Medical flashcard titled "SLE — The Big Picture" with clean clinical layout. Card 1 of 10. Bold title at top. Content sections: DEFINITION box: "Systemic Lupus Erythematosus — chronic autoimmune multisystem inflammatory disease. Autoantibodies against nuclear antigens cause widespread tissue damage via immune complex deposition." EPIDEMIOLOGY box with icons: Female:Male = 9:1 ratio, Peak age 15–44 years, Higher prevalence in Black and Hispanic women. PATHOGENESIS box: "Defective clearance of apoptotic cells → nuclear debris → anti-dsDNA + anti-Smith antibodies → immune complex deposition → complement activation → inflammation". KEY TRIGGER box: "UV light, infections, drugs, hormones, stress". Color scheme: deep navy blue and white with gold accents. Professional medical education style.

Medical flashcard titled "SLE — Classification Criteria (SLICC 2012 / ACR-EULAR 2019)" Card 2 of 10. Divided into two columns: LEFT COLUMN labeled "CLINICAL DOMAINS" with checklist items: 1. Acute cutaneous lupus (malar rash) 2. Chronic cutaneous lupus (discoid rash) 3. Oral ulcers 4. Non-scarring alopecia 5. Synovitis (2+ joints) 6. Serositis (pleuritis/pericarditis) 7. Renal (proteinuria >500mg/24h or RBC casts) 8. Neurological (seizures, psychosis, myelitis, neuropathy) 9. Hemolytic anemia 10. Leukopenia/Lymphopenia 11. Thrombocytopenia. RIGHT COLUMN labeled "IMMUNOLOGICAL DOMAINS": ANA (entry criterion), Anti-dsDNA, Anti-Smith, Antiphospholipid antibodies, Low complement (C3/C4/CH50), Direct Coombs test. BOTTOM BANNER: "SLICC: ≥4/11 criteria OR biopsy-proven LN + ANA/anti-dsDNA. ACR-EULAR: ANA required + score ≥10". Navy blue header, white body, red accent highlights. Medical education style.

Medical flashcard titled "SLE — Skin Manifestations" Card 3 of 10. Three main sections with colored header bars: SECTION 1 (red bar) "ACUTE CUTANEOUS (ACLE)": Malar/butterfly rash — erythema over nose and cheeks sparing nasolabial folds. Photosensitive. Non-scarring. Strongly associated with active systemic SLE. Generalized ACLE = widespread photosensitive rash. SECTION 2 (orange bar) "SUBACUTE CUTANEOUS (SCLE)": Annular or papulosquamous lesions. Photosensitive, non-scarring. Anti-Ro/SSA antibodies. ~50% meet SLE criteria. SECTION 3 (teal bar) "CHRONIC CUTANEOUS (CCLE / DLE)": Discoid lesions — erythematous plaques with follicular plugging, central atrophy, scarring, dyspigmentation. Mostly skin-only disease. SECTION 4 (gray bar) "LE-NONSPECIFIC LESIONS": Non-scarring alopecia, oral ulcers (painless), Raynaud phenomenon, vasculitis, bullous SLE, livedo reticularis. BOTTOM NOTE: "Malar rash ≠ malar flushing — spares nasolabial folds". Clean clinical design, navy/white background.

Medical flashcard titled "SLE — Renal Manifestations (Lupus Nephritis)" Card 4 of 10. Top banner: "Occurs in >50% of SLE patients. Leading cause of morbidity". Main content: ISN/RPS Classification table with 6 rows: Class I = Minimal mesangial LN (normal light microscopy); Class II = Mesangial proliferative LN (mesangial hypercellularity); Class III = Focal LN (<50% glomeruli, segmental/global lesions); Class IV = Diffuse LN (≥50% glomeruli, MOST SEVERE, "wire loop" lesions); Class V = Membranous LN (subepithelial deposits, nephrotic syndrome); Class VI = Advanced sclerosing LN (≥90% globally sclerosed). CLINICAL FEATURES box: Hematuria, proteinuria (>500mg/24h), hypertension, casts, nephrotic syndrome, progressive CKD. KEY LAB box: Anti-dsDNA levels and complement (↓C3/C4) correlate with disease activity. Treatment arrows: Class I-II → conservative; Class III/IV → high-dose steroids + MMF or cyclophosphamide. Color: navy header, white body, red warnings for Class IV. Medical education style.