Lisa abbreviation

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LISA abbreviation meaning common uses

In surfactant therapy

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LISA "less invasive surfactant administration" neonatal

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In surfactant therapy, LISA stands for:

LISA = Less Invasive Surfactant Administration

It is a technique for delivering surfactant to preterm infants with - or at risk of - Respiratory Distress Syndrome (RDS) without endotracheal intubation.

How it works

A thin, soft catheter (e.g., a vascular catheter or feeding tube) is passed into the trachea of a spontaneously breathing infant
Surfactant is instilled through the catheter while the infant remains on nasal CPAP (nCPAP)
The catheter is then removed; CPAP is maintained throughout

Why LISA over conventional intubation?

Feature	Conventional (INSURE)	LISA
Ventilation during surfactant	Endotracheal tube + PPV	Thin catheter only; infant breathes spontaneously
CPAP interruption	Yes	Minimal/none
Risk of ventilator-induced lung injury	Higher	Lower
Surfactant distribution	Good	Good (spontaneous breathing aids distribution)
BPD risk	Higher	Reduced

Clinical context

LISA combines the benefits of CPAP (preventing atelectasis, preserving surfactant function, avoiding intubation) with the benefit of exogenous surfactant replacement. It has been increasingly adopted in Europe and Australia and is now supported by multiple systematic reviews and meta-analyses.

Recent evidence (2023-2026) confirms its safety and efficacy:

A 2024 umbrella systematic review (PMID 38503270) found LISA superior to INSURE (Intubate-Surfactant-Extubate) in preterm neonates
A 2024 network meta-analysis (PMID 39736686) confirmed LISA among the most effective surfactant delivery strategies for neonatal RDS
A 2026 meta-analysis (PMID 42389956) specifically confirmed the safety profile of LISA in preterm infants
Creasy & Resnik's Maternal-Fetal Medicine, Management Principles section on Surfactant Therapy

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