Medical educational diagram showing the Mechanism of Action (MOA) of HRZE tuberculosis drugs. Four sections, each with a mycobacterium cell illustration: 1. H - Isoniazid: blocks mycolic acid synthesis by inhibiting InhA (enoyl-ACP reductase), disrupting the cell wall. Label: "Isoniazid (H) - Inhibits mycolic acid synthesis" 2. R - Rifampicin: binds to bacterial RNA polymerase (beta subunit), blocking mRNA transcription. Label: "Rifampicin (R) - Inhibits RNA polymerase / transcription" 3. Z - Pyrazinamide: converted to pyrazinoic acid in acidic environment, disrupts membrane energy, inhibits fatty acid synthase I. Label: "Pyrazinamide (Z) - Disrupts membrane potential / fatty acid synthesis (active in acidic pH)" 4. E - Ethambutol: inhibits arabinosyl transferase enzyme, blocking arabinogalactan synthesis in the cell wall. Label: "Ethambutol (E) - Inhibits arabinosyl transferase / cell wall arabinogalactan synthesis" Clean clinical infographic style, color-coded panels (blue, red, orange, green), bold drug names, clear arrows showing drug targets within a stylized TB bacterium cross-section. Title at top: "HRZE - First-Line Anti-TB Drugs: Mechanism of Action"