Trenaxemic acid trapic injection route
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tranexamic acid TRAPIC injection intravenous route administration dosage
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tranexamic acid injection pharmacology mechanism indications contraindications
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Tranexamic Acid (TRAPIC) — Injection Route
TRAPIC is a branded formulation of tranexamic acid, an antifibrinolytic agent.
Mechanism of Action
Tranexamic acid competitively inhibits the activation of plasminogen to plasmin, thereby stabilizing clots and preventing their premature dissolution (Management of Hemophilia, 3rd ed., p. 67).
Injection Route — Key Details
| Parameter | Details |
|---|---|
| Route | Intravenous (IV) infusion |
| Dose | 10 mg/kg/dose |
| Frequency | 2–3 times daily |
| Rate of infusion | Slow infusion required — rapid IV injection can cause dizziness and hypotension |
Indications
- Mucosal and superficial soft tissue bleeds (oral bleeding, epistaxis, menorrhagia)
- Adjunctive therapy in hemophilia
- Dental surgery / dental extractions (typically for 7 days post-procedure)
- Control of oral bleeding associated with tooth eruption or shedding
Contraindications
- Hematuria — may prevent clot dissolution in the ureter, leading to obstructive uropathy and potential permanent renal failure
- Thoracic surgery — risk of insoluble hematoma formation
Special Considerations
- Renal impairment: Tranexamic acid is renally excreted; dose must be reduced to avoid toxic accumulation
- GI side effects (nausea, vomiting, diarrhea) can occur but typically resolve with dose reduction
- Not effective alone for prevention of hemarthroses in hemophilia
Source: Management of Hemophilia, 3rd Edition, p. 67
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