Dose of ars
Reading Document
Medical Text Search
arsenic trioxide dose dosage regimen
GradeResponse
The search returned monitoring info but not specific dosing. Let me supplement from established clinical knowledge:
Arsenic Trioxide (As₂O₃) — Dosage
Indications & Standard Doses
| Indication | Dose | Schedule |
|---|---|---|
| APL – Induction (relapsed/refractory or newly diagnosed) | 0.15 mg/kg/day IV | Daily until bone marrow remission (max 60 doses) |
| APL – Consolidation | 0.15 mg/kg/day IV | 5 days/week × 5 weeks (25 doses), starting 3–6 weeks after induction |
| Multiple Myeloma (investigational) | 0.25 mg/kg/day IV | Varies by protocol |
Pediatric dose (≥5 years): Same weight-based dose — 0.15 mg/kg/day IV.
Administration
- Given as a 2-hour IV infusion (can extend to 4 hours if vasomotor reactions occur)
- Maximum single dose: generally not to exceed 10 mg/day (in practice, most adults receive ~10 mg/day)
Key Monitoring (per Cardio-Oncology guidelines, p. 54)
- ECG weekly for first 8 weeks — QTc prolongation occurs in 26–93% of patients (typically 1–5 weeks post-infusion)
- Electrolytes (K⁺, Mg²⁺) — risk of hypokalaemia and hypomagnesaemia
- Renal function — arsenic trioxide can cause renal dysfunction
- Correct electrolyte abnormalities before starting therapy
- Hold if QTc >500 ms
Dose Adjustments
| Situation | Action |
|---|---|
| QTc >500 ms | Hold until QTc <460 ms |
| Grade 3–4 renal toxicity | Reduce dose or hold |
| Grade 3–4 hepatotoxicity | Hold; restart at lower dose when resolved |
The most common clinical use is Acute Promyelocytic Leukemia (APL), where arsenic trioxide (often combined with ATRA) is the backbone of both induction and consolidation therapy.
This is a shared conversation. Sign in to Orris to start your own chat.