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NEET PG 2026 - Expected Questions & High-Yield Topic Predictions

How the Exam is Trending (Big Picture)

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Subject-Wise Expected Questions & High-Yield Topics

1. GENERAL MEDICINE - 25-30 Questions (Highest weightage)

• STEMI: criteria, management, anticoagulation, reperfusion window
• Heart failure: HFpEF vs HFrEF, BNP, management
• ECG interpretation: MI, arrhythmias, blocks (image-based)
• Atrial fibrillation: CHA2DS2-VASc, rate vs rhythm control

• Diabetes mellitus: diagnostic criteria, HbA1c targets, drug of choice in CKD/pregnancy
• Thyroid disorders: Graves' disease, Hashimoto's, thyroid storm
• Addison's disease vs Cushing's - classic differentiators
• Paget's disease of bone - ALP, imaging

• Stroke: NIHSS, tPA window (4.5 hours), mechanical thrombectomy criteria
• Epilepsy: drug of choice by seizure type
• Meningitis: CSF findings table (bacterial vs viral vs TB vs fungal)

• HIV: CD4 count thresholds, ART initiation, IRIS in HIV-TB
• TB: NTEP protocols, MDR-TB regimen, drug side effects
• Malaria: severe malaria criteria, artesunate vs quinine

• SLE: ANA, anti-dsDNA, complement levels, SLEDAI
• RA: RF, anti-CCP, pannus formation, DMARDs
• Gout: urate crystals, allopurinol vs febuxostat timing

• CKD staging (KDIGO), GFR-based drug adjustments
• Glomerulonephritis: nephritic vs nephrotic syndrome tables
• AKI: AKIN criteria, RIFLE criteria

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2. OBSTETRICS & GYNAECOLOGY - 25-30 Questions (Tied for highest)

• Pre-eclampsia/Eclampsia: BP criteria (>140/90), HELLP syndrome, MgSO4 protocol (Pritchard/Zuspan)
• Gestational diabetes: O'Sullivan test, GCT vs OGTT cutoffs
• Rh isoimmunization: MCA Doppler PSV (>1.5 MoM), IUT timing
• IUGR: symmetric vs asymmetric, umbilical artery Doppler

• Cord prolapse: immediate management (knee-chest position, cesarean)
• Atonic PPH: Bakri balloon, uterotonic sequence (oxytocin → misoprostol → carboprost)
• Shoulder dystocia: McRoberts maneuver, Zavanelli
• Episiotomy: repair layers in order (mucosa → muscle → skin)

• Adenomyosis: MRI diagnosis (junctional zone >12mm)
• Premature ovarian insufficiency: raised FSH, lowered AMH
• Cervical cancer: FIGO staging, HPV types 16 and 18
• Endometrial cancer: risk factors (obesity, PCOS, tamoxifen), staging

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3. GENERAL SURGERY - 20-25 Questions

• Appendicitis: Alvarado score, imaging, operative vs non-operative
• Intestinal obstruction: X-ray findings (Rigler sign, valvulae conniventes vs haustrae)
• Achalasia cardia: manometry findings (high LES pressure, absent peristalsis)
• Courvoisier's law: palpable gallbladder + painless jaundice = pancreatic head carcinoma

• Gallstones: Mirizzi syndrome, choledocholithiasis
• Pancreatitis: Ranson's criteria, Balthazar score
• Hepatocellular carcinoma: AFP, Barcelona staging, TACE

• Diffuse axonal injury: RTA, CT findings (petechial hemorrhages at grey-white junction)
• ATLS sequence: primary survey ABCDE
• Splenic injury grades, conservative vs operative management

• Parks classification of anal fistula
• Colorectal cancer: Dukes vs TNM staging, screening colonoscopy
• Congenital diaphragmatic hernia: Bochdalek (left), Morgagni (right)

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4. PATHOLOGY - 15-20 Questions (Many image-based)

• AML M3 (APML): t(15;17), PML-RARA, treated with ATRA
• CML: t(9;22) Philadelphia chromosome, BCR-ABL, imatinib
• Follicular lymphoma: t(14;18), bcl-2 overexpression
• Reed-Sternberg cells: Hodgkin's lymphoma (CD15, CD30)

• Tumor markers: PSA, AFP, CEA, CA-125, CA 19-9 - which cancer?
• Oncogenes vs tumor suppressor genes: RB1, TP53, BRCA1/2
• Carcinogenesis steps: initiation, promotion, progression

• Primary biliary cholangitis: AMA-M2 positive
• Hepatitis: bridging necrosis, ground-glass hepatocytes (Hep B)
• Renal pathology: membranous vs FSGS vs minimal change - electron microscopy pattern

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5. PHARMACOLOGY - 15-20 Questions

• Mechanism of resistance: beta-lactamase, MRSA (mecA gene), fluoroquinolone resistance
• Drug of choice: typhoid (azithromycin/ceftriaxone), MRSA (vancomycin/linezolid), MDR-TB
• Aminoglycosides: ototoxicity, nephrotoxicity, once-daily dosing rationale

• Beta-blockers: cardioselective vs non-selective, contraindications (asthma, Prinzmetal angina)
• Anti-arrhythmics: Vaughan-Williams classification
• Anticoagulants: heparin (APTT monitoring) vs warfarin (PT/INR) vs NOACs

• Anti-epileptics: valproate (teratogen - neural tube defects), lamotrigine in pregnancy
• Drug interactions: warfarin + NSAIDs, metformin + contrast, MAOIs + tyramine

• GLP-1 agonists (semaglutide) in obesity/T2DM
• SGLT2 inhibitors: cardiac and renal benefits beyond glucose control
• Biologic agents: TNF inhibitors in RA/IBD, monoclonal antibodies

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6. MICROBIOLOGY - 12-18 Questions

• Staphylococcus: coagulase positive/negative, toxins, scalded skin syndrome
• Mycobacterium tuberculosis: Ziehl-Neelsen, culture media (LJ medium), cord factor
• H. pylori: urease breath test, triple therapy

• HIV: window period, ELISA vs Western Blot, viral load
• Hepatitis B: surface antigen/antibody interpretation table (HBsAg, anti-HBs, HBeAg)
• COVID-19 updates: vaccines, variants (exam-relevant points)

• Malaria: Plasmodium life cycle, thick and thin smear, gametocyte shapes
• Toxoplasma: congenital toxoplasmosis, immunocompromised reactivation

• Hypersensitivity reactions: Type I-IV - classic examples for each
• Vaccine schedule (UIP): BCG, OPV, Pentavalent - ages and doses

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7. PSM / COMMUNITY MEDICINE - 12-16 Questions

• NTEP (formerly RNTCP): Nikshay, PMDT, DRTB treatment
• NPCDCS: screening for cancer, DM, CVD
• Ayushman Bharat PM-JAY: coverage amount, beneficiaries
• NHM: sub-centre, PHC, CHC population norms

• Sensitivity vs Specificity vs PPV vs NPV - formula + calculation
• NNT (Number Needed to Treat)
• Odds Ratio vs Relative Risk
• Screening criteria: Wilson & Jungner

• Incidence vs Prevalence
• Attack rate, case fatality rate
• Study designs: case-control vs cohort (most commonly tested)

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8. BIOCHEMISTRY - 12-15 Questions

• Enzyme kinetics: Km, Vmax, Michaelis-Menten, inhibitor types
• Vitamins: deficiency diseases + clinical features (fat-soluble vs water-soluble)
• Inborn errors of metabolism: PKU, alkaptonuria, maple syrup urine disease
• Molecular biology: PCR, Southern/Northern/Western blot - which detects what
• Lipid metabolism: familial hypercholesterolemia, statins' mechanism

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9. PEDIATRICS - 12-15 Questions

• Growth milestones: weight, height, head circumference by age
• Neonatal jaundice: physiological vs pathological cutoffs, exchange transfusion criteria
• IMNCI: classification of pneumonia, diarrhea with dehydration
• Vaccines: live attenuated vs killed, contraindications
• Nutritional deficiencies: kwashiorkor vs marasmus

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10. SHORT SUBJECTS (Combined 30-40 Questions)

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Cross-Exam Convergence: Topics That Appear in NEET PG + INICET + FMGE

1. STEMI management (fibrinolysis window, PCI preference, drugs)
2. Pre-eclampsia & MgSO4 protocol (Pritchard regimen doses)
3. PPH management (uterotonic sequence, Bakri balloon, B-Lynch suture)
4. AML-M3 / t(15;17) - ATRA treatment
5. HIV CD4 count thresholds (ART start, prophylaxis levels)
6. TB drug side effects (ethambutol → optic neuritis, rifampicin → orange urine/hepatitis, isoniazid → peripheral neuropathy)
7. Sensitivity/Specificity calculations (PSM)
8. Mallampati score / airway grading (Anesthesia)
9. Glaucoma types (open angle = painless, slow; closed angle = acute painful, halos)
10. Hypersensitivity Type I-IV with classic examples

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Image-Based Question Preparation (18-25% of Paper)

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INICET-Specific Higher Difficulty Areas

• Molecular oncology: specific translocations for all major lymphomas/leukemias
• Pharmacogenomics: G6PD and primaquine hemolysis, HLA-B*5701 and abacavir
• Rare genetic disorders: storage diseases (Gaucher, Niemann-Pick, Fabry) - enzyme deficiency + substrate
• Advanced statistics: meta-analysis, forest plots, publication bias
• Cardiology depth: Brugada syndrome, Long QT syndrome, channelopathies

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Smart Preparation Strategy

1. Do PYQs first - At least 5 years of NEET PG + 3 years of INICET recalled papers
2. Image bank daily - 10-15 images every day (ECG, X-ray, histo, fundus)
3. Prioritize the 30-70 rule - 30% of topics generate 70% of questions (Medicine, OBG, Surgery, Pharmacology, PSM)
4. National programs last month - Memorize NTEP, Ayushman Bharat, immunization schedule
5. Mock tests weekly - Simulate 200 questions in 3.5 hours; target >70% accuracy