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Rosuvastatin side effects

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rosuvastatin side effects adverse reactions

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statin myopathy rhabdomyolysis muscle toxicity

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Common side effects of rosuvastatin (Crestor) include:
  • Muscle symptoms: muscle aches, tenderness, cramps, weakness
  • Headache
  • Abdominal pain, nausea, constipation
  • Mild liver enzyme elevation on blood tests
Less common but important:
  1. Myopathy/rhabdomyolysis (serious muscle injury)
    • Warning signs: severe muscle pain, profound weakness, dark/cola urine
    • Statin-associated myotoxicity is a known risk; severe symptoms need urgent evaluation and stopping the drug pending clinician review (Harrison’s, p. 12814).
  2. Liver injury (rare)
    • Warning signs: jaundice, dark urine, severe fatigue, right upper abdominal pain.
  3. New-onset diabetes (small increased risk in susceptible patients, especially with higher-intensity statin use).
  4. Kidney effects (rare; usually secondary to severe rhabdomyolysis).
Notes:
  • Rosuvastatin is generally well tolerated in studies, including South Asian populations, with no major differences in serious lab adverse events in comparative trials (Patient-Centered Management of Dyslipidemia: Part 2, p. 71).
  • Risk of muscle toxicity rises with interacting drugs (for statins broadly), higher doses, older age, renal impairment, and hypothyroidism.
If you want, I can give you a quick checklist of which symptoms are monitor-at-home vs seek urgent care while on rosuvastatin.
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