mkdir -p /home/daytona/workspace/antibiotic-infusion && ls /home/daytona/workspa…

~/antibiotic-infusion/generate_pdf.py

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.units import cm, mm
from reportlab.platypus import (
    SimpleDocTemplate, Paragraph, Spacer, Table, TableStyle,
    HRFlowable, KeepTogether
)
from reportlab.lib.enums import TA_CENTER, TA_LEFT
from reportlab.pdfbase import pdfmetrics

OUTPUT = "/home/daytona/workspace/antibiotic-infusion/Antibiotic_Infusion_Reference.pdf"

doc = SimpleDocTemplate(
    OUTPUT,
    pagesize=A4,
    rightMargin=1.5*cm, leftMargin=1.5*cm,
    topMargin=1.5*cm, bottomMargin=1.5*cm
)

W, H = A4
styles = getSampleStyleSheet()

# ── Custom styles ──────────────────────────────────────────────────────────────
DARK_BLUE  = colors.HexColor("#1a3a5c")
MID_BLUE   = colors.HexColor("#2e6da4")
LIGHT_BLUE = colors.HexColor("#d6e8f7")
HEADER_BG  = colors.HexColor("#1a3a5c")
ROW_ALT    = colors.HexColor("#f0f6fc")
WHITE      = colors.white
ORANGE     = colors.HexColor("#e07b00")
GREEN      = colors.HexColor("#1a7a4a")

title_style = ParagraphStyle(
    "Title", fontSize=18, textColor=WHITE, alignment=TA_CENTER,
    fontName="Helvetica-Bold", spaceAfter=2
)
subtitle_style = ParagraphStyle(
    "Subtitle", fontSize=9, textColor=colors.HexColor("#cce0f5"),
    alignment=TA_CENTER, fontName="Helvetica", spaceAfter=0
)
section_style = ParagraphStyle(
    "Section", fontSize=11, textColor=WHITE, fontName="Helvetica-Bold",
    alignment=TA_LEFT, spaceAfter=2, spaceBefore=6,
    backColor=MID_BLUE, leftIndent=4, rightIndent=4,
    borderPad=3
)
note_style = ParagraphStyle(
    "Note", fontSize=7.5, textColor=colors.HexColor("#555555"),
    fontName="Helvetica-Oblique", spaceAfter=4, leftIndent=4
)
footer_style = ParagraphStyle(
    "Footer", fontSize=7, textColor=colors.HexColor("#888888"),
    alignment=TA_CENTER, fontName="Helvetica"
)

def section_header(text):
    return Paragraph(f"  {text}", section_style)

def make_table(headers, rows, col_widths):
    """Build a styled table."""
    header_row = [Paragraph(f"<b>{h}</b>", ParagraphStyle(
        "TH", fontSize=8, textColor=WHITE, fontName="Helvetica-Bold",
        alignment=TA_CENTER, leading=10
    )) for h in headers]

    body_rows = []
    for row in rows:
        body_rows.append([
            Paragraph(str(cell), ParagraphStyle(
                "TD", fontSize=7.8, fontName="Helvetica",
                alignment=TA_LEFT, leading=10, leftIndent=2
            )) for cell in row
        ])

    data = [header_row] + body_rows

    style = TableStyle([
        ("BACKGROUND",   (0, 0), (-1, 0),  HEADER_BG),
        ("TEXTCOLOR",    (0, 0), (-1, 0),  WHITE),
        ("ROWBACKGROUNDS",(0,1),(-1,-1), [WHITE, ROW_ALT]),
        ("GRID",         (0, 0), (-1, -1), 0.3, colors.HexColor("#b0c8e0")),
        ("VALIGN",       (0, 0), (-1, -1), "MIDDLE"),
        ("TOPPADDING",   (0, 0), (-1, -1), 3),
        ("BOTTOMPADDING",(0, 0), (-1, -1), 3),
        ("LEFTPADDING",  (0, 0), (-1, -1), 4),
        ("RIGHTPADDING", (0, 0), (-1, -1), 4),
        ("ROUNDEDCORNERS", [3]),
    ])
    return Table(data, colWidths=col_widths, style=style, repeatRows=1)

# ── Content ────────────────────────────────────────────────────────────────────
story = []

# ── Title Banner ──
banner_data = [[
    Paragraph("ANTIBIOTIC IV INFUSION REFERENCE", title_style),
    Paragraph("Dose · Interval · Infusion Time", subtitle_style)
]]
banner_table = Table(banner_data, colWidths=[W - 3*cm])
banner_table.setStyle(TableStyle([
    ("BACKGROUND", (0,0), (-1,-1), DARK_BLUE),
    ("TOPPADDING",  (0,0), (-1,-1), 10),
    ("BOTTOMPADDING",(0,0),(-1,-1), 8),
    ("LEFTPADDING", (0,0), (-1,-1), 8),
    ("ROUNDEDCORNERS", [5]),
]))
story.append(banner_table)
story.append(Spacer(1, 0.25*cm))

src_note = Paragraph(
    "Source: Harrison's Principles of Internal Medicine 22E (2025) · Goldman-Cecil Medicine · Lippincott Pharmacology",
    ParagraphStyle("src", fontSize=7, textColor=colors.HexColor("#555"), alignment=TA_CENTER,
                   fontName="Helvetica-Oblique")
)
story.append(src_note)
story.append(Spacer(1, 0.3*cm))

# ── PK Principle Box ──
pk_text = (
    "<b>Pharmacodynamic Principle:</b> "
    "Beta-lactams are <b>time-dependent</b> killers — extend infusion to maximise time above MIC. "
    "Aminoglycosides &amp; fluoroquinolones are <b>concentration-dependent</b> — peak level drives killing."
)
pk_para = Paragraph(pk_text, ParagraphStyle(
    "PK", fontSize=8, fontName="Helvetica", textColor=DARK_BLUE,
    backColor=colors.HexColor("#fff9e6"), borderColor=ORANGE, borderWidth=0.5,
    borderPad=6, spaceAfter=6, leading=12
))
story.append(pk_para)
story.append(Spacer(1, 0.2*cm))

# ─────────────────────────────────────────────────────────────────────────────
# Table column widths (total usable = W - 3cm ≈ 17cm)
C = W - 3*cm   # ~17 cm
cw4 = [C*0.26, C*0.22, C*0.20, C*0.32]
cw3 = [C*0.32, C*0.24, C*0.44]

HDR4 = ["Drug", "Dose", "Interval", "Infusion Time / Notes"]
HDR3 = ["Drug", "Dose / Interval", "Infusion Time / Notes"]

# ── 1. PENICILLINS ────────────────────────────────────────────────────────────
story.append(section_header("1. PENICILLINS"))
penicillin_rows = [
    ["Penicillin G",         "2–4 MU IV",    "q4h",    "15–30 min; continuous infusion for high-dose regimens"],
    ["Ampicillin",           "2 g IV",        "q4–6h",  "15–30 min"],
    ["Ampicillin-sulbactam", "3 g IV",        "q6h",    "15–30 min"],
    ["Nafcillin / Oxacillin","2 g IV",        "q4h",    "30–60 min"],
    ["Piperacillin-tazobactam","3.375–4.5 g IV","q6–8h","⚡ Extended: 4 hours (preferred for P. aeruginosa)"],
]
story.append(make_table(HDR4, penicillin_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 2. CEPHALOSPORINS ─────────────────────────────────────────────────────────
story.append(section_header("2. CEPHALOSPORINS"))
ceph_rows = [
    ["Cefazolin",                "2 g IV",     "q8h",   "30–60 min"],
    ["Ceftriaxone",              "2 g IV",     "q12–24h","30 min"],
    ["Ceftazidime",              "2 g IV",     "q8h",   "30–60 min; extended 3–4h for resistant organisms"],
    ["Cefepime",                 "2 g IV",     "q8–12h","30 min (standard); extended 3–4h for resistant organisms"],
    ["Ceftazidime-avibactam",    "2.25 g IV",  "q8h",   "⚡ 3 hours"],
    ["Ceftolozane-tazobactam",   "3 g IV",     "q8h",   "1 hour"],
]
story.append(make_table(HDR4, ceph_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 3. CARBAPENEMS ────────────────────────────────────────────────────────────
story.append(section_header("3. CARBAPENEMS"))
carb_rows = [
    ["Meropenem",                     "1–2 g IV",   "q8h",  "⚡ 3 hours (P. aeruginosa/severe); 30 min standard"],
    ["Imipenem-cilastatin",            "0.5–1 g IV", "q6h",  "30–60 min"],
    ["Imipenem-cilastatin-relebactam", "1.25 g IV",  "q6h",  "30 min"],
    ["Doripenem",                      "0.5 g IV",   "q8h",  "⚡ 1 hour (mandatory)"],
    ["Ertapenem",                      "1 g IV",     "q24h", "30 min"],
]
story.append(make_table(HDR4, carb_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 4. MONOBACTAM ─────────────────────────────────────────────────────────────
story.append(section_header("4. MONOBACTAM"))
mono_rows = [
    ["Aztreonam", "1.5–2 g IV", "q6–8h", "30–60 min (use in β-lactam allergy with Gram-negative cover)"],
]
story.append(make_table(HDR4, mono_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 5. GLYCOPEPTIDES ─────────────────────────────────────────────────────────
story.append(section_header("5. GLYCOPEPTIDES"))
glyco_rows = [
    ["Vancomycin",  "15–20 mg/kg IV (actual body weight)", "q8–12h",
     "⚠ MINIMUM 60 min (≥1 h); NEVER rapid bolus → Red Man Syndrome, hypotension, cardiac arrest. Adjust to trough: 15–20 µg/mL (Staph); 10–15 µg/mL (Strep/Entero). Surgical prophylaxis: complete within 120 min pre-incision."],
]
story.append(make_table(HDR4, glyco_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 6. LIPOPEPTIDE ────────────────────────────────────────────────────────────
story.append(section_header("6. LIPOPEPTIDE"))
lipo_rows = [
    ["Daptomycin", "6–10 mg/kg IV (up to 12 mg/kg for enterococcal/VRE IE)", "q24h",
     "30 min (IV infusion) OR 2-min IV bolus. Do NOT use in pneumonia — inactivated by surfactant."],
]
story.append(make_table(HDR4, lipo_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 7. AMINOGLYCOSIDES ────────────────────────────────────────────────────────
story.append(section_header("7. AMINOGLYCOSIDES"))
amino_rows = [
    ["Gentamicin (IE synergy, divided dose)", "1 mg/kg IV",    "q8h",   "⚡ 20–30 min. Target peak ~3–5 µg/mL, trough ≤1 µg/mL"],
    ["Gentamicin (streptococcal IE, OD dose)","3 mg/kg IV",    "q24h",  "30–60 min"],
    ["Amikacin",                              "15 mg/kg IV",   "q24h",  "30–60 min. Target peak 56–64 µg/mL, trough <1 µg/mL"],
]
story.append(make_table(HDR4, amino_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 8. FLUOROQUINOLONES ───────────────────────────────────────────────────────
story.append(section_header("8. FLUOROQUINOLONES"))
fq_rows = [
    ["Ciprofloxacin (IV)",  "400 mg IV",     "q8–12h",  "⚡ 60 min (surgical prophylaxis: complete within 120 min pre-incision)"],
    ["Ciprofloxacin (PO)",  "500 mg PO",     "q12h",    "Oral — N/A"],
    ["Levofloxacin (IV)",   "500–750 mg IV", "q24h",    "60–90 min"],
]
story.append(make_table(HDR4, fq_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 9. LINCOSAMIDE (CLINDAMYCIN) ─────────────────────────────────────────────
story.append(section_header("9. LINCOSAMIDE — Clindamycin"))
clinda_rows = [
    ["Clindamycin (IV)", "600–900 mg IV", "q6–8h",
     "⚠ 20–60 min; NEVER rapid IV push (hypotension, cardiopulmonary arrest). Max rate: 30 mg/min → 600 mg over ≥20 min, 900 mg over ≥30 min. Add to beta-lactam in necrotising fasciitis/gas gangrene for toxin suppression."],
    ["Clindamycin (PO)", "300–450 mg PO", "q6–8h",  "Oral — N/A"],
]
story.append(make_table(HDR4, clinda_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 10. NITROIMIDAZOLE ────────────────────────────────────────────────────────
story.append(section_header("10. NITROIMIDAZOLE — Metronidazole"))
metro_rows = [
    ["Metronidazole (loading)", "15 mg/kg IV", "Once",  "⚡ Over 1 hour"],
    ["Metronidazole (maintenance)", "7.5 mg/kg IV", "q6h", "Over 1 hour"],
]
story.append(make_table(HDR4, metro_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 11. OXAZOLIDINONES ────────────────────────────────────────────────────────
story.append(section_header("11. OXAZOLIDINONES"))
oxazo_rows = [
    ["Linezolid",  "600 mg IV or PO", "q12h",  "30–120 min (IV); avoid tyramine-rich foods (MAO-I activity)"],
    ["Tedizolid",  "200 mg IV or PO", "q24h",  "1 hour (IV)"],
]
story.append(make_table(HDR4, oxazo_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 12. LIPOGLYCOPEPTIDES ─────────────────────────────────────────────────────
story.append(section_header("12. LIPOGLYCOPEPTIDES (Long-acting)"))
lipogly_rows = [
    ["Dalbavancin",  "1500 mg IV single dose", "Once",  "30 min"],
    ["Oritavancin",  "1200 mg IV single dose", "Once",  "⚡ 3 hours"],
    ["Telavancin",   "7.5–10 mg/kg IV",        "q24h",  "60 min"],
]
story.append(make_table(HDR4, lipogly_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 13. POLYMYXINS ────────────────────────────────────────────────────────────
story.append(section_header("13. POLYMYXINS"))
poly_rows = [
    ["Polymyxin B (loading)",    "20,000–25,000 IU/kg IV", "Once", "Over 1 hour"],
    ["Polymyxin B (maintenance)","1.25–1.5 mg/kg IV",      "q12h", "60 min"],
    ["Fosfomycin (IV, MDR)",     "8 g IV",                 "q8h",  "⚡ Over 6 hours — always in combination"],
]
story.append(make_table(HDR4, poly_rows, cw4))
story.append(Spacer(1, 0.2*cm))

# ── 14. TETRACYCLINES ─────────────────────────────────────────────────────────
story.append(section_header("14. TETRACYCLINES"))
tetra_rows = [
    ["Doxycycline (IV)", "100 mg IV", "q12h", "Over 1–4 hours (slowly; phlebitis risk with rapid infusion)"],
    ["Doxycycline (PO)", "100 mg PO", "q12h", "Oral — N/A; take with food to reduce GI upset"],
]
story.append(make_table(HDR4, tetra_rows, cw4))
story.append(Spacer(1, 0.35*cm))

# ── QUICK SUMMARY TABLE ───────────────────────────────────────────────────────
story.append(HRFlowable(width="100%", thickness=1, color=MID_BLUE))
story.append(Spacer(1, 0.15*cm))
summary_title = Paragraph("⚡ QUICK INFUSION TIME SUMMARY", ParagraphStyle(
    "SumTitle", fontSize=10, fontName="Helvetica-Bold", textColor=DARK_BLUE,
    spaceAfter=4
))
story.append(summary_title)

sum_rows = [
    ["Most beta-lactams (standard)",         "30–60 min",    "Standard practice for all routine doses"],
    ["Piperacillin-tazobactam (extended)",   "4 hours",      "Preferred for P. aeruginosa / resistant organisms"],
    ["Meropenem (extended)",                 "3 hours",      "Preferred for P. aeruginosa / resistant organisms"],
    ["Ceftazidime-avibactam",                "3 hours",      "Always extend — per guidelines"],
    ["Doripenem",                            "1 hour",       "Fixed infusion time"],
    ["Vancomycin",                           "≥60 min",      "⚠ NEVER rapid — Red Man Syndrome / arrest"],
    ["Aminoglycosides",                      "20–30 min",    "Fixed for accurate peak/trough monitoring"],
    ["Clindamycin",                          "20–60 min",    "⚠ NEVER bolus — max 30 mg/min"],
    ["Fluoroquinolones",                     "60 min",       "Reduces phlebitis / QT risk"],
    ["Metronidazole",                        "60 min",       "Both loading and maintenance doses"],
    ["Oritavancin",                          "3 hours",      "Long single-dose infusion"],
    ["Fosfomycin IV",                        "6 hours",      "Always in combination for MDR"],
    ["Polymyxin B (load)",                   "60 min",       "Loading dose only"],
]
sum_hdrs = ["Drug / Class", "Infusion Time", "Key Note"]
sum_cw = [C*0.30, C*0.18, C*0.52]
story.append(make_table(sum_hdrs, sum_rows, sum_cw))
story.append(Spacer(1, 0.3*cm))

# ── Footer ────────────────────────────────────────────────────────────────────
story.append(HRFlowable(width="100%", thickness=0.5, color=colors.HexColor("#b0c8e0")))
story.append(Spacer(1, 0.1*cm))
story.append(Paragraph(
    "Sources: Harrison's Principles of Internal Medicine 22E (2025, McGraw Hill) · Goldman-Cecil Medicine · "
    "Lippincott Illustrated Reviews: Pharmacology · Campbell-Walsh-Wein Urology 15E  |  "
    "For clinical use, always verify doses against local guidelines and adjust for renal/hepatic function.",
    footer_style
))

# ── Build ──────────────────────────────────────────────────────────────────────
doc.build(story)
print(f"PDF created: {OUTPUT}")

cd /home/daytona/workspace/antibiotic-infusion && python generate_pdf.py