You have about 24 hours - here is your complete exam preparation guide for BSNS 102: Applied Anatomy & Applied Physiology (75 Marks, 3 Hours).
BSNS 102 - Complete Exam Prep Guide
SECTION-A: APPLIED ANATOMY (37 Marks)
Q1. MCQ Answers (6 x 1 = 6 Marks)
| # | Question | Answer |
|---|
| i | A joint with a fluid-filled cavity is | (c) A synovial joint |
| ii | Endocrine glands | (b) Are ductless |
| iii | Plasma membrane does NOT contain | (b) Nucleic acid |
| iv | Meningeal layer closest to skull bone | (a) Dura mater |
| v | Heart is located in | (c) Thoracic cavity |
| vi | Lobes in right lung | (d) 3 (the option listed as "4" is wrong; right lung = 3 lobes - upper, middle, lower) |
Note on vi: The correct answer is 3. The right lung has 3 lobes (upper, middle, lower); the left lung has 2.
Q2. Long Answer - Choose ONE (1 x 10 = 10 Marks)
Option (i): Name the Endocrine Glands + Describe the Thyroid Gland
Endocrine Glands of the Body:
- Hypothalamus
- Pituitary gland (master gland - anterior + posterior)
- Thyroid gland
- Parathyroid glands (4 small glands)
- Adrenal glands (2 - cortex + medulla)
- Pancreas (Islets of Langerhans)
- Gonads - ovaries (female) / testes (male)
- Pineal gland
- Thymus
Thyroid Gland - Detail:
- Location: Anterior in the neck, below and lateral to the thyroid cartilage. Lies deep to the sternohyoid, sternothyroid, and omohyoid muscles in the visceral compartment of the neck.
- Structure: Two lateral lobes connected by an isthmus. The isthmus crosses the anterior surface of the 2nd and 3rd tracheal cartilages. A pyramidal lobe may ascend from the isthmus.
- Development: Arises as a median outgrowth from the floor of the pharynx (at the foramen cecum of the tongue) and migrates down via the thyroglossal duct.
Blood Supply:
- Superior thyroid artery - first branch of external carotid artery
- Inferior thyroid artery - branch of thyrocervical trunk (from subclavian artery)
- Thyroid ima artery - occasional branch from brachiocephalic trunk
Venous Drainage:
- Superior and middle thyroid veins drain into the internal jugular vein
- Inferior thyroid veins drain into the brachiocephalic vein
Nerve Supply: Sympathetic fibers from the superior, middle, and inferior cervical sympathetic ganglia.
Histology: Follicles lined by follicular cells - store thyroglobulin (colloid). Parafollicular (C) cells secrete calcitonin.
Functions/Hormones:
- T3 (triiodothyronine) and T4 (thyroxine) - regulate basal metabolic rate, growth, protein synthesis
- Calcitonin - lowers blood calcium
Draw a labeled diagram of the thyroid gland showing lobes, isthmus, arteries, and veins.
Option (ii): Classification of Joints + Synovial Joints
Classification of Joints:
1. Fibrous Joints (Synarthroses - immovable)
- Sutures - skull bones
- Syndesmosis - inferior tibiofibular joint
- Gomphosis - teeth in socket
2. Cartilaginous Joints (Amphiarthroses - slightly movable)
- Primary (Synchondrosis) - epiphyseal plates, 1st sternocostal joint
- Secondary (Symphysis) - pubic symphysis, intervertebral discs
3. Synovial Joints (Diarthroses - freely movable)
- Have a fluid-filled synovial cavity
- Features: articular cartilage, synovial membrane, joint capsule, synovial fluid, ligaments
Types of Synovial Joints:
| Type | Movement | Example |
|---|
| Hinge | Uniaxial (flexion/extension) | Elbow, knee, interphalangeal |
| Pivot | Rotation | Atlantoaxial joint, radioulnar |
| Ball & Socket | Multiaxial | Hip, shoulder |
| Condyloid | Biaxial | Radiocarpal (wrist) |
| Saddle | Biaxial | Carpometacarpal of thumb |
| Plane (Gliding) | Gliding | Intercarpal, acromioclavicular |
Applied Anatomy of Hip Joint (Ball & Socket - example):
- Head of femur fits into acetabulum
- Strengthened by iliofemoral, pubofemoral, and ischiofemoral ligaments
- Ligamentum teres carries artery to head of femur
- Clinical: Hip dislocation most commonly posterior; fractures common in elderly
Q3. Short Answer - Attempt Any THREE (3 x 5 = 15 Marks)
(i) Stomach - Position, Parts, Blood Supply, Nerve Supply, Applied Anatomy
Position: Left hypochondriac and epigastric region of the abdomen.
Parts:
- Cardia - surrounds cardio-esophageal junction
- Fundus - above the cardiac orifice (contains gas)
- Body - main part
- Pyloric antrum + pyloric canal
- Pylorus - sphincter controlling emptying into duodenum
Curvatures:
- Lesser curvature (right border) - shorter, has the angular notch (incisura angularis)
- Greater curvature (left border) - longer, gives attachment to greater omentum
Blood Supply:
- Left gastric artery (branch of coeliac trunk) - along lesser curvature
- Right gastric artery (from proper hepatic artery) - along lesser curvature
- Right gastro-omental/epiploic (from gastroduodenal artery) - along greater curvature
- Left gastro-omental/epiploic (from splenic artery) - along greater curvature
- Short gastric arteries (from splenic artery) - to fundus
Nerve Supply:
- Parasympathetic: Vagus nerve (CN X) - increases secretion and motility
- Sympathetic: T6-T9 via coeliac plexus - decreases motility, vasomotor
Applied Anatomy:
- Peptic ulcers most common in lesser curvature and pyloric antrum
- Pyloric stenosis in infants causes projectile vomiting
- Gastric cancer common in pyloric antrum
(ii) Blood Supply of the Heart
Arterial Supply - Coronary Arteries (arise from aortic sinuses just above aortic valve):
Right Coronary Artery (RCA):
- Supplies right atrium, right ventricle, SA node (60%), AV node (80%), posterior 1/3 of IVS
- Branches: Marginal branch, Posterior interventricular (posterior descending) artery
Left Coronary Artery (LCA):
Divides into:
- Left Anterior Descending (LAD) - supplies anterior 2/3 of IVS, anterior wall of both ventricles (most important! Called "widow-maker")
- Left Circumflex (LCx) - supplies left atrium, lateral and posterior left ventricle
Venous Drainage:
- Great cardiac vein - follows LAD, drains into coronary sinus
- Middle cardiac vein - follows posterior descending artery
- Small cardiac vein - follows marginal branch
- Coronary sinus - collects most venous blood, drains into right atrium
- Anterior cardiac veins - drain directly into right atrium
Applied Anatomy (Coronary artery disease):
- RCA occlusion: inferior MI, heart block (SA/AV node affected)
- LAD occlusion: anterior MI (most lethal)
- LCx occlusion: lateral MI
(iii) Describe the Uterus in its Parts
Position: Located in the pelvic cavity, between the bladder (anteriorly) and rectum (posteriorly). Normally anteverted and anteflexed.
Parts:
- Fundus - dome-shaped part above the fallopian tube openings
- Body (Corpus) - main central part; triangular shaped cavity
- Isthmus - narrow constriction between body and cervix (~1 cm)
- Cervix - cylindrical lower segment protruding into vagina. Has internal os (above) and external os (below). Divided into supravaginal and vaginal portions.
Layers of Uterine Wall:
- Perimetrium (outer serosa)
- Myometrium (middle smooth muscle - thickest layer)
- Endometrium (inner mucosa - undergoes cyclical changes)
Blood Supply:
- Uterine artery (branch of internal iliac artery) - crosses ureter at level of internal os ("water under the bridge")
Supports:
- Transverse cervical (cardinal) ligaments - main support
- Uterosacral ligaments
- Pubocervical ligaments
- Round ligaments (maintain anteversion)
Applied:
- Uterine prolapse - weakening of supports (common after multiple vaginal deliveries)
- Fibroids develop in myometrium
- Cervical cancer - common at squamocolumnar junction (transformation zone)
(iv) Draw a Labelled Diagram of the Eyeball
Label these structures:
Outer coat (Fibrous):
- Sclera (posterior 5/6 - white, protective)
- Cornea (anterior 1/6 - transparent, major refractive surface)
Middle coat (Vascular/Uvea):
- Choroid (posterior - highly vascular, nourishes retina)
- Ciliary body (with ciliary muscle - controls lens shape for accommodation)
- Iris (colored ring with pupil in center; dilates/constricts to control light)
Inner coat:
- Retina (contains photoreceptors: rods for dim light, cones for color/fine detail)
- Macula lutea with fovea centralis (point of sharpest vision)
- Optic disc / Optic nerve head (blind spot - no photoreceptors)
Contents:
- Aqueous humor (anterior/posterior chambers - maintains intraocular pressure)
- Lens (biconvex, transparent; suspended by zonular fibers from ciliary body)
- Vitreous humor (posterior chamber - gel-like, maintains shape)
Always draw a clearly labeled cross-section diagram - examiners expect it!
(v) Classify the Nervous System
NERVOUS SYSTEM
├── Central Nervous System (CNS)
│ ├── Brain
│ │ ├── Cerebrum (cortex, basal ganglia)
│ │ ├── Cerebellum
│ │ ├── Diencephalon (thalamus, hypothalamus)
│ │ └── Brainstem (midbrain, pons, medulla)
│ └── Spinal Cord
│
└── Peripheral Nervous System (PNS)
├── Somatic NS (voluntary)
│ ├── Afferent (sensory) - skin/muscles to CNS
│ └── Efferent (motor) - CNS to skeletal muscle
└── Autonomic NS (involuntary)
├── Sympathetic ("fight or flight")
│ └── T1-L2 outflow; neurotransmitter: noradrenaline
└── Parasympathetic ("rest and digest")
└── Cranial (III,VII,IX,X) + Sacral (S2-S4); NT: acetylcholine
Draw this as a branching diagram in the exam.
Q4. Very Short - Attempt Any THREE (3 x 2 = 6 Marks)
(i) Types of Muscles
- Skeletal (Striated/Voluntary) - attached to bones, conscious control, multinucleated, rapid contractions
- Cardiac (Striated/Involuntary) - only in heart, uninucleated, has intercalated discs, autorhythmic
- Smooth (Non-striated/Involuntary) - walls of viscera/vessels, spindle-shaped, slow sustained contractions
(ii) Layers of Skin (from outside to inside)
Epidermis (5 layers, mnemonic: Come Let's Get Some Beer):
- Stratum Corneum (outermost - dead keratinized cells)
- Stratum Lucidum (only in thick skin)
- Stratum Granulosum
- Stratum Spinosum
- Stratum Basale/Germinativum (deepest - cell division)
Dermis - below epidermis: papillary layer + reticular layer (collagen, blood vessels, nerves)
Hypodermis (subcutaneous) - fat, connective tissue
(iii) Define Micturition
Micturition is the process of voluntary voiding of urine from the urinary bladder through the urethra. It involves detrusor muscle contraction (bladder wall smooth muscle) and relaxation of the internal and external urethral sphincters. Controlled by micturition center in pons (pontine micturition center) and sacral spinal cord (S2-S4).
(iv) Define Hemostasis
Hemostasis is the physiological process that stops bleeding from an injured blood vessel. It involves three sequential steps:
- Vascular spasm - immediate vasoconstriction
- Platelet plug formation - primary hemostasis (platelet adhesion → activation → aggregation)
- Coagulation - secondary hemostasis (coagulation cascade → fibrin clot)
Finally: fibrinolysis dissolves the clot once healing occurs.
SECTION-B: APPLIED PHYSIOLOGY (38 Marks)
Q1. MCQ Answers (7 x 1 = 7 Marks)
| # | Question | Answer |
|---|
| i | Movement through selectively permeable membrane | (d) Osmosis |
| ii | Most body heat loss occurs through | (c) Skin (~85% via radiation/convection/evaporation) |
| iii | Most nutrient absorption occurs in | (c) Small intestine |
| iv | Functional unit of the kidney | (d) Nephrons |
| v | Gas exchange takes place in | (c) Alveolar sac (alveoli) |
| vi | Hepatic veins drain liver blood to | (b) Superior vena cava - via the inferior vena cava (actually: (a) Inferior vena cava - hepatic veins drain into IVC) |
| vii | Exocrine pancreas produces | (a) Pancreatic juice rich in enzymes (lipase, amylase, proteases) |
Clarification on vi: Hepatic veins drain into the Inferior Vena Cava (IVC) - answer is (a).
Q2. Long Answer - Choose ONE (1 x 10 = 10 Marks)
Option (i): Mechanism of Urine Formation
Urine formation involves three main processes in the nephron (functional unit of kidney):
Urinary excretion = Filtration - Reabsorption + Secretion
Step 1: Glomerular Filtration
- Occurs at the glomerulus (tuft of capillaries) inside Bowman's capsule
- Blood pressure drives fluid from glomerular capillaries into Bowman's capsule
- Glomerular Filtration Rate (GFR) = ~125 mL/min = ~180 L/day
- Filtrate contains water, glucose, amino acids, urea, creatinine, ions - NO large proteins or cells
- Driving force: Net filtration pressure = hydrostatic pressure - (oncotic pressure + capsule pressure)
Step 2: Tubular Reabsorption
- ~99% of filtrate is reabsorbed back into blood
- Proximal Convoluted Tubule (PCT): reabsorbs ~65% of Na+, water, all glucose, amino acids, bicarbonate (active transport + osmosis)
- Loop of Henle: concentrates urine; descending limb - permeable to water; ascending limb - active NaCl reabsorption (impermeable to water) - creates concentration gradient in medulla
- Distal Convoluted Tubule (DCT): Na+ reabsorption regulated by Aldosterone; water reabsorption by ADH
- Collecting duct: final water reabsorption controlled by ADH (antidiuretic hormone)
Step 3: Tubular Secretion
- Substances move from peritubular capillaries INTO the tubular lumen
- Secreted: H+ ions (acid-base balance), K+ ions, NH3, drugs, creatinine
- Helps regulate blood pH
Final Urine:
- Volume: ~1.5 L/day
- Contains: urea, creatinine, uric acid, excess salts, water
- Urine flows: renal pelvis → ureter → bladder → urethra
Draw a labeled nephron diagram showing PCT, Loop of Henle, DCT, and collecting duct.
Option (ii): Blood Pressure - Definition + Factors Regulating
Definition: Blood pressure is the lateral force exerted by blood per unit area on the walls of blood vessels. Normal BP = 120/80 mmHg (systolic/diastolic).
- Systolic BP (SBP): Pressure during ventricular contraction
- Diastolic BP (DBP): Pressure during ventricular relaxation
- Mean Arterial Pressure (MAP): DBP + 1/3 pulse pressure ≈ ~93 mmHg
BP = Cardiac Output (CO) x Peripheral Vascular Resistance (PVR)
Factors Regulating Blood Pressure:
1. Cardiac Output
- Determined by heart rate x stroke volume
- Stroke volume affected by: preload, contractility, afterload
- β-adrenergic stimulation increases HR and contractility
2. Peripheral Vascular Resistance
- Regulated at the level of arterioles
- Vasoconstrictors: angiotensin II, catecholamines (noradrenaline), endothelin
- Vasodilators: nitric oxide (NO), kinins, prostaglandins, histamine
3. Renin-Angiotensin-Aldosterone System (RAAS)
- Low BP → juxtaglomerular cells release Renin
- Renin converts angiotensinogen → Angiotensin I
- ACE converts Angiotensin I → Angiotensin II
- Angiotensin II: powerful vasoconstrictor + stimulates Aldosterone release
- Aldosterone: increases Na+ and water retention → increases blood volume → increases BP
4. Blood Volume
- More blood volume = more preload = higher CO = higher BP
- Controlled by: aldosterone (Na+ retention), ADH (water retention), ANP (atrial natriuretic peptide - promotes Na+ excretion when BP too high)
5. Nervous System (Short-term regulation)
- Baroreceptors (in carotid sinus and aortic arch) detect stretch → signal to vasomotor center in medulla
- High BP → parasympathetic activation (vagus) → decreased HR + vasodilation
- Low BP → sympathetic activation → increased HR + vasoconstriction
6. Humoral Factors
- Vasopressin (ADH): vasoconstriction + water retention
- Atrial Natriuretic Peptide (ANP): vasodilation + Na+ excretion (decreases BP)
Q3. Short Answer - Attempt Any THREE (3 x 5 = 15 Marks)
(i) Functions of the Placenta
The placenta has 5 main functions (mnemonic: TEMPE):
1. Transport / Exchange
- O2 and CO2: by simple diffusion (O2 mother→fetus; CO2 fetus→mother)
- Glucose: facilitated diffusion
- Amino acids, vitamins, minerals: active transport
- Immunoglobulins (IgG): pinocytosis (passive immunity to fetus)
- Waste products (urea, bilirubin): fetus→mother by diffusion
- Mechanisms: simple diffusion, facilitated diffusion, active transport, pinocytosis
2. Endocrine (Hormone Production)
- hCG (Human Chorionic Gonadotropin): maintains corpus luteum in early pregnancy, basis of pregnancy test
- hPL (Human Placental Lactogen): alters maternal metabolism, promotes fetal growth
- Progesterone: maintains uterine lining, prevents contractions
- Estrogen: uterine growth, breast development
- Relaxin: loosens pelvic ligaments for birth
3. Metabolism
- Synthesizes glycogen, cholesterol, fatty acids in early pregnancy as energy source for embryo
4. Protection (Placental Barrier)
- Prevents some harmful substances and microorganisms from reaching fetus
- However: not absolute - alcohol, certain drugs, rubella virus, syphilis, and some medications can cross
5. Excretion
- Fetal metabolic waste (urea, CO2, bilirubin) excreted into maternal circulation
(ii) Refractive Errors of the Eye
Refractive error occurs when the eye cannot focus light correctly onto the retina.
1. Myopia (Nearsightedness)
- Light focuses in FRONT of retina
- Cause: eyeball too long OR cornea/lens too curved
- Can see near objects clearly; distant objects blurry
- Correction: Concave (diverging) lens
2. Hypermetropia (Farsightedness)
- Light focuses BEHIND the retina
- Cause: eyeball too short OR lens too flat
- Can see far objects; near objects blurry
- Correction: Convex (converging) lens
3. Astigmatism
- Uneven curvature of cornea or lens - different focal points in different planes
- Objects appear blurry/distorted at all distances
- Correction: Cylindrical lens
4. Presbyopia
- Age-related loss of lens elasticity (after age 40)
- Cannot accommodate (focus on near objects)
- Correction: Reading glasses (convex lens)
5. Aphakia
- Absence of lens (post cataract surgery)
- Corrected by thick convex lens or intraocular lens implant
(iii) Functions of the Hypothalamus
The hypothalamus is located in the diencephalon; it is the main link between the nervous and endocrine systems.
Major Functions:
1. Autonomic Nervous System Control
- Posterior hypothalamus: activates sympathetic ("fight or flight") responses - increases HR, BP, pupil dilation
- Anterior hypothalamus: activates parasympathetic responses
2. Temperature Regulation (Thermostat of the body)
- Anterior hypothalamus: responds to heat - promotes sweating, vasodilation (heat loss)
- Posterior hypothalamus: responds to cold - promotes shivering, vasoconstriction (heat conservation)
- Fever: pyrogens raise hypothalamic set point
3. Hunger and Satiety
- Lateral hypothalamus: hunger center (lesion → starvation)
- Ventromedial nucleus: satiety center (lesion → obesity)
4. Thirst and Water Balance
- Lateral hypothalamus: thirst center
- Controls ADH (vasopressin) release from posterior pituitary to regulate water reabsorption
5. Endocrine Control (via Pituitary)
- Releases releasing and inhibiting hormones:
- GnRH, TRH, CRH, GHRH, Somatostatin, Dopamine
- Controls anterior pituitary (master gland) → controls thyroid, adrenals, gonads, growth
6. Circadian Rhythm
- Suprachiasmatic nucleus (SCN) - biological clock, regulates sleep-wake cycle
7. Emotional Behavior / Limbic System
- Involved in rage, fear, sexual behavior
8. Oxytocin and ADH Production
- Produced in hypothalamus, stored and released from posterior pituitary
(iv) Classification and Functions of Leukocytes (WBCs)
Classification:
LEUKOCYTES (WBCs)
├── GRANULOCYTES (Polymorphonuclear - multilobed nucleus)
│ ├── Neutrophils (60-70%) - stain pink
│ ├── Eosinophils (2-4%) - stain red
│ └── Basophils (<1%) - stain blue
│
└── AGRANULOCYTES (Mononuclear - rounded nucleus)
├── Lymphocytes (20-30%)
│ ├── T cells (cell-mediated immunity)
│ ├── B cells (antibody/humoral immunity)
│ └── NK cells (natural killer)
└── Monocytes (2-8%) → become Macrophages in tissues
Functions:
| Cell | Function |
|---|
| Neutrophils | First responders to infection; phagocytosis of bacteria; respiratory burst (oxygen radicals) |
| Eosinophils | Kill parasites (worms); involved in allergic reactions and asthma; remove fibrin during inflammation |
| Basophils | Release histamine in allergic reactions; increase vascular permeability |
| T Lymphocytes | Cell-mediated immunity; CD4 helper T cells; CD8 cytotoxic T cells; immune memory |
| B Lymphocytes | Produce antibodies (immunoglobulins) for humoral immunity |
| NK Cells | Kill virus-infected and cancer cells (no prior sensitization needed) |
| Monocytes/Macrophages | Phagocytosis of dead cells and microorganisms; antigen presentation; clean up after infection |
Normal WBC count: 4,000 - 11,000 cells/µL
Q4. Very Short - Attempt Any THREE (3 x 2 = 6 Marks)
(i) Types of Neurons
By Function:
- Sensory (Afferent) neurons - carry impulses from receptors to CNS
- Motor (Efferent) neurons - carry impulses from CNS to effectors (muscles/glands)
- Interneurons (Association neurons) - connect sensory and motor neurons within CNS
By Structure (number of processes):
- Multipolar (most neurons in brain/spinal cord) - one axon, multiple dendrites
- Bipolar (retina, olfactory) - one axon, one dendrite
- Unipolar/Pseudounipolar (dorsal root ganglia) - one process that divides
(ii) 2 Functions of Testosterone
- Development of male secondary sexual characteristics - beard, deep voice, enlargement of penis/testes, pubic hair, muscle bulk
- Spermatogenesis - essential for sperm production in the seminiferous tubules of testes
(Bonus: also promotes protein anabolism, bone growth, and libido)
(iii) Functions of Saliva
- Digestion - Salivary amylase (ptyalin) begins carbohydrate digestion in the mouth; lingual lipase begins fat digestion
- Lubrication - mucin lubricates food bolus for swallowing
- Cleansing - washes away food particles and bacteria; reduces tooth decay
- Antibacterial - contains lysozyme, IgA, lactoferrin (antimicrobial protection)
- Dissolves food - dissolves taste chemicals to stimulate taste buds
- Buffers - bicarbonate in saliva neutralizes acids, protects enamel
(iv) Cyanosis
Cyanosis is the bluish discoloration of the skin and mucous membranes caused by reduced oxygenation of blood (increased concentration of deoxygenated hemoglobin > 5 g/dL in capillaries).
Types:
- Central cyanosis - affects lips, tongue, mucous membranes; due to heart/lung disease (e.g., congenital heart disease, severe pneumonia)
- Peripheral cyanosis - affects fingers, toes; due to poor circulation (e.g., cold exposure, shock, Raynaud's)
Quick Revision Summary (Last 30 Minutes Before Exam)
Section A MCQs: c, b, b, a, c, 3 (right lung)
Section B MCQs: d, c, c, d, c, a, a
High-value topics to prioritize tonight:
- Urine formation (3 steps: filtration-reabsorption-secretion) - draw nephron
- Blood pressure regulation (RAAS, baroreceptors, CO x PVR)
- Thyroid gland (location, blood supply, hormones) - draw diagram
- Leukocyte classification table
- Hypothalamus functions (8 functions)
- Placenta functions (TEMPE mnemonic)
Must draw diagrams for: Thyroid gland, Eyeball, Nephron, Nervous system classification tree
Good luck tomorrow - you've got this! 💪