Dose of sucralfate syrup
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sucralfate syrup dose dosing regimen adults children
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Sucralfate Syrup – Dosing
Sucralfate oral suspension/syrup is available as 1 g/10 mL.
Adults
| Indication | Dose | Frequency | Duration |
|---|---|---|---|
| Duodenal ulcer (active) | 1 g (10 mL) | 4 times daily (QID) | 4–8 weeks |
| Duodenal ulcer (maintenance) | 1 g (10 mL) | Twice daily (BID) | Long-term |
| Gastric ulcer / GERD | 1 g (10 mL) | 4 times daily (QID) | 4–8 weeks |
| Stress ulcer prophylaxis (ICU) | 1 g (10 mL) | 4–6 times daily | Duration of risk |
| Esophagitis / mucositis | 1 g (10 mL) | 4 times daily (QID) | As needed |
Standard adult dose: 1 g (10 mL) QID — taken 1 hour before meals and at bedtime on an empty stomach.
Pediatric Dosing
| Age Group | Dose | Frequency |
|---|---|---|
| Children (2–12 years) | 40–80 mg/kg/day | Divided every 6 hours (QID) |
| Infants/neonates | 25–50 mg/kg/day | Divided every 6 hours (QID) |
Maximum pediatric dose generally does not exceed the adult dose (4 g/day).
Key Administration Points
- Take on an empty stomach, 30–60 minutes before meals and at bedtime
- Do not crush tablets if using tablet form; syrup is preferred for ease of administration and for tube-fed patients
- Avoid antacids within 30 minutes before or after sucralfate (reduces efficacy)
- Avoid co-administering with other drugs (e.g., fluoroquinolones, digoxin, warfarin, phenytoin) as sucralfate can reduce their absorption — separate by 2 hours
- Not significantly absorbed systemically; safe in renal caution is warranted due to aluminum content in patients with renal failure (risk of aluminum toxicity)
Maximum Daily Dose
- Adults: 4 g/day (4 doses of 1 g each)
- Children: Typically ≤ 4 g/day
Ml?
The syrup concentration is 1 g / 10 mL, so:
Adults
| Dose | Volume |
|---|---|
| 1 g (standard dose) | 10 mL |
| Daily (QID) | 40 mL/day (10 mL × 4) |
Children (40–80 mg/kg/day ÷ 4 doses)
| Weight | Daily dose | Per dose (QID) |
|---|---|---|
| 10 kg | 400–800 mg | 2–4 mL |
| 20 kg | 800–1600 mg | 4–8 mL |
| 30 kg | 1200–2400 mg | 6–12 mL |
Standard adult dose = 10 mL (1 g) four times daily, taken 30–60 min before meals and at bedtime.
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