Adrenergic Receptors - Simplified 🧠

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.units import cm
from reportlab.platypus import (
    SimpleDocTemplate, Paragraph, Spacer, Table, TableStyle,
    HRFlowable, Image, KeepTogether, PageBreak
)
from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_JUSTIFY
from reportlab.platypus import BalancedColumns
import os

OUTPUT = "/tmp/workspace/adrenergic-pdf/Adrenergic_Receptors.pdf"
IMG_PATH = "/tmp/workspace/adrenergic-pdf/receptor_image.png"

doc = SimpleDocTemplate(
    OUTPUT,
    pagesize=A4,
    rightMargin=1.8*cm,
    leftMargin=1.8*cm,
    topMargin=2*cm,
    bottomMargin=2*cm,
)

W, H = A4
CONTENT_W = W - 3.6*cm

# ── Colour palette ─────────────────────────────────────────────
C_TITLE   = colors.HexColor("#1a237e")   # dark navy
C_A1      = colors.HexColor("#c62828")   # deep red
C_A2      = colors.HexColor("#ad1457")   # pink-red
C_B1      = colors.HexColor("#1565c0")   # blue
C_B2      = colors.HexColor("#2e7d32")   # green
C_B3      = colors.HexColor("#e65100")   # orange
C_MNEM    = colors.HexColor("#4a148c")   # purple
C_LIGHT   = colors.HexColor("#e8eaf6")   # light lavender bg
C_HEADER  = colors.HexColor("#283593")   # table header

# ── Styles ──────────────────────────────────────────────────────
styles = getSampleStyleSheet()

def S(name, **kw):
    return ParagraphStyle(name, **kw)

sTitle = S("sTitle", fontSize=22, textColor=C_TITLE, alignment=TA_CENTER,
           fontName="Helvetica-Bold", spaceAfter=4, leading=26)
sSubtitle = S("sSubtitle", fontSize=11, textColor=colors.HexColor("#5c6bc0"),
              alignment=TA_CENTER, fontName="Helvetica-Oblique", spaceAfter=2)
sSectionHead = S("sSectionHead", fontSize=14, textColor=colors.white,
                 fontName="Helvetica-Bold", leftIndent=6, leading=18)
sReceptorName = S("sReceptorName", fontSize=13, fontName="Helvetica-Bold",
                  spaceAfter=2, leading=16)
sBody = S("sBody", fontSize=9.5, fontName="Helvetica", leading=14,
          spaceAfter=3, alignment=TA_JUSTIFY)
sBullet = S("sBullet", fontSize=9.5, fontName="Helvetica", leading=14,
            leftIndent=14, bulletIndent=5, spaceAfter=2)
sMnem = S("sMnem", fontSize=11, fontName="Helvetica-BoldOblique",
          textColor=C_MNEM, alignment=TA_CENTER, leading=16, spaceAfter=4)
sCaption = S("sCaption", fontSize=8.5, fontName="Helvetica-Oblique",
             textColor=colors.grey, alignment=TA_CENTER, spaceAfter=4)
sTableHead = S("sTableHead", fontSize=9, fontName="Helvetica-Bold",
               textColor=colors.white, alignment=TA_CENTER, leading=12)
sTableCell = S("sTableCell", fontSize=8.5, fontName="Helvetica", leading=12,
               alignment=TA_LEFT)
sTableCellC = S("sTableCellC", fontSize=8.5, fontName="Helvetica", leading=12,
                alignment=TA_CENTER)
sWarning = S("sWarning", fontSize=9.5, fontName="Helvetica-Bold",
             textColor=colors.HexColor("#b71c1c"), alignment=TA_CENTER)

# ── Helper builders ─────────────────────────────────────────────
def section_bar(text, color):
    tbl = Table([[Paragraph(text, sSectionHead)]], colWidths=[CONTENT_W])
    tbl.setStyle(TableStyle([
        ("BACKGROUND", (0,0), (-1,-1), color),
        ("ROUNDEDCORNERS", [6,6,6,6]),
        ("TOPPADDING",    (0,0), (-1,-1), 5),
        ("BOTTOMPADDING", (0,0), (-1,-1), 5),
        ("LEFTPADDING",   (0,0), (-1,-1), 10),
    ]))
    return tbl

def info_box(text, bg=C_LIGHT, border=C_TITLE):
    tbl = Table([[Paragraph(text, sMnem)]], colWidths=[CONTENT_W])
    tbl.setStyle(TableStyle([
        ("BACKGROUND",    (0,0), (-1,-1), bg),
        ("BOX",           (0,0), (-1,-1), 1.5, border),
        ("ROUNDEDCORNERS",[8,8,8,8]),
        ("TOPPADDING",    (0,0), (-1,-1), 8),
        ("BOTTOMPADDING", (0,0), (-1,-1), 8),
    ]))
    return tbl

def make_table(header_row, data_rows, col_widths, col_colors=None):
    header = [Paragraph(h, sTableHead) for h in header_row]
    rows   = [[Paragraph(str(c), sTableCell) for c in row] for row in data_rows]
    all_rows = [header] + rows
    tbl = Table(all_rows, colWidths=col_widths, repeatRows=1)
    style = [
        ("BACKGROUND",    (0,0), (-1,0),  C_HEADER),
        ("ROWBACKGROUNDS",(0,1), (-1,-1), [colors.white, colors.HexColor("#f5f5f5")]),
        ("GRID",          (0,0), (-1,-1), 0.4, colors.HexColor("#bdbdbd")),
        ("TOPPADDING",    (0,0), (-1,-1), 5),
        ("BOTTOMPADDING", (0,0), (-1,-1), 5),
        ("LEFTPADDING",   (0,0), (-1,-1), 6),
        ("RIGHTPADDING",  (0,0), (-1,-1), 6),
        ("VALIGN",        (0,0), (-1,-1), "MIDDLE"),
    ]
    if col_colors:
        for row_idx, bg in col_colors:
            style.append(("BACKGROUND", (0, row_idx), (-1, row_idx), bg))
    tbl.setStyle(TableStyle(style))
    return tbl

# ── Content ─────────────────────────────────────────────────────
story = []

# ---- PAGE 1: Title + Intro ----------------------------------------
story.append(Paragraph("Adrenergic Receptors", sTitle))
story.append(Paragraph("Simplified Study Guide — Types, Effects & Memory Tricks", sSubtitle))
story.append(HRFlowable(width=CONTENT_W, thickness=2, color=C_TITLE, spaceAfter=8))

# Master mnemonic box
story.append(info_box(
    "🔑  MASTER TRICK\n"
    "\"A1 Squeezes  ·  A2 Brakes  ·  B1 Pumps  ·  B2 Opens  ·  B3 Burns\"",
    bg=colors.HexColor("#ede7f6"), border=C_MNEM
))
story.append(Spacer(1, 10))

# Second messenger table
story.append(section_bar("⚡  Second Messengers (Signal Inside the Cell)", C_TITLE))
story.append(Spacer(1, 4))
story.append(make_table(
    ["Receptor", "Second Messenger", "Simple Think"],
    [
        ["α1",      "↑ IP3 / DAG",  "Opens a fire hose"],
        ["α2",      "↓ cAMP",        "Puts out the fire (inhibits)"],
        ["β (all)", "↑ cAMP",        "Revs the engine"],
    ],
    col_widths=[CONTENT_W*0.18, CONTENT_W*0.30, CONTENT_W*0.52]
))
story.append(Spacer(1, 12))

# ---- ALPHA RECEPTORS -----------------------------------------------
story.append(section_bar("🔴  ALPHA (α) RECEPTORS", C_A1))
story.append(Spacer(1, 6))

# α1
story.append(Paragraph('<font color="#c62828"><b>α1 — "The SQUEEZER"</b></font>  (Postsynaptic)', sReceptorName))
story.append(Paragraph(
    "Located on effector organs. Activated by noradrenaline/adrenaline. "
    "Uses IP3/DAG as second messenger.",
    sBody))
story.append(make_table(
    ["Location", "Effect", "Memory Hook"],
    [
        ["Blood vessels",         "Constriction (vasoconstriction)", "Squeeze the pipe"],
        ["GI sphincter (anal)",   "Increase in tone (tightens)",     "Clamp it shut"],
        ["Urinary sphincter",     "Increase in tone (tightens)",     "Hold it in"],
        ["Radial muscle (iris)",  "Contraction → Mydriasis",         "Wide eyes in fear!"],
    ],
    col_widths=[CONTENT_W*0.30, CONTENT_W*0.38, CONTENT_W*0.32]
))
story.append(Spacer(1, 4))
story.append(info_box(
    "💡  Fear Story: Scared person = eyes wide (mydriasis) + can't pee (sphincter tight) + blood to muscles (vasoconstriction)",
    bg=colors.HexColor("#ffebee"), border=C_A1
))
story.append(Spacer(1, 10))

# α2
story.append(Paragraph('<font color="#ad1457"><b>α2 — "The BRAKE"</b></font>  (Two locations!)', sReceptorName))
story.append(Paragraph("Uses ↓ cAMP as second messenger.", sBody))

story.append(make_table(
    ["Sub-type", "Location", "Effect"],
    [
        ["Presynaptic α2\n(Auto-brake)",  "Sympathetic nerve endings",         "Decreases NA release (negative feedback)"],
        ["Postsynaptic α2",               "Vascular smooth muscle",             "Vasoconstriction + Venoconstriction"],
        ["Postsynaptic α2",               "Pancreas (β-cells of Langerhans)",   "↓ Insulin secretion"],
        ["Postsynaptic α2",               "Ciliary epithelium",                 "↓ Aqueous humour secretion"],
    ],
    col_widths=[CONTENT_W*0.28, CONTENT_W*0.36, CONTENT_W*0.36]
))
story.append(Spacer(1, 4))
story.append(info_box(
    '💡  "α2 = Auto-Brake" — the nerve tells itself to stop releasing noradrenaline!',
    bg=colors.HexColor("#fce4ec"), border=C_A2
))
story.append(Spacer(1, 12))

# ---- BETA RECEPTORS ------------------------------------------------
story.append(section_bar("🔵  BETA (β) RECEPTORS", C_B1))
story.append(Spacer(1, 6))

# β1
story.append(Paragraph('<font color="#1565c0"><b>β1 — "The HEART &amp; KIDNEY PUMP"</b></font>', sReceptorName))
story.append(Paragraph("All β receptors use ↑ cAMP. Remember: you have 1 heart → β1!", sBody))
story.append(make_table(
    ["Location", "Effect", "Trick"],
    [
        ["Heart",  "Cardiac stimulation (↑ rate + ↑ force)",  "1 Heart = β1"],
        ["Kidney", "Promotes renin release",                   "Re-nin = kidney pump"],
    ],
    col_widths=[CONTENT_W*0.25, CONTENT_W*0.45, CONTENT_W*0.30]
))
story.append(Spacer(1, 10))

# β2
story.append(Paragraph('<font color="#2e7d32"><b>β2 — "The RELAXER &amp; OPENER"</b></font>', sReceptorName))
story.append(Paragraph("Think: 2 Lungs → β2 relaxes them! Also relaxes uterus, vessels, bladder.", sBody))

story.append(Paragraph("<b>Stimulatory effects (activates):</b>", sBullet))
story.append(make_table(
    ["Location", "Effect"],
    [
        ["Liver",              "Glycogenolysis (glycogen → glucose)"],
        ["Skeletal muscle",    "Contraction"],
        ["Ciliary epithelium", "↑ Aqueous humour secretion"],
        ["All cells",          "K⁺ uptake into cells"],
    ],
    col_widths=[CONTENT_W*0.35, CONTENT_W*0.65]
))
story.append(Spacer(1, 4))

story.append(Paragraph("<b>Inhibitory effects (relaxes):</b>", sBullet))
story.append(make_table(
    ["Location", "Effect"],
    [
        ["Bronchial smooth muscle",         "Relaxation (bronchodilation) ← Asthma inhalers work here!"],
        ["Uterus (pregnant)",               "Relaxation (tocolysis)"],
        ["Vascular smooth muscle",          "Relaxation (vasodilation)"],
        ["Bladder smooth muscle",           "Relaxation"],
        ["GI smooth muscle",                "Relaxation (shared with α-receptors)"],
    ],
    col_widths=[CONTENT_W*0.35, CONTENT_W*0.65]
))
story.append(Spacer(1, 4))
story.append(info_box(
    '💡  "β2 = BRONCHI Relax" — salbutamol (Ventolin) is a β2 agonist used in asthma!',
    bg=colors.HexColor("#e8f5e9"), border=C_B2
))
story.append(Spacer(1, 10))

# β3
story.append(Paragraph('<font color="#e65100"><b>β3 — "The FAT BURNER"</b></font>', sReceptorName))
story.append(make_table(
    ["Location", "Effect", "Trick"],
    [["Adipose tissue", "Lipolysis (fat breakdown)", 'β3 → 3 letters in "FAT" = Burns FAT!']],
    col_widths=[CONTENT_W*0.28, CONTENT_W*0.38, CONTENT_W*0.34]
))
story.append(Spacer(1, 12))

# ---- PAGE BREAK → Summary table + Mnemonic + Image ---------------
story.append(PageBreak())

story.append(section_bar("📋  MASTER QUICK-REFERENCE TABLE", C_TITLE))
story.append(Spacer(1, 6))
story.append(make_table(
    ["Receptor", "Key Location(s)", "Main Effect", "2nd Messenger", "One Word"],
    [
        ["α1",     "Blood vessels, sphincters, iris",           "Constriction / Contraction",     "↑ IP3/DAG", "SQUEEZE"],
        ["α2 pre", "Presynaptic nerve endings",                  "↓ NA release (auto-brake)",      "↓ cAMP",    "BRAKE"],
        ["α2 post","Vessels, pancreas, ciliary",                 "Vasoconstriction, ↓ insulin",    "↓ cAMP",    "INHIBIT"],
        ["β1",     "Heart, kidney",                              "Cardiac stimulation, renin↑",    "↑ cAMP",    "PUMP"],
        ["β2",     "Lungs, uterus, vessels, liver",             "Relaxation + glycogenolysis",    "↑ cAMP",    "OPEN"],
        ["β3",     "Adipose tissue",                             "Lipolysis",                      "↑ cAMP",    "BURN"],
    ],
    col_widths=[
        CONTENT_W*0.10,
        CONTENT_W*0.27,
        CONTENT_W*0.28,
        CONTENT_W*0.17,
        CONTENT_W*0.18,
    ],
    col_colors=[
        (1, colors.HexColor("#ffebee")),
        (2, colors.HexColor("#fce4ec")),
        (3, colors.HexColor("#fce4ec")),
        (4, colors.HexColor("#e3f2fd")),
        (5, colors.HexColor("#e8f5e9")),
        (6, colors.HexColor("#fff3e0")),
    ]
))
story.append(Spacer(1, 12))

# ---- Fight or Flight Story ----------------------------------------
story.append(section_bar("🧠  FIGHT OR FLIGHT — THE STORY TO REMEMBER IT ALL", C_MNEM))
story.append(Spacer(1, 6))

fight_data = [
    ["🔴 α1",  "Pupils widen (mydriasis)",              "See the danger clearly"],
    ["🔴 α1",  "Blood vessels constrict",               "Redirect blood to muscles"],
    ["🔴 α1",  "Sphincters tighten",                    "No time for bathroom breaks!"],
    ["🔵 β1",  "Heart beats faster & stronger",         "Pump blood for action"],
    ["🟢 β2",  "Lungs open (bronchodilation)",          "Breathe in more oxygen"],
    ["🟢 β2",  "Liver releases glucose",                "Instant energy fuel"],
    ["🟠 β3",  "Fat breaks down",                       "Long-term energy supply"],
    ["🟣 α2",  "Nerve auto-brakes NA release",          "Prevents noradrenaline overdose"],
]
story.append(make_table(
    ["Receptor", "What Happens", "Why"],
    fight_data,
    col_widths=[CONTENT_W*0.14, CONTENT_W*0.44, CONTENT_W*0.42]
))
story.append(Spacer(1, 12))

# ---- Memory Image -------------------------------------------------
story.append(section_bar("🖼️  VISUAL MEMORY DIAGRAM", C_TITLE))
story.append(Spacer(1, 8))

if os.path.exists(IMG_PATH):
    img = Image(IMG_PATH, width=CONTENT_W*0.88, height=CONTENT_W*0.66)
    img.hAlign = "CENTER"
    story.append(img)
    story.append(Paragraph("Fig. Adrenergic receptor distribution and effects — memory diagram", sCaption))
story.append(Spacer(1, 10))

# ---- Final mega mnemonic ------------------------------------------
story.append(section_bar("🎯  FINAL MEGA MNEMONIC", C_MNEM))
story.append(Spacer(1, 6))
story.append(info_box(
    '"A1 Squeezes my Muscles  ·  A2 Brakes the Nerve\n'
    'B1 Pumps my Heart  ·  B2 Opens my Lungs  ·  B3 Burns my Fat"',
    bg=colors.HexColor("#ede7f6"), border=C_MNEM
))
story.append(Spacer(1, 8))

# Clinical Pearl
story.append(section_bar("💊  QUICK CLINICAL PEARLS", colors.HexColor("#00695c")))
story.append(Spacer(1, 4))
pearls = [
    ["β2 agonists (salbutamol)", "Asthma — relax bronchi"],
    ["β1 blockers (atenolol)",   "Hypertension / heart rate control"],
    ["α1 blockers (prazosin)",   "Hypertension — dilate vessels"],
    ["α2 agonists (clonidine)",  "Centrally lowers BP by reducing NA release"],
    ["β3 agonists (mirabegron)", "Overactive bladder — relax detrusor"],
]
story.append(make_table(
    ["Drug Class (Example)", "Clinical Use"],
    pearls,
    col_widths=[CONTENT_W*0.45, CONTENT_W*0.55]
))
story.append(Spacer(1, 10))

# Footer note
story.append(HRFlowable(width=CONTENT_W, thickness=1, color=colors.HexColor("#9fa8da"), spaceAfter=4))
story.append(Paragraph(
    "Source: Autonomic Pharmacology (Bertram G. Katzung et al.) • Compiled for exam revision",
    sCaption
))

# ── Build ───────────────────────────────────────────────────────
doc.build(story)
print(f"PDF created: {OUTPUT}")
print(f"File size: {os.path.getsize(OUTPUT)/1024:.1f} KB")