Yes, DNS (dextrose-normal saline) 500 mL can be given after NS 500 mL if it is specifically prescribed and appropriate for the patient.
They serve different purposes:
- NS 0.9%: usually for volume depletion/resuscitation or sodium replacement.
- DNS: provides sodium plus glucose, often for maintenance or to help prevent starvation ketosis. It is not usually the first-choice fluid for rapid resuscitation.
Before starting DNS, check the reason for fluids and reassess blood pressure, pulse, urine output, lung signs, blood glucose, sodium, kidney/heart function, and total fluid received. Patients with diabetes, hyperglycemia, heart failure, renal failure, or risk of fluid overload need particular caution.
If the patient has symptomatic hypoglycemia, glucose treatment should be given promptly rather than waiting until the NS finishes.
Do not mix fluids in the same bag or change the sequence/rate without the prescriber’s order. IV fluid therapy should be prescribed according to whether the goal is resuscitation, replacement, or maintenance, with ongoing monitoring, as outlined in
NICE IV-fluid guidance.