"Create a structured, exam‑oriented physiotherapy protocol for common adult neuro patients. Present the content in a clear Goal–Intervention table format. Include both classical and latest techniques (e.g., NDT, mirror therapy, bobath , hydrotherapy , bfr, roods , cme, motor relearning , robotic gait training, VR rehab, brain–computer interface). Where different approaches apply to different conditions, mention both explicitly (for example: fast icing for flaccid stage, slow icing for spasticity). The output should beenough that simply reading it will allow a student to understand, recall, and write the protocol in exams without needing extra references.
physiotherapy protocol neuro rehabilitation stroke TBI SCI Parkinson Guillain Barre NDT Bobath mirror therapy VR BCI robotic gait training 2024 2025
| Principle | Clinical Meaning |
|---|---|
| Neuroplasticity | The CNS can reorganize itself in response to activity. All interventions exploit this. |
| Task-specificity | Practice of the actual task drives the most relevant cortical map change. |
| Intensity & Repetition | High-dose, repetitive practice is superior to low-dose (Massed Practice). |
| Motor Learning | Acquisition, retention, transfer of skill. Blocked practice early; random practice late. |
| Timing | Earlier intervention = better outcomes (critical/sensitive periods). |
| Approach / Technique | Full Name & Core Concept |
|---|---|
| NDT / Bobath | Neurodevelopmental Treatment. Inhibit abnormal tone & reflexes; facilitate normal movement patterns. Handling techniques used by therapist. |
| Brunnstrom | Exploit synergy patterns (flexor/extensor) as a stepping stone to voluntary control across 6 recovery stages. |
| Rood's | Sensory stimulation (cutaneous, proprioceptive) to facilitate or inhibit muscle tone. Fast icing = facilitation; Slow stroking = inhibition. |
| PNF | Proprioceptive Neuromuscular Facilitation. Diagonal & spiral patterns; overflow; rhythmic stabilisation. |
| MRP | Motor Relearning Programme (Carr & Shepherd). Task-oriented; eliminate unnecessary muscle activity; practice in context. |
| Mirror Therapy | Visual illusion of the paretic limb moving; activates mirror neuron system. |
| CIMT | Constraint-Induced Movement Therapy. Constrains the unaffected limb to force use of the paretic limb. |
| CME | Cognitive Movement Therapy (Perfetti). Hypothesis-testing approach; patient uses sensory information to solve motor problems. |
| Hydrotherapy | Water-based exercise using buoyancy, resistance, hydrostatic pressure. |
| BFR | Blood Flow Restriction Training. Low-load exercise with partial occlusion to achieve strength gains. |
| Robotic Gait Training | Exoskeleton or end-effector devices (Lokomat, ReWalk) providing task-repetitive gait. |
| VR Rehab | Virtual Reality rehabilitation; immersive task practice with feedback. |
| BCI | Brain-Computer Interface. Neural signals directly drive external device or FES to close the motor loop. |
| NMES / FES | Neuromuscular/Functional Electrical Stimulation. Elicits contraction via surface electrodes. |
| TMS / tDCS | Non-invasive brain stimulation augmenting cortical excitability. |
| Stage | Features | Tone |
|---|---|---|
| Flaccid | No voluntary movement, deep reflexes absent/reduced | Hypotonic |
| Spastic | Abnormal synergies, hyperreflexia, clonus | Hypertonic |
| Recovery | Selective movement returns, synergies break down | Normalising |
| Goal | Technique / Intervention | Key Details |
|---|---|---|
| Prevent complications (early) | Positioning, PROM, chest physio | Anti-spastic positions; semi-recumbent; arm supported on pillow; affected LE in neutral |
| Facilitate tone - Flaccid stage | Rood's Fast Icing | Ice applied quickly over hypotonic muscle belly; also tapping, quick stretch, vibration to facilitate contraction |
| Inhibit tone - Spastic stage | Rood's Slow Icing / Slow Stroking | Slow ice over paraspinals or muscle belly; prolonged stretch; neutral warmth via wrapping |
| Inhibit spasticity & facilitate normal movement | NDT / Bobath | Therapist uses reflex inhibiting patterns (RIPs) and key points of control (trunk, shoulder girdle, pelvis); inhibit abnormal tone before facilitating movement |
| Use synergy patterns as stepping stone | Brunnstrom | Stage 1-2: facilitate flexion synergy; Stage 3: use synergy for function; Stage 4-6: break out of synergy progressively |
| Upper limb activation - severe paresis | Mirror Therapy | Paretic hand hidden behind mirror; patient watches reflection of normal hand moving; 15-30 min/day; best in flaccid/early spastic stage |
| Forced use of paretic limb | CIMT | Mitt/sling on unaffected hand for 90% waking hours; 6h/day massed practice; minimum 10-20° active wrist/finger extension required |
| Sensorimotor re-education | CME (Perfetti) | 1st level: passive discrimination; 2nd level: active discrimination with eyes closed; 3rd level: complex recognition; focuses on sensory-cognitive loop |
| Gait re-education - early | NDT gait training + Bobath | Weight shifting, trunk control, step initiation through key point facilitation at pelvis; use of parallel bars |
| Gait re-education - technology | Robotic Gait Training (Lokomat) | Body weight support (20-40% initially) + motorised exoskeleton; high-repetition gait cycles; progress by reducing BWS |
| Gait immersive practice | VR Rehabilitation | Exergames, avatar-based overground walking simulations; auditory/visual biofeedback; improves balance, step length |
| Cortical reorganisation | BCI | EEG/ECoG signals decode motor intent → drive FES or robotic orthosis; creates contingent afferent feedback; best for chronic severe paresis |
| Task-oriented practice | Motor Relearning Programme (MRP) | Carr & Shepherd: analyse task → practice components → practice whole task → transfer; eliminates compensation |
| Aquatic rehab | Hydrotherapy | Buoyancy reduces weight-bearing; warm water reduces spasticity (37-38°C); use for early standing, gait, UL movement |
| Shoulder subluxation | Bobath slings, NMES to supraspinatus/deltoid, positioning | Prevent inferior subluxation; NMES 20-40 Hz, 15 min sessions |
| Muscle strengthening (chronic) | PNF + BFR | BFR at 40-80% limb occlusion pressure; low-load resistance (20-30% 1RM); 4 sets (30-15-15-15 reps); prevents disuse atrophy |
| Balance training | Postural control exercises, Wii balance board, VR balance | Tandem stance, single-leg stance on stable then unstable surface; dual-task training |
| Cognitive-motor integration | TMS / tDCS adjunct | Inhibitory 1Hz rTMS over contralesional hemisphere (or excitatory over ipsilesional); paired with PT for upper limb |
| Goal | Technique / Intervention | Key Details |
|---|---|---|
| Coma stimulation (Level I-II) | Multisensory stimulation programme | Auditory (familiar voices), tactile (different textures), olfactory, visual; 15-20 min sessions, 4-6x/day |
| Reduce tone & prevent contractures | Bobath positioning, serial casting, splinting | Anti-spastic positioning; standing frame 30-60 min daily; dynamic orthoses at night |
| Improve arousal & attention (Level III-IV) | Structured sensory stimulation, graded activity | Short sessions (<20 min); minimal distractors; one-step commands |
| Motor control & coordination | NDT/Bobath + MRP | Normalise tone first; then task practice; emphasise trunk stability |
| Cognitive-motor dual task | CME + VR | VR environments for attention, memory, problem-solving with simultaneous motor task |
| Balance & gait | Robotic gait training + BWS treadmill | Lokomat for severe gait impairment; BWS treadmill for moderate; progress to overground walking |
| Post-traumatic ataxia | Frenkel's exercises, Cawthorne-Cooksey exercises | Gaze stabilisation; head movement exercises; coordination exercises from lying → sitting → standing |
| Hydrotherapy | Warm water pool therapy | Proprioceptive input; reduces fear of falling; vestibular stimulation in water; balance retraining |
| Spasticity management | Rood's slow icing, PNF rhythmic stabilisation | Slow stroking down paraspinals to reduce tone; prolonged stretch; combined with botulinum toxin if severe |
| Upper limb function | Mirror therapy + CIMT (when appropriate) | When cognitive level adequate (Level VI+); mirror therapy for hemiparesis component |
| Return to community | VR simulation, dual-task training | Crossing roads (VR), kitchen tasks, driving simulation; generalization of skills |
| Goal | Technique / Intervention | Key Details |
|---|---|---|
| Respiratory support (cervical SCI) | Chest physiotherapy, assisted cough, incentive spirometry | Glossopharyngeal breathing; manual-assisted cough (quad cough technique); IPPB |
| Prevent pressure injuries | Pressure relief techniques, positioning | Turn every 2h; wheelchair push-ups (weight reliefs) every 30 min |
| Manage spinal shock - flaccid phase | PROM, positioning, Rood's facilitation | Fast icing, tapping, brushing over key muscle groups; maintain joint ROM |
| Spasticity management - chronic UMN | Rood's slow icing, hydrotherapy, Bobath inhibition | Warm water (hydrotherapy) 37-38°C significantly reduces spasticity; prolonged stretch; tilt table standing |
| Muscle re-education - incomplete | PNF, NMES, BFR | PNF proprioceptive facilitation; NMES for quad/hamstring/triceps surae; BFR for residual voluntary muscle |
| Robotic gait training | Exoskeleton (ReWalk, Ekso, Lokomat) | AIS C-D patients; 20-40% BWS initially; progress stepping with robotic assistance; 45 min sessions 3-5x/week |
| BCI + FES | Closed-loop BCI-FES | Motor intent (EEG) → triggers FES to muscles; allows voluntary-like grasp in C5-C6 tetraplegics; most advanced technique |
| Transfers & mat activities | Mat programme (rolling, supine → sit → stand) | Rolling: head-hip relationship; long sitting: balance training; transfers: wheelchair ↔ bed ↔ car |
| Wheelchair propulsion training | Ergonomic technique, pressure relief | Propulsion arc 100-120°; smooth long strokes; avoid repetitive strain |
| Standing programme | Tilt table → standing frame → parallel bars | Prevents osteoporosis, DVT, contractures; 60-80° tilt; 30-60 min/day |
| Hydrotherapy | Aquatic therapy | Halliwick method for water confidence; buoyancy allows standing/gait impossible on land; resistance training |
| BFR training | Blood Flow Restriction | Preserves/builds muscle in partially innervated limbs; 20-30% 1RM with 40-80% LOP cuff; reduces atrophy |
| VR rehab | Immersive motor imagery + FES | Mental practice + VR visualization activates dormant motor pathways; enhances neuroplasticity in incomplete SCI |
| Autonomic dysreflexia | Education and positioning | Sit patient upright immediately; remove noxious stimulus; monitor BP; not an exercise intervention - a safety protocol |
| Goal | Technique / Intervention | Key Details |
|---|---|---|
| Reduce rigidity | Rood's slow rhythmic movements, warm hydrotherapy, PROM | Slow rhythmic rotation (log roll technique); passive range before active exercise; warm water 37-38°C |
| Improve gait (festination, freezing) | Cueing strategies | Auditory cues (metronome at 10% above comfortable cadence); visual cues (lines on floor, laser shoes); rhythmic auditory stimulation (RAS) |
| LSVT BIG | Lee Silverman Voice Treatment - BIG | High-amplitude, high-intensity movements; calibration tasks; 16 sessions over 4 weeks; improves gait, upper limb, balance |
| Postural correction | NDT/Bobath, Alexander Technique, mirror feedback | Trunk extension exercises; mirror work for postural awareness; prone lying for hip extension |
| Balance training | Tai Chi, VR balance training, sensory organization exercises | Tai Chi: evidence Grade A for falls reduction in PD; VR: Wii balance board, games with balance challenge |
| Robotic gait training | Lokomat, split-belt treadmill | Treadmill training at slightly faster speed forces longer steps; addresses hypokinesia; 20-30 min, 3x/week |
| Freezing of Gait (FOG) | Attentional strategies, stepping over obstacles, tango dancing | Count 1-2-1-2 to break freeze; step over imaginary line; tango specifically studied for FOG and balance |
| VR Rehabilitation | Exergaming, interactive balance tasks | Nintendo Wii, Kinect-based games; improves dual-task walking; high patient engagement |
| Dual-task training | Walking + cognitive tasks | Motorola talk while walking; carry a glass; counting backwards; reduces dual-task interference |
| Hydrotherapy | Aquatic exercise programme | Reduces rigidity; buoyancy supports balance training; gait in chest-deep water; 30-45 min 2-3x/week |
| BFR | Low-load resistance with BFR | Prevents sarcopenia; important in elderly PD patients who cannot tolerate heavy loads |
| Respiratory | Diaphragmatic breathing, chest expansion | Restrictive pattern due to rigidity; Incentive spirometry; singing therapy adjunct |
| Goal | Technique / Intervention | Key Details |
|---|---|---|
| Acute phase: prevent complications | Passive ROM, positioning, chest physio | PROM twice daily; anti-pressure sore positioning; ventilatory support if VC < 15-20 mL/kg |
| Chest physiotherapy | Postural drainage, percussion, assisted cough | Diaphragm may be involved; IPPB; nasopharyngeal suctioning if bulbar involvement |
| Facilitate muscle activity | Rood's fast icing, tapping, vibration | GENTLE facilitation only; fast icing over flaccid muscles; avoid fatigue |
| Hydrotherapy - recovery phase | Warm aquatic therapy | Water supports weak limbs; early mobility possible; warm water reduces pain; 36-37°C |
| Progressive strengthening | PNF, graded resistance | Start with gravity eliminated positions; PNF diagonals; progress slowly; rest: activity ratio 1:4 initially |
| Gait re-education | Parallel bars → walking aids → independent | Tilt table for orthostatic training first; graduated standing; ankle-foot orthoses if foot drop persists |
| Fatigue management | Energy conservation techniques | Pacing; rest breaks; prioritization of activities; activity diary |
| Pain management | TENS, hydrotherapy, positioning | Neuropathic pain common; TENS 80-100 Hz for pain relief; warm water; supportive positioning |
| Sensory re-education | Graded sensory stimulation, CME | Progress through textures; proprioceptive retraining on wobble board; CME second-level tasks |
| BFR (late recovery) | BFR training for residual weakness | Safely builds strength without excessive neuromuscular demand; when patient has voluntary control |
| Psychosocial | Goal-setting, pacing education | Anxiety common; set achievable weekly goals; normalise slow recovery trajectory |
| Goal | Technique / Intervention | Key Details |
|---|---|---|
| Fatigue management | Energy conservation, pacing, cooling vest | Exercise in cooled environments; cooling vest reduces Uhthoff's; activity pacing (50-60% energy reserve rule) |
| Spasticity | Rood's inhibitory techniques, hydrotherapy, stretching | COOL water (28-30°C) preferred (not warm - worsens Uhthoff's); slow sustained stretching; standing frame |
| Balance & coordination | Frenkel's exercises, VR balance training | Frenkel's: lying → sitting → standing sequence for ataxia; VR: Kinect-based balance games |
| Gait | Robotic gait training, FES for foot drop | FES (NESS L300) for foot drop; Lokomat for significant gait impairment; treadmill training |
| Strength | Aquatic resistance, BFR | BFR ideal in MS: high strength gains with low thermal load; aquatic resistance if no Uhthoff's issue |
| Cognitive-motor | Dual-task training, VR cognitive-motor tasks | Cognitive fatigue and motor fatigue co-occur; dual-task paradigms improve both |
| Upper limb | Mirror therapy, task-specific practice | For unilateral upper limb paresis/cerebellar dysfunction |
| Relapse phase | Rest + gentle positioning + PROM | No active exercise during acute relapse; maintain ROM only |
| Goal | Technique / Intervention | Key Details |
|---|---|---|
| Spasticity management | NDT/Bobath, Rood slow inhibitory, hydrotherapy | Reflex inhibiting postures; slow sustained stretch; warm water (37-38°C); serial casting |
| Selective motor control | CME + task-specific training | CME first-level (passive discrimination) progressing to active tasks; sensorimotor integration |
| Strength & function | PNF, BFR, task-specific strength training | Evidence shows strength training does NOT worsen spasticity in CP; BFR for low-load gains |
| Gait | Robotic gait training + orthotic management | Lokomat for high-repetition gait; AFOs for foot clearance; improve symmetry |
| Upper limb (hemiplegia) | CIMT, mirror therapy, VR | CIMT effective in adult hemiplegic CP; VR provides high-repetition UL tasks |
| Balance | Core stability, postural control programme, VR | Swiss ball exercises; perturbation training; VR exergaming for balance |
| Stimulus Type | Effect | Temperature Specifics |
|---|---|---|
| Fast icing (quick application, 3-5 sec) | Facilitates muscle contraction (flaccid stage) | Ice cube applied rapidly; used in GBS, flaccid hemiplegia |
| Slow icing / prolonged cold | Inhibits muscle tone (spastic stage) | 3-5 min application; reduces gamma motor neuron activity |
| Slow stroking (down paraspinals) | Inhibits general tone | Parasympathetic effect; 3-5 min |
| Fast brushing (Ayres brushing) | Facilitates tone and muscle activity | Electrical brush; wait 30-45 min to observe effect |
| Vibration (high frequency 100-300Hz) | Facilitates muscle via tonic vibration reflex | Applied over muscle belly or tendon |
| Neutral warmth (wrapping) | Inhibits tone | Maintained temperature neutral zone; reduces spasticity |
| Heavy joint compression | Facilitates postural muscles | Weight-bearing, approximation techniques |
| Traction | Facilitates flexor muscles | Gentle joint distraction |
| Component | Description |
|---|---|
| Key Points of Control | Proximal: shoulder girdle, pelvis, trunk. Distal: hand, foot. Therapist handles at KPCs to influence tone throughout body. |
| Reflex Inhibiting Patterns (RIPs) | Postures opposite to synergy patterns that inhibit spasticity (e.g., shoulder protraction/external rotation counters upper limb flexor synergy) |
| Weight-bearing | Used to normalise tone and provide proprioceptive input |
| Preparation | Always reduce tone before facilitating movement |
| Carryover | 24-hour management; family training |
| Current evidence | NDT not superior to other task-oriented approaches in RCTs, but widely used for handling and positioning |
| Aspect | Detail |
|---|---|
| Mechanism | Activates mirror neuron system; visual feedback of "moving" paretic limb stimulates motor cortex |
| Setup | Mirror sagittal plane; paretic hand behind mirror; patient views reflection of unaffected hand |
| Duration | 15-30 min/session, daily, minimum 4 weeks |
| Best for | Stroke (flaccid-spastic transition), CRPS, phantom limb pain, GBS recovery |
| Contraindicated | Severe cognitive impairment, neglect, severe visual field defect |
| Evidence | Cochrane review: improves UL motor function and pain; moderate quality evidence |
| Level | Task Description |
|---|---|
| 1st degree | Therapist moves patient passively; patient recognizes shape/texture with eyes closed |
| 2nd degree | Patient actively guides movement; discriminates sensory information |
| 3rd degree | Complex, multi-joint movements in different environmental contexts |
| Core principle | Movement is a cognitive act; sensory hypothesis testing drives motor recovery |
| Step | Action |
|---|---|
| 1. Task Analysis | Observe what patient can/cannot do; compare with normal |
| 2. Practice of missing components | Isolate and practice deficient components |
| 3. Practice of whole task | Integrate components into full task |
| 4. Transfer of training | Practice in varied environments; use real objects |
| Key tasks | Upper limb reach/manipulation, sit-to-stand, balance, walking |
| Core principle | Eliminate unnecessary muscle activity (compensation); optimise economy of movement |
| Parameter | Value |
|---|---|
| Cuff pressure | 40-80% of Limb Occlusion Pressure (LOP) |
| Load | 20-30% of 1-Rep Maximum |
| Sets x Reps | 4 sets: 30-15-15-15 reps (with 30-60 sec inter-set rest) |
| Mechanism | Metabolite accumulation + hypoxia → growth hormone surge + satellite cell activation |
| Neurological use | Stroke (chronic), SCI (residual innervation), MS, PD, GBS recovery |
| Contraindications | DVT, severe hypertension, open wounds, severe peripheral vascular disease |
| Evidence | Builds muscle strength comparable to high-load training at much lower loads |
| Device Type | Example Devices | Mechanism |
|---|---|---|
| Exoskeleton | Lokomat, ReWalk, Ekso Bionics | Full limb guidance; motorised joints; combined with body weight support (BWS) treadmill |
| End-effector | Gait Trainer GT1, G-EO | Footplates simulate gait cycle; less joint control; better functional arm outcomes |
| Parameters | BWS: 20-40% initially → reduce to 0%; 20-40 min/session; 3-5x/week | |
| Neurological plasticity | Repetitive, high-dose gait cycles drive subcortical and cortical map reorganization | |
| Conditions | Stroke, SCI (AIS C-D), TBI, MS, CP | |
| Key finding | Combines with VR feedback gives superior outcomes vs. robotic training alone |
| System Type | Example | Use |
|---|---|---|
| Immersive VR | HTC Vive, Oculus Quest | Full sensory immersion; best for UL reaching, gait, balance |
| Non-immersive | Nintendo Wii, Kinect | Accessible; balance, coordination, dual-task |
| Robot + VR | Armeo Spring with VR screen | Upper limb gravity-supported practice with gamified tasks |
| Mechanism | Neuroplasticity via enriched sensory environment; high motivation and engagement; biofeedback | |
| Evidence | Moderate-quality evidence for UL function and balance in stroke; emerging in TBI, SCI, PD | |
| Conditions | Stroke, TBI, SCI, PD, MS, CP, GBS |
| Type | Mechanism | Clinical Application |
|---|---|---|
| Non-invasive EEG-based | Motor imagery EEG signals decoded → control robotic hand or FES | Chronic stroke with severe paresis; SCI |
| Invasive (ECoG/LFP) | Electrodes on/in cortex; higher resolution signals | Research stage; locked-in syndrome |
| Closed-loop BCI-FES | Motor intent → FES stimulates muscles → sensory feedback to brain | C5-C6 SCI hand function; chronic stroke UL |
| Mechanism | Contingent afferent feedback during active motor attempt → Hebbian plasticity | |
| Current status | Evidence emerging; primarily in research/specialist centres; showing significant promise for chronic, severe cases |
| Parameter | Stroke / CP / SCI | GBS | PD | MS |
|---|---|---|---|---|
| Water temp | 37-38°C (warm to reduce spasticity) | 36-37°C (warm, comfortable) | 36-38°C | 28-30°C (COOL - Uhthoff's!) |
| Level | Chest/neck deep: maximum offloading | Start shallow; progress | Waist-deep standing | Chest-deep |
| Techniques | Halliwick, Bad Ragaz Ring Method | Gentle float, walking | Walking, turning, balance | Resistance, balance |
| Buoyancy benefit | Allows movement impossible on land | Supports weak limbs | Reduces fall fear | Offloads joints |
| Situation | Rood's Technique | Rationale |
|---|---|---|
| Flaccid hemiplegia (stroke, TBI) | Fast icing, tapping, quick stretch, vibration, fast brushing | Facilitates motor neuron pool → elicits muscle contraction |
| Spasticity (stroke - spastic stage, SCI-UMN) | Slow icing, slow stroking, neutral warmth, prolonged stretch | Inhibits gamma motor neurons → reduces tonic stretch reflex |
| GBS (flaccid, ascending) | Fast icing + gentle facilitation | Stimulates denervated/underactive muscles; avoid overload |
| CP (spastic) | Slow stroking, neutral warmth, inhibitory positioning | Persistent UMN overactivity requires consistent inhibition |
| PD (rigidity) | Slow rhythmic movement, warmth | Relaxes rigidity; not true spasticity so different mechanism |
| Stage | Stroke | SCI | GBS |
|---|---|---|---|
| Acute (0-7 days) | Positioning, PROM, Bobath handling, chest PT | Respiratory PT, PROM, tilt table | Rest, PROM, respiratory, monitoring |
| Subacute (1-4 weeks) | Sitting balance, standing, MRP task practice, mirror therapy | Mat activities, transfers, standing, FES | Gentle facilitation, hydrotherapy |
| Early rehab (1-3 months) | Gait training, CIMT, robotic gait, VR | Robotic gait (incomplete), wheelchair, ADL | Progressive strengthening, PNF, gait |
| Late rehab / Chronic (3+ months) | BFR, advanced VR, BCI, community reintegration | BFR, BCI-FES, advanced exoskeleton, community | BFR (if residual), return to work programme |
| Technique | Highest Evidence for | Evidence Grade |
|---|---|---|
| CIMT | Chronic stroke UL | Grade A (multiple RCTs, Cochrane) |
| Mirror Therapy | Stroke UL + pain | Grade A (Cochrane review) |
| Treadmill + BWS | Stroke gait | Grade A |
| Robotic gait (Lokomat) | Stroke, SCI | Grade A-B (many RCTs) |
| LSVT BIG | Parkinson's gait & UL | Grade A |
| Tai Chi | PD balance & falls | Grade A |
| VR Rehabilitation | Stroke UL & balance | Grade B (moderate evidence) |
| BCI | Chronic stroke, SCI | Grade B-C (emerging) |
| BFR | Neurological weakness | Grade B |
| Hydrotherapy | Spasticity, gait, MS | Grade B |
| Rood's approach | Tone management | Grade C (clinical consensus) |
| NDT/Bobath | Tone, positioning, handling | Grade B (for handling; not superior to task practice) |
| CME (Perfetti) | Sensorimotor stroke | Grade B |
| Brunnstrom | Stage-guided practice | Grade C (historical; still used in synergy exploitation) |
single protocol table