In PAH, the small pulmonary arteries become narrowed and stiff because of vasoconstriction, vascular-wall remodeling, and sometimes thrombosis. This raises pulmonary vascular resistance.
The main pulmonary artery must then carry blood against persistently high pressure. Over time:
So, pulmonary artery dilatation is a chronic pressure-and-flow consequence of PAH, similar in principle to dilatation of the aorta in longstanding systemic hypertension. Its size does not always parallel the current pulmonary pressure exactly, because the vessel can continue to remodel over time. A study indexed on
PubMed found progressive main pulmonary artery enlargement in PAH even when pressure changes did not closely track it.