Here is a thorough, evidence-based guide to lowering both triglycerides and cholesterol:
Lifestyle Changes (First-Line for Everyone)
Diet
- Cut saturated and trans fats - Found in red meat, butter, full-fat dairy, fried foods, and packaged snacks. These are the biggest dietary drivers of high LDL cholesterol.
- Reduce refined carbs and sugar - White bread, sugary drinks, pastries, and white rice spike triglycerides significantly. This is the most important dietary change specifically for triglycerides.
- Eat more soluble fiber - Oats, beans, lentils, apples, and barley bind cholesterol in the gut and reduce LDL absorption.
- Eat more unsaturated fats - Olive oil, avocados, walnuts, almonds, and fatty fish (salmon, mackerel, sardines) lower LDL and triglycerides while raising HDL.
- Omega-3 fatty acids - Fatty fish (2+ servings/week) or fish oil supplements can significantly reduce triglycerides.
- Limit alcohol - Alcohol is directly converted into triglycerides by the liver. Even moderate amounts can raise levels noticeably.
Exercise
Regular aerobic exercise is one of the most effective ways to lower triglycerides and raise HDL ("good") cholesterol. Aim for at least 150 minutes of moderate-intensity activity per week (brisk walking, cycling, swimming). Exercise also improves how your body handles glucose, which reduces triglyceride production.
Weight Loss
Even losing 5-10% of body weight can produce meaningful reductions in triglycerides, LDL, and total cholesterol, and raise HDL.
Quit Smoking
Smoking lowers HDL cholesterol. Stopping smoking improves HDL levels within weeks.
Medications (When Lifestyle Is Not Enough)
According to Harrison's Principles of Internal Medicine and Lippincott Illustrated Reviews: Pharmacology, drug therapy is often required in addition to lifestyle changes for people at high cardiovascular risk:
| Drug Class | Primary Effect | Examples |
|---|
| Statins | Lower LDL 25-50%, lower TG 5-30%, raise HDL 5-9% | Atorvastatin, Rosuvastatin, Simvastatin |
| Fibrates | Lower triglycerides primarily | Fenofibrate, Gemfibrozil |
| Omega-3 (Rx) | Lower triglycerides significantly | Icosapent ethyl (Vascepa), Lovaza |
| Ezetimibe | Blocks cholesterol absorption, lowers LDL | Zetia |
| PCSK9 inhibitors | Powerfully lower LDL (for very high-risk patients) | Evolocumab, Alirocumab |
| Niacin | Raises HDL, lowers TG and LDL | Niaspan |
| Bile acid sequestrants | Lower LDL via gut | Cholestyramine, Colesevelam |
Statins are the first-line drug for most people with high cholesterol and cardiovascular risk. For predominantly high triglycerides, fibrates or prescription omega-3 fatty acids are commonly used.
Key Targets to Aim For
| Lipid | Optimal Level |
|---|
| LDL cholesterol | < 100 mg/dL (< 70 mg/dL if high-risk) |
| Triglycerides | < 150 mg/dL |
| HDL cholesterol | > 40 mg/dL (men), > 50 mg/dL (women) |
| Total cholesterol | < 200 mg/dL |
Important Note
These are general guidelines. Whether you need medication depends on your personal cardiovascular risk, not just your numbers alone. A doctor will factor in your age, blood pressure, smoking history, diabetes status, and family history before recommending treatment. Always discuss your lipid results with your doctor before starting or stopping any medication.
Sources: Harrison's Principles of Internal Medicine 22E, p. 421; Lippincott Illustrated Reviews: Pharmacology, p. 475-482