const pptxgen = require("pptxgenjs");
const pres = new pptxgen();
pres.layout = "LAYOUT_WIDE";
pres.title = "CNS & Endocrine Pathology - High Yield MCQ Study Guide";
pres.author = "Orris Study Guide";

// ─── THEME COLORS ────────────────────────────────────────────────────────────
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  cardBg:  "1E293B",
  cardBg2: "162032",
  accent:  "38BDF8",
};

// ─── HELPER: slide background ────────────────────────────────────────────────
function darkSlide(slide) {
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}
function lightSlide(slide) {
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// ─── HELPER: section header bar ──────────────────────────────────────────────
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// ─── HELPER: card box ────────────────────────────────────────────────────────
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// ─── HELPER: small label pill ────────────────────────────────────────────────
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// ─── HELPER: arrow right ─────────────────────────────────────────────────────
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ═══════════════════════════════════════════════════════════════════════════════
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  // Title
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// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 2 — CNS SECTION INTRO
// ═══════════════════════════════════════════════════════════════════════════════
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    { label: "02", text: "Brain Tumors", color: C.purple },
    { label: "03", text: "Cerebrovascular Disease", color: C.red },
    { label: "04", text: "Neurodegeneration", color: C.green },
    { label: "05", text: "CNS Infections", color: C.orange },
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}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 3 — DEMYELINATING DISEASES: MS vs GBS
// ═══════════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "01 | Demyelinating Diseases: MS vs GBS", C.tealDk);

  // MS Card
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  s.addText("MULTIPLE SCLEROSIS (MS)", { x: 0.3, y: 1.0, w: 6.0, h: 0.5, fontSize: 13, bold: true, color: C.white, valign: "middle", margin: 0 });

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    ["Mnemonic", "SPASM: Sensory, Pain, Ataxia,\nSphincter, Motor"],
    ["Age/Sex", "Young women 20-40"],
    ["Pathology", "Oligodendrocyte destruction\n→ White matter demyelination"],
    ["Location", "Periventricular plaques\n'Dawson's Fingers' on MRI"],
    ["CSF", "Oligoclonal IgG bands"],
    ["Signs", "Uhthoff's (heat worsens)\nLhermitte's (neck flex = shock)"],
    ["Treatment", "Beta-interferon (modify)\nSteroids (acute attack)"],
  ];
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  s.addShape(pres.shapes.RECTANGLE, { x: 6.9, y: 1.0, w: 6.2, h: 0.5, fill: { color: C.purple }, line: { color: C.purple } });
  s.addText("GUILLAIN-BARRE SYNDROME (GBS)", { x: 7.0, y: 1.0, w: 6.0, h: 0.5, fontSize: 13, bold: true, color: C.white, valign: "middle", margin: 0 });

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    ["Mnemonic", "'Goes Bottom-to-Shoulder'\n= Ascending paralysis"],
    ["Trigger", "Post-infection\n(Campylobacter jejuni #1)"],
    ["Pathology", "Schwann cell destruction\n→ Peripheral demyelination"],
    ["Presentation", "Ascending flaccid paralysis\n+ Areflexia"],
    ["CSF", "ALBUMINOCYTOLOGIC\nDISSOCIATION\n(High protein, normal WBC)"],
    ["Risk", "Respiratory failure\n(monitor FVC!)"],
    ["Treatment", "IVIG or Plasmapheresis"],
  ];
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  // MCQ TRAP banner
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}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 4 — BRAIN TUMORS TABLE
// ═══════════════════════════════════════════════════════════════════════════════
{
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  sectionBar(s, "02 | Brain Tumors — High-Yield Table + GAME Mnemonic", C.purple);

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    { letter: "G", text: "liomas (most common overall)", color: C.teal },
    { letter: "A", text: "denocarcinoma mets (#1 in adults)", color: C.orange },
    { letter: "M", text: "eningioma (most common BENIGN)", color: C.green },
    { letter: "E", text: "pendymoma (4th ventricle, child)", color: C.purple },
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    ["Pilocytic Astrocytoma", "Cerebellum", "Child", "Rosenthal fibers | BENIGN Grade I"],
    ["Medulloblastoma", "Cerebellum (4th V)", "Child", "Homer-Wright rosettes | Radiosensitive"],
    ["Ependymoma", "4th Ventricle", "Child", "Perivascular pseudorosettes"],
    ["GBM (Grade IV)", "Temporal/Frontal", "Elderly", "Butterfly pattern | Pseudopalisading necrosis"],
    ["Oligodendroglioma", "Frontal lobe", "Adult", "Fried egg cells | 1p/19q deletion"],
    ["Meningioma", "Parasagittal", "Adult F", "Psammoma bodies | Whorled pattern | BENIGN"],
    ["Schwannoma (CN VIII)", "CPA angle", "Adult", "S100+ | Bilateral = NF2"],
    ["Craniopharyngioma", "Suprasellar", "Child", "Calcification | Cholesterol crystals"],
  ];
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  const colX = [0.2, 2.85, 5.1, 6.45];
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}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 5 — STROKE FLOWCHART
// ═══════════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "03 | Cerebrovascular Disease — Stroke Classification Flowchart", C.red);

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  // Branches
  // Ischemic branch (left)
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  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 1.0, y: 2.2, w: 3.5, h: 0.7, fill: { color: C.tealDk }, line: { color: C.teal }, rectRadius: 0.07 });
  s.addText("ISCHEMIC  (87%)", { x: 1.0, y: 2.2, w: 3.5, h: 0.7, fontSize: 14, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });

  // Sub: Thrombotic
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  card(s, 0.3, 3.45, 2.0, 1.5, C.cardBg);
  s.addText("THROMBOTIC", { x: 0.3, y: 3.45, w: 2.0, h: 0.38, fontSize: 10, bold: true, color: C.teal, align: "center", valign: "middle", margin: 0 });
  s.addText("Atherosclerotic plaque\nGradual onset\nWake-up stroke", { x: 0.3, y: 3.85, w: 2.0, h: 1.05, fontSize: 8.5, color: C.offWhite, valign: "top", margin: 4 });

  // Sub: Embolic
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  card(s, 2.3, 3.45, 2.0, 1.5, C.cardBg);
  s.addText("EMBOLIC", { x: 2.3, y: 3.45, w: 2.0, h: 0.38, fontSize: 10, bold: true, color: C.teal, align: "center", valign: "middle", margin: 0 });
  s.addText("From heart (Afib #1)\nSudden onset\nMiddle cerebral art.", { x: 2.3, y: 3.85, w: 2.0, h: 1.05, fontSize: 8.5, color: C.offWhite, valign: "top", margin: 4 });

  // Hemorrhagic branch (right)
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  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 8.8, y: 2.2, w: 3.5, h: 0.7, fill: { color: "#7F1D1D" }, line: { color: C.red }, rectRadius: 0.07 });
  s.addText("HEMORRHAGIC  (13%)", { x: 8.8, y: 2.2, w: 3.5, h: 0.7, fontSize: 14, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });

  // Sub: ICH
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  card(s, 8.3, 3.45, 2.0, 1.5, C.cardBg);
  s.addText("INTRACEREBRAL", { x: 8.3, y: 3.45, w: 2.0, h: 0.38, fontSize: 9, bold: true, color: C.red, align: "center", valign: "middle", margin: 0 });
  s.addText("HTN #1 cause\nCharcot-Bouchard\naneurysms\nPutamen most common", { x: 8.3, y: 3.85, w: 2.0, h: 1.05, fontSize: 8, color: C.offWhite, valign: "top", margin: 4 });

  // Sub: SAH
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  card(s, 10.0, 3.45, 2.2, 1.5, C.cardBg);
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  s.addText("Berry aneurysm #1\n'Worst HA of life'\nXanthochromia CSF\nADPKD association", { x: 10.0, y: 3.85, w: 2.2, h: 1.05, fontSize: 8, color: C.offWhite, valign: "top", margin: 4 });

  // EDH vs SDH comparison
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    ["", "EPIDURAL (EDH)", "SUBDURAL (SDH)"],
    ["Vessel", "Middle meningeal ARTERY", "Bridging VEINS"],
    ["CT shape", "Biconvex (lens-shaped)", "Crescent-shaped"],
    ["Lucid interval", "YES (classic)", "Sometimes"],
    ["Cause", "Temporal bone fracture", "Elderly / alcoholics"],
    ["Speed", "Fast (arterial)", "Slow (venous)"],
  ];
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  const eX = [4.1, 5.45, 8.4];
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    row.forEach((cell, ci) => {
      const bg = ri === 0 ? C.orange : (ri % 2 === 0 ? C.cardBg : C.cardBg2);
      const fg = ri === 0 ? C.navy : (ci === 0 ? C.gray : C.offWhite);
      s.addShape(pres.shapes.RECTANGLE, { x: eX[ci], y: 5.58 + ri * 0.32, w: eCols[ci], h: 0.3, fill: { color: bg }, line: { color: C.orange, transparency: 60 } });
      s.addText(cell, { x: eX[ci] + 0.05, y: 5.58 + ri * 0.32, w: eCols[ci] - 0.1, h: 0.3, fontSize: 8.5, bold: ri === 0, color: fg, valign: "middle", margin: 0 });
    });
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}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 6 — NEURODEGENERATION
// ═══════════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "04 | Neurodegenerative Diseases — The Big 4", C.green);

  const diseases = [
    {
      name: "ALZHEIMER'S",
      mnemonic: "ABCs of Alzheimer's",
      color: C.teal,
      points: ["A - Amyloid-β plaques (extracellular)","B - Brain atrophy (hippocampus 1st)","C - Chromosome 21 / ApoE4","D - Downreg. ACh","E - Early = short-term memory loss","F - Fibrillary tangles (tau, intracell.)","Rx: Donepezil (AChEI)"],
    },
    {
      name: "PARKINSON'S",
      mnemonic: "TRAP",
      color: C.purple,
      points: ["T - Tremor (resting, pill-rolling)","R - Rigidity (cogwheel)","A - Akinesia/bradykinesia","P - Postural instability","Path: Lewy bodies (α-synuclein)","Location: Substantia Nigra","Rx: Levodopa/Carbidopa (gold std)"],
    },
    {
      name: "ALS",
      mnemonic: "All Limbs, Spared Sensation",
      color: C.orange,
      points: ["UMN + LMN both involved","NO sensory loss","NO cognitive decline","NO autonomic dysfunction","Gene: SOD1 mutation","Progressive respiratory failure","Rx: Riluzole (only disease-modifying)"],
    },
    {
      name: "LEWY BODY",
      mnemonic: "VIPs Fluctuate",
      color: C.red,
      points: ["V - Visual hallucinations (early)","I - Identity: Parkinsonism early","P - Psychiatric (REM sleep disorder)","Fluctuating cognition","Lewy bodies (α-synuclein)","Sensitive to antipsychotics","Rx: Rivastigmine"],
    },
  ];
  diseases.forEach((d, i) => {
    const x = 0.2 + i * 3.27;
    card(s, x, 1.0, 3.05, 6.35, C.cardBg);
    s.addShape(pres.shapes.RECTANGLE, { x, y: 1.0, w: 3.05, h: 0.48, fill: { color: d.color }, line: { color: d.color } });
    s.addText(d.name, { x: x + 0.05, y: 1.0, w: 2.95, h: 0.48, fontSize: 12, bold: true, color: C.white, valign: "middle", margin: 0 });
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: x + 0.1, y: 1.55, w: 2.85, h: 0.35, fill: { color: d.color, transparency: 50 }, line: { color: d.color, transparency: 30 }, rectRadius: 0.05 });
    s.addText(d.mnemonic, { x: x + 0.1, y: 1.55, w: 2.85, h: 0.35, fontSize: 9, bold: true, italic: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    d.points.forEach((p, pi) => {
      s.addText("• " + p, { x: x + 0.12, y: 2.02 + pi * 0.73, w: 2.85, h: 0.65, fontSize: 8.5, color: C.offWhite, valign: "top", margin: 0 });
    });
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 7 — CNS INFECTIONS
// ═══════════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "05 | CNS Infections — Meningitis, Encephalitis, Prions", C.orange);

  // CSF Table
  s.addText("CSF Analysis Quick Comparison", { x: 0.2, y: 1.0, w: 12.9, h: 0.4, fontSize: 14, bold: true, color: C.orange });
  const csfH = ["Feature", "BACTERIAL", "VIRAL (Aseptic)", "FUNGAL / TB"];
  const csfR = [
    ["Appearance", "Turbid / Cloudy", "Clear", "Clear or Turbid"],
    ["WBC", "High PMNs (>1000)", "High Lymphocytes", "High Lymphocytes"],
    ["Glucose", "VERY LOW (<40)", "Normal", "Low"],
    ["Protein", "VERY HIGH (>200)", "Slightly High", "High"],
    ["Opening Pressure", "Elevated", "Normal/slightly elevated", "Elevated"],
  ];
  const csfCW = [2.1, 2.9, 3.0, 3.0];
  const csfCX = [0.2, 2.35, 5.3, 8.35];
  const csfHC = [C.cardBg, C.red, C.tealDk, C.purple];
  csfH.forEach((h, ci) => {
    s.addShape(pres.shapes.RECTANGLE, { x: csfCX[ci], y: 1.45, w: csfCW[ci], h: 0.42, fill: { color: csfHC[ci] }, line: { color: csfHC[ci] } });
    s.addText(h, { x: csfCX[ci] + 0.05, y: 1.45, w: csfCW[ci] - 0.1, h: 0.42, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0, align: ci > 0 ? "center" : "left" });
  });
  csfR.forEach((row, ri) => {
    row.forEach((cell, ci) => {
      s.addShape(pres.shapes.RECTANGLE, { x: csfCX[ci], y: 1.9 + ri * 0.42, w: csfCW[ci], h: 0.4, fill: { color: ri % 2 === 0 ? C.cardBg : C.cardBg2 }, line: { color: C.gray, transparency: 80 } });
      s.addText(cell, { x: csfCX[ci] + 0.05, y: 1.9 + ri * 0.42, w: csfCW[ci] - 0.1, h: 0.4, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0, align: ci > 0 ? "center" : "left" });
    });
  });

  // Bugs by age
  s.addText("Bacterial Meningitis Bugs by Age Group", { x: 0.2, y: 4.15, w: 6.5, h: 0.38, fontSize: 13, bold: true, color: C.orange });
  const ages = [
    { age: "0-3 months", bugs: "GBS, E. coli, Listeria", memo: "GEL", color: C.red },
    { age: "3m - 18 yrs", bugs: "N. meningitidis, S. pneumoniae, H. influenzae", memo: "NMSH", color: C.orange },
    { age: "Adults 18-50", bugs: "S. pneumoniae, N. meningitidis", memo: "SN", color: C.teal },
    { age: "Elderly / Immunocomp.", bugs: "S. pneumoniae, Listeria", memo: "SPL", color: C.purple },
  ];
  ages.forEach((a, i) => {
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 0.2, y: 4.6 + i * 0.7, w: 1.8, h: 0.55, fill: { color: a.color }, line: { color: a.color }, rectRadius: 0.06 });
    s.addText(a.age, { x: 0.2, y: 4.6 + i * 0.7, w: 1.8, h: 0.55, fontSize: 8.5, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(a.bugs, { x: 2.1, y: 4.6 + i * 0.7, w: 4.1, h: 0.55, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
    pill(s, "Memo: " + a.memo, 6.3, 4.65 + i * 0.7, 1.4, 0.38, a.color);
  });

  // Right side: HSV & Crypto
  card(s, 8.0, 4.1, 5.1, 1.6, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 8.0, y: 4.1, w: 5.1, h: 0.38, fill: { color: C.red, transparency: 20 }, line: { color: C.red } });
  s.addText("HSV Encephalitis", { x: 8.05, y: 4.1, w: 5.0, h: 0.38, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
  s.addText("Temporal lobe | Fever + personality change + seizures\nCSF: PCR for HSV DNA | Treatment: IV ACYCLOVIR (STAT!)", { x: 8.05, y: 4.52, w: 5.0, h: 1.1, fontSize: 9, color: C.offWhite, valign: "top", margin: 0 });

  card(s, 8.0, 5.85, 5.1, 1.55, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 8.0, y: 5.85, w: 5.1, h: 0.38, fill: { color: C.purple, transparency: 20 }, line: { color: C.purple } });
  s.addText("Cryptococcal Meningitis + CJD (Prion)", { x: 8.05, y: 5.85, w: 5.0, h: 0.38, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0 });
  s.addText("Crypto: HIV (CD4<100) | India Ink halo | Rx: Ampho B + 5-FC\nCJD: Spongiform vacuolation | Myoclonus + rapid dementia", { x: 8.05, y: 6.27, w: 5.0, h: 1.05, fontSize: 9, color: C.offWhite, valign: "top", margin: 0 });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 8 — ENDOCRINE SECTION INTRO
// ═══════════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  s.background = { color: "0A1628" };
  s.addShape(pres.shapes.RECTANGLE, { x: 13.0, y: 0, w: 0.3, h: 7.5, fill: { color: C.green }, line: { color: C.green } });
  s.addText("SECTION 2", { x: 0.6, y: 0.5, w: 12, h: 0.5, fontSize: 14, bold: true, color: C.green, charSpacing: 4 });
  s.addText("Endocrine\nPathology", { x: 0.6, y: 1.1, w: 12, h: 2.2, fontSize: 52, bold: true, color: C.white, fontFace: "Calibri" });
  s.addShape(pres.shapes.RECTANGLE, { x: 0.6, y: 3.4, w: 4, h: 0.05, fill: { color: C.green }, line: { color: C.green } });
  const topics = [
    { label: "01", text: "Pituitary Disorders", color: C.teal },
    { label: "02", text: "Thyroid Disorders", color: C.green },
    { label: "03", text: "Adrenal Disorders", color: C.orange },
    { label: "04", text: "Diabetes Mellitus", color: C.red },
  ];
  topics.forEach((t, i) => {
    s.addShape(pres.shapes.RECTANGLE, { x: 0.6, y: 3.7 + i * 0.78, w: 0.45, h: 0.48, fill: { color: t.color }, line: { color: t.color } });
    s.addText(t.label, { x: 0.6, y: 3.7 + i * 0.78, w: 0.45, h: 0.48, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(t.text, { x: 1.2, y: 3.75 + i * 0.78, w: 9, h: 0.4, fontSize: 18, color: C.white, valign: "middle", margin: 0 });
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 9 — PITUITARY
// ═══════════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "Endocrine 01 | Pituitary Disorders — Hormones & Adenomas", C.teal);

  // FLAT PiG
  s.addText("Anterior Pituitary — Mnemonic: FLAT PiG", { x: 0.2, y: 1.0, w: 7.5, h: 0.38, fontSize: 13, bold: true, color: C.teal });
  const hormones = [
    { letter: "F", h: "FSH", note: "Follicle stimulating" },
    { letter: "L", h: "LH", note: "Luteinizing hormone" },
    { letter: "A", h: "ACTH", note: "Adrenocorticotropic" },
    { letter: "T", h: "TSH", note: "Thyroid stimulating" },
    { letter: "Pi", h: "PRL", note: "Prolactin" },
    { letter: "G", h: "GH", note: "Growth hormone" },
  ];
  hormones.forEach((h, i) => {
    const x = 0.2 + i * 2.15;
    s.addShape(pres.shapes.ELLIPSE, { x, y: 1.5, w: 1.8, h: 0.8, fill: { color: C.tealDk, transparency: 20 }, line: { color: C.teal } });
    s.addText(h.letter, { x, y: 1.5, w: 0.55, h: 0.8, fontSize: 18, bold: true, color: C.accent, align: "center", valign: "middle", margin: 0 });
    s.addText(h.h + "\n" + h.note, { x: x + 0.5, y: 1.5, w: 1.3, h: 0.8, fontSize: 8, color: C.white, valign: "middle", margin: 0 });
  });
  s.addText("Posterior: ADH + Oxytocin (made in hypothalamus, stored in posterior pituitary)", { x: 0.2, y: 2.4, w: 12.9, h: 0.35, fontSize: 10, italic: true, color: C.gray });

  // Adenoma table
  s.addText("Pituitary Adenoma Types", { x: 0.2, y: 2.85, w: 7.5, h: 0.38, fontSize: 13, bold: true, color: C.teal });
  const adH = ["Adenoma", "Hormone", "Presentation"];
  const adR = [
    ["Prolactinoma (#1)", "Prolactin", "Amenorrhea + galactorrhea (F); Impotence (M) | Rx: Cabergoline"],
    ["Somatotroph", "GH", "Acromegaly (adult) / Gigantism (child) | Rx: Transsphenoidal surgery"],
    ["Corticotroph", "ACTH", "Cushing's DISEASE | Suppressed by high-dose dexamethasone"],
    ["Non-functioning", "None", "Mass effects: Bitemporal hemianopia (optic chiasm compression)"],
  ];
  const adCW = [2.4, 1.8, 8.7];
  const adCX = [0.2, 2.65, 4.5];
  adH.forEach((h, ci) => {
    s.addShape(pres.shapes.RECTANGLE, { x: adCX[ci], y: 3.28, w: adCW[ci], h: 0.38, fill: { color: C.tealDk }, line: { color: C.tealDk } });
    s.addText(h, { x: adCX[ci] + 0.05, y: 3.28, w: adCW[ci] - 0.1, h: 0.38, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0 });
  });
  adR.forEach((row, ri) => {
    row.forEach((cell, ci) => {
      s.addShape(pres.shapes.RECTANGLE, { x: adCX[ci], y: 3.7 + ri * 0.55, w: adCW[ci], h: 0.52, fill: { color: ri % 2 === 0 ? C.cardBg : C.cardBg2 }, line: { color: C.teal, transparency: 70 } });
      s.addText(cell, { x: adCX[ci] + 0.05, y: 3.7 + ri * 0.55, w: adCW[ci] - 0.1, h: 0.52, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
    });
  });

  // DI flowchart
  s.addText("Diabetes Insipidus Flowchart", { x: 0.2, y: 5.95, w: 12.9, h: 0.38, fontSize: 13, bold: true, color: C.accent });
  // DI node
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 5.0, y: 6.38, w: 3.3, h: 0.55, fill: { color: C.tealDk }, line: { color: C.teal }, rectRadius: 0.07 });
  s.addText("DIABETES INSIPIDUS\n(Dilute urine, high serum Na)", { x: 5.0, y: 6.38, w: 3.3, h: 0.55, fontSize: 8.5, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
  // Branches
  arrowDown(s, 5.45, 7.0, 0.3, 0.35, C.teal);
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 3.8, y: 7.0, w: 2.6, h: 0.38, fill: { color: C.teal, transparency: 25 }, line: { color: C.teal }, rectRadius: 0.06 });
  s.addText("CENTRAL DI  (ADH deficient)\nRx: Desmopressin", { x: 3.8, y: 7.0, w: 2.6, h: 0.38, fontSize: 8, color: C.white, align: "center", valign: "middle", margin: 0 });
  arrowDown(s, 7.55, 7.0, 0.3, 0.35, C.purple);
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 7.1, y: 7.0, w: 2.6, h: 0.38, fill: { color: C.purple, transparency: 25 }, line: { color: C.purple }, rectRadius: 0.06 });
  s.addText("NEPHROGENIC DI (ADH resistant)\nRx: Thiazides + Low Na diet", { x: 7.1, y: 7.0, w: 2.6, h: 0.38, fontSize: 8, color: C.white, align: "center", valign: "middle", margin: 0 });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 10 — THYROID
// ═══════════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "Endocrine 02 | Thyroid Disorders — Hypo vs Hyper + Cancer", C.green);

  // Hypo card
  card(s, 0.2, 1.0, 6.15, 3.4, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 1.0, w: 6.15, h: 0.45, fill: { color: "#1B4332" }, line: { color: C.green } });
  s.addText("HYPOTHYROIDISM  — Mnemonic: SLOW BM", { x: 0.3, y: 1.0, w: 6.0, h: 0.45, fontSize: 12, bold: true, color: C.green, valign: "middle", margin: 0 });
  const hypo = [
    ["S", "Sensitivity to cold"],
    ["L", "Lethargy + depression"],
    ["O", "Obesity (weight gain)"],
    ["W", "Water retention (myxedema)"],
    ["B", "Bradycardia"],
    ["M", "Menorrhagia + constipation"],
  ];
  hypo.forEach(([l, v], i) => {
    const col = i % 2, row = Math.floor(i / 2);
    s.addShape(pres.shapes.ELLIPSE, { x: 0.3 + col * 3.0, y: 1.55 + row * 0.65, w: 0.35, h: 0.35, fill: { color: C.green }, line: { color: C.green } });
    s.addText(l, { x: 0.3 + col * 3.0, y: 1.55 + row * 0.65, w: 0.35, h: 0.35, fontSize: 12, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(v, { x: 0.75 + col * 3.0, y: 1.55 + row * 0.65, w: 2.6, h: 0.35, fontSize: 9, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Cause #1 (West): Hashimoto's (anti-TPO, anti-Tg) | Rx: Levothyroxine", { x: 0.3, y: 3.6, w: 5.9, h: 0.38, fontSize: 8.5, italic: true, color: C.gray, valign: "middle", margin: 0 });

  // Hyper card
  card(s, 6.95, 1.0, 6.15, 3.4, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 6.95, y: 1.0, w: 6.15, h: 0.45, fill: { color: "#1C3D2B" }, line: { color: C.teal } });
  s.addText("HYPERTHYROIDISM  — Mnemonic: FAST THY", { x: 7.05, y: 1.0, w: 6.0, h: 0.45, fontSize: 12, bold: true, color: C.teal, valign: "middle", margin: 0 });
  const hyper = [
    ["F", "Flushing, heat intolerance"],
    ["A", "Arrhythmia (Afib), anxiety"],
    ["S", "Skinny (wt loss, diarrhea)"],
    ["T", "Tremor + tachycardia"],
    ["T", "Thyroid goiter"],
    ["HY", "High T3/T4, young women"],
  ];
  hyper.forEach(([l, v], i) => {
    const col = i % 2, row = Math.floor(i / 2);
    s.addShape(pres.shapes.ELLIPSE, { x: 7.05 + col * 3.0, y: 1.55 + row * 0.65, w: 0.35, h: 0.35, fill: { color: C.teal }, line: { color: C.teal } });
    s.addText(l, { x: 7.05 + col * 3.0, y: 1.55 + row * 0.65, w: 0.35, h: 0.35, fontSize: 10, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(v, { x: 7.5 + col * 3.0, y: 1.55 + row * 0.65, w: 2.6, h: 0.35, fontSize: 9, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Graves' triad: Hyperthyroid + Exophthalmos + Pretibial myxedema | Rx: PTU (pregnancy), I-131, Beta-blocker", { x: 7.05, y: 3.6, w: 5.9, h: 0.38, fontSize: 8.5, italic: true, color: C.gray, valign: "middle", margin: 0 });

  // Thyroid cancer
  s.addText("Thyroid Cancer — PaFoMeAn (Best to Worst Prognosis)", { x: 0.2, y: 4.55, w: 12.9, h: 0.38, fontSize: 13, bold: true, color: C.orange });
  const cancers = [
    { name: "PAPILLARY", pct: "80%", color: C.green, key: "Orphan Annie nuclei\nPsammoma bodies\nRET/PTC mutation\nCervical LN mets (still good Px)" },
    { name: "FOLLICULAR", pct: "10%", color: C.teal, key: "Hematogenous spread\nVascular invasion\nNo lymph node mets\nRAI responsive" },
    { name: "MEDULLARY", pct: "5-8%", color: C.orange, key: "C-cells → Calcitonin\nAmyloid stroma\nRET mutation\nMEN2A/2B" },
    { name: "ANAPLASTIC", pct: "<5%", color: C.red, key: "Elderly patients\nRapidly fatal\nNO response to RAI\nWorst prognosis" },
  ];
  cancers.forEach((c, i) => {
    const x = 0.2 + i * 3.27;
    card(s, x, 5.0, 3.05, 2.3, C.cardBg);
    s.addShape(pres.shapes.RECTANGLE, { x, y: 5.0, w: 3.05, h: 0.4, fill: { color: c.color }, line: { color: c.color } });
    s.addText(c.name + "  " + c.pct, { x: x + 0.05, y: 5.0, w: 2.95, h: 0.4, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0 });
    s.addText(c.key, { x: x + 0.1, y: 5.45, w: 2.85, h: 1.8, fontSize: 8.5, color: C.offWhite, valign: "top", margin: 0 });
  });
  s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 7.28, w: 12.9, h: 0.15, fill: { color: C.green }, line: { color: C.green } });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 11 — ADRENAL
// ═══════════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "Endocrine 03 | Adrenal Disorders — GFR Zones + Cushing/Addison/Pheo", C.orange);

  // GFR zones diagram
  s.addText("Adrenal Zones — Mnemonic: GFR (outside → in)", { x: 0.2, y: 1.0, w: 6.5, h: 0.38, fontSize: 13, bold: true, color: C.orange });
  const zones = [
    { name: "GLOMERULOSA", makes: "Aldosterone", color: C.teal, x: 0.2, w: 4.2 },
    { name: "FASCICULATA", makes: "Cortisol (longest zone)", color: C.orange, x: 0.2, w: 3.2 },
    { name: "RETICULARIS", makes: "Androgens (DHEA)", color: C.purple, x: 0.2, w: 2.2 },
    { name: "MEDULLA", makes: "Catecholamines (Epi >> NE)", color: C.red, x: 0.2, w: 1.4 },
  ];
  zones.forEach((z, i) => {
    s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 1.5 + i * 0.62, w: z.w + 1.5, h: 0.55, fill: { color: z.color, transparency: 30 }, line: { color: z.color } });
    s.addText(z.name + ": " + z.makes, { x: 0.3, y: 1.5 + i * 0.62, w: z.w + 1.3, h: 0.55, fontSize: 9.5, bold: true, color: C.white, valign: "middle", margin: 0 });
  });
  s.addText("'Go Find Rex' — and Rex lives in the Medulla", { x: 0.2, y: 4.05, w: 5.5, h: 0.35, fontSize: 9, italic: true, color: C.gray });

  // Cushing's
  card(s, 6.0, 1.0, 7.1, 3.0, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 6.0, y: 1.0, w: 7.1, h: 0.4, fill: { color: C.orange, transparency: 20 }, line: { color: C.orange } });
  s.addText("Cushing's Syndrome — Mnemonic: CUSHINGS", { x: 6.1, y: 1.0, w: 6.9, h: 0.4, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
  const cush = ["C - Central obesity (moon face, buffalo hump)", "U - Urine cortisol elevated", "S - Striae (purple)", "H - Hypertension", "I - Insulin resistance", "N - No menses (amenorrhea)", "G - Glucose elevated", "S - Skin thinning + easy bruising"];
  cush.forEach((c, i) => {
    const col = i % 2, row = Math.floor(i / 2);
    s.addText("• " + c, { x: 6.1 + col * 3.5, y: 1.5 + row * 0.48, w: 3.4, h: 0.42, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Dx Test: High-dose Dex suppresses PITUITARY only (not ectopic ACTH, not adrenal)", { x: 6.1, y: 3.62, w: 6.9, h: 0.35, fontSize: 8.5, italic: true, color: C.gray, margin: 0 });

  // Addison's
  card(s, 0.2, 4.45, 4.3, 2.75, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 4.45, w: 4.3, h: 0.4, fill: { color: C.teal, transparency: 20 }, line: { color: C.teal } });
  s.addText("Addison's — SHADE", { x: 0.3, y: 4.45, w: 4.1, h: 0.4, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
  ["S - Skin hyperpigmentation (ACTH→MSH)", "H - Hypotension + Hyperkalemia", "A - Anemia", "D - Dehydration (Na wasting)", "E - Electrolytes: Low Na, High K"].forEach((p, i) => {
    s.addText("• " + p, { x: 0.3, y: 4.95 + i * 0.43, w: 4.0, h: 0.38, fontSize: 9, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Rx: IV Hydrocortisone + IV Saline (Addisonian crisis)", { x: 0.3, y: 7.0, w: 4.0, h: 0.35, fontSize: 8, italic: true, color: C.gray });

  // Conn's
  card(s, 4.7, 4.45, 4.1, 2.75, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 4.7, y: 4.45, w: 4.1, h: 0.4, fill: { color: C.green, transparency: 20 }, line: { color: C.green } });
  s.addText("Conn's — HANK", { x: 4.8, y: 4.45, w: 3.9, h: 0.4, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
  ["H - Hypertension (resistant)", "A - Alkalosis (metabolic)", "N - No renin (low renin)", "K - K+ low (hypokalemia)"].forEach((p, i) => {
    s.addText("• " + p, { x: 4.8, y: 4.95 + i * 0.52, w: 3.85, h: 0.48, fontSize: 9, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Cause: Adrenal adenoma | Rx: Spironolactone", { x: 4.8, y: 7.0, w: 3.85, h: 0.35, fontSize: 8, italic: true, color: C.gray });

  // Pheo
  card(s, 9.0, 4.45, 4.1, 2.75, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 9.0, y: 4.45, w: 4.1, h: 0.4, fill: { color: C.red, transparency: 20 }, line: { color: C.red } });
  s.addText("Pheochromocytoma — 5 P's", { x: 9.1, y: 4.45, w: 3.9, h: 0.4, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
  ["P - Paroxysmal HTN", "P - Palpitations", "P - Perspiration (diaphoresis)", "P - Pallor", "P - Pain (headache)"].forEach((p, i) => {
    s.addText("• " + p, { x: 9.1, y: 4.95 + i * 0.43, w: 3.85, h: 0.38, fontSize: 9, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Rule of 10s | Dx: Urine metanephrines | Rx: Alpha-block FIRST then Beta-block then surgery", { x: 9.1, y: 6.65, w: 3.85, h: 0.55, fontSize: 7.5, italic: true, color: C.gray });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 12 — DIABETES MELLITUS
// ═══════════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "Endocrine 04 | Diabetes Mellitus — T1 vs T2, DKA vs HHS, Drugs", C.red);

  // T1 vs T2 table
  s.addText("Type 1 vs Type 2 Diabetes", { x: 0.2, y: 1.0, w: 12.9, h: 0.38, fontSize: 13, bold: true, color: C.red });
  const dmH = ["Feature", "TYPE 1", "TYPE 2"];
  const dmR = [
    ["Pathology", "Autoimmune beta-cell destruction", "Insulin resistance + relative deficiency"],
    ["Age", "< 30 (child / young adult)", "> 40 (middle-aged / elderly)"],
    ["Body type", "Thin", "Obese"],
    ["Ketoacidosis", "YES — DKA (classic)", "Rare — HHS instead"],
    ["Autoantibodies", "Anti-GAD, Anti-islet cell", "None"],
    ["HLA link", "DR3, DR4", "No HLA link"],
    ["Treatment", "Insulin ONLY", "Lifestyle → Metformin → add-ons → Insulin"],
  ];
  const dmCW = [2.2, 5.3, 5.5];
  const dmCX = [0.2, 2.45, 7.8];
  dmH.forEach((h, ci) => {
    s.addShape(pres.shapes.RECTANGLE, { x: dmCX[ci], y: 1.43, w: dmCW[ci], h: 0.38, fill: { color: ci === 1 ? C.tealDk : (ci === 2 ? "#7F1D1D" : C.cardBg) }, line: { color: C.red } });
    s.addText(h, { x: dmCX[ci] + 0.05, y: 1.43, w: dmCW[ci] - 0.1, h: 0.38, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0, align: ci === 0 ? "left" : "center" });
  });
  dmR.forEach((row, ri) => {
    row.forEach((cell, ci) => {
      s.addShape(pres.shapes.RECTANGLE, { x: dmCX[ci], y: 1.85 + ri * 0.46, w: dmCW[ci], h: 0.44, fill: { color: ri % 2 === 0 ? C.cardBg : C.cardBg2 }, line: { color: C.red, transparency: 80 } });
      s.addText(cell, { x: dmCX[ci] + 0.05, y: 1.85 + ri * 0.46, w: dmCW[ci] - 0.1, h: 0.44, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
    });
  });

  // DKA vs HHS
  s.addText("DKA vs HHS — Critical Comparison", { x: 0.2, y: 5.15, w: 7.0, h: 0.38, fontSize: 13, bold: true, color: C.orange });
  const dkaH = ["Feature", "DKA (Type 1)", "HHS (Type 2)"];
  const dkaR = [
    ["Glucose", "> 250 mg/dL", "> 600 mg/dL"],
    ["pH", "< 7.3 (ACIDOSIS)", "Normal (> 7.3)"],
    ["Ketones", "YES (+++)", "Minimal / absent"],
    ["Osmolality", "Mildly elevated", "> 320 mOsm/kg"],
    ["Mortality", "~1%", "~15% (worse!)"],
  ];
  const dkaCW = [2.0, 2.5, 2.5];
  const dkaCX = [0.2, 2.25, 4.8];
  dkaH.forEach((h, ci) => {
    s.addShape(pres.shapes.RECTANGLE, { x: dkaCX[ci], y: 5.57, w: dkaCW[ci], h: 0.38, fill: { color: ci === 1 ? C.tealDk : (ci === 2 ? "#7F1D1D" : C.cardBg) }, line: { color: C.orange } });
    s.addText(h, { x: dkaCX[ci] + 0.05, y: 5.57, w: dkaCW[ci] - 0.1, h: 0.38, fontSize: 9, bold: true, color: C.white, valign: "middle", margin: 0, align: ci === 0 ? "left" : "center" });
  });
  dkaR.forEach((row, ri) => {
    row.forEach((cell, ci) => {
      s.addShape(pres.shapes.RECTANGLE, { x: dkaCX[ci], y: 5.99 + ri * 0.42, w: dkaCW[ci], h: 0.4, fill: { color: ri % 2 === 0 ? C.cardBg : C.cardBg2 }, line: { color: C.orange, transparency: 70 } });
      s.addText(cell, { x: dkaCX[ci] + 0.05, y: 5.99 + ri * 0.42, w: dkaCW[ci] - 0.1, h: 0.4, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
    });
  });

  // Oral drugs
  s.addText("Key Oral Antidiabetics", { x: 7.6, y: 5.15, w: 5.5, h: 0.38, fontSize: 13, bold: true, color: C.green });
  const drugs = [
    { name: "Metformin", memo: "#1 T2DM | No hypoglycemia | Lactic acidosis risk", color: C.green },
    { name: "Sulfonylureas", memo: "Stimulate insulin secretion | CAN cause hypoglycemia", color: C.orange },
    { name: "GLP-1 agonists", memo: "Weight loss | Used in obese T2DM", color: C.teal },
    { name: "SGLT2 inhibitors", memo: "Glucosuria | UTI risk | Cardioprotective", color: C.purple },
  ];
  drugs.forEach((d, i) => {
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 7.6, y: 5.6 + i * 0.47, w: 2.0, h: 0.38, fill: { color: d.color }, line: { color: d.color }, rectRadius: 0.06 });
    s.addText(d.name, { x: 7.6, y: 5.6 + i * 0.47, w: 2.0, h: 0.38, fontSize: 9, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(d.memo, { x: 9.7, y: 5.6 + i * 0.47, w: 3.4, h: 0.38, fontSize: 8, color: C.offWhite, valign: "middle", margin: 0 });
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  s.addText("CRAMPS Complications: Cardiovascular | Retinopathy | Atherosclerosis | Micro-albuminuria (nephropathy) | Peripheral neuropathy | Susceptibility to infection", { x: 7.6, y: 7.5, w: 5.5, h: 0.38, fontSize: 7.5, italic: true, color: C.gray });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 13 — ONE-LINE KILLERS / RAPID RECALL
// ═══════════════════════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  s.background = { color: C.navy };
  sectionBar(s, "RAPID RECALL — One-Line Killers for MCQs", C.teal);

  const killers = [
    ["Periventricular lesions, young woman", "Multiple Sclerosis", C.teal],
    ["Ascending paralysis after Campylobacter", "GBS", C.teal],
    ["'Worst HA of my life'", "SAH (Berry aneurysm)", C.red],
    ["Xanthochromia in CSF", "Subarachnoid Hemorrhage", C.red],
    ["Temporal lobe + fever + personality change", "HSV Encephalitis → ACYCLOVIR", C.orange],
    ["Pill-rolling tremor + cogwheel rigidity", "Parkinson's — Lewy bodies", C.purple],
    ["Beta-amyloid + neurofibrillary tangles", "Alzheimer's Disease", C.purple],
    ["Orphan Annie nuclei + Psammoma bodies", "Papillary Thyroid Cancer", C.green],
    ["Calcitonin-secreting tumor", "Medullary Thyroid Ca (MEN2)", C.green],
    ["High aldosterone + low renin + low K+", "Conn's Syndrome", C.orange],
    ["Paroxysmal HTN + diaphoresis + headache", "Pheochromocytoma", C.red],
    ["Skin hyperpigmentation + low Na + high K+", "Addison's Disease", C.teal],
    ["Moon face + buffalo hump + purple striae", "Cushing's Syndrome", C.orange],
    ["Bitemporal hemianopia", "Pituitary tumor (chiasm compression)", C.purple],
    ["High protein + normal WBC in CSF", "GBS (albuminocytologic dissociation)", C.teal],
    ["India Ink halo + HIV patient", "Cryptococcus meningitis", C.green],
    ["Spongiform vacuolation + myoclonus", "CJD (Prion disease)", C.red],
    ["Butterfly glioma crossing corpus callosum", "GBM (Grade IV)", C.purple],
    ["Homer-Wright rosettes, child, cerebellum", "Medulloblastoma", C.orange],
    ["Fried egg cells + 1p/19q deletion", "Oligodendroglioma", C.teal],
  ];
  // Two columns
  const left = killers.slice(0, 10);
  const right = killers.slice(10);
  [left, right].forEach((col, ci) => {
    col.forEach(([clue, ans, color], ri) => {
      const x = ci === 0 ? 0.2 : 6.75;
      const y = 1.0 + ri * 0.63;
      s.addShape(pres.shapes.RECTANGLE, { x, y, w: 6.4, h: 0.55, fill: { color: C.cardBg }, line: { color: color, transparency: 50 } });
      s.addShape(pres.shapes.RECTANGLE, { x, y, w: 0.12, h: 0.55, fill: { color: color }, line: { color: color } });
      s.addText(clue, { x: x + 0.2, y, w: 3.8, h: 0.55, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
      s.addShape(pres.shapes.RIGHT_ARROW, { x: x + 4.05, y: y + 0.15, w: 0.3, h: 0.25, fill: { color: color }, line: { color: color } });
      s.addText(ans, { x: x + 4.45, y, w: 1.85, h: 0.55, fontSize: 8, bold: true, color: color, valign: "middle", margin: 0 });
    });
  });
}

// ═══════════════════════════════════════════════════════════════════════════════
// SLIDE 14 — CLOSING
// ═══════════════════════════════════════════════════════════════════════════════
{
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  s.background = { color: C.navy };
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 0.18, h: 7.5, fill: { color: C.teal }, line: { color: C.teal } });
  s.addShape(pres.shapes.RECTANGLE, { x: 13.12, y: 0, w: 0.18, h: 7.5, fill: { color: C.teal }, line: { color: C.teal } });
  s.addText("Good luck on your exams!", { x: 1.0, y: 1.2, w: 11.3, h: 1.2, fontSize: 42, bold: true, color: C.white, align: "center", fontFace: "Calibri" });
  s.addText("Master these mnemonics and you will ace your MCQs.", { x: 1.0, y: 2.5, w: 11.3, h: 0.6, fontSize: 20, color: C.teal, align: "center" });
  s.addShape(pres.shapes.RECTANGLE, { x: 3.5, y: 3.2, w: 6.3, h: 0.04, fill: { color: C.teal }, line: { color: C.teal } });
  const mnems = [
    { label: "CNS", text: "SPASM (MS)  |  GAME (Tumors)  |  TRAP (Parkinson's)  |  ABCs (Alzheimer's)  |  CAME (Pediatric tumors)" },
    { label: "Endocrine", text: "FLAT PiG (Pituitary)  |  SLOW BM (Hypo)  |  FAST THY (Hyper)  |  PaFoMeAn (Thyroid Ca)" },
    { label: "Adrenal", text: "GFR zones  |  CUSHINGS  |  SHADE (Addison's)  |  HANK (Conn's)  |  5 P's + Rule of 10s (Pheo)" },
    { label: "Diabetes", text: "CRAMPS (complications)  |  RAIN (insulin types)  |  DKA vs HHS comparison" },
  ];
  mnems.forEach((m, i) => {
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 1.0, y: 3.45 + i * 0.85, w: 1.6, h: 0.6, fill: { color: C.tealDk }, line: { color: C.teal }, rectRadius: 0.06 });
    s.addText(m.label, { x: 1.0, y: 3.45 + i * 0.85, w: 1.6, h: 0.6, fontSize: 10, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(m.text, { x: 2.75, y: 3.48 + i * 0.85, w: 10.0, h: 0.55, fontSize: 9.5, color: C.offWhite, valign: "middle", margin: 0 });
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  s.addText("Prepared by Orris — Your AI Study Companion", { x: 1.0, y: 7.0, w: 11.3, h: 0.35, fontSize: 10, color: C.gray, align: "center" });
}

// ═══ WRITE FILE ═══════════════════════════════════════════════════════════════
pres.writeFile({ fileName: "/home/daytona/workspace/med-study-pptx/CNS_Endocrine_HighYield.pptx" })
  .then(() => console.log("SUCCESS: Presentation written."))
  .catch(e => { console.error("ERROR:", e); process.exit(1); });

const pptxgen = require("pptxgenjs");
const pres = new pptxgen();
pres.layout = "LAYOUT_WIDE";
pres.title = "CNS & Endocrine Pathology - High Yield MCQ Study Guide";

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  green:   "10B981",
  red:     "EF4444",
  orange:  "F59E0B",
  purple:  "8B5CF6",
  white:   "FFFFFF",
  offWhite:"F1F5F9",
  gray:    "94A3B8",
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  cardBg:  "1E293B",
  cardBg2: "162032",
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function darkSlide(s) { s.background = { color: C.darkBg }; }

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    line: { color: C.teal, width: 1 },
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  s.addText(text, { x, y, w, h, fontSize: 8, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
}

// ═══ SLIDE 1 — TITLE ═══════════════════════════════════════════════════════════
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  const s = pres.addSlide();
  s.background = { color: C.navy };
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 13.3, h: 0.18, fill: { color: C.teal }, line: { color: C.teal } });
  s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 7.32, w: 13.3, h: 0.18, fill: { color: C.teal }, line: { color: C.teal } });
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  s.addText("CNS & Endocrine Pathology", { x: 0.5, y: 1.5, w: 9.5, h: 1.3, fontSize: 42, bold: true, color: C.white, fontFace: "Calibri" });
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// ═══ SLIDE 2 — CNS SECTION INTRO ══════════════════════════════════════════════
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  s.addText("Central Nervous System\nPathology", { x: 0.6, y: 1.1, w: 12, h: 2, fontSize: 44, bold: true, color: C.white, fontFace: "Calibri" });
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    { label: "02", text: "Brain Tumors", color: C.purple },
    { label: "03", text: "Cerebrovascular Disease", color: C.red },
    { label: "04", text: "Neurodegeneration", color: C.green },
    { label: "05", text: "CNS Infections", color: C.orange },
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// ═══ SLIDE 3 — MS vs GBS ══════════════════════════════════════════════════════
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  sectionBar(s, "01 | Demyelinating Diseases: Multiple Sclerosis vs Guillain-Barre Syndrome", C.tealDk);

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    ["Age/Sex", "Young women 20-40"],
    ["Pathology", "Oligodendrocyte destruction\nWhite matter demyelination"],
    ["Location", "Periventricular plaques\nDawson's Fingers on MRI"],
    ["CSF", "Oligoclonal IgG bands"],
    ["Signs", "Uhthoff's (heat worsens)\nLhermitte's (neck flex = shock)"],
    ["Treatment", "Beta-interferon (modify)\nSteroids (acute attack)"],
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    ["Presentation", "Ascending flaccid paralysis\n+ Areflexia"],
    ["CSF", "ALBUMINOCYTOLOGIC\nDISSOCIATION\n(High protein, normal WBC)"],
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    ["Treatment", "IVIG or Plasmapheresis"],
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  gbsData.forEach(([k, v], i) => {
    s.addShape(pres.shapes.RECTANGLE, { x: 7.0, y: 1.62 + i * 0.65, w: 1.6, h: 0.58, fill: { color: C.purple, transparency: 30 }, line: { color: C.purple, width: 1 } });
    s.addText(k, { x: 7.0, y: 1.62 + i * 0.65, w: 1.6, h: 0.58, fontSize: 9, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(v, { x: 8.7, y: 1.62 + i * 0.65, w: 4.3, h: 0.58, fontSize: 9, color: C.offWhite, valign: "middle", margin: 0 });
  });

  s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 7.1, w: 12.9, h: 0.38, fill: { color: C.red, transparency: 20 }, line: { color: C.red, width: 1 } });
  s.addText("MCQ TRAP:  MS = CENTRAL (UMN) = Spastic + Hyperreflexia     |     GBS = PERIPHERAL (LMN) = Flaccid + Areflexia", { x: 0.3, y: 7.1, w: 12.7, h: 0.38, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
}

// ═══ SLIDE 4 — BRAIN TUMORS ════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "02 | Brain Tumors — High-Yield Table + Mnemonics (GAME / CAME)", C.purple);

  const game = [
    { letter: "G", text: "liomas (most common overall)", color: C.teal },
    { letter: "A", text: "denocarcinoma mets (#1 in adults)", color: C.orange },
    { letter: "M", text: "eningioma (most common BENIGN)", color: C.green },
    { letter: "E", text: "pendymoma (4th ventricle, child)", color: C.purple },
  ];
  game.forEach((g, i) => {
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 0.2 + i * 3.25, y: 1.0, w: 3.0, h: 0.85, fill: { color: g.color, transparency: 25 }, line: { color: g.color, width: 1 }, rectRadius: 0.07 });
    s.addText(g.letter, { x: 0.2 + i * 3.25, y: 1.0, w: 0.65, h: 0.85, fontSize: 26, bold: true, color: g.color, align: "center", valign: "middle", margin: 0 });
    s.addText(g.text, { x: 0.85 + i * 3.25, y: 1.0, w: 2.4, h: 0.85, fontSize: 10, color: C.white, valign: "middle", margin: 0 });
  });

  const headers = ["Tumor", "Location", "Age", "Key MCQ Fact"];
  const rows = [
    ["Pilocytic Astrocytoma", "Cerebellum", "Child", "Rosenthal fibers | BENIGN Grade I"],
    ["Medulloblastoma", "Cerebellum (4th V)", "Child", "Homer-Wright rosettes | Radiosensitive"],
    ["Ependymoma", "4th Ventricle", "Child", "Perivascular pseudorosettes"],
    ["GBM (Grade IV)", "Temporal/Frontal", "Elderly", "Butterfly pattern | Pseudopalisading necrosis | GFAP+"],
    ["Oligodendroglioma", "Frontal lobe", "Adult", "Fried egg cells | 1p/19q deletion"],
    ["Meningioma", "Parasagittal", "Adult F", "Psammoma bodies | Whorled pattern | BENIGN extra-axial"],
    ["Schwannoma (CN VIII)", "CPA angle", "Adult", "S100+ | Bilateral = NF2"],
    ["Craniopharyngioma", "Suprasellar", "Child", "Calcification | Cholesterol crystals | Bitemporal hemianopia"],
  ];
  const colW = [2.6, 2.2, 1.3, 6.8];
  const colX = [0.2, 2.85, 5.1, 6.45];
  headers.forEach((h, ci) => {
    s.addShape(pres.shapes.RECTANGLE, { x: colX[ci], y: 2.0, w: colW[ci], h: 0.4, fill: { color: C.purple }, line: { color: C.purple } });
    s.addText(h, { x: colX[ci] + 0.05, y: 2.0, w: colW[ci] - 0.1, h: 0.4, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0 });
  });
  rows.forEach((row, ri) => {
    const bg = ri % 2 === 0 ? C.cardBg : C.cardBg2;
    row.forEach((cell, ci) => {
      s.addShape(pres.shapes.RECTANGLE, { x: colX[ci], y: 2.44 + ri * 0.6, w: colW[ci], h: 0.58, fill: { color: bg }, line: { color: C.cardBg, width: 0 } });
      s.addText(cell, { x: colX[ci] + 0.05, y: 2.44 + ri * 0.6, w: colW[ci] - 0.1, h: 0.58, fontSize: 9, color: C.offWhite, valign: "middle", margin: 0 });
    });
  });

  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 0.2, y: 7.1, w: 12.9, h: 0.35, fill: { color: C.orange, transparency: 25 }, line: { color: C.orange, width: 1 }, rectRadius: 0.05 });
  s.addText("PEDIATRIC (CAME):  Craniopharyngioma  |  Astrocytoma (pilocytic)  |  Medulloblastoma  |  Ependymoma", { x: 0.3, y: 7.1, w: 12.7, h: 0.35, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0 });
}

// ═══ SLIDE 5 — STROKE FLOWCHART ════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "03 | Cerebrovascular Disease — Stroke Classification Flowchart", C.red);

  // Stroke central node
  s.addShape(pres.shapes.ELLIPSE, { x: 5.25, y: 1.05, w: 2.8, h: 0.9, fill: { color: C.red }, line: { color: C.red } });
  s.addText("STROKE", { x: 5.25, y: 1.05, w: 2.8, h: 0.9, fontSize: 18, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });

  // Ischemic branch
  s.addShape(pres.shapes.DOWN_ARROW, { x: 2.7, y: 1.6, w: 0.3, h: 0.45, fill: { color: C.teal }, line: { color: C.teal } });
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 1.0, y: 2.1, w: 3.5, h: 0.68, fill: { color: C.tealDk }, line: { color: C.teal, width: 1 }, rectRadius: 0.07 });
  s.addText("ISCHEMIC (87%)", { x: 1.0, y: 2.1, w: 3.5, h: 0.68, fontSize: 14, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });

  s.addShape(pres.shapes.DOWN_ARROW, { x: 1.3, y: 2.85, w: 0.3, h: 0.4, fill: { color: C.teal }, line: { color: C.teal } });
  card(s, 0.3, 3.3, 2.0, 1.55, C.cardBg);
  s.addText("THROMBOTIC", { x: 0.3, y: 3.3, w: 2.0, h: 0.38, fontSize: 10, bold: true, color: C.teal, align: "center", valign: "middle", margin: 0 });
  s.addText("Atherosclerotic plaque\nGradual onset\nWake-up stroke", { x: 0.3, y: 3.7, w: 2.0, h: 1.1, fontSize: 8.5, color: C.offWhite, valign: "top", margin: 4 });

  s.addShape(pres.shapes.DOWN_ARROW, { x: 2.65, y: 2.85, w: 0.3, h: 0.4, fill: { color: C.teal }, line: { color: C.teal } });
  card(s, 2.38, 3.3, 2.0, 1.55, C.cardBg);
  s.addText("EMBOLIC", { x: 2.38, y: 3.3, w: 2.0, h: 0.38, fontSize: 10, bold: true, color: C.teal, align: "center", valign: "middle", margin: 0 });
  s.addText("From heart (Afib #1)\nSudden onset\nMCA most common", { x: 2.38, y: 3.7, w: 2.0, h: 1.1, fontSize: 8.5, color: C.offWhite, valign: "top", margin: 4 });

  // Hemorrhagic branch
  s.addShape(pres.shapes.DOWN_ARROW, { x: 10.0, y: 1.6, w: 0.3, h: 0.45, fill: { color: C.red }, line: { color: C.red } });
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 8.8, y: 2.1, w: 3.5, h: 0.68, fill: { color: "7F1D1D" }, line: { color: C.red, width: 1 }, rectRadius: 0.07 });
  s.addText("HEMORRHAGIC (13%)", { x: 8.8, y: 2.1, w: 3.5, h: 0.68, fontSize: 14, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });

  s.addShape(pres.shapes.DOWN_ARROW, { x: 9.1, y: 2.85, w: 0.3, h: 0.4, fill: { color: C.red }, line: { color: C.red } });
  card(s, 8.3, 3.3, 2.0, 1.55, C.cardBg);
  s.addText("INTRACEREBRAL", { x: 8.3, y: 3.3, w: 2.0, h: 0.38, fontSize: 9, bold: true, color: C.red, align: "center", valign: "middle", margin: 0 });
  s.addText("HTN #1 cause\nCharcot-Bouchard\naneurysms\nPutamen most common", { x: 8.3, y: 3.7, w: 2.0, h: 1.1, fontSize: 8, color: C.offWhite, valign: "top", margin: 4 });

  s.addShape(pres.shapes.DOWN_ARROW, { x: 10.65, y: 2.85, w: 0.3, h: 0.4, fill: { color: C.red }, line: { color: C.red } });
  card(s, 10.0, 3.3, 2.2, 1.55, C.cardBg);
  s.addText("SUBARACHNOID", { x: 10.0, y: 3.3, w: 2.2, h: 0.38, fontSize: 9, bold: true, color: C.red, align: "center", valign: "middle", margin: 0 });
  s.addText("Berry aneurysm #1\n'Worst HA of life'\nXanthochromia CSF\nADPKD association", { x: 10.0, y: 3.7, w: 2.2, h: 1.1, fontSize: 8, color: C.offWhite, valign: "top", margin: 4 });

  // EDH vs SDH table
  s.addText("EDH vs SDH Hematoma", { x: 4.4, y: 5.0, w: 4.5, h: 0.38, fontSize: 13, bold: true, color: C.orange, align: "center" });
  const edhSdh = [
    ["", "EPIDURAL (EDH)", "SUBDURAL (SDH)"],
    ["Vessel", "Middle meningeal ARTERY", "Bridging VEINS"],
    ["CT shape", "Biconvex (lens)", "Crescent-shaped"],
    ["Lucid interval", "YES (classic)", "Sometimes"],
    ["Cause", "Temporal bone fracture", "Elderly / alcoholics"],
  ];
  const eCols = [1.3, 4.0, 3.8];
  const eX = [4.2, 5.55, 9.6];
  edhSdh.forEach((row, ri) => {
    row.forEach((cell, ci) => {
      const bg = ri === 0 ? C.orange : (ri % 2 === 0 ? C.cardBg : C.cardBg2);
      const fg = ri === 0 ? C.navy : (ci === 0 ? C.gray : C.offWhite);
      s.addShape(pres.shapes.RECTANGLE, { x: eX[ci], y: 5.42 + ri * 0.35, w: eCols[ci], h: 0.33, fill: { color: bg }, line: { color: C.cardBg, width: 0 } });
      s.addText(cell, { x: eX[ci] + 0.05, y: 5.42 + ri * 0.35, w: eCols[ci] - 0.1, h: 0.33, fontSize: 9, bold: ri === 0, color: fg, valign: "middle", margin: 0 });
    });
  });
  s.addText("Mnemonic:  EDH = ARTERY = FAST  |  SDH = VEIN = SLOW", { x: 4.2, y: 7.15, w: 8.9, h: 0.3, fontSize: 10, bold: true, color: C.orange, align: "center", margin: 0 });
}

// ═══ SLIDE 6 — NEURODEGENERATION ══════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "04 | Neurodegenerative Diseases — The Big 4 (APAL)", C.green);

  const diseases = [
    {
      name: "ALZHEIMER'S",
      mnemonic: "ABCs of Alzheimer's",
      color: C.teal,
      points: ["A - Amyloid-β plaques (extracellular)","B - Brain atrophy (hippocampus 1st)","C - Chromosome 21 / ApoE4","D - Downreg. ACh (Rx: Donepezil)","E - Early = short-term memory loss","F - Fibrillary tangles (tau, intracell.)"],
    },
    {
      name: "PARKINSON'S",
      mnemonic: "TRAP",
      color: C.purple,
      points: ["T - Tremor (resting, pill-rolling)","R - Rigidity (cogwheel)","A - Akinesia / bradykinesia","P - Postural instability","Path: Lewy bodies (alpha-synuclein)","Location: Substantia Nigra","Rx: Levodopa/Carbidopa (gold std)"],
    },
    {
      name: "ALS",
      mnemonic: "All Limbs, Spared Sensation",
      color: C.orange,
      points: ["UMN + LMN both involved (unique)","NO sensory loss","NO cognitive decline","NO autonomic dysfunction","Gene: SOD1 mutation","Rx: Riluzole (only disease-modifying)"],
    },
    {
      name: "LEWY BODY",
      mnemonic: "VIPs Fluctuate",
      color: C.red,
      points: ["V - Visual hallucinations (EARLY)","I - Identity: Parkinsonism early","P - Psychiatric (REM sleep disorder)","Fluctuating cognition (hallmark)","Lewy bodies (alpha-synuclein)","Sensitive to antipsychotics!"],
    },
  ];
  diseases.forEach((d, i) => {
    const x = 0.2 + i * 3.27;
    card(s, x, 1.0, 3.05, 6.35, C.cardBg);
    s.addShape(pres.shapes.RECTANGLE, { x, y: 1.0, w: 3.05, h: 0.48, fill: { color: d.color }, line: { color: d.color } });
    s.addText(d.name, { x: x + 0.05, y: 1.0, w: 2.95, h: 0.48, fontSize: 12, bold: true, color: C.white, valign: "middle", margin: 0 });
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: x + 0.1, y: 1.55, w: 2.85, h: 0.35, fill: { color: d.color, transparency: 50 }, line: { color: d.color, width: 1 }, rectRadius: 0.05 });
    s.addText(d.mnemonic, { x: x + 0.1, y: 1.55, w: 2.85, h: 0.35, fontSize: 9, bold: true, italic: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    d.points.forEach((p, pi) => {
      s.addText("• " + p, { x: x + 0.12, y: 2.02 + pi * 0.75, w: 2.85, h: 0.68, fontSize: 8.5, color: C.offWhite, valign: "top", margin: 0 });
    });
  });
}

// ═══ SLIDE 7 — CNS INFECTIONS ══════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "05 | CNS Infections — Meningitis Bugs, CSF Table, Encephalitis, Prions", C.orange);

  // CSF Table
  s.addText("CSF Analysis — Quick Comparison", { x: 0.2, y: 1.0, w: 12.9, h: 0.38, fontSize: 13, bold: true, color: C.orange });
  const csfH = ["Feature", "BACTERIAL", "VIRAL (Aseptic)", "FUNGAL / TB"];
  const csfR = [
    ["Appearance", "Turbid / Cloudy", "Clear", "Clear or Turbid"],
    ["WBC", "High PMNs (>1000)", "High Lymphocytes", "High Lymphocytes"],
    ["Glucose", "VERY LOW (<40)", "Normal", "Low"],
    ["Protein", "VERY HIGH (>200)", "Slightly High", "High"],
    ["Opening P", "Elevated", "Normal/slight", "Elevated"],
  ];
  const csfCW = [2.1, 2.9, 3.0, 3.0];
  const csfCX = [0.2, 2.35, 5.3, 8.35];
  const csfHC = [C.cardBg, C.red, C.tealDk, C.purple];
  csfH.forEach((h, ci) => {
    s.addShape(pres.shapes.RECTANGLE, { x: csfCX[ci], y: 1.42, w: csfCW[ci], h: 0.42, fill: { color: csfHC[ci] }, line: { color: csfHC[ci] } });
    s.addText(h, { x: csfCX[ci] + 0.05, y: 1.42, w: csfCW[ci] - 0.1, h: 0.42, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0, align: ci > 0 ? "center" : "left" });
  });
  csfR.forEach((row, ri) => {
    row.forEach((cell, ci) => {
      s.addShape(pres.shapes.RECTANGLE, { x: csfCX[ci], y: 1.87 + ri * 0.42, w: csfCW[ci], h: 0.4, fill: { color: ri % 2 === 0 ? C.cardBg : C.cardBg2 }, line: { color: C.cardBg, width: 0 } });
      s.addText(cell, { x: csfCX[ci] + 0.05, y: 1.87 + ri * 0.42, w: csfCW[ci] - 0.1, h: 0.4, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0, align: ci > 0 ? "center" : "left" });
    });
  });

  // Bugs by age
  s.addText("Bacterial Meningitis Bugs by Age", { x: 0.2, y: 4.15, w: 6.5, h: 0.38, fontSize: 13, bold: true, color: C.orange });
  const ages = [
    { age: "0-3 months", bugs: "Group B Strep, E. coli, Listeria", memo: "GEL", color: C.red },
    { age: "3m - 18 yrs", bugs: "N. meningitidis, S. pneumoniae, H. influenzae", memo: "NSH", color: C.orange },
    { age: "Adults 18-50", bugs: "S. pneumoniae, N. meningitidis", memo: "SN", color: C.teal },
    { age: "Elderly / Immunocompromised", bugs: "S. pneumoniae + Listeria", memo: "SPL", color: C.purple },
  ];
  ages.forEach((a, i) => {
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 0.2, y: 4.6 + i * 0.68, w: 2.1, h: 0.55, fill: { color: a.color }, line: { color: a.color }, rectRadius: 0.06 });
    s.addText(a.age, { x: 0.2, y: 4.6 + i * 0.68, w: 2.1, h: 0.55, fontSize: 8, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(a.bugs, { x: 2.45, y: 4.6 + i * 0.68, w: 3.8, h: 0.55, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
    pill(s, "Memo: " + a.memo, 6.4, 4.65 + i * 0.68, 1.35, 0.4, a.color);
  });

  // Signs
  s.addText("Kernig's sign: Hip 90° flex - can't extend knee fully", { x: 0.2, y: 7.22, w: 7.5, h: 0.25, fontSize: 8.5, italic: true, color: C.gray });

  // HSV + Crypto boxes
  card(s, 8.0, 4.1, 5.1, 1.6, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 8.0, y: 4.1, w: 5.1, h: 0.38, fill: { color: C.red, transparency: 25 }, line: { color: C.red, width: 1 } });
  s.addText("HSV-1 Encephalitis", { x: 8.05, y: 4.1, w: 5.0, h: 0.38, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
  s.addText("Temporal lobe | Fever + personality change + temporal seizures\nCSF: PCR for HSV DNA | Treatment: IV ACYCLOVIR (stat!)", { x: 8.05, y: 4.52, w: 5.0, h: 1.1, fontSize: 9, color: C.offWhite, valign: "top", margin: 0 });

  card(s, 8.0, 5.85, 5.1, 1.55, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 8.0, y: 5.85, w: 5.1, h: 0.38, fill: { color: C.purple, transparency: 25 }, line: { color: C.purple, width: 1 } });
  s.addText("Cryptococcus + Prion Disease (CJD)", { x: 8.05, y: 5.85, w: 5.0, h: 0.38, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0 });
  s.addText("Crypto: HIV CD4<100 | India Ink halo | Rx: Ampho B + Flucytosine\nCJD: Spongiform vacuolation | Myoclonus + rapid dementia | PrP protein", { x: 8.05, y: 6.27, w: 5.0, h: 1.05, fontSize: 9, color: C.offWhite, valign: "top", margin: 0 });
}

// ═══ SLIDE 8 — ENDOCRINE INTRO ═════════════════════════════════════════════════
{
  const s = pres.addSlide();
  s.background = { color: "0A1628" };
  s.addShape(pres.shapes.RECTANGLE, { x: 13.0, y: 0, w: 0.3, h: 7.5, fill: { color: C.green }, line: { color: C.green } });
  s.addText("SECTION 2", { x: 0.6, y: 0.5, w: 12, h: 0.5, fontSize: 14, bold: true, color: C.green, charSpacing: 4 });
  s.addText("Endocrine\nPathology", { x: 0.6, y: 1.1, w: 12, h: 2.2, fontSize: 52, bold: true, color: C.white, fontFace: "Calibri" });
  s.addShape(pres.shapes.RECTANGLE, { x: 0.6, y: 3.4, w: 4, h: 0.05, fill: { color: C.green }, line: { color: C.green } });
  const topics = [
    { label: "01", text: "Pituitary Disorders", color: C.teal },
    { label: "02", text: "Thyroid Disorders", color: C.green },
    { label: "03", text: "Adrenal Disorders", color: C.orange },
    { label: "04", text: "Diabetes Mellitus", color: C.red },
  ];
  topics.forEach((t, i) => {
    s.addShape(pres.shapes.RECTANGLE, { x: 0.6, y: 3.7 + i * 0.78, w: 0.45, h: 0.48, fill: { color: t.color }, line: { color: t.color } });
    s.addText(t.label, { x: 0.6, y: 3.7 + i * 0.78, w: 0.45, h: 0.48, fontSize: 11, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(t.text, { x: 1.2, y: 3.75 + i * 0.78, w: 9, h: 0.4, fontSize: 18, color: C.white, valign: "middle", margin: 0 });
  });
}

// ═══ SLIDE 9 — PITUITARY ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "Endocrine 01 | Pituitary Disorders — Hormones, Adenomas & DI Flowchart", C.teal);

  s.addText("Anterior Pituitary — Mnemonic: FLAT PiG", { x: 0.2, y: 1.0, w: 7.5, h: 0.38, fontSize: 13, bold: true, color: C.teal });
  const hormones = [
    { letter: "F", h: "FSH", note: "Follicle stimulating" },
    { letter: "L", h: "LH", note: "Luteinizing hormone" },
    { letter: "A", h: "ACTH", note: "Adrenocorticotropic" },
    { letter: "T", h: "TSH", note: "Thyroid stimulating" },
    { letter: "Pi", h: "PRL", note: "Prolactin" },
    { letter: "G", h: "GH", note: "Growth hormone" },
  ];
  hormones.forEach((h, i) => {
    const x = 0.2 + i * 2.15;
    s.addShape(pres.shapes.ELLIPSE, { x, y: 1.48, w: 1.8, h: 0.82, fill: { color: C.tealDk, transparency: 25 }, line: { color: C.teal, width: 1 } });
    s.addText(h.letter, { x, y: 1.48, w: 0.55, h: 0.82, fontSize: 18, bold: true, color: C.accent, align: "center", valign: "middle", margin: 0 });
    s.addText(h.h + "\n" + h.note, { x: x + 0.5, y: 1.48, w: 1.3, h: 0.82, fontSize: 8, color: C.white, valign: "middle", margin: 0 });
  });
  s.addText("Posterior: ADH + Oxytocin (made in hypothalamus, stored in posterior pituitary)", { x: 0.2, y: 2.4, w: 12.9, h: 0.35, fontSize: 10, italic: true, color: C.gray });

  s.addText("Pituitary Adenoma Types", { x: 0.2, y: 2.82, w: 7.5, h: 0.38, fontSize: 13, bold: true, color: C.teal });
  const adH = ["Adenoma", "Hormone", "Presentation"];
  const adR = [
    ["Prolactinoma (#1)", "Prolactin", "Amenorrhea + galactorrhea (F); Impotence (M) | Rx: Cabergoline"],
    ["Somatotroph", "GH", "Acromegaly (adult) / Gigantism (child) | Rx: Transsphenoidal surgery"],
    ["Corticotroph", "ACTH", "Cushing's DISEASE | Suppressed by high-dose dexamethasone"],
    ["Non-functioning", "None", "Mass effects: Bitemporal hemianopia (optic chiasm compression)"],
  ];
  const adCW = [2.4, 1.8, 8.7];
  const adCX = [0.2, 2.65, 4.5];
  adH.forEach((h, ci) => {
    s.addShape(pres.shapes.RECTANGLE, { x: adCX[ci], y: 3.25, w: adCW[ci], h: 0.38, fill: { color: C.tealDk }, line: { color: C.tealDk } });
    s.addText(h, { x: adCX[ci] + 0.05, y: 3.25, w: adCW[ci] - 0.1, h: 0.38, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0 });
  });
  adR.forEach((row, ri) => {
    row.forEach((cell, ci) => {
      s.addShape(pres.shapes.RECTANGLE, { x: adCX[ci], y: 3.67 + ri * 0.55, w: adCW[ci], h: 0.52, fill: { color: ri % 2 === 0 ? C.cardBg : C.cardBg2 }, line: { color: C.cardBg, width: 0 } });
      s.addText(cell, { x: adCX[ci] + 0.05, y: 3.67 + ri * 0.55, w: adCW[ci] - 0.1, h: 0.52, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
    });
  });

  // DI flowchart
  s.addText("Diabetes Insipidus — Flowchart", { x: 0.2, y: 5.95, w: 12.9, h: 0.35, fontSize: 13, bold: true, color: C.accent });
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 4.5, y: 6.35, w: 4.3, h: 0.55, fill: { color: C.tealDk }, line: { color: C.teal, width: 1 }, rectRadius: 0.07 });
  s.addText("DIABETES INSIPIDUS (Dilute urine, high serum Na)", { x: 4.5, y: 6.35, w: 4.3, h: 0.55, fontSize: 9, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });

  s.addShape(pres.shapes.DOWN_ARROW, { x: 5.0, y: 6.95, w: 0.3, h: 0.38, fill: { color: C.teal }, line: { color: C.teal } });
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 3.5, y: 7.0, w: 2.8, h: 0.4, fill: { color: C.teal, transparency: 25 }, line: { color: C.teal, width: 1 }, rectRadius: 0.06 });
  s.addText("CENTRAL DI (ADH deficient)\nRx: Desmopressin", { x: 3.5, y: 7.0, w: 2.8, h: 0.4, fontSize: 8.5, color: C.white, align: "center", valign: "middle", margin: 0 });

  s.addShape(pres.shapes.DOWN_ARROW, { x: 7.97, y: 6.95, w: 0.3, h: 0.38, fill: { color: C.purple }, line: { color: C.purple } });
  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 7.0, y: 7.0, w: 2.8, h: 0.4, fill: { color: C.purple, transparency: 25 }, line: { color: C.purple, width: 1 }, rectRadius: 0.06 });
  s.addText("NEPHROGENIC DI (ADH resistant)\nRx: Thiazides + Low Na diet", { x: 7.0, y: 7.0, w: 2.8, h: 0.4, fontSize: 8.5, color: C.white, align: "center", valign: "middle", margin: 0 });
}

// ═══ SLIDE 10 — THYROID ════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "Endocrine 02 | Thyroid Disorders — Hypo vs Hyper + Cancer PaFoMeAn", C.green);

  card(s, 0.2, 1.0, 6.15, 3.4, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 1.0, w: 6.15, h: 0.45, fill: { color: "1B4332" }, line: { color: "1B4332" } });
  s.addText("HYPOTHYROIDISM — Mnemonic: SLOW BM", { x: 0.3, y: 1.0, w: 6.0, h: 0.45, fontSize: 12, bold: true, color: C.green, valign: "middle", margin: 0 });
  const hypo = [
    ["S", "Sensitivity to cold"],
    ["L", "Lethargy + depression"],
    ["O", "Obesity (weight gain)"],
    ["W", "Water retention (myxedema)"],
    ["B", "Bradycardia"],
    ["M", "Menorrhagia + constipation"],
  ];
  hypo.forEach(([l, v], i) => {
    const col = i % 2, row = Math.floor(i / 2);
    s.addShape(pres.shapes.ELLIPSE, { x: 0.3 + col * 3.0, y: 1.55 + row * 0.65, w: 0.35, h: 0.35, fill: { color: C.green }, line: { color: C.green } });
    s.addText(l, { x: 0.3 + col * 3.0, y: 1.55 + row * 0.65, w: 0.35, h: 0.35, fontSize: 12, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(v, { x: 0.75 + col * 3.0, y: 1.55 + row * 0.65, w: 2.6, h: 0.35, fontSize: 9, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Cause #1 West: Hashimoto's (anti-TPO, anti-Tg, Hurthle cells) | Rx: Levothyroxine", { x: 0.3, y: 3.62, w: 5.9, h: 0.35, fontSize: 8.5, italic: true, color: C.gray, valign: "middle", margin: 0 });

  card(s, 6.95, 1.0, 6.15, 3.4, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 6.95, y: 1.0, w: 6.15, h: 0.45, fill: { color: "1C3D2B" }, line: { color: "1C3D2B" } });
  s.addText("HYPERTHYROIDISM — Mnemonic: FAST THY", { x: 7.05, y: 1.0, w: 6.0, h: 0.45, fontSize: 12, bold: true, color: C.teal, valign: "middle", margin: 0 });
  const hyper = [
    ["F", "Flushing, heat intolerance"],
    ["A", "Arrhythmia (Afib), anxiety"],
    ["S", "Skinny (wt loss, diarrhea)"],
    ["T", "Tremor + tachycardia"],
    ["T", "Thyroid goiter"],
    ["HY", "High T3/T4, young women"],
  ];
  hyper.forEach(([l, v], i) => {
    const col = i % 2, row = Math.floor(i / 2);
    s.addShape(pres.shapes.ELLIPSE, { x: 7.05 + col * 3.0, y: 1.55 + row * 0.65, w: 0.35, h: 0.35, fill: { color: C.teal }, line: { color: C.teal } });
    s.addText(l, { x: 7.05 + col * 3.0, y: 1.55 + row * 0.65, w: 0.35, h: 0.35, fontSize: 10, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(v, { x: 7.5 + col * 3.0, y: 1.55 + row * 0.65, w: 2.6, h: 0.35, fontSize: 9, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Graves' triad: Hyperthyroid + Exophthalmos + Pretibial myxedema | Rx: PTU (pregnancy), I-131, Beta-blocker", { x: 7.05, y: 3.62, w: 5.9, h: 0.35, fontSize: 8.5, italic: true, color: C.gray, valign: "middle", margin: 0 });

  s.addText("Thyroid Cancer — PaFoMeAn (Best to Worst Prognosis)", { x: 0.2, y: 4.55, w: 12.9, h: 0.38, fontSize: 13, bold: true, color: C.orange });
  const cancers = [
    { name: "PAPILLARY  80%", color: C.green, key: "Orphan Annie nuclei\nPsammoma bodies\nRET/PTC mutation\nCervical LN mets (good Px)" },
    { name: "FOLLICULAR  10%", color: C.teal, key: "Hematogenous spread\nVascular invasion\nNo LN mets\nRAI responsive" },
    { name: "MEDULLARY  5-8%", color: C.orange, key: "C-cells - Calcitonin\nAmyloid stroma\nRET mutation\nMEN2A / MEN2B" },
    { name: "ANAPLASTIC  <5%", color: C.red, key: "Elderly patients\nRapidly fatal\nNo RAI response\nWorst prognosis" },
  ];
  cancers.forEach((c, i) => {
    const x = 0.2 + i * 3.27;
    card(s, x, 5.0, 3.05, 2.4, C.cardBg);
    s.addShape(pres.shapes.RECTANGLE, { x, y: 5.0, w: 3.05, h: 0.4, fill: { color: c.color }, line: { color: c.color } });
    s.addText(c.name, { x: x + 0.05, y: 5.0, w: 2.95, h: 0.4, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0 });
    s.addText(c.key, { x: x + 0.1, y: 5.45, w: 2.85, h: 1.85, fontSize: 8.5, color: C.offWhite, valign: "top", margin: 0 });
  });
}

// ═══ SLIDE 11 — ADRENAL ════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "Endocrine 03 | Adrenal Disorders — GFR Zones + Cushing/Addison/Conn/Pheo", C.orange);

  s.addText("Adrenal Zones — GFR Mnemonic (outside to inside)", { x: 0.2, y: 1.0, w: 5.7, h: 0.38, fontSize: 13, bold: true, color: C.orange });
  const zones = [
    { name: "G - Glomerulosa", makes: "Aldosterone", color: C.teal, w: 5.2 },
    { name: "F - Fasciculata", makes: "Cortisol (longest zone)", color: C.orange, w: 4.0 },
    { name: "R - Reticularis", makes: "Androgens (DHEA)", color: C.purple, w: 3.0 },
    { name: "Medulla", makes: "Catecholamines (Epi >> NE)", color: C.red, w: 2.2 },
  ];
  zones.forEach((z, i) => {
    s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 1.48 + i * 0.62, w: z.w, h: 0.55, fill: { color: z.color, transparency: 30 }, line: { color: z.color, width: 1 } });
    s.addText(z.name + "  →  " + z.makes, { x: 0.3, y: 1.48 + i * 0.62, w: z.w - 0.15, h: 0.55, fontSize: 9.5, bold: true, color: C.white, valign: "middle", margin: 0 });
  });
  s.addText("Memory: 'Go Find Rex' — Rex lives in the Medulla", { x: 0.2, y: 4.02, w: 5.7, h: 0.3, fontSize: 9, italic: true, color: C.gray });

  card(s, 5.9, 1.0, 7.2, 2.9, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 5.9, y: 1.0, w: 7.2, h: 0.4, fill: { color: C.orange, transparency: 20 }, line: { color: C.orange, width: 1 } });
  s.addText("Cushing's Syndrome — Mnemonic: CUSHINGS", { x: 6.0, y: 1.0, w: 7.0, h: 0.4, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
  const cush = ["C - Central obesity (moon face, buffalo hump)","U - Urine cortisol elevated","S - Striae (purple)","H - Hypertension","I - Insulin resistance","N - No menses (amenorrhea)","G - Glucose elevated","S - Skin thinning + easy bruising"];
  cush.forEach((c, i) => {
    const col = i % 2, row = Math.floor(i / 2);
    s.addText("• " + c, { x: 6.0 + col * 3.5, y: 1.5 + row * 0.46, w: 3.4, h: 0.42, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Dx: High-dose Dex suppresses PITUITARY only — not ectopic ACTH, not adrenal", { x: 6.0, y: 3.55, w: 7.0, h: 0.32, fontSize: 8.5, italic: true, color: C.gray, margin: 0 });

  card(s, 0.2, 4.42, 4.3, 2.8, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 4.42, w: 4.3, h: 0.4, fill: { color: C.teal, transparency: 20 }, line: { color: C.teal, width: 1 } });
  s.addText("Addison's Disease — SHADE", { x: 0.3, y: 4.42, w: 4.1, h: 0.4, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
  ["S - Skin hyperpigmentation (ACTH→MSH)","H - Hypotension + Hyperkalemia","A - Anemia (normocytic)","D - Dehydration (Na wasting)","E - Electrolytes: Low Na, High K"].forEach((p, i) => {
    s.addText("• " + p, { x: 0.3, y: 4.9 + i * 0.42, w: 4.0, h: 0.38, fontSize: 8.8, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Rx: IV Hydrocortisone + IV Saline (crisis)", { x: 0.3, y: 7.0, w: 4.0, h: 0.3, fontSize: 8, italic: true, color: C.gray });

  card(s, 4.7, 4.42, 4.0, 2.8, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 4.7, y: 4.42, w: 4.0, h: 0.4, fill: { color: C.green, transparency: 20 }, line: { color: C.green, width: 1 } });
  s.addText("Conn's Syndrome — HANK", { x: 4.8, y: 4.42, w: 3.8, h: 0.4, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
  ["H - Hypertension (resistant)","A - Alkalosis (metabolic)","N - No renin (low renin = primary)","K - K+ low (hypokalemia)"].forEach((p, i) => {
    s.addText("• " + p, { x: 4.8, y: 4.9 + i * 0.48, w: 3.8, h: 0.45, fontSize: 9, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Cause: Adrenal adenoma | Rx: Surgery or Spironolactone", { x: 4.8, y: 7.0, w: 3.8, h: 0.3, fontSize: 8, italic: true, color: C.gray });

  card(s, 8.9, 4.42, 4.2, 2.8, C.cardBg);
  s.addShape(pres.shapes.RECTANGLE, { x: 8.9, y: 4.42, w: 4.2, h: 0.4, fill: { color: C.red, transparency: 20 }, line: { color: C.red, width: 1 } });
  s.addText("Pheochromocytoma — 5 P's", { x: 9.0, y: 4.42, w: 4.0, h: 0.4, fontSize: 11, bold: true, color: C.white, valign: "middle", margin: 0 });
  ["P - Paroxysmal HTN","P - Palpitations","P - Perspiration (diaphoresis)","P - Pallor","P - Pain (headache)"].forEach((p, i) => {
    s.addText("• " + p, { x: 9.0, y: 4.9 + i * 0.42, w: 3.95, h: 0.38, fontSize: 9, color: C.offWhite, valign: "middle", margin: 0 });
  });
  s.addText("Rule of 10s | Dx: Urine metanephrines\nRx: Alpha-block FIRST, then beta-block, then surgery", { x: 9.0, y: 6.65, w: 3.95, h: 0.55, fontSize: 7.5, italic: true, color: C.gray });
}

// ═══ SLIDE 12 — DIABETES ═══════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  darkSlide(s);
  sectionBar(s, "Endocrine 04 | Diabetes Mellitus — T1 vs T2, DKA vs HHS, Drugs", C.red);

  s.addText("Type 1 vs Type 2 Diabetes", { x: 0.2, y: 1.0, w: 12.9, h: 0.38, fontSize: 13, bold: true, color: C.red });
  const dmH = ["Feature", "TYPE 1", "TYPE 2"];
  const dmR = [
    ["Pathology", "Autoimmune beta-cell destruction", "Insulin resistance + relative deficiency"],
    ["Age", "< 30 (child / young adult)", "> 40 (middle-aged / elderly)"],
    ["Body type", "Thin", "Obese"],
    ["Ketoacidosis", "YES — DKA (classic)", "Rare — HHS instead"],
    ["Autoantibodies", "Anti-GAD, Anti-islet cell", "None"],
    ["HLA link", "DR3, DR4", "No HLA link"],
    ["Treatment", "Insulin ONLY", "Lifestyle - Metformin - add-ons - Insulin"],
  ];
  const dmCW = [2.2, 5.3, 5.5];
  const dmCX = [0.2, 2.45, 7.8];
  dmH.forEach((h, ci) => {
    s.addShape(pres.shapes.RECTANGLE, { x: dmCX[ci], y: 1.42, w: dmCW[ci], h: 0.38, fill: { color: ci === 1 ? C.tealDk : (ci === 2 ? "7F1D1D" : C.cardBg) }, line: { color: C.red, width: 1 } });
    s.addText(h, { x: dmCX[ci] + 0.05, y: 1.42, w: dmCW[ci] - 0.1, h: 0.38, fontSize: 10, bold: true, color: C.white, valign: "middle", margin: 0, align: ci === 0 ? "left" : "center" });
  });
  dmR.forEach((row, ri) => {
    row.forEach((cell, ci) => {
      s.addShape(pres.shapes.RECTANGLE, { x: dmCX[ci], y: 1.84 + ri * 0.46, w: dmCW[ci], h: 0.44, fill: { color: ri % 2 === 0 ? C.cardBg : C.cardBg2 }, line: { color: C.cardBg, width: 0 } });
      s.addText(cell, { x: dmCX[ci] + 0.05, y: 1.84 + ri * 0.46, w: dmCW[ci] - 0.1, h: 0.44, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
    });
  });

  s.addText("DKA vs HHS — Critical Comparison", { x: 0.2, y: 5.15, w: 7.0, h: 0.38, fontSize: 13, bold: true, color: C.orange });
  const dkaH = ["Feature", "DKA (Type 1)", "HHS (Type 2)"];
  const dkaR = [
    ["Glucose", "> 250 mg/dL", "> 600 mg/dL"],
    ["pH", "< 7.3 (ACIDOSIS)", "Normal (> 7.3)"],
    ["Ketones", "YES (+++)", "Minimal / absent"],
    ["Osmolality", "Mildly elevated", "> 320 mOsm/kg"],
    ["Mortality", "~1%", "~15% (worse!)"],
  ];
  const dkaCW = [2.0, 2.5, 2.5];
  const dkaCX = [0.2, 2.25, 4.8];
  dkaH.forEach((h, ci) => {
    s.addShape(pres.shapes.RECTANGLE, { x: dkaCX[ci], y: 5.57, w: dkaCW[ci], h: 0.38, fill: { color: ci === 1 ? C.tealDk : (ci === 2 ? "7F1D1D" : C.cardBg) }, line: { color: C.orange, width: 1 } });
    s.addText(h, { x: dkaCX[ci] + 0.05, y: 5.57, w: dkaCW[ci] - 0.1, h: 0.38, fontSize: 9, bold: true, color: C.white, valign: "middle", margin: 0, align: ci === 0 ? "left" : "center" });
  });
  dkaR.forEach((row, ri) => {
    row.forEach((cell, ci) => {
      s.addShape(pres.shapes.RECTANGLE, { x: dkaCX[ci], y: 5.99 + ri * 0.42, w: dkaCW[ci], h: 0.4, fill: { color: ri % 2 === 0 ? C.cardBg : C.cardBg2 }, line: { color: C.cardBg, width: 0 } });
      s.addText(cell, { x: dkaCX[ci] + 0.05, y: 5.99 + ri * 0.42, w: dkaCW[ci] - 0.1, h: 0.4, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
    });
  });

  s.addText("Key Oral Antidiabetics", { x: 7.6, y: 5.15, w: 5.5, h: 0.38, fontSize: 13, bold: true, color: C.green });
  const drugs = [
    { name: "Metformin", memo: "#1 T2DM | No hypoglycemia | Lactic acidosis risk", color: C.green },
    { name: "Sulfonylureas", memo: "Stimulate insulin secretion | CAN cause hypoglycemia", color: C.orange },
    { name: "GLP-1 agonists", memo: "Weight loss | Used in obese T2DM (Liraglutide)", color: C.teal },
    { name: "SGLT2 inhibitors", memo: "Glucosuria | UTI risk | Cardioprotective (Empagliflozin)", color: C.purple },
  ];
  drugs.forEach((d, i) => {
    s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 7.6, y: 5.6 + i * 0.48, w: 2.0, h: 0.38, fill: { color: d.color }, line: { color: d.color }, rectRadius: 0.06 });
    s.addText(d.name, { x: 7.6, y: 5.6 + i * 0.48, w: 2.0, h: 0.38, fontSize: 9, bold: true, color: C.white, align: "center", valign: "middle", margin: 0 });
    s.addText(d.memo, { x: 9.7, y: 5.6 + i * 0.48, w: 3.4, h: 0.38, fontSize: 8, color: C.offWhite, valign: "middle", margin: 0 });
  });

  s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 7.6, y: 7.1, w: 5.5, h: 0.35, fill: { color: C.red, transparency: 40 }, line: { color: C.red, width: 1 }, rectRadius: 0.05 });
  s.addText("CRAMPS Complications: Cardiovascular | Retinopathy | Atherosclerosis | Micro-albuminuria | Peripheral neuropathy | Susceptibility to infection", { x: 7.65, y: 7.1, w: 5.4, h: 0.35, fontSize: 7.5, color: C.white, valign: "middle", margin: 0 });
}

// ═══ SLIDE 13 — ONE-LINE KILLERS ═══════════════════════════════════════════════
{
  const s = pres.addSlide();
  s.background = { color: C.navy };
  sectionBar(s, "RAPID RECALL — One-Line Killers for MCQs", C.teal);

  const killers = [
    ["Periventricular lesions, young woman", "Multiple Sclerosis", C.teal],
    ["Ascending paralysis after Campylobacter", "GBS", C.teal],
    ["'Worst HA of my life'", "SAH — Berry aneurysm", C.red],
    ["Xanthochromia in CSF", "Subarachnoid Hemorrhage", C.red],
    ["Temporal lobe + fever + personality change", "HSV Encephalitis — ACYCLOVIR", C.orange],
    ["Pill-rolling tremor + cogwheel rigidity", "Parkinson's — Lewy bodies", C.purple],
    ["Beta-amyloid + neurofibrillary tangles", "Alzheimer's Disease", C.purple],
    ["Orphan Annie nuclei + Psammoma bodies", "Papillary Thyroid Cancer", C.green],
    ["Calcitonin-secreting tumor", "Medullary Thyroid Ca (MEN2)", C.green],
    ["High aldosterone + low renin + low K+", "Conn's Syndrome", C.orange],
    ["Paroxysmal HTN + diaphoresis", "Pheochromocytoma", C.red],
    ["Skin hyperpigmentation + low Na + high K+", "Addison's Disease", C.teal],
    ["Moon face + buffalo hump + purple striae", "Cushing's Syndrome", C.orange],
    ["Bitemporal hemianopia", "Pituitary tumor (chiasm compression)", C.purple],
    ["High protein + normal WBC in CSF", "GBS (albuminocytologic dissociation)", C.teal],
    ["India Ink halo + HIV patient", "Cryptococcus meningitis", C.green],
    ["Spongiform vacuolation + myoclonus", "CJD — Prion disease", C.red],
    ["Butterfly glioma crossing corpus callosum", "GBM (Grade IV)", C.purple],
    ["Homer-Wright rosettes, child, cerebellum", "Medulloblastoma", C.orange],
    ["Fried egg cells + 1p/19q deletion", "Oligodendroglioma", C.teal],
  ];
  const left = killers.slice(0, 10);
  const right = killers.slice(10);
  [left, right].forEach((col, ci) => {
    col.forEach(([clue, ans, color], ri) => {
      const x = ci === 0 ? 0.2 : 6.75;
      const y = 1.0 + ri * 0.63;
      s.addShape(pres.shapes.RECTANGLE, { x, y, w: 6.4, h: 0.55, fill: { color: C.cardBg }, line: { color: color, width: 1 } });
      s.addShape(pres.shapes.RECTANGLE, { x, y, w: 0.12, h: 0.55, fill: { color: color }, line: { color: color } });
      s.addText(clue, { x: x + 0.2, y, w: 3.8, h: 0.55, fontSize: 8.5, color: C.offWhite, valign: "middle", margin: 0 });
      s.addShape(pres.shapes.RIGHT_ARROW, { x: x + 4.05, y: y + 0.15, w: 0.3, h: 0.25, fill: { color: color }, line: { color: color } });
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}

// ═══ SLIDE 14 — CLOSING ════════════════════════════════════════════════════════
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    { label: "CNS", text: "SPASM (MS)  |  GAME / CAME (Tumors)  |  TRAP (Parkinson's)  |  ABCs (Alzheimer's)" },
    { label: "Endocrine", text: "FLAT PiG (Pituitary)  |  SLOW BM (Hypo)  |  FAST THY (Hyper)  |  PaFoMeAn (Thyroid Ca)" },
    { label: "Adrenal", text: "GFR zones  |  CUSHINGS  |  SHADE (Addison's)  |  HANK (Conn's)  |  5 P's (Pheo)" },
    { label: "Diabetes", text: "CRAMPS (complications)  |  RAIN (insulin types)  |  DKA vs HHS comparison" },
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