For scrub typhus, doxycycline is typically:

Continue until the patient has been afebrile for at least 3 days and is clinically improving. A minimum 5 to 7-day course is generally used; many scrub-typhus regimens use 7 days. Do not use a single dose or very short course because relapse may occur. The CDC scrub typhus guidance recommends doxycycline for suspected infection at all ages.

For pregnancy or a serious doxycycline allergy, treatment should be chosen with an infectious-disease clinician, often using an alternative such as azithromycin.