Paediatric dose of ambrxol and salbutamol acc to weight
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ambroxol salbutamol paediatric dose by weight mg/kg syrup
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Paediatric Dosing: Ambroxol & Salbutamol (by Weight)
Ambroxol
Standard oral syrup (15 mg/5 mL = 3 mg/mL)
| Age Group | Weight (approx.) | Dose | Frequency |
|---|---|---|---|
| < 2 years | < 12 kg | 1.25 mL (3.75 mg) | 2 times/day |
| 2-5 years | 12-18 kg | 2.5 mL (7.5 mg) | 2-3 times/day |
| 6-12 years | 18-35 kg | 5 mL (15 mg) | 2-3 times/day |
| > 12 years | > 35 kg | 10 mL (30 mg) | 2-3 times/day |
Weight-based dose (mg/kg):
- General rule: 1.2-1.6 mg/kg/dose, 2-3 times daily
- Infants <2 years: up to 1.7-2.0 mg/kg/dose (used in studies, twice daily)
- Maximum dose in children: typically 15 mg per dose (for children up to ~12 years)
Note: Ambroxol is not recommended in children under 2 years in many guidelines without physician supervision. Some formulations are contraindicated under 2 years.
Salbutamol (Albuterol)
Oral Syrup (2 mg/5 mL)
| Age / Weight | Volume | Dose | Frequency |
|---|---|---|---|
| 2 months-<4 months (4-<6 kg) | 1.0 mL | 0.4 mg | 3 times/day |
| 4 months-<12 months (6-<10 kg) | 2.0 mL | 0.8 mg | 3 times/day |
| 12 months-<3 years (10-<14 kg) | 2.5 mL | 1.0 mg | 3 times/day |
| 3 years-5 years (14-19 kg) | 5.0 mL | 2.0 mg | 3 times/day |
Weight-based dose: 0.1-0.15 mg/kg/dose, 3 times daily (max 2 mg/dose in young children; 4 mg/dose in older children)
Nebulization
| Weight | Dose | Frequency |
|---|---|---|
| < 25 kg | 2.5 mg in 2.5 mL normal saline | Every 20 min (acute) or 3-4x/day |
| 25-50 kg | 5 mg | Every 20 min (acute) or 3-4x/day |
| > 50 kg | 10 mg | As above |
Nebulizer solution: 0.5 mL of 5 mg/mL + 2 mL normal saline for standard nebulization
MDI (100 mcg/puff, with spacer)
| Weight | Puffs (Acute) |
|---|---|
| < 20 kg | 2-4 puffs (reliever); 5 puffs (acute/ED) every 20 min |
| > 20 kg | 4-8 puffs (reliever); 10 puffs (acute/ED) every 20 min |
Combined Ambroxol + Salbutamol Syrup
(e.g. formulations with Ambroxol 15 mg + Salbutamol 1 mg per 5 mL)
- Children > 2 years: 5 mL, 3-4 times a day
- Adults: 5-10 mL, 3-4 times a day
- Not recommended for children < 2 years
Key Notes
- Always check the specific product concentration before dosing - formulations vary.
- Ambroxol dosing is based on WHO/IMCI guidelines and published clinical trial data (PMC study).
- Salbutamol syrup dosing follows WHO IMCI guidelines.
- Salbutamol IV/parenteral in severe cases: 0.5-1 mcg/kg/min infusion (specialist use only).
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