Define heart failure, types and treatment
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Searching across definition, types, and treatment of heart failure in parallel.
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heart failure definition classification types HFrEF HFpEF HFmrEF
Management of Heart Failure With Preserved Ejection Fraction
Page 3
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heart failure treatment management pharmacotherapy guidelines
Management of Cardiovascular Disease in Patients with Diabetes
Page 46
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Here is a comprehensive overview of heart failure:
Heart Failure
Definition
Heart failure (HF) is a clinical syndrome in which the heart is unable to pump sufficient blood to meet the body's metabolic demands, or can only do so at elevated filling pressures. It is characterized by symptoms (dyspnea, fatigue, fluid retention) resulting from structural or functional cardiac abnormality.
Classification by Ejection Fraction
The most clinically important classification is based on Left Ventricular Ejection Fraction (LVEF), as it guides therapy:
| Type | Abbreviation | LVEF | Description |
|---|---|---|---|
| HF with Reduced EF | HFrEF | < 40% | Systolic dysfunction; impaired contractility |
| HF with Mildly Reduced EF | HFmrEF | 40–49% | Intermediate group; may represent improving HFrEF or worsening HFpEF |
| HF with Preserved EF | HFpEF | ≥ 50% | Diastolic dysfunction; impaired relaxation/filling |
Per the Universal Definition of HF and U.S. Heart Failure Collaboratory consensus, HFpEF is defined as a clinical diagnosis of HF with LVEF ≥50%. HFmrEF provides a distinct category for individuals with stable preserved EF where measurement variability may exist (Management of Heart Failure With Preserved Ejection Fraction, p. 3).
Other Classification Systems
By Onset
- Acute HF — Rapid onset, often requiring hospitalization (e.g., acute pulmonary edema, cardiogenic shock)
- Chronic HF — Gradual, longstanding; may decompensate acutely
By Side
- Left-sided HF — Pulmonary congestion, dyspnea, orthopnea, paroxysmal nocturnal dyspnea
- Right-sided HF — Systemic venous congestion, peripheral edema, ascites, JVD
- Biventricular HF — Both ventricles affected
By Output
- Low-output HF — Most common; reduced cardiac output (ischemic, dilated cardiomyopathy)
- High-output HF — Normal/elevated CO but still insufficient (e.g., severe anemia, thyrotoxicosis, AV fistula)
NYHA Functional Classification
| Class | Description |
|---|---|
| I | No symptoms with ordinary activity |
| II | Mild symptoms; slight limitation |
| III | Marked limitation; comfortable only at rest |
| IV | Symptoms at rest; unable to carry any activity |
Common Etiologies
- Coronary artery disease / MI (most common in developed countries)
- Hypertension
- Dilated, hypertrophic, or restrictive cardiomyopathy
- Valvular heart disease
- Arrhythmias (e.g., AF)
- Myocarditis
- Diabetes mellitus
- Congenital heart disease
Treatment
HFrEF (LVEF < 40%) — Pharmacotherapy
The 2021 ESC Guidelines recommend quadruple therapy as the cornerstone of HFrEF treatment, initiated early and up-titrated rapidly (Management of Cardiovascular Disease in Patients with Diabetes, p. 46):
| Drug Class | Examples | Key Benefit |
|---|---|---|
| ARNI (preferred) or ACE-I/ARB | Sacubitril/valsartan; Enalapril; Losartan | Reduce preload/afterload, neurohormonal blockade |
| Beta-blocker | Carvedilol, Metoprolol succinate, Bisoprolol | Reduce HR, reverse remodeling |
| MRA (Mineralocorticoid receptor antagonist) | Spironolactone, Eplerenone | Reduce fibrosis, diuresis |
| SGLT2 inhibitor | Dapagliflozin, Empagliflozin | Reduce HF hospitalization and CV death |
The STRONG-HF trial demonstrated that early, intensive up-titration to target doses within 2 weeks of discharge reduced 180-day HF rehospitalization or all-cause death by 34% (HR 0.66; 95% CI 0.50–0.86).
Additional agents:
- Loop diuretics (e.g., furosemide) — for congestion/volume overload relief
- Ivabradine — if HR ≥70 bpm on maximum beta-blocker
- Hydralazine + nitrate — if ACE-I/ARB/ARNI not tolerated (especially in Black patients)
- Digoxin — for symptom control in select cases
HFpEF (LVEF ≥ 50%) — Management
HFpEF has fewer proven disease-modifying therapies, but management includes:
- SGLT2 inhibitors (Dapagliflozin/Empagliflozin) — now recommended; reduce HF hospitalizations
- Diuretics — for symptomatic congestion
- Control of underlying causes: hypertension, AF, obesity, diabetes
- MRAs (spironolactone) — modest benefit in some patients
- Emerging: GLP-1 receptor agonists in obese HFpEF
Device Therapy
| Device | Indication |
|---|---|
| ICD (Implantable Cardioverter-Defibrillator) | LVEF ≤35%, NYHA II–III, on optimal medical therapy |
| CRT (Cardiac Resynchronization Therapy) | LVEF ≤35% + LBBB + QRS ≥150 ms |
| LVAD (Left Ventricular Assist Device) | Advanced HF; bridge to transplant or destination therapy |
| Heart transplantation | End-stage HF refractory to all therapy |
Non-Pharmacological Measures
- Sodium and fluid restriction
- Daily weight monitoring
- Cardiac rehabilitation and exercise training
- Smoking cessation, alcohol limitation
- Multidisciplinary HF clinic follow-up
Key Takeaway
Heart failure management is ejection-fraction driven. HFrEF has robust evidence for quadruple pharmacotherapy (ARNI/ACE-I + beta-blocker + MRA + SGLT2i). HFpEF management primarily targets symptoms and underlying comorbidities, with SGLT2 inhibitors being the most recent evidence-based addition across both phenotypes.
Difference in right and left sided heart failure
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right sided heart failure causes symptoms clinical features
Harrison's Principles of Internal Medicine, Twenty First Edition
Page 10123
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left sided heart failure causes symptoms clinical features pathophysiology
Management of Cardiovascular Disease in Patients with Diabetes
Page 44
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Here is a detailed comparison of right-sided vs. left-sided heart failure:
Right-Sided vs. Left-Sided Heart Failure
Core Concept
| Left-Sided HF | Right-Sided HF | |
|---|---|---|
| Failing chamber | Left ventricle (± left atrium) | Right ventricle (± right atrium) |
| Backed-up circulation | Pulmonary (lungs) | Systemic venous (body) |
| Primary congestion | Pulmonary congestion | Systemic venous congestion |
Pathophysiology
Left-Sided HF
The left ventricle fails to eject blood forward into the aorta → blood backs up into the pulmonary circulation → increased pulmonary capillary wedge pressure → pulmonary edema and dyspnea.
Can be:
- Systolic (HFrEF) — impaired contraction, reduced EF
- Diastolic (HFpEF) — impaired relaxation, elevated filling pressures
Right-Sided HF
The right ventricle fails to pump blood into the pulmonary artery → blood backs up into the systemic venous circulation → engorgement of peripheral veins, liver, and dependent tissues.
Most common cause of right HF is untreated left HF — chronic pulmonary hypertension from left-sided disease eventually strains the RV.
Causes
| Left-Sided HF | Right-Sided HF |
|---|---|
| Coronary artery disease / MI | Left-sided HF (most common cause) |
| Hypertension | Pulmonary hypertension (PAH) |
| Dilated cardiomyopathy | Right ventricular MI |
| Aortic / mitral valve disease | Pulmonary embolism |
| Myocarditis | COPD / cor pulmonale |
| Arrhythmias (AF) | Tricuspid / pulmonary valve disease |
| Diabetes, obesity | Congenital heart disease |
Symptoms
| Symptom | Left-Sided HF | Right-Sided HF |
|---|---|---|
| Dyspnea on exertion | ✅ Hallmark | Mild (from low CO) |
| Orthopnea | ✅ Classic | Absent |
| Paroxysmal nocturnal dyspnea (PND) | ✅ Classic | Absent |
| Peripheral edema | Mild/late | ✅ Prominent |
| Ascites | Absent | ✅ Present |
| Fatigue | Present | Present |
| Nausea / anorexia | Absent | ✅ (hepatic/gut congestion) |
| Right upper quadrant discomfort | Absent | ✅ (hepatomegaly) |
| Nocturia | Present | Present |
| Weight gain | Mild | ✅ Pronounced |
Signs on Examination
| Sign | Left-Sided HF | Right-Sided HF |
|---|---|---|
| Elevated JVP (JVD) | Absent (unless biventricular) | ✅ Hallmark |
| Pulmonary crackles (crepitations) | ✅ Hallmark | Absent |
| S3 gallop | ✅ LV origin | ✅ RV origin (louder on inspiration) |
| Displaced apex beat | ✅ (LV enlargement) | Absent |
| RV heave / parasternal heave | Absent | ✅ Present |
| Pitting edema (ankles, legs, sacrum) | Mild/late | ✅ Prominent |
| Hepatomegaly / hepatojugular reflux | Absent | ✅ Present |
| Ascites | Absent | ✅ Present (advanced) |
| Loud P2 (pulmonic component) | Absent | ✅ (pulmonary HTN) |
| Tricuspid regurgitation murmur | Absent | ✅ (RV dilation) |
| Cardiac cachexia | Late | Late |
Per Harrison's Principles of Internal Medicine (p. 10123), right-sided HF features include tachypnea, loud P2, pulmonic/tricuspid regurgitation murmur, palpable RV heave, elevated JVP, and dependent edema.
Investigations
| Test | Left-Sided HF | Right-Sided HF |
|---|---|---|
| CXR | Pulmonary edema, Kerley B lines, cardiomegaly, pleural effusion | Cardiomegaly (RV), prominent pulmonary arteries, clear lung fields |
| ECG | LVH, LBBB, ischemic changes | RVH, right axis deviation, RBBB, P pulmonale |
| Echo | ↓ LVEF, LV dilation/hypertrophy, diastolic dysfunction | RV dilation, RV dysfunction, TR, ↑ RVSP |
| BNP/NT-proBNP | ✅ Elevated | ✅ Elevated |
| LFTs | Normal | ✅ Elevated (congestive hepatopathy) |
| Renal function | Cardiorenal syndrome | Cardiorenal syndrome |
Complications
| Left-Sided HF | Right-Sided HF | |
|---|---|---|
| Pulmonary edema | ✅ | — |
| Cardiogenic shock | ✅ | ✅ (massive PE, RV MI) |
| Progression to right HF | ✅ (via pulmonary HTN) | — |
| Congestive hepatopathy / cirrhosis | — | ✅ |
| Malabsorption / protein-losing enteropathy | — | ✅ (gut congestion) |
| Arrhythmias | ✅ | ✅ |
Summary
The fundamental distinction is where blood backs up:
- Left HF → fluid into the lungs → respiratory symptoms dominate (dyspnea, orthopnea, PND, crackles)
- Right HF → fluid into the body → systemic congestion dominates (JVD, edema, hepatomegaly, ascites)
In clinical practice, most advanced heart failure is biventricular — left-sided failure chronically elevates pulmonary pressures, which eventually causes RV failure, combining both symptom sets.
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