Giant Cell Tumour (GCT) is a locally aggressive benign bone tumour occurring most often at the epiphysis of long bones in young adults. It is characterized histologically by numerous multinucleated giant cells on a background of mononuclear stromal cells. Common sites include the distal femur, proximal tibia, and distal radius. Treatment is mainly surgical (extended curettage with adjuvants or en bloc resection), and denosumab is used for unresectable or recurrent cases.

Now let me get the main clinical content from Campbell's Operative Orthopaedics on GCT:

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