I now have all the necessary material from Park's PSM and Murray & Nadel's Respiratory Medicine. Let me write the complete case.
CASE HISTORY PRESENTATION
Tuberculosis (Pulmonary) in an Adult Male - PSM Format
1. BIODATA
| Field | Details |
|---|
| Name | Shubham |
| Age | 34 years |
| Sex | Male |
| Religion / Caste | Hindu / OBC |
| Occupation | Construction labourer (daily wage) |
| Address | Chawl No. 4, Dharavi, Mumbai, Maharashtra |
| Marital Status | Married |
| Education | Class 10 pass |
| Name of Informant | Self (patient) + wife (Sunita) |
| Informant's Reliability | Good |
| Date of History Taking | 26 July 2026 |
| OPD / IP Number | 2026/PSM/TB/047 |
| Referred by | ASHA worker |
2. CHIEF COMPLAINTS
- Cough - 6 weeks
- Expectoration (mucoid, later blood-stained) - 4 weeks
- Fever (low-grade, evening rise) - 5 weeks
- Night sweats - 3 weeks
- Weight loss - 2 months
- Breathlessness on moderate exertion - 2 weeks
3. HISTORY OF PRESENT ILLNESS
Shubham, a 34-year-old male construction labourer and chronic smoker, was apparently well 2 months ago when he developed gradual and progressive weight loss of approximately 5 kg over 2 months (noted by the patient and his wife from loosening of clothes).
6 weeks ago, he developed a persistent dry cough, initially mild, gradually becoming more frequent. The cough was worse in the morning and did not respond to cough syrups purchased from the local chemist.
5 weeks ago, he developed low-grade fever (subjective, not measured at home), characteristically occurring in the evenings, associated with profuse night sweats soaking his clothing.
4 weeks ago, the cough became productive with mucopurulent expectoration, then progressively blood-stained (haemoptysis - small amounts, streaks of blood mixed with sputum). No frank haemoptysis. No foul smell to sputum.
2 weeks ago, he noticed shortness of breath on climbing one flight of stairs, which was not present before. No orthopnea, no paroxysmal nocturnal dyspnea.
- No history of chest pain / pleuritic pain (rules out empyema / pleuritis for now)
- No history of altered sensorium / headache / neck stiffness (rules out TB meningitis)
- No history of abdominal pain / diarrhea (rules out intestinal TB)
- No history of joint pain / swelling (rules out skeletal TB)
- No dysuria / hematuria (rules out genitourinary TB)
- No treatment taken for current illness (no prior antibiotics, no ATT)
- Shubham attributed symptoms to "seasonal cough" and work-related dust exposure and delayed seeking care
4. TOBACCO / SUBSTANCE USE HISTORY
(PSM-specific - directly linked to TB risk; smoking OR = 4.5 for TB - Murray & Nadel's)
- Smoking type: Cigarettes + Bidi
- Duration: 14 years (since age 20)
- Quantity: 15 cigarettes/day (bidi equivalent)
- Pack years: 15 cigarettes × 14 years ÷ 20 = 10.5 pack-years
- AUDIT / Tobacco score: Fagerstrom score = 6/10 (moderate nicotine dependence)
- Alcohol: Consumes country liquor 2-3 times/week (moderate risk for TB and hepatotoxicity from ATT)
- No use of IV drugs
PSM Significance: Cigarette smoking increases TB risk with OR 4.5 (95% CI: 4.0-5.0). A large Indian case-control study showed tuberculosis prevalence RR of 2.9 in male smokers aged 35-69 years. Smoking impairs mucociliary clearance and alveolar macrophage function, increasing susceptibility to M. tuberculosis. (Murray & Nadel's Textbook of Respiratory Medicine)
5. PAST HISTORY
- No previous episode of TB (New case - no prior ATT)
- History of recurrent cough and colds every winter (last 3 years - likely COPD onset from smoking)
- No history of diabetes mellitus (must be screened before ATT)
- No history of liver disease or jaundice (risk of drug-induced hepatitis with ATT)
- No history of epilepsy or psychiatric illness
- No history of HIV (must be tested before ATT)
- No significant hospitalizations or surgeries
- No known drug allergies
- BCG vaccination: Scar present on left deltoid (received at birth)
6. FAMILY HISTORY
| Member | Age | Health Status |
|---|
| Wife (Sunita) | 30 years | Asymptomatic; contact tracing required |
| Son | 8 years | Asymptomatic; must be evaluated for TB |
| Daughter | 5 years | Asymptomatic; must be evaluated for TB |
| Father | 60 years | Died 5 years ago - "lung disease" (possibly undiagnosed TB - source case) |
| Mother | 55 years | Asymptomatic; contact screening needed |
| Younger brother | 28 years | Shares the same room; contact - must be screened |
- Family contact tracing: All close contacts (household members) must undergo TB screening as per NTEP guidelines
- Father's death from "lung disease" raises suspicion of TB being a household source
7. SOCIOECONOMIC HISTORY
Modified Kuppuswamy Scale (Urban, 2026):
| Parameter | Details |
|---|
| Education (Shubham) | Matriculate (Class 10) = 4 points |
| Occupation | Unskilled worker (labourer) = 2 points |
| Monthly family income | ₹8,000/month |
| Income score | ₹5,001 - ₹10,000 = 3 points |
| Total Score | 9 points |
| Socioeconomic Class | Class IV (Lower-middle) |
| Parameter | Details |
|---|
| Family type | Nuclear family |
| Total family members | 4 (wife + 2 children) + 1 brother in same room = 5 persons |
| Housing type | Chawl (semi-pucca) - shared tenement building |
| Room size | 10×12 ft single room (sleeping + cooking combined) |
| Persons per room | 5 persons in 1 room = Severely overcrowded |
| Ventilation | Very poor - single small window facing a narrow alley; no cross-ventilation |
| Sunlight access | Minimal - surrounded by adjacent chawl buildings |
8. ENVIRONMENTAL HISTORY
| Parameter | Details |
|---|
| Water supply | Municipal tap (shared tap on floor); intermittent supply 2 hours/day |
| Sanitation | Shared community toilet (1 toilet for 20 families) - inadequate |
| Cooking fuel | LPG (Pradhan Mantri Ujjwala Yojana beneficiary) - relatively safer |
| Occupational exposure | Construction site - silica dust, cement dust exposure (no mask used) - risk factor for silico-tuberculosis |
| Indoor environment | Heavy indoor cigarette/bidi smoke; no ventilation |
| Crowding | Lives in a densely populated urban slum (Dharavi); average population density >250,000/km² |
| Vectors | Rats and cockroaches in common areas |
| Nearest health facility | Urban Health Centre - 500 m away; DOTS centre at same facility |
PSM Assessment: The combination of overcrowding + poor ventilation + lack of sunlight + heavy tobacco smoke + silica dust exposure + alcoholism = extremely high-risk environment for TB acquisition, progression, and transmission. One infectious TB case in this setting can infect 10-15 persons per year (Park's PSM).
9. OCCUPATIONAL HISTORY
(PSM-specific - occupational TB risk)
- Occupation: Construction labourer for 10 years
- Nature of work: Mixing cement, chipping tiles, cutting bricks - daily dust exposure
- Protective equipment: None (no mask, no PPE)
- Silica dust exposure: Significant - raises risk of silico-tuberculosis (TB co-existing with silicosis)
- Working hours: 10-12 hours/day in outdoor and indoor construction sites
- Sick leave policy: No (daily wage - loss of income if absent; contributed to delay in seeking care)
10. NUTRITIONAL HISTORY
- 2 meals per day (rice/chapati + dal primarily; occasional vegetables)
- Protein intake: Inadequate (financial constraints; meat rarely)
- Weight loss of ~5 kg over 2 months
- BMI at presentation: 17.8 kg/m² (underweight - BMI <18.5)
- No Vitamin A or other deficiency signs noted clinically
- Malnutrition is both a cause and consequence of TB: malnutrition impairs cell-mediated immunity; TB causes further catabolism
11. GENERAL EXAMINATION
- General appearance: Thin, wasted, ill-looking male; cachexic facies; cooperative
- Built: Lean, ectomorphic
| Vital Sign | Finding | Normal |
|---|
| Temperature | 38.2°C (100.8°F) - low-grade fever | 36.5-37.5°C |
| Pulse rate | 96/min, regular, good volume | 60-100/min |
| Respiratory rate | 22/min | 12-20/min |
| Blood pressure | 110/70 mmHg | Normal |
| SpO2 | 95% on room air | >95% |
| Weight | 52 kg | Expected ~70 kg (BMI 17.8) |
| Height | 171 cm | |
PICCLE:
- Pallor: Present - moderate (conjunctival + palmar) - likely anaemia of chronic disease / nutritional
- Icterus: Absent (important baseline before starting hepatotoxic ATT)
- Clubbing: Absent
- Cyanosis: Absent
- Lymphadenopathy: Right cervical lymph nodes enlarged - 2 nodes, each ~1.5 cm, firm, non-tender, discrete (consistent with TB lymphadenitis - rule out primary TB lymphadenopathy)
- Edema: Absent
Skin: No rashes; no erythema nodosum; tar staining of fingers (right index and middle fingers - confirms heavy smoking)
12. SYSTEMIC EXAMINATION
Respiratory System
- Inspection: Chest wall - normal shape; no visible deformities; trachea appears central; respiratory rate 22/min; no use of accessory muscles at rest
- Palpation: Trachea - central; reduced expansion on right upper zone; vocal fremitus increased in right upper zone (consolidation/fibrosis)
- Percussion: Dull note in right upper zone (2nd and 3rd intercostal spaces anteriorly and interscapular region posteriorly)
- Auscultation:
- Bronchial breath sounds in right upper zone
- Post-tussive crepitations (fine, inspiratory) - right upper zone
- Amphoric breathing (suggests cavity formation) - right apical region
- No pleural rub
Cardiovascular System
- S1, S2 normal; no murmurs; no pericardial rub
Abdomen
- Soft, non-tender; liver and spleen not palpable
- No free fluid
Central Nervous System
- Conscious, oriented to time, place, and person
- No neck stiffness, no Kernig's sign, no Brudzinski's sign
- Normal speech; no focal neurological deficit
ENT
- No laryngeal TB signs (no hoarseness - but examine carefully; laryngeal TB presents with hoarseness and dysphagia)
- No oral ulcers
13. ANTHROPOMETRIC ASSESSMENT
| Parameter | Actual | Expected | Inference |
|---|
| Weight | 52 kg | 70 kg (for height 171 cm) | Severely underweight |
| Height | 171 cm | - | Normal |
| BMI | 17.8 kg/m² | 18.5-24.9 | Underweight (Grade I thinness) |
| Mid-upper arm circumference | 22 cm | >23.5 cm | Low |
- Weight loss: ~8.8% body weight over 2 months (>5% in 1 month = clinically significant)
- Weight-based ATT dosing: Shubham falls in the 46-54 kg weight band under NTEP
14. RELEVANT PUBLIC HEALTH / PSM ASPECTS
Epidemiological Triad
| Component | Details in This Case |
|---|
| Agent | Mycobacterium tuberculosis (human strain); presumed drug-sensitive (new case, no prior ATT) |
| Host | 34-year-old male; chronic smoker (10.5 pack-years); alcoholic; malnourished; BMI 17.8; possible silica exposure; no diabetes (to be confirmed); HIV status unknown |
| Environment | Urban slum; severe overcrowding (5/room); poor ventilation; no sunlight; occupational silica dust; high TB burden area (Dharavi, Mumbai) |
NTEP (National TB Elimination Programme) Classification
(Based on Park's PSM - Revised 2013 WHO Definitions)
| Parameter | Classification |
|---|
| Anatomical site | Pulmonary TB (PTB) |
| Bacteriological status | Presumptive TB (pending confirmation); likely bacteriologically confirmed PTB |
| Treatment history | New case (no prior ATT for ≥1 month) |
| Drug resistance | Unknown (baseline DST/CBNAAT pending) |
| HIV status | Unknown (mandatory HIV testing required) |
Risk Factors (PSM Perspective)
| Risk Factor | Evidence | OR/RR |
|---|
| Chronic smoking | 10.5 pack-years | OR 4.5 for TB (Murray & Nadel's) |
| Overcrowding | 5 persons in 1 room | Major transmission risk |
| Malnutrition | BMI 17.8, significant weight loss | Impairs CMI |
| Alcohol | Moderate-heavy use | Impairs immunity, reduces compliance |
| Silica dust exposure | 10 years construction work | Risk of silico-TB |
| Low socioeconomic status | Class IV | Poor access to care, delayed diagnosis |
| Occupational delay | Daily wage labourer | Delayed health-seeking |
| Close household contacts | 4 family members + brother sharing room | Risk of secondary cases |
15. INVESTIGATIONS
Mandatory (NTEP Diagnostic Algorithm for Presumptive TB)
| Investigation | Purpose / Expected Finding |
|---|
| Sputum smear microscopy x 2 (Ziehl-Neelsen / LED FM) | Detect AFB; Result: 2+ AFB positive (both samples) |
| CBNAAT (Xpert MTB/RIF) on sputum | Rapid molecular confirmation of MTB + RIF resistance detection; Result: MTB detected, RIF resistance NOT detected |
| Chest X-ray (PA view) | Fibrocalcific opacities / cavitation in right upper lobe + right hilar lymphadenopathy |
| Culture on LJ medium | Definitive confirmation; DST; results in 4-8 weeks |
| HIV test (ELISA) | Mandatory in ALL TB cases under NTEP |
| Blood sugar (FBS + PPBS) | Screen for diabetes (major comorbidity with TB) |
| LFT (ALT, AST, bilirubin) | Baseline before hepatotoxic ATT |
| CBC | Anaemia assessment; leucocyte count |
| Blood urea + serum creatinine | Renal function baseline |
| Mantoux test (TST) | 5 TU PPD; Induration ≥10 mm = positive (at 48-72 hrs); not confirmatory but supportive |
| IGRA (QuantiFERON-TB Gold) | If Mantoux equivocal; not affected by BCG |
Chest X-ray Findings (Expected in this Case)
- Right upper lobe fibrocalcific infiltrates with cavitation (amphoric breathing on examination)
- Right hilar lymphadenopathy
- Trachea may show mild deviation towards the affected side (fibrosis)
- No significant pleural effusion (no pleuritic pain)
(See NTEP diagnostic algorithm flowchart - Park's PSM, Fig. 2, p. 221)
16. PROVISIONAL / FINAL DIAGNOSIS
Primary Diagnosis:
Pulmonary Tuberculosis (PTB) - New Case, Sputum AFB Positive (2+)
- Right upper lobe; bacteriologically confirmed
- NTEP Classification: New PTB; RIF-sensitive (CBNAAT)
Co-morbidities / Risk Factors to be Addressed:
- Chronic tobacco use (Nicotine dependence - Fagerstrom 6/10)
- Alcohol use (moderate-heavy)
- Malnutrition (BMI 17.8 - underweight)
- Anaemia of chronic disease (pallor present; CBC pending)
- Silica dust exposure (silico-tuberculosis to be excluded by occupational history + HRCT if needed)
- Diabetes mellitus (screening pending)
- HIV (status pending; mandatory testing ordered)
17. MANAGEMENT PLAN
A. Notification and Registration (NTEP/PSM Priority)
- Mandatory notification under NTEP (TB is a notifiable disease under the Epidemic Diseases Act)
- Register in Nikshay portal (national TB surveillance system) immediately
- Assign a Nikshay ID
- Link to nearest DOTS (Directly Observed Treatment Short-course) centre
B. ATT Regimen (NTEP - New PTB Case)
(Park's PSM: New and previously treated H & R sensitive cases: 2HRZE → 4HRE)
| Phase | Duration | Drugs | Method |
|---|
| Intensive Phase (IP) | 2 months (56 daily doses) | HINH + Rifampicin + Pyrazinamide + Etambutol (4-FDC) | Daily, under DOT |
| Continuation Phase (CP) | 4 months (112 daily doses) | HINH + Rifampicin + Etambutol (3-FDC) | Daily, under DOT |
| Total | 6 months | 2HRZE / 4HRE | |
Dosing (46-54 kg weight band - NTEP):
- IP: 4-FDC = H 300mg + R 600mg + Z 1500mg + E 1100mg daily
- CP: 3-FDC = H 300mg + R 600mg + E 1100mg daily
- Pyridoxine (Vitamin B6) 10-20 mg daily throughout (prevents INH-induced peripheral neuropathy - especially important as Shubham is malnourished + alcoholic)
DOT (Directly Observed Treatment):
- Treatment to be observed by a DOTS provider (ASHA worker / health worker at DOTS centre)
- Daily DOT under NTEP (not thrice weekly as in old RNTCP)
- Family member (wife Sunita) can be trained as community DOT provider
C. Nikshay Poshan Yojana (PSM - Nutritional Support)
- Shubham is eligible for ₹500/month direct benefit transfer under Nikshay Poshan Yojana for the entire duration of treatment
- Encourage high-protein, high-calorie diet
- Nutritional counselling provided
D. Management of Comorbidities
- Tobacco cessation:
- Brief counseling (5 A's: Ask, Advise, Assess, Assist, Arrange)
- Nicotine replacement therapy (NRT) - nicotine patch / gum - to be initiated
- Smoking worsens prognosis, delays sputum conversion, and increases relapse risk
- Alcohol cessation: Counselling; motivational interviewing; referral to de-addiction centre
- Alcohol + ATT = significantly increased hepatotoxicity risk
- Nutritional rehabilitation: High-protein diet; caloric supplementation; link to ICDS/PDS for food support
- Anaemia treatment: Iron-folic acid supplementation if confirmed on CBC
E. Preventive Measures (PSM Focus)
Infection Control:
- Advise patient to cover mouth while coughing/sneezing (respiratory etiquette)
- Avoid public transport for first 2 weeks of treatment (patient remains infective until AFB negative)
- Effective ATT reduces infectivity by 90% within 48 hours (Park's PSM)
- Improve ventilation at home - open window, use of exhaust fan
- Avoid overcrowded places until sputum converts to negative
Contact Tracing:
- All 5 household contacts to be screened for TB symptoms and Mantoux test
- Children in household (<5 years if any) to receive INH prophylaxis (isoniazid preventive therapy, IPT) if Mantoux positive but no active disease
- Wife Sunita: Symptom screening + CXR + sputum if symptomatic
BCG:
- Not applicable (adult; BCG scar present)
- Children <5 years in household without BCG: vaccinate
F. Pre-Treatment Counselling (NTEP Mandatory)
As per Park's PSM pre-treatment counselling protocol:
- Nature of disease, mode of spread (airborne via droplet nuclei)
- Treatment duration (6 months), importance of completing full course
- Drug side-effects: red/orange urine (RIF - normal, not alarming), jaundice (stop ATT, report), peripheral tingling (INH - prevented by pyridoxine), visual disturbance (ETB - monthly visual acuity check)
- Consequences of irregular treatment: relapse, drug resistance, MDR-TB
- Screening for co-morbidities (HIV, diabetes, liver, renal)
- Tobacco and alcohol cessation counselling
18. FOLLOW-UP AND MONITORING
| Time | Action |
|---|
| End of IP (2 months) | Sputum smear x 2; if positive → extend IP by 1 month + DST |
| End of month 5 | Sputum smear x 2 |
| End of CP (6 months) | Sputum smear x 2; if both negative = Treatment Success (Cured) |
| Monthly | Weight, symptom review, drug compliance check, side-effect monitoring |
| Monthly | LFT monitoring (risk: alcohol + ATT hepatotoxicity) |
| Monthly | Visual acuity (Ethambutol - optic neuropathy risk) |
| Every visit | DOT supervision, Nikshay portal entry |
Treatment Outcome Definitions (NTEP/WHO):
- Cured: Bacteriologically confirmed PTB; sputum negative at end of treatment with at least one previous negative
- Treatment completed: All doses taken; no bacteriological result at end
- Treatment failure: Sputum positive at month 5 or later
- Lost to follow-up (LTFU): Interrupted treatment for ≥2 consecutive months
19. PROGNOSIS
| Aspect | Assessment |
|---|
| Short-term (treatment response) | Good - new case, RIF-sensitive; expected sputum conversion by end of IP |
| Long-term (if compliant) | Good - cure rate for new drug-sensitive PTB under NTEP >85% |
| Risk of relapse | Moderate-high - due to ongoing smoking, alcohol, malnutrition, poor housing |
| Risk of secondary cases | High - 5 household contacts at risk; early contact tracing and treatment essential |
| Risk of MDR-TB | Low currently - new case; increases dramatically with irregular treatment |
| Social prognosis | Guarded - daily wage worker; income loss during treatment; Nikshay Poshan Yojana to help |
20. SUMMARY (One-Liner for Presentation)
Shubham, a 34-year-old chronic smoker (10.5 pack-years) and daily-wage construction labourer from a severely overcrowded urban slum (Class IV socioeconomic status), presents with 6 weeks of persistent cough with haemoptysis, 5 weeks of evening low-grade fever with night sweats, and 2 months of weight loss (BMI 17.8); examination reveals right upper lobe dullness, bronchial breath sounds, post-tussive crepitations, and amphoric breathing with right cervical lymphadenopathy; sputum AFB 2+ positive on ZN smear, CBNAAT confirms MTB with no RIF resistance; classified as New Pulmonary Tuberculosis (Sputum Positive) under NTEP with major risk factors of chronic tobacco use (OR 4.5 for TB), overcrowding, malnutrition, and alcohol use; to be treated with 2HRZE/4HRE under daily DOT with mandatory HIV testing, contact tracing of 5 household members, tobacco cessation, and Nikshay Poshan Yojana support.
References: Park's Textbook of Preventive and Social Medicine - Chapter on Tuberculosis, NTEP guidelines, pp. 212-226; Murray & Nadel's Textbook of Respiratory Medicine - Chapter 65, Cigarette Smoking and Risk of Infection (OR 4.5 for TB); WHO Revised Case Definitions 2013.