History of Breathlessness (Dyspnoea)
Dyspnoea is the subjective sense of difficulty breathing or breathlessness. Pulmonary and cardiac conditions together account for up to 85% of underlying causes; up to one-third of patients have multifactorial aetiology (Harrison's, p. 1108).
1. Characterise the Symptom
Ask the patient to describe the breathlessness in their own words:
- "Does it feel like you can't get enough air in?"
- "Does your chest feel tight?"
- "Do you feel like you have to work hard to breathe?"
| Quality | Suggests |
|---|
| Air hunger / "cannot get enough air" | Heart failure, pulmonary oedema, hypercapnia |
| Chest tightness / constriction | Asthma, angina |
| Increased effort / work of breathing | COPD, neuromuscular disease, pleural effusion |
| Rapid shallow breathing | Pulmonary embolism, anxiety |
| Inability to take a deep breath ("unsatisfying breath") | Anxiety / hyperventilation syndrome |
2. Onset and Duration
| Pattern | Suggests |
|---|
| Sudden onset (seconds–minutes) | Pneumothorax, PE, acute pulmonary oedema, foreign body, arrhythmia |
| Hours | Asthma exacerbation, cardiac failure decompensation, pneumonia |
| Days to weeks | Pleural effusion, subacute heart failure, anaemia, malignancy |
| Months to years (chronic) | COPD, ILD, heart failure, pulmonary hypertension |
3. Severity
Quantify functional limitation:
MRC (Medical Research Council) Dyspnoea Scale:
| Grade | Description |
|---|
| 1 | Breathless only with strenuous exercise |
| 2 | Breathless when hurrying on level ground or walking up a slight hill |
| 3 | Walks slower than contemporaries on level ground due to breathlessness, or has to stop |
| 4 | Stops for breath after walking ~100 m on level ground |
| 5 | Too breathless to leave the house, or breathless when dressing/undressing |
Also ask: NYHA class (if cardiac) — exertion tolerance in terms of daily activities.
4. Timing and Pattern
- Exertional vs. rest: exertional → cardiac or respiratory; at rest → severe disease or psychogenic
- Nocturnal:
- Orthopnoea (breathless lying flat, relieved sitting up) → left heart failure, bilateral pleural effusions, diaphragmatic paralysis
- Paroxysmal Nocturnal Dyspnoea (PND) (wakes from sleep, relieved after sitting upright for minutes) → left ventricular failure
- Nocturnal wheeze → asthma (classically 2–4 am)
- Positional:
- Trepopnoea (breathless lying on one side) → unilateral pleural effusion, unilateral lung disease
- Platypnoea (breathless sitting up, relieved lying flat) → hepatopulmonary syndrome, ASD with right-to-left shunt
- Episodic vs. constant: episodic → asthma, PE, cardiac arrhythmia; constant → COPD, ILD, heart failure
5. Aggravating and Relieving Factors
| Factor | Suggests |
|---|
| Exercise | Cardiac/respiratory (most causes) |
| Allergens, cold air, exercise, NSAIDs | Asthma |
| Lying flat | LVF, bilateral effusions |
| Sitting upright relieves | LVF (orthopnoea) |
| Inhaler use relieves | Asthma, COPD |
| Stress / anxiety | Hyperventilation syndrome |
| Dust / occupational exposure | Occupational asthma, hypersensitivity pneumonitis |
6. Associated Symptoms
Respiratory:
- Cough — productive (COPD, pneumonia, bronchiectasis), dry (ILD, ACE inhibitor, cardiac failure)
- Wheeze — asthma, COPD, cardiac asthma
- Stridor — upper airway obstruction (foreign body, anaphylaxis, epiglottitis)
- Haemoptysis — PE, malignancy, TB, bronchiectasis, mitral stenosis
- Sputum — colour, quantity, consistency
Cardiac:
- Chest pain — ischaemia (angina/ACS), pleuritic pain (PE, pneumonia, pericarditis)
- Palpitations — arrhythmia (AF can precipitate acute pulmonary oedema)
- Ankle swelling — right or biventricular heart failure
- Orthopnoea / PND (as above)
Systemic:
- Fever / chills → infection (pneumonia, sepsis)
- Weight loss / night sweats → malignancy, TB
- Fatigue → anaemia, heart failure, malignancy
- Leg swelling / calf pain → DVT → PE
Neurological / Muscular:
- Limb weakness, bulbar symptoms → neuromuscular (MND, Guillain-Barré, myasthenia)
7. Past Medical History
- Cardiac: IHD, heart failure, hypertension, valvular disease, AF, congenital heart disease
- Respiratory: asthma, COPD, TB, previous pneumonia, pneumothorax, ILD
- Thromboembolic: prior DVT/PE, thrombophilia
- Metabolic: anaemia, thyroid disease (hyperthyroidism, hypothyroidism with pleural effusion), renal failure, liver disease (hepatopulmonary syndrome, ascites)
- Malignancy: primary lung, lymphoma, pleural mesothelioma
- Immunosuppression: HIV (PCP, TB), post-transplant
8. Drug History
| Drug | Effect |
|---|
| ACE inhibitors | Chronic dry cough → secondary dyspnoea |
| Beta-blockers | Bronchospasm in asthmatics |
| NSAIDs / aspirin | Aspirin-exacerbated respiratory disease |
| Amiodarone | Pulmonary toxicity / ILD |
| Methotrexate, bleomycin, nitrofurantoin | Drug-induced ILD |
| Opioids | Respiratory depression |
9. Social History
- Smoking: pack-year history → COPD, lung cancer, IHD
- Occupational exposure:
| Occupation | Risk |
|---|
| Mining / sandblasting | Pneumoconiosis, silicosis |
| Asbestos (shipyards, construction) | Asbestosis, mesothelioma |
| Farming / bird keeping | Hypersensitivity pneumonitis |
| Spray painting, bakers | Occupational asthma |
- Travel: TB (endemic area), coccidioidomycosis, histoplasmosis
- Pets: bird droppings → hypersensitivity pneumonitis
- Alcohol: aspiration pneumonia, alcoholic cardiomyopathy
- Illicit drugs: cocaine (pulmonary haemorrhage), IV drugs (septic emboli)
10. Family History
- Asthma / atopy
- Alpha-1 antitrypsin deficiency (early COPD, non-smoker)
- Pulmonary hypertension (heritable PAH — BMPR2 mutation)
- Cystic fibrosis
- Cardiomyopathy
Summary: SOCRATES + Contextual Framework
S — Site/Character What does the breathlessness feel like?
O — Onset Sudden / gradual / episodic?
C — Character Exertional / nocturnal / positional?
R — Radiation —
A — Associated Sx Cough, wheeze, chest pain, oedema, haemoptysis
T — Timing/Pattern Constant / episodic / progressive?
E — Exacerbating Sx Exercise, allergens, lying flat, occupation
S — Severity MRC grade / NYHA class / baseline function
Key Differentials at a Glance
| Diagnosis | Characteristic Features |
|---|
| Left ventricular failure | Orthopnoea, PND, ankle oedema, basal crackles, S3 gallop |
| COPD | Smoker, chronic productive cough, progressive exertional dyspnoea |
| Asthma | Episodic, nocturnal, wheeze, atopy, variability |
| Pulmonary Embolism | Sudden onset, pleuritic chest pain, haemoptysis, risk factors (immobility, surgery, malignancy) |
| Pneumonia | Fever, productive cough, pleuritic pain, focal signs |
| Pneumothorax | Sudden onset, pleuritic pain, young tall male or underlying lung disease |
| ILD / Pulmonary fibrosis | Progressive, dry cough, fine bibasal crackles, occupational/drug exposure |
| Anaemia | Pallor, fatigue, no respiratory/cardiac signs, Hb low |
| Pulmonary hypertension | Progressive exertional dyspnoea, syncope on exertion, loud P2, right heart signs |
| Anxiety / hyperventilation | Situational, "can't take a deep breath", tingling, no objective signs |
Red Flags Requiring Urgent Assessment
- Sudden onset dyspnoea at rest
- Haemoptysis
- Stridor
- Cyanosis
- Oxygen saturation <92%
- Associated chest pain
- Dyspnoea while supine or during sleep (PND)
- Dyspnoea on exertion with syncope (pulmonary hypertension, HOCM, aortic stenosis)
- Rapidly progressive dyspnoea over days