggregate surfactant = remnant/catabolic form; taken up by AT2 cells or catabolised by AMs",
  "Lipofibroblasts (interstitial cells) may provide fatty acid substrate for AT2 cell surfactant synthesis"
], "Fishman's Pulmonary Diseases & Disorders, Ch. 5, p. 90–94 (Pulmonary Surfactant)");

// SLIDE 11 — Surfactant proteins in host defence
contentSlide(pres, "03B — Surfactant Proteins as Innate Immune Mediators (Fishman's Ch. 5)", [
  "SP-A (hydrophilic, 26 kDa glycoprotein, gene SFTPA1/2, chr. 10):",
  "  Binds and aggregates microbial pathogens → enhances opsonisation by AMs",
  "  Promotes mucociliary clearance of bacteria",
  "  Regulates surfactant pool size and extracellular lipid structure",
  "  SP-A knockout mice are highly susceptible to bacterial, viral, and fungal pathogens",
  "SP-D (collagenous Ca2+-dependent lectin, structurally related to SP-A):",
  "  Binds glycolipids/glycoproteins on pathogens (C-type lectin domain)",
  "  Modulates macrophage, neutrophil, and eosinophil function",
  "Both SP-A and SP-D interact with CD14, TLR2, LAIR-1, SPR-210 to regulate inflammation",
  "Clinical link: SFTPA mutations → pulmonary fibrosis (UIP pattern) + adenocarcinoma risk"
], "Fishman's Pulmonary Diseases & Disorders, Ch. 5, p. 19–34 (SP-A, SP-D)");

// SLIDE 12 — Surfactant disorders
contentSlide(pres, "03C — Disorders of Surfactant Homeostasis (Fishman's Ch. 5)", [
  "IRDS (Infant Respiratory Distress Syndrome):",
  "  Premature lungs lack mature surfactant → alveolar collapse → respiratory failure",
  "  Treatment: exogenous surfactant replacement + antenatal corticosteroids",
  "ARDS (Adult RDS):",
  "  Plasma proteins (from alveolar leak) inactivate surfactant",
  "  Surfactant function inhibited during acute lung injury",
  "  Exogenous surfactant therapy less successful in adults due to diffuse protein leak",
  "GM-CSF signalling regulates surfactant clearance by AMs:",
  "  Deficient GM-CSF signalling → pulmonary alveolar proteinosis (PAP) — accumulation of surfactant material",
  "SP-B deficiency (SFTPB mutations) → fatal neonatal respiratory failure"
], "Fishman's Pulmonary Diseases & Disorders, Ch. 5, p. 76–99");

// SLIDE 13 — SECTION 4: LUNG IMMUNOLOGY
sectionSlide(pres, "04", "Lung Immunology", "Sections 3–4 — Fishman's: Innate and adaptive immune functions of the lung");

// SLIDE 14 — Innate immunity
twoColSlide(pres,
  "04A — Innate Immunity of the Lung (Fishman's Section 3)",
  "Physical Barriers",
  [
    "Mucociliary escalator (see Slide 8)",
    "Tight junctions of bronchial epithelium limit paracellular entry",
    "Airway surface liquid (ASL): contains lysozyme, lactoferrin, defensins, secretory IgA",
    "Reflex mechanisms: cough, sneeze, bronchospasm — expel pathogens",
    "Nasal turbinates: trap particles >10 µm by inertial impaction"
  ],
  "Cellular Innate Immunity",
  [
    "Alveolar macrophages: first responders; phagocytosis, pattern recognition via TLRs",
    "Neutrophils: recruited rapidly in bacterial infection; produce ROS and NETs",
    "Mast cells: release histamine, heparin, tryptase; key in allergic and anaphylactic responses",
    "NK cells: rare in normal lung; anti-viral, anti-tumour",
    "Innate lymphoid cells (ILCs): emerging role in lung defence and repair"
  ],
  "Fishman's Pulmonary Diseases & Disorders, Section 3 (Lung Immunology)"
);

// SLIDE 15 — Adaptive immunity
twoColSlide(pres,
  "04B — Adaptive Immunity & Humoral Defences (Fishman's Ch. 19–22)",
  "Adaptive Cellular Immunity",
  [
    "Dendritic cells: antigen presentation to naïve T cells in draining lymph nodes",
    "T helper (Th1/Th2/Th17) responses regulate macrophage activation, eosinophils, neutrophils",
    "Cytotoxic T cells: key in viral pneumonia clearance",
    "T-regulatory cells limit excessive lung inflammation",
    "MALT (mucosal-associated lymphoid tissue) in bronchi — BALT"
  ],
  "Humoral Immunity",
  [
    "Secretory IgA: dominant antibody in bronchial secretions",
    "Dimeric IgA transported across epithelium by polymeric IgA receptor (pIgR)",
    "IgG: opsonises bacteria in alveolar space",
    "Complement activation by IgM/IgG → enhanced phagocytosis",
    "B cell deficiency → recurrent sinopulmonary infections (hypogammaglobulinaemia)"
  ],
  "Fishman's Pulmonary Diseases & Disorders, Ch. 19–22"
);

// SLIDE 16 — SECTION 5: METABOLIC
sectionSlide(pres, "05", "Metabolic & Biochemical Functions", "Eicosanoids, ACE, vasoactive substances, redox signalling");

// SLIDE 17 — Eicosanoids & biochemical
contentSlide(pres, "05 — Metabolic Functions of the Lung (Fishman's Ch. 24–25)", [
  "Eicosanoid Synthesis (Ch. 24 — Chemokines, Adipokines, Growth Factors in the Lung):",
  "  Pulmonary endothelium and macrophages are major sources of prostaglandins, thromboxanes, leukotrienes",
  "  PGI2 (prostacyclin) — synthesised by endothelium; potent vasodilator and anti-platelet agent",
  "  TXA2 — synthesised by platelets/macrophages; vasoconstrictor and platelet aggregant",
  "  Leukotrienes (LTC4, LTD4) — key in asthma bronchoconstriction; synthesised by mast cells/eosinophils",
  "ACE-mediated Angiotensin I → II conversion — pulmonary endothelium is the dominant site",
  "Inactivation: serotonin, bradykinin, norepinephrine metabolised by pulmonary endothelium",
  "Redox Signalling (Ch. 25 — Oxidative Stress in Lung Diseases):",
  "  Lung generates superoxide, H2O2 via NADPH oxidase (NOX) and mitochondria",
  "  Protective: kills pathogens; Pathological: contributes to ARDS, IPF, COPD when excessive"
], "Fishman's Pulmonary Diseases & Disorders, Ch. 24–25");

// SLIDE 18 — SUMMARY
summarySlide(pres, [
  {icon:"🛡️", title:"Structural Defence",  desc:"Alveolar lining layer, macrophages, DCs, mast cells, plasma cells"},
  {icon:"🌀", title:"Mucociliary Clearance",desc:"Ciliated epithelium + mucus blanket escalator; secretory IgA"},
  {icon:"🫧", title:"Surfactant Synthesis", desc:"AT2 cells; DPPC reduces surface tension; SP-A/SP-D = innate immunity"},
  {icon:"🔬", title:"Innate Immunity",     desc:"AMs, neutrophils, TLRs, complement, antimicrobial peptides"},
  {icon:"🧬", title:"Adaptive Immunity",   desc:"DCs, T cells, B cells, IgA/IgG, BALT"},
  {icon:"⚗️",  title:"Metabolic Functions", desc:"ACE, eicosanoids (PGI2, TXA2, leukotrienes), redox signalling"}
]);

// SLIDE 19 — CLOSING
let cl = pres.addSlide();
cl.addShape(pres.ShapeType.rect, {x:0,y:0,w:10,h:5.625,fill:{color:BG_DARK}});
cl.addShape(pres.ShapeType.rect, {x:0,y:0,w:10,h:0.12,fill:{color:ACCENT2}});
cl.addShape(pres.ShapeType.rect, {x:0,y:5.505,w:10,h:0.12,fill:{color:ACCENT2}});
cl.addShape(pres.ShapeType.rect, {x:7.8,y:0.12,w:2.2,h:5.385,fill:{color:BG_MID}});
cl.addText("Thank You", {
  x:0.5,y:1.6,w:7.0,h:1.1,
  fontSize:44,bold:true,color:WHITE,fontFace:"Calibri",align:"left",margin:0
});
cl.addText("The lung — a structural, immunological and metabolic organ,\nnot merely a device for gas exchange.", {
  x:0.5,y:2.9,w:7.0,h:1.1,
  fontSize:18,color:"9ED4E0",fontFace:"Calibri",align:"left",margin:0
});
cl.addText("Primary Reference: Fishman's Pulmonary Diseases & Disorders, 2-Volume Set (9781260473940)\nCh. 2 (Structural Design), Ch. 5 (Surfactant), Ch. 6 (Mucociliary), Ch. 19–25 (Immunology & Metabolism)\nSupplementary: Egan's Fundamentals of Respiratory Care (Stoller et al.) — Ch. 9", {
  x:0.5,y:4.35,w:7.0,h:1.0,
  fontSize:10,color:"5A8EA0",fontFace:"Calibri",align:"left",margin:0
});

// SAVE
pres.writeFile({fileName:"/home/daytona/workspace/lung-nonresp-ppt/NonRespFunctions_Fishman_Egans.pptx"})
  .then(()=>console.log("DONE: /home/daytona/workspace/lung-nonresp-ppt/NonRespFunctions_Fishman_Egans.pptx"))
  .catch(e=>{console.error(e);process.exit(1);});

cd /home/daytona/workspace/lung-nonresp-ppt && node create_ppt_fishman.js

ls -lh /home/daytona/workspace/lung-nonresp-ppt/