Giddiness history
giddiness dizziness history taking clinical approach
Benign Paroxysmal Positional Vertigo
Page 14
vertigo dizziness differential diagnosis causes
Harrison's Principles of Internal Medicine, Twenty First Edition
Page 718
| Descriptor | Likely Category |
|---|---|
| Spinning/rotation (world or self moving) | Vertigo (vestibular) |
| Lightheadedness / nearly fainting | Pre-syncope (cardiovascular/orthostatic) |
| Unsteadiness / imbalance | Disequilibrium (cerebellar, proprioceptive, or bilateral vestibular) |
| Floating / wooziness / non-specific | Psychogenic / hyperventilation / medication |
| Duration | Think |
|---|---|
| Seconds (positional) | BPPV |
| Minutes | TIA, cardiac arrhythmia |
| 20 min – several hours | Meniere's disease |
| Days | Vestibular neuritis / labyrinthitis |
| Constant, weeks–months | Central lesion, psychogenic |
| Drug Class | Examples |
|---|---|
| Ototoxic | Aminoglycosides, cisplatin, furosemide |
| Antihypertensives | Beta-blockers, ACE inhibitors, calcium channel blockers |
| Antiepileptics | Carbamazepine, phenytoin |
| Benzodiazepines / sedatives | — |
| Antidepressants | SSRIs, TCAs |
| Antihistamines | — |
| Quinine | — |
Loc history
loss of consciousness history taking clinical approach
Harrison's Principles of Internal Medicine, Twenty First Edition
Page 714
syncope seizure LOC differential diagnosis causes
Harrison's Principles of Internal Medicine, Twenty First Edition
Page 712
| Symptom | Suggests |
|---|---|
| Lightheadedness, nausea, diaphoresis, blurred vision, warmth | Vasovagal syncope |
| Palpitations immediately before LOC | Cardiac arrhythmia |
| Chest pain, dyspnoea | Cardiac (MI, PE, aortic dissection) |
| Headache (thunderclap) | Subarachnoid haemorrhage |
| Aura (unpleasant smell, déjà vu, abdominal rising sensation, fear) | Epileptic seizure |
| Focal neurological symptoms (diplopia, vertigo, dysarthria) | Posterior circulation TIA/stroke |
| No warning whatsoever | Cardiac arrhythmia, BPPV, drop attack |
| Feature | Syncope | Seizure |
|---|---|---|
| Duration of LOC | Seconds to <5 min | Often >5 min (post-ictal phase follows) |
| Skin colour | Pallor (vasovagal) or flushing | Cyanosis during tonic phase |
| Movements | Brief myoclonic jerks, arrhythmic, <30 s | Sustained tonic-clonic, rhythmic, >30 s |
| Tongue biting | Rare, tip of tongue | Common, lateral tongue |
| Incontinence | Occasionally | Common |
| Eyes | Usually open, may deviate upward | Open, may deviate to one side |
| Breathing | Shallow or brief apnoea | Stertorous during seizure |
| Posturing | Mild flexor/extensor possible | Sustained tonic posturing |
Per Harrison's (p. 712): myoclonic jerks occur in up to 90% of syncopal episodes and must not be mistaken for seizure.
| Feature | Syncope | Seizure |
|---|---|---|
| Recovery | Rapid (seconds–minutes), immediate orientation | Prolonged confusion (minutes–hours) |
| Post-ictal confusion / drowsiness | Absent or brief | Prominent |
| Headache | Absent | Common (post-ictal headache) |
| Muscle aches | Absent | Common (after tonic-clonic) |
| Nausea / vomiting | May occur (vasovagal) | May occur |
| Amnesia for event | Usually present for both | Present |
| Todd's paresis (focal limb weakness) | Absent | May be present |
| Drug/Substance | Mechanism |
|---|---|
| Antihypertensives, diuretics, nitrates | Orthostatic hypotension |
| Antiarrhythmics, QT-prolonging drugs | Arrhythmia (torsades de pointes) |
| Antiepileptics (missed dose) | Seizure breakthrough |
| Insulin / oral hypoglycaemics | Hypoglycaemia |
| Alcohol | Seizure (withdrawal or intoxication) |
| Recreational drugs (cocaine, amphetamines) | Arrhythmia, seizure |
| Antidepressants (TCAs) | Arrhythmia, QT prolongation |
BEFORE → DURING → AFTER
(Prodrome) (Eyewitness) (Recovery)
Triggers Movements Confusion duration
Warnings Duration Headache / myalgia
Position Colour Orientation
Incontinence Todd's paresis
| Cause | Key Distinguishing Features |
|---|---|
| Vasovagal syncope | Warm/crowded trigger, prodrome, rapid recovery |
| Orthostatic hypotension | On standing, elderly/dehydrated/medications |
| Cardiac arrhythmia | No warning, any position, rapid recovery, cardiac history |
| HOCM / Aortic stenosis | Exertional, murmur on exam |
| Epileptic seizure | Aura, prolonged tonic-clonic, lateral tongue bite, post-ictal confusion |
| PNEA (psychogenic) | No injury, long duration, waxing-waning, psychiatric history |
| Hypoglycaemia | Diabetic on medication, diaphoresis, gradual onset |
| TIA / posterior circulation | Neurological prodrome, elderly, vascular risk factors |
| Subarachnoid haemorrhage | Thunderclap headache, meningism |
Breathlessness
breathlessness dyspnoea history taking clinical approach
Harrison's Principles of Internal Medicine, Twenty First Edition
Page 1117
dyspnoea differential diagnosis causes cardiac respiratory
Harrison's Principles of Internal Medicine, Twenty First Edition
Page 1108
| Quality | Suggests |
|---|---|
| Air hunger / "cannot get enough air" | Heart failure, pulmonary oedema, hypercapnia |
| Chest tightness / constriction | Asthma, angina |
| Increased effort / work of breathing | COPD, neuromuscular disease, pleural effusion |
| Rapid shallow breathing | Pulmonary embolism, anxiety |
| Inability to take a deep breath ("unsatisfying breath") | Anxiety / hyperventilation syndrome |
| Pattern | Suggests |
|---|---|
| Sudden onset (seconds–minutes) | Pneumothorax, PE, acute pulmonary oedema, foreign body, arrhythmia |
| Hours | Asthma exacerbation, cardiac failure decompensation, pneumonia |
| Days to weeks | Pleural effusion, subacute heart failure, anaemia, malignancy |
| Months to years (chronic) | COPD, ILD, heart failure, pulmonary hypertension |
| Grade | Description |
|---|---|
| 1 | Breathless only with strenuous exercise |
| 2 | Breathless when hurrying on level ground or walking up a slight hill |
| 3 | Walks slower than contemporaries on level ground due to breathlessness, or has to stop |
| 4 | Stops for breath after walking ~100 m on level ground |
| 5 | Too breathless to leave the house, or breathless when dressing/undressing |
| Factor | Suggests |
|---|---|
| Exercise | Cardiac/respiratory (most causes) |
| Allergens, cold air, exercise, NSAIDs | Asthma |
| Lying flat | LVF, bilateral effusions |
| Sitting upright relieves | LVF (orthopnoea) |
| Inhaler use relieves | Asthma, COPD |
| Stress / anxiety | Hyperventilation syndrome |
| Dust / occupational exposure | Occupational asthma, hypersensitivity pneumonitis |
| Drug | Effect |
|---|---|
| ACE inhibitors | Chronic dry cough → secondary dyspnoea |
| Beta-blockers | Bronchospasm in asthmatics |
| NSAIDs / aspirin | Aspirin-exacerbated respiratory disease |
| Amiodarone | Pulmonary toxicity / ILD |
| Methotrexate, bleomycin, nitrofurantoin | Drug-induced ILD |
| Opioids | Respiratory depression |
| Occupation | Risk |
|---|---|
| Mining / sandblasting | Pneumoconiosis, silicosis |
| Asbestos (shipyards, construction) | Asbestosis, mesothelioma |
| Farming / bird keeping | Hypersensitivity pneumonitis |
| Spray painting, bakers | Occupational asthma |
S — Site/Character What does the breathlessness feel like?
O — Onset Sudden / gradual / episodic?
C — Character Exertional / nocturnal / positional?
R — Radiation —
A — Associated Sx Cough, wheeze, chest pain, oedema, haemoptysis
T — Timing/Pattern Constant / episodic / progressive?
E — Exacerbating Sx Exercise, allergens, lying flat, occupation
S — Severity MRC grade / NYHA class / baseline function
| Diagnosis | Characteristic Features |
|---|---|
| Left ventricular failure | Orthopnoea, PND, ankle oedema, basal crackles, S3 gallop |
| COPD | Smoker, chronic productive cough, progressive exertional dyspnoea |
| Asthma | Episodic, nocturnal, wheeze, atopy, variability |
| Pulmonary Embolism | Sudden onset, pleuritic chest pain, haemoptysis, risk factors (immobility, surgery, malignancy) |
| Pneumonia | Fever, productive cough, pleuritic pain, focal signs |
| Pneumothorax | Sudden onset, pleuritic pain, young tall male or underlying lung disease |
| ILD / Pulmonary fibrosis | Progressive, dry cough, fine bibasal crackles, occupational/drug exposure |
| Anaemia | Pallor, fatigue, no respiratory/cardiac signs, Hb low |
| Pulmonary hypertension | Progressive exertional dyspnoea, syncope on exertion, loud P2, right heart signs |
| Anxiety / hyperventilation | Situational, "can't take a deep breath", tingling, no objective signs |