You are answering a USMLE-style medical question. Question: A 48-year-old woman comes to the physician because of a 7-day history of progressively worsening shortness of breath. She has a history of asthma and has frequent exacerbations despite receiving maximal medical therapy. Physical examination shows scattered expiratory wheezing. Laboratory studies show a leukocyte count of 9,800/mm3 (13% eosinophils) and elevated serum concentration of immunoglobulin E. An x-ray of the chest shows thickened bronchial walls and perihilar opacities. Sputum culture shows scattered septate hyphae that branch at 45 degrees. Which of the following is most likely to be increased in this patient? Options: A) IL-28 B) TGF-β C) IFN-α D) IL-4 Reply with ONLY the letter of the correct answer (A, B, C, or D). No explanation.