Andhra University B Pharmacy 4th semester syllabus organic chemistry physical pharmaceutics pharmacognosy pharmacology medicinal chemistry

https://www.carewellpharma.in/bpharmacy/syllabus/4th-sem

ls /home/daytona/workspace/ 2>/dev/null && mkdir -p /home/daytona/workspace/bpha…

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// ─────────────────────────────────────────────
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// ─────────────────────────────────────────────
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// COVER
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children.push(new Paragraph({
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  children: [new TextRun({ text: "B. PHARMACY - 4th SEMESTER", bold: true, size: 36, color: "2E74B5" })]
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  children: [new TextRun({ text: "Pharmaceutical Organic Chemistry - III", bold: true, size: 44, color: "1F3864" })]
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  children: [new TextRun({ text: "Covers: Stereoisomerism | Named Reactions | Heterocyclic Chemistry | Alkaloids", size: 24, color: "404040" })]
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// TOC
children.push(pageBreak());
children.push(h1("Table of Contents"));
const tocItems = [
  "Unit 1 - Stereoisomerism",
  "  1.1  Optical Isomerism",
  "  1.2  Enantiomers and Diastereomers",
  "  1.3  Elements of Symmetry",
  "  1.4  DL and RS Nomenclature Systems",
  "  1.5  Racemic Modification and Resolution",
  "  1.6  Asymmetric Synthesis",
  "Unit 2 - Geometrical and Conformational Isomerism",
  "  2.1  Geometrical Isomerism",
  "  2.2  Conformational Isomerism",
  "  2.3  Atropisomerism",
  "  2.4  Stereospecific and Stereoselective Reactions",
  "Unit 3 - Named Reactions with Mechanisms",
  "  3.1  Aldol Condensation",
  "  3.2  Claisen Condensation",
  "  3.3  Perkin Reaction",
  "  3.4  Reformatsky Reaction",
  "  3.5  Beckmann Rearrangement",
  "  3.6  Fries Rearrangement",
  "  3.7  Claisen Rearrangement",
  "  3.8  Gattermann Reaction",
  "  3.9  Gattermann-Koch Reaction",
  "  3.10 Rosenmund Reduction",
  "  3.11 Stephen's Reaction",
  "  3.12 Elbs Reaction",
  "  3.13 Borodine-Hunsdiecker Reaction",
  "Unit 4 - Heterocyclic Chemistry",
  "  4.1  Introduction and Aromatic Character",
  "  4.2  Furan, Thiophene, Pyrrole",
  "  4.3  Pyrazole, Imidazole, Oxazole, Thiazole",
  "  4.4  Quinoline (Skraup Synthesis)",
  "  4.5  Isoquinoline (Bischler-Napieralski)",
  "  4.6  Indole, Benzofuran, Benzothiophene",
  "Unit 5 - Alkaloids and Terpenes",
  "  5.1  Classification of Alkaloids",
  "  5.2  Isolation of Alkaloids",
  "  5.3  Important Alkaloids",
  "  5.4  Terpenes and Isoprene Rule",
  "Quick Revision Tables",
  "Previous Year AU Questions"
];
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// ─────────────────────────────────────────────
// UNIT 1
// ─────────────────────────────────────────────
children.push(pageBreak());
children.push(h1("UNIT 1 - STEREOISOMERISM"));
children.push(infoBox("Definition", "Stereoisomers are compounds with the same molecular formula and sequence of bonded elements but that differ in the three-dimensional orientations of their atoms."));
children.push(spacer());

children.push(h2("1.1 Optical Isomerism"));
children.push(para("Optical isomers are non-superimposable mirror-image molecules. The key requirement is chirality - the molecule must lack an internal plane of symmetry."));
children.push(spacer());
children.push(infoBox("Optical Activity", "A compound is optically active if it rotates the plane of plane-polarized light. (+) dextrorotatory = rotates right; (-) levorotatory = rotates left."));
children.push(spacer());
children.push(twoColTable("Term", "Definition / Key Point", [
  ["Chiral molecule", "Non-superimposable on its mirror image; lacks a plane, center, or axis of symmetry"],
  ["Achiral molecule", "Superimposable on its mirror image; has a plane of symmetry"],
  ["Chiral center (*)","A carbon atom bonded to 4 different groups (sp3 carbon)"],
  ["Plane of symmetry", "An imaginary plane dividing molecule into two mirror-image halves"],
  ["Center of symmetry", "A point through which every atom has an identical atom at equal distance"],
  ["Axis of symmetry", "An axis about which rotation gives an identical structure"],
  ["Specific rotation [alpha]", "[alpha] = observed rotation / (concentration x path length)"]
]));
children.push(spacer());

children.push(h2("1.2 Enantiomers and Diastereomers"));
children.push(twoColTable("Type", "Description", [
  ["Enantiomers", "Mirror images of each other; same physical properties except direction of optical rotation; same melting point, boiling point, solubility. Differ in biological activity."],
  ["Diastereomers", "Stereoisomers that are NOT mirror images. Different physical AND chemical properties. Easier to separate by conventional methods."],
  ["Meso compounds", "Molecules with chiral centers but an internal plane of symmetry - optically INACTIVE despite having stereocenters. e.g., meso-tartaric acid."],
  ["Racemic mixture", "Equal (1:1) mixture of (+) and (-) enantiomers. Optically inactive (external compensation). Denoted (+/-) or dl."]
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children.push(noteBox("Meso compounds are a favourite AU question. Always explain that optical inactivity is due to internal compensation by the plane of symmetry, not because there are no stereocenters."));
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children.push(h2("1.3 Elements of Symmetry"));
children.push(para("A molecule is achiral (optically inactive) if it has ANY ONE of the following:"));
children.push(bullet("Plane of symmetry (sigma) - most common test"));
children.push(bullet("Center of symmetry (i) - also called center of inversion"));
children.push(bullet("Alternating axis of symmetry (Sn)"));
children.push(spacer());

children.push(h2("1.4 Nomenclature Systems: DL and RS"));
children.push(h3("DL System (Fischer Convention)"));
children.push(para("Based on the configuration of (+)-glyceraldehyde as the reference standard (D-configuration)."));
children.push(bullet("D - configuration: -OH on the right side in Fischer projection"));
children.push(bullet("L - configuration: -OH on the left side in Fischer projection"));
children.push(bullet("NOT directly related to direction of optical rotation (+/-)"));
children.push(bullet("D-glucose is dextrorotatory; D-fructose is levorotatory"));
children.push(spacer());
children.push(h3("RS System (Cahn-Ingold-Prelog, CIP Rules)"));
children.push(para("A systematic, absolute method for assigning configuration to each stereocenter."));
children.push(spacer());
children.push(para("Step-by-Step Procedure:", { bold: true }));
children.push(numbered("Assign priorities to the 4 substituents on the chiral carbon using CIP rules (1 = highest priority)."));
children.push(numbered("Priority Rule 1: Higher atomic number = higher priority (e.g., Br > Cl > O > N > C > H)."));
children.push(numbered("Priority Rule 2: If tie at first atom, compare atoms attached to it (like a tournament)."));
children.push(numbered("Priority Rule 3: For isotopes, higher mass = higher priority."));
children.push(numbered("Orient molecule so that the LOWEST priority group (4) points AWAY from you."));
children.push(numbered("Read the direction of remaining three groups (1 -> 2 -> 3)."));
children.push(numbered("Clockwise = R (Rectus = right); Counterclockwise = S (Sinister = left)."));
children.push(spacer());
children.push(noteBox("RS system is used for every compound in Medicinal Chemistry. Practice assigning R/S to: alanine, lactic acid, 2-bromobutane, glyceraldehyde. These are common AU examples."));
children.push(spacer());

children.push(h2("1.5 Racemic Modification and Resolution"));
children.push(h3("Racemic Modification"));
children.push(para("Formation of a racemic mixture from an optically active compound. Three methods:"));
children.push(bullet("Thermal racemization - heating causes loss of optical activity"));
children.push(bullet("Chemical racemization - treating with acid/base (enolization)"));
children.push(bullet("Photochemical racemization - UV light induced"));
children.push(spacer());
children.push(h3("Resolution of Racemic Mixtures"));
children.push(para("Separation of a racemate into individual enantiomers. Four methods:"));
children.push(twoColTable("Method", "Principle and Example", [
  ["Mechanical separation", "Pasteur's method - manually separating crystals of (+) and (-) sodium ammonium tartrate under a microscope. Only works for conglomerate crystals."],
  ["Chemical resolution", "React racemate with a pure chiral agent (resolving agent) to form diastereomeric salts -> separate by fractional crystallization -> remove resolving agent. Most practical method. e.g., Racemic acid + brucine."],
  ["Biochemical resolution", "Enzymes or microorganisms selectively metabolize one enantiomer. e.g., Penicillium glaucum preferentially destroys (+)-tartrate."],
  ["Chromatographic resolution", "Chiral stationary phase in HPLC separates enantiomers based on different interactions with chiral column material."]
]));
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children.push(h2("1.6 Asymmetric Synthesis"));
children.push(infoBox("Definition", "A reaction in which a new chiral center is created and one enantiomer/diastereomer is formed preferentially or exclusively."));
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children.push(twoColTable("Type", "Description", [
  ["Partial asymmetric synthesis", "Unequal amounts of enantiomers formed (enantiomeric excess > 0 but < 100%). Uses chiral starting material, reagent, catalyst, or solvent."],
  ["Absolute asymmetric synthesis", "Only one enantiomer formed (100% ee). Achieved using circularly polarized light or highly specific chiral catalysts (rare)."],
  ["Prochiral center", "An achiral center that becomes chiral when one of its identical groups is replaced by a different group."]
]));

// ─────────────────────────────────────────────
// UNIT 2
// ─────────────────────────────────────────────
children.push(pageBreak());
children.push(h1("UNIT 2 - GEOMETRICAL AND CONFORMATIONAL ISOMERISM"));

children.push(h2("2.1 Geometrical Isomerism"));
children.push(para("Occurs due to restricted rotation around a double bond or ring, when each carbon bears two DIFFERENT substituents."));
children.push(spacer());
children.push(h3("Nomenclature Systems"));
children.push(twoColTable("System", "Rule", [
  ["cis-trans", "cis = same groups on same side of double bond; trans = same groups on opposite sides. Used when both carbons have one H and one substituent."],
  ["E-Z system (CIP)", "Assign priorities to both groups on each C of double bond. Z (zusammen = together) = higher priority groups on same side. E (entgegen = opposite) = higher priority groups on opposite sides. Used when cis-trans is ambiguous."],
  ["syn-anti system", "Used for oximes, hydrazones, and semicarbazones. syn = -OH/-NH2 and higher priority on same side."]
]));
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children.push(h3("Methods to Determine Configuration of Geometrical Isomers"));
children.push(bullet("Physical properties: cis isomers have higher dipole moment, lower melting point; trans isomers have higher melting point, lower solubility (symmetry)"));
children.push(bullet("Chemical methods: Cyclization - only cis-maleic acid (not trans-fumaric) forms maleic anhydride on heating (both carboxyls must be cis for ring closure)"));
children.push(bullet("Spectroscopic: NMR coupling constant - J (vicinal) is ~6-12 Hz for cis and ~12-18 Hz for trans alkene protons"));
children.push(spacer());

children.push(h2("2.2 Conformational Isomerism"));
children.push(para("Conformers are different spatial arrangements of atoms in a molecule obtained by rotation about single bonds. They interconvert rapidly at room temperature."));
children.push(spacer());
children.push(h3("Ethane Conformations"));
children.push(twoColTable("Conformer", "Description", [
  ["Eclipsed (least stable)", "Dihedral angle = 0 degrees. H atoms on front and back carbons are aligned. Maximum torsional strain (~12 kJ/mol). Highest energy."],
  ["Staggered (most stable)", "Dihedral angle = 60 degrees. H atoms on front and back are maximally separated. Minimum torsional strain. Lowest energy."]
]));
children.push(spacer());
children.push(h3("n-Butane Conformations (Newman Projection about C2-C3)"));
children.push(twoColTable("Conformer", "Energy and Reason", [
  ["Anti (most stable)", "Methyl groups at 180 degrees (anti). Minimum steric strain. Most stable conformation."],
  ["Gauche", "Methyl groups at 60 degrees. Steric interaction between methyl groups. ~3.8 kJ/mol less stable than anti."],
  ["Eclipsed (CH3-H)", "Dihedral 120 degrees. Intermediate torsional + mild steric strain."],
  ["Fully eclipsed (least stable)", "Methyl groups at 0 degrees. Maximum steric (methyl-methyl) + torsional strain. Least stable."]
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children.push(spacer());
children.push(h3("Cyclohexane Conformations"));
children.push(bullet("Chair conformation: most stable - all bonds perfectly staggered, no angle strain"));
children.push(bullet("Boat conformation: less stable due to flagpole H-H interactions and eclipsed bonds"));
children.push(bullet("Twist-boat: intermediate, relieves some flagpole strain but still unfavorable"));
children.push(bullet("Half-chair: highest energy transition state between chair and boat"));
children.push(spacer());
children.push(infoBox("Axial vs Equatorial", "In chair cyclohexane, substituents prefer EQUATORIAL position to avoid 1,3-diaxial interactions. Bulky groups strongly prefer equatorial. Ring flip converts axial to equatorial positions."));
children.push(spacer());

children.push(h2("2.3 Atropisomerism (Stereoisomerism in Biphenyls)"));
children.push(para("In biphenyl compounds, rotation about the C-C bond joining the two rings is restricted when ortho substituents are sufficiently bulky. This creates non-superimposable mirror-image forms."));
children.push(spacer());
children.push(para("Conditions for optical activity in biphenyls:"));
children.push(bullet("Each ring must have at least two different ortho substituents"));
children.push(bullet("The two rings must not be coplanar due to steric hindrance from ortho groups"));
children.push(bullet("Rotation about the central C-C bond must be completely restricted"));
children.push(spacer());

children.push(h2("2.4 Stereospecific and Stereoselective Reactions"));
children.push(twoColTable("Type", "Definition and Example", [
  ["Stereospecific", "The stereochemistry of the reactant determines the stereochemistry of the product. Different stereoisomers of the reactant give different stereoisomers of the product. e.g., Bromine addition to cis vs trans-2-butene gives different products (syn addition -> anti addition product via cyclic bromonium ion)."],
  ["Stereoselective", "One stereoisomeric product is formed preferentially over another, regardless of the starting material configuration. e.g., Reduction of a ketone with LiAlH4 may give predominantly one alcohol."]
]));

// ─────────────────────────────────────────────
// UNIT 3 - NAMED REACTIONS
// ─────────────────────────────────────────────
children.push(pageBreak());
children.push(h1("UNIT 3 - NAMED REACTIONS WITH MECHANISMS"));
children.push(para("This unit is the most mark-yielding in AU exams. For each reaction, learn: Reagents + Conditions | Step-by-step mechanism | Product and its significance."));
children.push(spacer());

// 3.1 Aldol
children.push(h2("3.1 Aldol Condensation"));
children.push(infoBox("Reaction", "Between two carbonyl compounds (both having alpha-H) in the presence of dilute acid or base to give a beta-hydroxy carbonyl compound (aldol), which on dehydration gives alpha,beta-unsaturated carbonyl compound."));
children.push(spacer());
children.push(para("General Equation:"));
children.push(para("2 CH3CHO  ──(dil. NaOH, 0-5°C)──>  CH3CH(OH)CH2CHO  ──(heat)──>  CH3CH=CHCHO + H2O", { italic: true }));
children.push(spacer());
children.push(h3("Base-Catalyzed Mechanism"));
children.push(numbered("Base (OH-) removes an alpha-H from one molecule of aldehyde to form a resonance-stabilized carbanion (enolate ion)."));
children.push(numbered("The enolate acts as a nucleophile and attacks the carbonyl carbon of a second aldehyde molecule."));
children.push(numbered("The resulting alkoxide ion accepts a proton from water to give the beta-hydroxy aldehyde (aldol product)."));
children.push(numbered("On heating, elimination of water (E1cb or E2) gives the alpha,beta-unsaturated carbonyl compound."));
children.push(spacer());
children.push(h3("Applications in Pharmacy"));
children.push(bullet("Synthesis of chalcones (used in antifungal, antimalarial drugs)"));
children.push(bullet("Synthesis of Vitamin A (retinol) via retinal"));
children.push(bullet("Cross-aldol condensation used in synthesis of complex molecules"));
children.push(spacer());
children.push(noteBox("AU often asks: 'What is aldol condensation? Give mechanism and mention the product when benzaldehyde and acetaldehyde react.' Answer: Cinnamaldehyde is formed (cross-aldol / Claisen-Schmidt reaction)."));
children.push(spacer());
children.push(divider());

// 3.2 Claisen Condensation
children.push(h2("3.2 Claisen Condensation"));
children.push(infoBox("Reaction", "Condensation between two molecules of an ester (or an ester and a carbonyl compound) in the presence of a strong base (sodium ethoxide) to give a beta-keto ester."));
children.push(spacer());
children.push(para("General Equation:"));
children.push(para("2 CH3COOC2H5  ──(NaOEt)──>  CH3COCH2COOC2H5  +  C2H5OH", { italic: true }));
children.push(para("(Ethyl acetate forms Ethyl acetoacetate = ethyl 3-oxobutanoate)", { italic: true }));
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children.push(h3("Mechanism"));
children.push(numbered("NaOEt removes an alpha-H from one ester molecule to form an enolate."));
children.push(numbered("The enolate attacks the carbonyl carbon (C=O) of the second ester molecule."));
children.push(numbered("A tetrahedral intermediate forms, which then collapses expelling -OEt (ethoxide) as leaving group."));
children.push(numbered("Product is the beta-keto ester; deprotonation at the acidic CH2 between the two carbonyls makes the reaction irreversible."));
children.push(spacer());
children.push(twoColTable("Variant", "Description", [
  ["Self-Claisen condensation", "Two identical ester molecules (e.g., 2 ethyl acetate -> ethyl acetoacetate)"],
  ["Mixed (crossed) Claisen", "Two different esters; one must lack alpha-H (e.g., ethyl benzoate + ethyl acetate)"],
  ["Dieckmann condensation", "Intramolecular Claisen condensation of a diester to form cyclic beta-keto ester. Used to make 5- and 6-membered rings."],
  ["Claisen-Schmidt", "Between an ester or aldehyde and a ketone (no alpha-H needed on aldehyde component)"]
]));
children.push(spacer());
children.push(divider());

// 3.3 Perkin Reaction
children.push(h2("3.3 Perkin Reaction"));
children.push(infoBox("Reaction", "Condensation of an aromatic aldehyde with an acid anhydride in the presence of the salt of the corresponding acid (as base catalyst) to give an alpha,beta-unsaturated acid (cinnamic acid type)."));
children.push(spacer());
children.push(para("Classic Example:"));
children.push(para("C6H5CHO + (CH3CO)2O  ──(CH3COONa, heat)──>  C6H5CH=CHCOOH + CH3COOH", { italic: true }));
children.push(para("(Benzaldehyde + Acetic anhydride -> Cinnamic acid + Acetic acid)", { italic: true }));
children.push(spacer());
children.push(h3("Mechanism"));
children.push(numbered("The carboxylate salt (base) removes an alpha-H from acetic anhydride to form an enolate (carbanion)."));
children.push(numbered("The enolate attacks the carbonyl carbon of benzaldehyde (nucleophilic addition)."));
children.push(numbered("A mixed anhydride intermediate is formed."));
children.push(numbered("Elimination of acetic acid gives cinnamic anhydride."));
children.push(numbered("Hydrolysis gives cinnamic acid."));
children.push(spacer());
children.push(bullet("Product: trans-Cinnamic acid (predominantly) due to thermodynamic stability of E-isomer"));
children.push(bullet("Application: Synthesis of cinnamic acid derivatives used as UV absorbers, antimicrobials, and in perfumery"));
children.push(spacer());
children.push(divider());

// 3.4 Reformatsky
children.push(h2("3.4 Reformatsky Reaction"));
children.push(infoBox("Reaction", "Reaction of an aldehyde or ketone with an alpha-halo ester (e.g., ethyl alpha-bromoacetate) in the presence of zinc metal to give a beta-hydroxy ester (after hydrolysis)."));
children.push(spacer());
children.push(para("General Equation:"));
children.push(para("RCHO + BrCH2COOC2H5  ──(Zn, dry ether)──> then H2O/H+  ──>  RCH(OH)CH2COOC2H5", { italic: true }));
children.push(spacer());
children.push(h3("Mechanism"));
children.push(numbered("Zinc inserts oxidatively into the C-Br bond of the alpha-bromo ester to form a zinc enolate (organozinc reagent - Reformatsky reagent)."));
children.push(numbered("The organozinc enolate (less reactive than Grignard - does not attack ester groups) attacks the carbonyl of the aldehyde/ketone."));
children.push(numbered("Hydrolysis of the zinc alkoxide intermediate gives the beta-hydroxy ester."));
children.push(spacer());
children.push(infoBox("Key Advantage", "Zinc enolate is mild - it does NOT attack its own ester group (self-condensation), unlike Grignard reagents. This allows selective addition to the aldehyde/ketone."));
children.push(bullet("Application: Synthesis of beta-lactam antibiotics; synthesis of beta-hydroxy acids and their dehydration to alpha,beta-unsaturated acids"));
children.push(spacer());
children.push(divider());

// 3.5 Beckmann
children.push(h2("3.5 Beckmann Rearrangement"));
children.push(infoBox("Reaction", "Acid-catalyzed rearrangement of a ketoxime (R1-C(=N-OH)-R2) to an amide (N-substituted). The group anti (trans) to the -OH migrates."));
children.push(spacer());
children.push(para("Classic Example:"));
children.push(para("Cyclohexanone oxime  ──(H2SO4 or PCl5)──>  Caprolactam  (a cyclic amide / lactam)", { italic: true }));
children.push(para("Industrial use: Caprolactam is the monomer for Nylon-6 polymer.", { italic: true }));
children.push(spacer());
children.push(h3("Mechanism"));
children.push(numbered("Protonation of the oxime -OH group forms a good leaving group (water)."));
children.push(numbered("The group that is trans (anti) to the -OH migrates to the nitrogen with simultaneous departure of water (1,2-shift, concerted)."));
children.push(numbered("The resulting nitrilium ion is attacked by water."));
children.push(numbered("After proton transfers and tautomerism, an amide (or lactam if cyclic) is formed."));
children.push(spacer());
children.push(noteBox("Key mechanism point for AU: The group migrating is ALWAYS the one trans/anti to the OH group (anti-periplanar). This is a 1,2-migration. Write this clearly."));
children.push(spacer());
children.push(divider());

// 3.6 Fries Rearrangement
children.push(h2("3.6 Fries Rearrangement"));
children.push(infoBox("Reaction", "Rearrangement of phenyl esters to hydroxy aryl ketones (ortho- and/or para-hydroxyaryl ketones) catalyzed by Lewis acids (AlCl3) or Bronsted acids."));
children.push(spacer());
children.push(para("General Equation:"));
children.push(para("ArOCOR  ──(AlCl3, heat)──>  ortho-HO-Ar-CO-R  +  para-HO-Ar-CO-R", { italic: true }));
children.push(spacer());
children.push(h3("Mechanism"));
children.push(numbered("AlCl3 coordinates with the carbonyl oxygen of the ester, forming a complex."));
children.push(numbered("Homolytic or heterolytic cleavage of the O-C(acyl) bond produces an acylium ion (RCO+) and a phenoxide."));
children.push(numbered("Acylium ion (electrophile) undergoes electrophilic aromatic substitution (EAS) on the phenoxide ring."));
children.push(numbered("Substitution occurs preferentially at the ortho position at low temperature and at the para position at high temperature."));
children.push(spacer());
children.push(twoColTable("Temperature", "Product", [
  ["Low temperature (<100°C)", "Ortho isomer predominates (intramolecular reaction favored)"],
  ["High temperature (>100°C)", "Para isomer predominates (intermolecular reaction favored)"]
]));
children.push(spacer());
children.push(bullet("Application: Synthesis of hydroxyaryl ketones used in sunscreens (e.g., 4-tert-butyl-4'-methoxydibenzoylmethane derivatives)"));
children.push(spacer());
children.push(divider());

// 3.7 Claisen Rearrangement
children.push(h2("3.7 Claisen Rearrangement (Aliphatic and Aromatic)"));
children.push(infoBox("Reaction", "Thermal [3,3]-sigmatropic rearrangement of allyl vinyl ethers to give gamma,delta-unsaturated carbonyl compounds (aliphatic Claisen) or allyl phenyl ethers to ortho-allyl phenols (aromatic Claisen)."));
children.push(spacer());
children.push(h3("Aromatic Claisen Rearrangement"));
children.push(para("Allyl phenyl ether  ──(heat, 200°C)──>  ortho-allyl phenol  (via cyclohexadienone intermediate)", { italic: true }));
children.push(spacer());
children.push(h3("Mechanism"));
children.push(numbered("The allyl group migrates through a concerted, pericyclic [3,3]-sigmatropic transition state (chair-like 6-membered cyclic transition state)."));
children.push(numbered("The allyl group bonds to the ortho position, forming a cyclohexadienone intermediate."));
children.push(numbered("Tautomerization restores aromaticity, giving the ortho-allyl phenol."));
children.push(numbered("If both ortho positions are blocked, a second rearrangement places the allyl group at the para position."));
children.push(spacer());
children.push(noteBox("The Claisen rearrangement is concerted (no intermediates, no ionic species) - it goes through a pericyclic transition state. This distinguishes it from the Fries rearrangement."));
children.push(spacer());
children.push(divider());

// 3.8 Gattermann
children.push(h2("3.8 Gattermann Reaction"));
children.push(infoBox("Reaction", "Formylation of aromatic compounds (especially phenols and phenol ethers) using a mixture of HCN and HCl (or Zn(CN)2) in the presence of Lewis acid catalyst (AlCl3 or ZnCl2) to introduce a -CHO group."));
children.push(spacer());
children.push(para("General Equation:"));
children.push(para("ArH + HCN + HCl  ──(AlCl3)──>  Ar-CHO + NH4Cl", { italic: true }));
children.push(spacer());
children.push(h3("Mechanism"));
children.push(numbered("AlCl3 activates HCN by forming a complex: H-C(=NH)-AlCl3 - this acts as the electrophilic formylating species."));
children.push(numbered("The activated species reacts with the aromatic ring via electrophilic aromatic substitution (EAS)."));
children.push(numbered("The intermediate imine (Schiff base analog) is formed on the ring."));
children.push(numbered("Hydrolysis of the imine gives the aldehyde (-CHO)."));
children.push(spacer());
children.push(twoColTable("Gattermann vs Gattermann-Koch", "Difference", [
  ["Gattermann", "Uses HCN + HCl + Lewis acid. Works on activated rings (phenols, ethers). Active rings required."],
  ["Gattermann-Koch", "Uses CO + HCl + Lewis acid (AlCl3 + CuCl). Works on unactivated (simple benzene, alkylbenzenes). Does NOT work on phenols/ethers."]
]));
children.push(spacer());
children.push(divider());

// 3.9 Gattermann-Koch
children.push(h2("3.9 Gattermann-Koch Reaction"));
children.push(infoBox("Reaction", "Introduction of a -CHO group into benzene and its alkyl derivatives using CO + HCl under high pressure with AlCl3/CuCl catalyst. Gives aromatic aldehydes."));
children.push(spacer());
children.push(para("General Equation:"));
children.push(para("C6H6 + CO + HCl  ──(AlCl3, CuCl, high pressure)──>  C6H5CHO  (Benzaldehyde)", { italic: true }));
children.push(spacer());
children.push(h3("Mechanism"));
children.push(numbered("CO + HCl in the presence of CuCl and AlCl3 generates the formyl cation (CHO+) or a complex that acts as formyl cation equivalent."));
children.push(numbered("This electrophile undergoes EAS with benzene ring."));
children.push(numbered("Deprotonation gives the aromatic aldehyde product."));
children.push(spacer());
children.push(bullet("Note: CuCl is needed because AlCl3 alone cannot generate the formyl cation from CO effectively"));
children.push(bullet("Application: Industrial production of benzaldehyde and tolualdehyde"));
children.push(spacer());
children.push(divider());

// 3.10 Rosenmund
children.push(h2("3.10 Rosenmund Reduction"));
children.push(infoBox("Reaction", "Selective reduction of an acid chloride (RCOCl) to an aldehyde (RCHO) using hydrogen gas over a specially poisoned palladium catalyst (Pd/BaSO4, with a sulfur or quinoline poison) to prevent over-reduction to the alcohol."));
children.push(spacer());
children.push(para("General Equation:"));
children.push(para("RCOCl + H2  ──(Pd/BaSO4, quinoline-S, xylene/toluene solvent)──>  RCHO + HCl", { italic: true }));
children.push(spacer());
children.push(h3("Key Points"));
children.push(bullet("The catalyst MUST be poisoned - if not poisoned, the aldehyde would be further reduced to the primary alcohol"));
children.push(bullet("BaSO4 is the support; quinoline-sulfur is the poison that modifies Pd activity"));
children.push(bullet("Works for both aliphatic and aromatic acid chlorides"));
children.push(bullet("Limitation: Cannot be used for alpha,beta-unsaturated acid chlorides (C=C also gets reduced)"));
children.push(spacer());
children.push(noteBox("A classic AU question: 'How will you distinguish Rosenmund reduction from Stephen's reduction?' Answer: Rosenmund starts from acid chloride (RCOCl); Stephen's starts from nitrile (RCN). Both give aldehydes."));
children.push(spacer());
children.push(divider());

// 3.11 Stephens
children.push(h2("3.11 Stephen's Reaction"));
children.push(infoBox("Reaction", "Reduction of a nitrile (RCN) to an aldehyde (RCHO) using stannous chloride (SnCl2) in dry HCl/diethyl ether, followed by hydrolysis of the intermediate aldimine tin complex."));
children.push(spacer());
children.push(para("General Equation:"));
children.push(para("RCN  ──(SnCl2, dry HCl/ether)──>  [RC(=NH)...SnCl2 complex]  ──(H2O)──>  RCHO + NH3", { italic: true }));
children.push(spacer());
children.push(h3("Mechanism"));
children.push(numbered("SnCl2 in dry HCl reduces the nitrile to an aldimine (imine, RC=NH) - but this is stabilized as a tin complex and NOT hydrolyzed in the anhydrous conditions."));
children.push(numbered("The complex [RCH=NH...SnCl2] is isolated."));
children.push(numbered("Upon aqueous hydrolysis, the imine is converted to the aldehyde: RCH=NH + H2O -> RCHO + NH3."));
children.push(spacer());
children.push(twoColTable("Feature", "Rosenmund vs Stephen's", [
  ["Starting material", "Acid chloride (RCOCl) vs Nitrile (RCN)"],
  ["Reagent", "H2/Pd-BaSO4 vs SnCl2/dry HCl"],
  ["Mechanism", "Catalytic hydrogenation vs Ionic reduction"],
  ["Limitation", "Needs halide; cannot use on C=C containing substrates vs Works on aromatic and aliphatic nitriles well"]
]));
children.push(spacer());
children.push(divider());

// 3.12 Elbs Reaction
children.push(h2("3.12 Elbs Reaction (Elbs Persulfate Oxidation)"));
children.push(infoBox("Reaction", "Hydroxylation of phenols using potassium persulfate (K2S2O8) in alkaline conditions to give para-hydroxyphenol (predominantly). An electrophilic aromatic substitution at the para position."));
children.push(spacer());
children.push(para("General Equation:"));
children.push(para("Phenol + K2S2O8  ──(dilute KOH/NaOH)──>  para-dihydroxybenzene (hydroquinone)", { italic: true }));
children.push(spacer());
children.push(h3("Mechanism"));
children.push(numbered("In alkaline conditions, phenol exists as phenoxide ion (PhO-)."));
children.push(numbered("Persulfate ion (S2O8(2-)) acts as the oxidant and generates a sulfate radical (SO4*-) or the persulfate acts as electrophile."));
children.push(numbered("Para-attack on phenoxide by the persulfate (electrophilic sulfonation)."));
children.push(numbered("Hydrolysis of the intermediate para-phenyl sulfate gives para-hydroxyphenol (hydroquinone)."));
children.push(spacer());
children.push(bullet("Product: para-Dihydroxybenzene (Hydroquinone) - predominantly para"));
children.push(bullet("If para is blocked, ortho substitution occurs"));
children.push(bullet("Application: Para-aminophenol synthesis (paracetamol precursor); hydroquinone synthesis for photography and skin-lightening agents"));
children.push(spacer());
children.push(divider());

// 3.13 Borodine-Hunsdiecker
children.push(h2("3.13 Borodine-Hunsdiecker Reaction (Silver Salt + Halogen)"));
children.push(infoBox("Reaction", "Decarboxylative halogenation of a carboxylic acid via its silver salt (RCOOAg) with bromine (Br2) or chlorine (Cl2) in CCl4 to give an alkyl halide with one less carbon."));
children.push(spacer());
children.push(para("General Equation:"));
children.push(para("RCOOAg + Br2  ──(CCl4, dry, reflux)──>  R-Br + CO2 + AgBr", { italic: true }));
children.push(para("(Carbon chain is shortened by one carbon)", { italic: true }));
children.push(spacer());
children.push(h3("Mechanism (Free Radical)"));
children.push(numbered("Bromine reacts with silver carboxylate to form acyloxy hypobromite intermediate: RCOO-Br + AgBr."));
children.push(numbered("The O-Br bond undergoes homolytic cleavage (thermally or photochemically) to generate carboxylate radical (RCOO*) and bromine radical (Br*)."));
children.push(numbered("Carboxylate radical rapidly loses CO2 (decarboxylation) to form alkyl radical (R*)."));
children.push(numbered("Alkyl radical abstracts bromine from Br2 (or from the Br* + Br2 equilibrium) to give R-Br + Br*."));
children.push(numbered("Chain reaction continues."));
children.push(spacer());
children.push(twoColTable("Feature", "Detail", [
  ["Mechanism type", "Free radical chain mechanism"],
  ["Conditions", "Dry CCl4 solvent; absence of moisture (moisture destroys AgBr)"],
  ["Reactivity", "Br2 > Cl2; I2 does not react"],
  ["Application", "Stepwise degradation of fatty acids; synthesis of specific alkyl halides"]
]));
children.push(spacer());

// ─────────────────────────────────────────────
// UNIT 4 - HETEROCYCLIC CHEMISTRY
// ─────────────────────────────────────────────
children.push(pageBreak());
children.push(h1("UNIT 4 - HETEROCYCLIC CHEMISTRY"));
children.push(infoBox("Definition", "Cyclic compounds containing at least one atom other than carbon in the ring. The heteroatom is usually N, O, or S. Pharmaceutically extremely important - over 60% of all drugs contain a heterocyclic ring."));
children.push(spacer());

children.push(h2("4.1 Aromaticity of Heterocycles (Huckel's Rule)"));
children.push(para("A heterocyclic compound is aromatic if it satisfies ALL of the following:"));
children.push(bullet("Cyclic and planar"));
children.push(bullet("Completely conjugated (alternating single and double bonds, or equivalent)"));
children.push(bullet("Follows Huckel's rule: (4n + 2) pi electrons, where n = 0, 1, 2..."));
children.push(spacer());
children.push(twoColTable("Compound", "Pi electrons and Aromaticity", [
  ["Furan (O in ring)", "6 pi electrons (4 from 2 C=C + 2 from lone pair of O). n=1. Aromatic. O lone pair participates in conjugation."],
  ["Thiophene (S in ring)", "6 pi electrons (4 from 2 C=C + 2 from lone pair of S). n=1. Aromatic. More aromatic than furan."],
  ["Pyrrole (NH in ring)", "6 pi electrons (4 from 2 C=C + 2 from N lone pair). n=1. Aromatic. N lone pair is part of the pi system (N is sp2)."],
  ["Pyridine (N=C in ring)", "6 pi electrons from 3 C=C/C=N bonds. n=1. Aromatic. N lone pair is NOT part of pi system (N is sp2, lone pair in sp2 orbital = basic site)."],
  ["Imidazole", "6 pi electrons. Two N atoms: one is pyrrole-type (N-H, lone pair in pi system) and one is pyridine-type (basic, lone pair exocyclic). Amphoteric."]
]));
children.push(spacer());

children.push(h2("4.2 Five-Membered Heterocycles: Furan, Thiophene, Pyrrole"));
children.push(h3("Synthesis and Reactions"));
children.push(twoColTable("Compound", "Key Synthesis and Reactions", [
  ["Furan", "Paal-Knorr synthesis: 1,4-dicarbonyl compound + dehydrating agent (P2O5). Undergoes EAS at C2 (position 2 and 5 most reactive). Diels-Alder reactions (acts as diene)."],
  ["Thiophene", "Paal-Knorr synthesis: 1,4-dicarbonyl compound + P2S5. Also from butane + S (industrial). EAS at C2. Most aromatic of the trio (sulfur best at donating lone pair)."],
  ["Pyrrole", "Paal-Knorr: 1,4-dicarbonyl + primary amine + acid. Also Knorr synthesis (from alpha-aminoketone). EAS at C2. N-H is weakly acidic (pKa ~17) - N-H proton can be removed."]
]));
children.push(spacer());
children.push(infoBox("Reactivity Order for EAS", "Pyrrole > Furan > Thiophene > Benzene. Pyrrole is most electron-rich due to N lone pair donation. EAS on these compounds occurs at position 2 (alpha) preferentially."));
children.push(spacer());

children.push(h2("4.3 Other Five-Membered Heterocycles"));
children.push(twoColTable("Compound", "Structure and Key Features", [
  ["Pyrazole (N-N ring)", "Two adjacent N atoms. Numbering: N1 bears H, N2 is pyridine-type basic nitrogen. Weakly acidic at N-H. Important in drug design (e.g., celecoxib contains pyrazole ring)."],
  ["Imidazole (1,3-diazole)", "N1 (pyrrole-type, bears H) and N3 (pyridine-type, basic). pKa of conjugate acid = 7 (ideal for biological systems). Present in histidine and histamine."],
  ["Oxazole (1,3-oxazole)", "O at 1, N at 3. Less aromatic than imidazole. Synthesis: from alpha-acylaminocarbonyl compounds."],
  ["Thiazole (1,3-thiazole)", "S at 1, N at 3. More stable than oxazole. Present in Vitamin B1 (thiamine) and in penicillin (thiazolidine ring). Synthesis: Hantzsch thiazole synthesis from alpha-halocarbonyl + thioamide."]
]));
children.push(spacer());

children.push(h2("4.4 Quinoline - Skraup Synthesis"));
children.push(infoBox("Reaction", "Synthesis of quinoline from aniline and glycerol (with an oxidizing agent - nitrobenzene or arsenic acid - and concentrated H2SO4 as catalyst)."));
children.push(spacer());
children.push(h3("Skraup Synthesis - Mechanism"));
children.push(numbered("Glycerol is dehydrated by H2SO4 to give acrolein (propenal, CH2=CH-CHO) in situ."));
children.push(numbered("Aniline undergoes Michael addition (1,4-addition) to acrolein to give a beta-anilinopropanal intermediate."));
children.push(numbered("Intramolecular electrophilic cyclization forms a dihydroquinoline."));
children.push(numbered("Nitrobenzene (or other oxidant) oxidizes the dihydroquinoline to quinoline (aromatization by removal of 2H)."));
children.push(spacer());
children.push(h3("Doebner-Miller Modification"));
children.push(para("Uses alpha,beta-unsaturated carbonyl compounds (e.g., crotonaldehyde, benzalacetaldehyde, cinnamic acid) instead of glycerol. Milder conditions, gives 2-substituted quinolines."));
children.push(spacer());
children.push(infoBox("Pharmaceutical Importance of Quinoline", "Quinine (antimalarial), Chloroquine (antimalarial), Ciprofloxacin (fluoroquinolone antibiotic), Nalidixic acid (first quinolone), Mefloquine (antimalarial)."));
children.push(spacer());

children.push(h2("4.5 Isoquinoline - Bischler-Napieralski Synthesis"));
children.push(infoBox("Reaction", "Cyclodehydration of beta-phenylethylamide using P2O5 or POCl3 to give a 3,4-dihydroisoquinoline, which is then oxidized to isoquinoline."));
children.push(spacer());
children.push(h3("Key Points"));
children.push(bullet("Isoquinoline has N at position 2 (unlike quinoline where N is at position 1)"));
children.push(bullet("Bischler-Napieralski gives 1,2,3,4-tetrahydroisoquinolines (important in opiate synthesis)"));
children.push(bullet("Pictet-Spengler reaction is an alternative: beta-phenylethylamine + aldehyde in acidic conditions"));
children.push(bullet("Isoquinoline derivatives: Papaverine, Berberine, Morphine (isoquinoline nucleus)"));
children.push(spacer());

children.push(h2("4.6 Indole, Benzofuran, Benzothiophene"));
children.push(twoColTable("Compound", "Synthesis and Importance", [
  ["Indole", "Fischer Indole Synthesis: arylhydrazone of aldehyde/ketone + acid catalyst (ZnCl2, H2SO4, BF3) gives 2-substituted or 3-substituted indoles. Most important synthesis. Present in: Tryptophan, serotonin, melatonin, indole alkaloids (vincristine, strychnine)."],
  ["Benzofuran", "From salicylaldehyde with alpha-halocarbonyl compounds. Present in amiodarone (antiarrhythmic drug)."],
  ["Benzothiophene", "From thiophenol + vinyl halide or from benzothiophenone. Present in raloxifene (SERM, used in osteoporosis)."]
]));

// ─────────────────────────────────────────────
// UNIT 5 - ALKALOIDS AND TERPENES
// ─────────────────────────────────────────────
children.push(pageBreak());
children.push(h1("UNIT 5 - ALKALOIDS AND TERPENES"));

children.push(h2("5.1 Alkaloids - Introduction and Classification"));
children.push(infoBox("Definition", "Alkaloids are naturally occurring, basic nitrogen-containing organic compounds of plant origin that have significant physiological (pharmacological) activity. Obtained mostly from plants (rarely animals)."));
children.push(spacer());
children.push(h3("General Properties"));
children.push(bullet("Usually colorless, crystalline solids (liquid: nicotine, coniine)"));
children.push(bullet("Bitter taste in dilute solution"));
children.push(bullet("Basic in nature (due to N atom); form salts with acids"));
children.push(bullet("Optically active (most levorotatory) - only levorotatory form is biologically active in most cases"));
children.push(bullet("Insoluble in water (as free base); soluble in organic solvents; salts are water-soluble"));
children.push(spacer());
children.push(h3("Classification of Alkaloids"));
children.push(twoColTable("Class", "Ring System / Example", [
  ["Pyridine/Piperidine alkaloids", "Piperidine ring. Examples: Nicotine, Coniine, Lobeline"],
  ["Pyrrolidine/Tropane alkaloids", "Tropane (bicyclic) ring. Examples: Atropine (hyoscyamine), Cocaine, Scopolamine"],
  ["Quinoline alkaloids", "Quinoline ring. Examples: Quinine, Quinidine, Cinchonine"],
  ["Isoquinoline alkaloids", "Isoquinoline ring. Examples: Morphine, Codeine, Papaverine, Berberine, Emetine"],
  ["Indole alkaloids", "Indole ring. Examples: Ergotamine, Reserpine, Strychnine, Brucine, Vincristine"],
  ["Imidazole alkaloids", "Imidazole ring. Examples: Pilocarpine, Histamine"],
  ["Purine alkaloids", "Purine ring. Examples: Caffeine, Theophylline, Theobromine"],
  ["Steroidal alkaloids", "Steroid nucleus. Examples: Solanine, Veratrine, Conessine"]
]));
children.push(spacer());

children.push(h2("5.2 Isolation and Purification of Alkaloids"));
children.push(h3("General Method of Isolation"));
children.push(numbered("The plant material is dried, powdered, and defatted (petroleum ether extraction removes fats/waxes)."));
children.push(numbered("The powder is moistened with an alkali (lime, ammonia, Na2CO3) to liberate free alkaloid base from its salt form."));
children.push(numbered("Extraction with organic solvent (chloroform, ether, ethyl acetate) - alkaloid base dissolves in organic layer."));
children.push(numbered("The organic layer is extracted with dilute acid (HCl) - alkaloid salts go into aqueous phase."));
children.push(numbered("The aqueous acid layer is basified with NH3 - alkaloid base precipitates or re-dissolves in organic solvent on re-extraction."));
children.push(numbered("Purification by recrystallization, chromatography (column, TLC), or precipitation."));
children.push(spacer());
children.push(h3("Detection Reactions"));
children.push(twoColTable("Reagent", "Positive Result", [
  ["Mayer's reagent (K2HgI4)", "Cream/white precipitate"],
  ["Wagner's reagent (I2/KI)", "Brown/reddish precipitate"],
  ["Dragendorff's reagent (KBiI4)", "Orange-red precipitate"],
  ["Marme's reagent (CdI2/KI)", "Yellow precipitate"]
]));
children.push(spacer());

children.push(h2("5.3 Important Alkaloids"));
children.push(twoColTable("Alkaloid", "Source, Class, and Uses", [
  ["Morphine", "Papaver somniferum (opium poppy). Isoquinoline (phenanthrene ring). Strong analgesic, antitussive, antidiarrheal. Highly addictive. Codeine (methylated) - milder."],
  ["Quinine", "Cinchona bark (Cinchona officinalis). Quinoline type. Antimalarial, cardiac antiarrhythmic. Also used as a muscle relaxant for cramps."],
  ["Atropine", "Atropa belladonna (deadly nightshade). Tropane type. Anticholinergic; used in preanaesthetic medication, organophosphate poisoning antidote, pupil dilation (mydriasis)."],
  ["Cocaine", "Erythroxylon coca. Tropane type. Local anaesthetic (first local anaesthetic discovered). Also highly addictive CNS stimulant (controlled substance)."],
  ["Nicotine", "Nicotiana tabacum. Pyridine-pyrrolidine type. Ganglionic stimulant, autonomic."],
  ["Ergotamine", "Claviceps purpurea fungus (ergot). Indole type. Vasoconstrictor; used in migraine treatment."],
  ["Vincristine/Vinblastine", "Catharanthus roseus (Vinca). Indole type. Antineoplastic (anti-cancer) - inhibit tubulin polymerization."]
]));
children.push(spacer());

children.push(h2("5.4 Terpenes and Isoprene Rule"));
children.push(infoBox("Isoprene Rule", "Most terpenes are built from repeating isoprene (2-methyl-1,3-butadiene, C5H8) units. The general formula is (C5H8)n."));
children.push(spacer());
children.push(twoColTable("Class", "No. of C atoms (n x C5) / Examples", [
  ["Monoterpenes", "C10 (2 isoprene units). Examples: Menthol, Camphor, Geraniol, Limonene, Citral"],
  ["Sesquiterpenes", "C15 (3 units). Examples: Farnesol, Bisabolol, Zingiberene (ginger), Artemisinin"],
  ["Diterpenes", "C20 (4 units). Examples: Vitamin A (retinol), Phytol, Taxol (paclitaxel, anticancer)"],
  ["Sesterterpenes", "C25 (5 units). Rare - mainly marine organisms"],
  ["Triterpenes", "C30 (6 units). Examples: Squalene, Lanosterol, Oleanolic acid, Ursolic acid"],
  ["Tetraterpenes", "C40 (8 units). Examples: Beta-carotene (pro-Vitamin A), Lycopene, Xanthophylls"],
  ["Polyterpenes", "More than C40. Examples: Rubber (polyisoprene), Gutta-percha"]
]));
children.push(spacer());

// ─────────────────────────────────────────────
// QUICK REVISION
// ─────────────────────────────────────────────
children.push(pageBreak());
children.push(h1("QUICK REVISION TABLES"));

children.push(h2("Named Reactions - One-Line Summary"));
children.push(threeColTable("Reaction", "Reagents/Conditions", "Product / Key Outcome", [
  ["Aldol condensation", "Dil. NaOH or HCl, 2 molecules with alpha-H", "beta-hydroxy carbonyl -> alpha,beta-unsaturated carbonyl"],
  ["Claisen condensation", "NaOEt, 2 esters", "beta-keto ester (e.g., ethyl acetoacetate)"],
  ["Perkin reaction", "ArCHO + Ac2O + CH3COONa, heat", "trans-Cinnamic acid (alpha,beta-unsaturated acid)"],
  ["Reformatsky", "Ketone/aldehyde + BrCH2COOEt + Zn, then H2O", "beta-Hydroxy ester"],
  ["Beckmann", "Ketoxime + H2SO4 or PCl5", "Amide (anti group migrates); lactam if cyclic"],
  ["Fries", "Phenyl ester + AlCl3; low T = ortho; high T = para", "Hydroxy aryl ketone"],
  ["Claisen rearrangement", "Allyl phenyl ether + heat (~200°C)", "ortho-Allyl phenol (pericyclic [3,3]-sigmatropic)"],
  ["Gattermann", "ArH + HCN + HCl + ZnCl2 or AlCl3", "ArCHO (activated rings: phenols, ethers)"],
  ["Gattermann-Koch", "ArH + CO + HCl + AlCl3/CuCl", "ArCHO (benzene, alkylbenzenes only)"],
  ["Rosenmund", "RCOCl + H2/Pd-BaSO4 (poisoned)", "RCHO (aldehyde, 1 less C than acid)"],
  ["Stephen's", "RCN + SnCl2/HCl, then H2O", "RCHO (aldehyde)"],
  ["Elbs", "Phenol + K2S2O8 + dil. KOH", "para-Dihydroxybenzene (Hydroquinone)"],
  ["Hunsdiecker", "RCOOAg + Br2 + CCl4", "RBr + CO2 + AgBr (free radical, -1C)"]
]));
children.push(spacer());

children.push(h2("Heterocyclic Rings - Structure and Drugs"));
children.push(threeColTable("Ring System", "Key Drugs / Molecules", "Synthesis", [
  ["Furan (O)", "Nitrofurantoin (urinary antiseptic), Furosemide", "Paal-Knorr (1,4-dicarbonyl + P2O5)"],
  ["Thiophene (S)", "Tenoxicam, Tiagabine, Raltitrexed", "Paal-Knorr (1,4-dicarbonyl + P2S5)"],
  ["Pyrrole (NH)", "Atorvastatin, Ketorolac, Porphyrins (heme)", "Paal-Knorr (1,4-dicarbonyl + amine)"],
  ["Imidazole (N1,N3)", "Metronidazole, Ketoconazole, Histidine", "Van Leusen; Debus synthesis"],
  ["Pyrazole (N1,N2)", "Celecoxib, Sildenafil, Antipyrine", "From 1,3-dicarbonyl + hydrazine"],
  ["Thiazole (S,N)", "Penicillin, Thiamine (B1), Famotidine", "Hantzsch thiazole synthesis"],
  ["Pyridine", "Nicotinic acid, Isoniazid, Chlorpheniramine", "Hantzsch pyridine synthesis"],
  ["Quinoline", "Quinine, Chloroquine, Ciprofloxacin", "Skraup synthesis; Doebner-Miller"],
  ["Indole (benzo[b]pyrrole)", "Serotonin, Tryptophan, Indomethacin, Vincristine", "Fischer Indole Synthesis"]
]));
children.push(spacer());

children.push(h2("Stereochemistry - Key Formulas"));
children.push(twoColTable("Formula / Rule", "Description", [
  ["Max. stereoisomers = 2^n", "n = number of stereocenters. For meso compounds, actual number is less."],
  ["[alpha]D = observed rotation / (c x l)", "Specific rotation; c = g/mL, l = path length in dm"],
  ["Enantiomeric excess (ee) = ((R-S)/(R+S)) x 100%", "Measure of optical purity of a mixture"],
  ["R = clockwise (1->2->3, lowest group away)", "Cahn-Ingold-Prelog RS assignment"],
  ["Huckel: 4n+2 pi electrons", "For aromaticity; n = 0 (2), 1 (6), 2 (10)..."]
]));
children.push(spacer());

// ─────────────────────────────────────────────
// AU PREVIOUS YEAR QUESTIONS
// ─────────────────────────────────────────────
children.push(pageBreak());
children.push(h1("FREQUENTLY ASKED AU QUESTIONS (Previous Years)"));
children.push(spacer());

children.push(h2("Long Questions (16 Marks) - Very Likely to Appear"));
children.push(numbered("Explain optical isomerism in detail. Discuss DL and RS systems of nomenclature with suitable examples. (Unit 1)"));
children.push(numbered("Define racemic modification. Explain the methods of resolution of racemic mixtures. (Unit 1)"));
children.push(numbered("Give the mechanism of Aldol condensation and Claisen condensation with suitable examples. (Unit 3)"));
children.push(numbered("Explain Beckmann rearrangement and Fries rearrangement with mechanism and applications. (Unit 3)"));
children.push(numbered("Write a detailed account of Skraup synthesis of quinoline. How is isoquinoline synthesized? (Unit 4)"));
children.push(numbered("Discuss the synthesis, aromaticity, and reactions of furan, thiophene, and pyrrole. (Unit 4)"));
children.push(numbered("Classify alkaloids with examples. Explain the general method of isolation of alkaloids. (Unit 5)"));
children.push(numbered("Explain the Isoprene rule. Classify terpenes with examples and their pharmaceutical importance. (Unit 5)"));
children.push(spacer());

children.push(h2("Short Questions (8 Marks) - Common in AU Papers"));
children.push(numbered("Define enantiomers and diastereomers. How are they distinguished?"));
children.push(numbered("What is a meso compound? Give two examples."));
children.push(numbered("Write the mechanism of Perkin reaction with an example."));
children.push(numbered("Distinguish between Rosenmund reduction and Stephen's reaction."));
children.push(numbered("Write the mechanism of Reformatsky reaction."));
children.push(numbered("What is Gattermann-Koch reaction? How does it differ from Gattermann reaction?"));
children.push(numbered("Explain Claisen rearrangement with mechanism."));
children.push(numbered("What is Elbs persulfate oxidation? Give mechanism."));
children.push(numbered("Write a note on Borodine-Hunsdiecker reaction."));
children.push(numbered("Explain conformational isomerism in cyclohexane with chair and boat forms."));
children.push(numbered("Write the Fischer Indole synthesis with mechanism."));
children.push(numbered("Give the pharmaceutical importance of alkaloids. Briefly describe morphine and quinine."));
children.push(spacer());

children.push(h2("Very Short / 2-Mark Questions"));
children.push(bullet("Define: optical activity, chirality, meso compound, racemic mixture"));
children.push(bullet("What is the isoprene rule?"));
children.push(bullet("Name two monoterpenes and two diterpenes"));
children.push(bullet("What is HCN used for in Gattermann reaction? Why CCl4 in Hunsdiecker reaction?"));
children.push(bullet("What is the Beckmann rearrangement used to produce industrially? (Caprolactam -> Nylon-6)"));
children.push(bullet("Name the ring systems in morphine, quinine, and cocaine"));
children.push(bullet("What is atropisomerism?"));
children.push(bullet("State Huckel's rule for aromaticity"));
children.push(spacer());

children.push(divider());
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    new TextRun({ text: "Best of Luck for Your Examinations!", bold: true, size: 28, color: "2E74B5" }),
    new TextRun({ text: "  |  Prepared for Andhra University B. Pharmacy 4th Semester  |  July 2026", size: 22, italics: true, color: "404040" })
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// ─────────────────────────────────────────────
// BUILD THE DOCUMENT
// ─────────────────────────────────────────────
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cd /home/daytona/workspace/bpharm-organic-chem && node generate_doc.js 2>&1

python3 /home/daytona/skills/docx/scripts/office/validate.py /home/daytona/works…

cd /home/daytona/workspace/bpharm-organic-chem && python3 -c " import zipfile, o…

python3 -c " import pdfplumber path = '/home/daytona/workspace/attachments/08b0d…

python3 -c " import subprocess, os path = '/home/daytona/workspace/attachments/0…

python3 << 'EOF' from pdf2image import convert_from_path import pytesseract, sys…

python3 << 'EOF' from pdf2image import convert_from_path import os path = '/hom…

mutool draw -F jpg -o /home/daytona/workspace/attachments/pages/page_%d.jpg '/ho…

mkdir -p /home/daytona/workspace/attachments/pages && pdftoppm -jpeg -r 100 -f 1…

pdftoppm -jpeg -r 100 -f 5 -l 12 '/home/daytona/workspace/attachments/08b0d002-e…

~/bpharm-organic-chem/generate_timetable.js

const {
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  HeadingLevel, AlignmentType, BorderStyle, WidthType, ShadingType,
  LevelFormat, PageNumber, Header, Footer, PageBreak, VerticalAlign
} = require('docx');
const fs = require('fs');

// ─── HELPERS ───────────────────────────────────────────────
function h1(text) {
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}
function h2(text) {
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}
function h3(text) {
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}
function para(text, opts = {}) {
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}
function bullet(text, boldPart) {
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}
function spacer(n = 80) { return new Paragraph({ children: [new TextRun("")], spacing: { after: n } }); }
function pgBreak() { return new Paragraph({ pageBreakBefore: true, children: [new TextRun("")] }); }

function cell(text, opts = {}) {
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}

function hdrRow(cols, fill = "1F3864") {
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        children: [new TextRun({ text: c, bold: true, size: 22, color: "FFFFFF" })]
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}

function infoBox(label, content, fill = "D6E8F7", labelColor = "1F3864") {
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    width: { size: 100, type: WidthType.PERCENTAGE },
    rows: [new TableRow({ children: [new TableCell({
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      children: [new Paragraph({ children: [
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}

function tipBox(text) {
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        new TextRun({ text, size: 22, color: "7F6000" })
      ]})]
    })]})]
  });
}

// ─── MAIN TIMETABLE TABLE ───────────────────────────────────
function dailyRow(day, date, morning, session1, session2, session3, session4, target, fill) {
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    children: [
      new TableCell({
        shading: { fill, type: ShadingType.CLEAR },
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        children: [new Paragraph({ children: [new TextRun({ text: morning, size: 20, italics: true, color: "555555" })] })]
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        margins: { top: 80, bottom: 80, left: 120, right: 120 },
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        children: [new Paragraph({ children: [new TextRun({ text: target, size: 20, bold: true, color: "1B5E20" })] })]
      })
    ]
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}

// ─── DOCUMENT CHILDREN ─────────────────────────────────────
const children = [];

// COVER PAGE
children.push(spacer(200));
children.push(new Paragraph({
  alignment: AlignmentType.CENTER, spacing: { after: 160 },
  children: [new TextRun({ text: "B. PHARMACY — 4th SEMESTER", bold: true, size: 40, color: "1F3864" })]
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children.push(new Paragraph({
  alignment: AlignmentType.CENTER, spacing: { after: 200 },
  children: [new TextRun({ text: "PERSONALISED 10-DAY EXAM TIMETABLE", bold: true, size: 52, color: "C00000" })]
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children.push(new Paragraph({
  alignment: AlignmentType.CENTER, spacing: { after: 160 },
  children: [new TextRun({ text: "Based on Your Official AU Syllabus  |  4 Hours Study/Day  |  College 8 AM–6 PM", size: 26, italics: true, color: "444444" })]
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children.push(new Table({
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  rows: [new TableRow({ children: [new TableCell({
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}));
children.push(spacer(120));
children.push(new Table({
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  rows: [new TableRow({ children: [
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}));

// ─── PAGE 2: HOW TO USE ──────────────────────────────────────
children.push(pgBreak());
children.push(h1("HOW TO USE THIS TIMETABLE"));
children.push(spacer());
children.push(h2("Your Daily Schedule Structure"));
children.push(new Table({
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  rows: [
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      cell("Morning Study – Session 1", { fill: "E3F2FD" }),
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      cell("Travel + Rest", { fill: "E8F5E9" }),
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      cell("Revision of morning topics + next topics", { fill: "E3F2FD" }),
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      cell("Dinner + Family Time", { fill: "FFF3E0" }),
      cell("1 Hour", { fill: "FFF3E0", center: true }),
      cell("No studying, recharge mentally", { fill: "FFF3E0" }),
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    new TableRow({ children: [
      cell("9:30 PM – 10:00 PM", { fill: "F1F8E9" }),
      cell("Quick Recall Review", { fill: "F1F8E9" }),
      cell("30 min", { fill: "F1F8E9", center: true }),
      cell("Glance at today's notes — don't study new topics", { fill: "F1F8E9" }),
    ]}),
    new TableRow({ children: [
      cell("10:00 PM", { fill: "FDECEA" }),
      cell("SLEEP (Mandatory)", { fill: "FDECEA", bold: true }),
      cell("7–8 hrs", { fill: "FDECEA", center: true }),
      cell("Sleep helps memory consolidation — non-negotiable", { fill: "FDECEA" }),
    ]}),
  ]
}));
children.push(spacer());
children.push(tipBox("Use college break periods (10 min between classes, lunch break) to review flash cards or re-read your morning notes. This passive revision adds ~1 extra effective hour daily."));
children.push(spacer());
children.push(h2("Subject Hours Budget (10 Days x 4 hrs = 40 hours total)"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["Subject", "Code", "Syllabus Hours", "Days Allocated", "Study Hours Assigned", "Difficulty"]),
    new TableRow({ children: [
      cell("Pharmaceutical Organic Chemistry III", { fill: "E3F2FD" }), cell("BP401T", { fill: "E3F2FD", center: true }), cell("45 hrs", { fill: "E3F2FD", center: true }), cell("Days 1–2", { fill: "E3F2FD", center: true }), cell("8 hrs", { fill: "E3F2FD", center: true, bold: true }), cell("High", { fill: "FDECEA", center: true, color: "C00000", bold: true })
    ]}),
    new TableRow({ children: [
      cell("Medicinal Chemistry I", { fill: "F3E5F5" }), cell("BP402T", { fill: "F3E5F5", center: true }), cell("45 hrs", { fill: "F3E5F5", center: true }), cell("Days 3–4", { fill: "F3E5F5", center: true }), cell("8 hrs", { fill: "F3E5F5", center: true, bold: true }), cell("High", { fill: "FDECEA", center: true, color: "C00000", bold: true })
    ]}),
    new TableRow({ children: [
      cell("Physical Pharmaceutics II", { fill: "E8F5E9" }), cell("BP403T", { fill: "E8F5E9", center: true }), cell("45 hrs", { fill: "E8F5E9", center: true }), cell("Days 5–6", { fill: "E8F5E9", center: true }), cell("8 hrs", { fill: "E8F5E9", center: true, bold: true }), cell("Medium", { fill: "FFF9C4", center: true, color: "7F6000", bold: true })
    ]}),
    new TableRow({ children: [
      cell("Pharmacology I", { fill: "FFF3E0" }), cell("BP404T", { fill: "FFF3E0", center: true }), cell("45 hrs", { fill: "FFF3E0", center: true }), cell("Days 7–8", { fill: "FFF3E0", center: true }), cell("8 hrs", { fill: "FFF3E0", center: true, bold: true }), cell("Medium", { fill: "FFF9C4", center: true, color: "7F6000", bold: true })
    ]}),
    new TableRow({ children: [
      cell("Pharmacognosy & Phytochemistry I", { fill: "E8EAF6" }), cell("BP405T", { fill: "E8EAF6", center: true }), cell("45 hrs", { fill: "E8EAF6", center: true }), cell("Day 9", { fill: "E8EAF6", center: true }), cell("4 hrs", { fill: "E8EAF6", center: true, bold: true }), cell("Low-Med", { fill: "E8F5E9", center: true, color: "2E7D32", bold: true })
    ]}),
    new TableRow({ children: [
      cell("Revision + Previous Year Q Papers", { fill: "FDECEA", bold: true }), cell("All", { fill: "FDECEA", center: true }), cell("—", { fill: "FDECEA", center: true }), cell("Day 10", { fill: "FDECEA", center: true }), cell("4 hrs", { fill: "FDECEA", center: true, bold: true }), cell("—", { fill: "FDECEA", center: true })
    ]}),
  ]
}));

// ─── PAGE 3: COLOUR KEY & UNIT MAP ──────────────────────────
children.push(pgBreak());
children.push(h1("UNIT-WISE SYLLABUS MAP (Your Exact AU Syllabus)"));
children.push(para("This is extracted directly from your uploaded syllabus PDF. Use this as your checklist — tick each unit after you finish it.", { italic: true }));
children.push(spacer());

// BP401T
children.push(h2("BP401T — Pharmaceutical Organic Chemistry III  (45 Hrs)"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["Unit", "Hours", "Topics", "Done?"]),
    new TableRow({ children: [cell("I", { fill: "E3F2FD", bold: true, center: true }), cell("10", { fill: "E3F2FD", center: true }), cell("Stereoisomerism: Optical isomerism, enantiomers, diastereomers, meso compounds, elements of symmetry, chiral/achiral molecules, DL & RS nomenclature, reactions of chiral molecules, racemic modification & resolution, asymmetric synthesis", { fill: "E3F2FD" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("II", { fill: "FFFFFF", bold: true, center: true }), cell("10", { fill: "FFFFFF", center: true }), cell("Geometrical isomerism (cis-trans, EZ, syn-anti), methods of configuration determination, conformational isomerism (ethane, n-butane, cyclohexane), atropisomerism in biphenyls, stereospecific & stereoselective reactions", { fill: "FFFFFF" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("III", { fill: "E3F2FD", bold: true, center: true }), cell("10", { fill: "E3F2FD", center: true }), cell("Heterocyclic compounds: Nomenclature & classification, synthesis/reactions/uses of Pyrrole, Furan, Thiophene; relative aromaticity & reactivity of Pyrrole, Furan, Thiophene", { fill: "E3F2FD" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("IV", { fill: "FFFFFF", bold: true, center: true }), cell("8", { fill: "FFFFFF", center: true }), cell("Pyrazole, Imidazole, Oxazole, Thiazole (synthesis/reactions/uses); Pyridine, Quinoline, Isoquinoline, Acridine, Indole — basicity of pyridine; Pyrimidine, Purine, azepines & derivatives", { fill: "FFFFFF" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("V", { fill: "E3F2FD", bold: true, center: true }), cell("7", { fill: "E3F2FD", center: true }), cell("Reactions of synthetic importance: NaBH4/LiAlH4 reduction, Clemmensen reduction, Birch reduction, Wolff-Kishner reduction, Oppenauer oxidation, Dakin reaction, Beckmann rearrangement, Schmidt rearrangement, Claisen-Schmidt condensation", { fill: "E3F2FD" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
  ]
}));
children.push(spacer());

// BP402T
children.push(h2("BP402T — Medicinal Chemistry I  (45 Hrs)"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["Unit", "Hours", "Topics", "Done?"], "2E74B5"),
    new TableRow({ children: [cell("I", { fill: "EBF3FB", bold: true, center: true }), cell("10", { fill: "EBF3FB", center: true }), cell("Introduction: history & development of medicinal chemistry; physicochemical properties (ionization, solubility, partition coefficient, H-bonding, protein binding, chelation, bioisosterism, optical/geometrical isomerism); drug metabolism — Phase I & II, stereo aspects", { fill: "EBF3FB" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("II", { fill: "FFFFFF", bold: true, center: true }), cell("10", { fill: "FFFFFF", center: true }), cell("ANS drugs — Adrenergic: biosynthesis & catabolism of catecholamines, alpha & beta receptors; SAR of sympathomimetics; drugs: Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine, Methyldopa, Clonidine, Dobutamine, Salbutamol*, Naphazoline etc.; Adrenergic antagonists: Tolazoline*, Phentolamine, Prazosin; Beta blockers SAR: Propranolol*, Atenolol, Metoprolol, Carvedilol", { fill: "FFFFFF" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("III", { fill: "EBF3FB", bold: true, center: true }), cell("10", { fill: "EBF3FB", center: true }), cell("Cholinergic neurotransmitters: biosynthesis/catabolism of ACh; muscarinic & nicotinic receptors; Direct acting (ACh, Carbachol*, Pilocarpine); Cholinesterase inhibitors (Physostigmine, Neostigmine*, Pyridostigmine, Edrophonium, Malathion); Cholinesterase reactivator: Pralidoxime; Cholinergic blockers: atropine, scopolamine, ipratropium*; synthetic blockers: Tropicamide, Dicyclomine*, Propantheline", { fill: "EBF3FB" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("IV", { fill: "FFFFFF", bold: true, center: true }), cell("8", { fill: "FFFFFF", center: true }), cell("CNS drugs: A. Sedatives & hypnotics — SAR of benzodiazepines (Diazepam*, Lorazepam, Alprazolam, Zolpidem); SAR barbiturates (Phenobarbital*, Amobarbital, Pentobarbital); Glutethimide, Paraldehyde; B. Antipsychotics — SAR phenothiazines (Chlorpromazine*, Trifluoperazine); Ring analogues (Clozapine, Haloperidol, Risperidone); C. Anticonvulsants — SAR, Phenytoin*, Carbamazepine*, Valproic acid, Ethosuximide*", { fill: "FFFFFF" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("V", { fill: "EBF3FB", bold: true, center: true }), cell("7", { fill: "EBF3FB", center: true }), cell("CNS drugs (continued): General anesthetics — Halothane*, Ketamine*; Narcotic & non-narcotic analgesics — SAR morphine analogues (Morphine sulphate, Codeine, Meperidine, Methadone*, Propoxyphene); narcotic antagonists (Naloxone); Anti-inflammatory: SAR, Aspirin, Mefenamic acid*, Indomethacin, Ibuprofen*, Naproxen, Diclofenac, Piroxicam, Acetaminophen", { fill: "EBF3FB" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
  ]
}));
children.push(spacer());

// BP403T
children.push(h2("BP403T — Physical Pharmaceutics II  (45 Hrs)"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["Unit", "Hours", "Topics", "Done?"], "2E7D32"),
    new TableRow({ children: [cell("I", { fill: "E8F5E9", bold: true, center: true }), cell("7", { fill: "E8F5E9", center: true }), cell("Colloidal dispersions: classification of dispersed systems, size & shapes of colloidal particles, optical/kinetic/electrical properties, effect of electrolytes, coacervation, peptization, protective action", { fill: "E8F5E9" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("II", { fill: "FFFFFF", bold: true, center: true }), cell("10", { fill: "FFFFFF", center: true }), cell("Rheology: Newtonian systems, law of flow, kinematic viscosity; Non-Newtonian systems (pseudoplastic, dilatant, plastic, thixotropy); determination of viscosity (capillary, falling sphere, rotational viscometers); Deformation of solids: Heckel equation, stress, strain, elastic modulus", { fill: "FFFFFF" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("III", { fill: "E8F5E9", bold: true, center: true }), cell("10", { fill: "E8F5E9", center: true }), cell("Coarse dispersions: Suspension — interfacial properties, settling, flocculated/deflocculated; Emulsions — theories of emulsification, microemulsion, multiple emulsions, stability, preservation, rheological properties, HLB method for formulation", { fill: "E8F5E9" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("IV", { fill: "FFFFFF", bold: true, center: true }), cell("10", { fill: "FFFFFF", center: true }), cell("Micromeretics: Particle size & distribution, mean particle size, number & weight distribution, methods for determining particle size (sieving, sedimentation, counting & separation), particle shape, specific surface, methods for surface area, permeability, adsorption, derived properties: porosity, packing, densities, bulkiness & flow properties", { fill: "FFFFFF" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("V", { fill: "E8F5E9", bold: true, center: true }), cell("10", { fill: "E8F5E9", center: true }), cell("Drug stability: Reaction kinetics (zero, pseudo-zero, first, second order), determination of reaction order, rate constants; Physical & chemical factors influencing degradation (temperature, solvent, ionic strength, dielectric constant, acid-base catalysis); simple numerical problems; Stabilization (hydrolysis & oxidation); Accelerated stability testing; expiration dating; photolytic degradation & prevention", { fill: "E8F5E9" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
  ]
}));
children.push(spacer());

// BP404T
children.push(h2("BP404T — Pharmacology I  (45 Hrs)"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["Unit", "Hours", "Topics", "Done?"], "7B1FA2"),
    new TableRow({ children: [cell("I", { fill: "F3E5F5", bold: true, center: true }), cell("8", { fill: "F3E5F5", center: true }), cell("General Pharmacology: definition, historical landmarks, scope; nature & source of drugs, essential drugs concept, routes of administration; agonists, antagonists, spare receptors, addiction, tolerance, dependence, tachyphylaxis, idiosyncrasy, allergy; Pharmacokinetics: membrane transport, absorption, distribution, metabolism, excretion, enzyme induction/inhibition, kinetics of elimination", { fill: "F3E5F5" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("II", { fill: "FFFFFF", bold: true, center: true }), cell("12", { fill: "FFFFFF", center: true }), cell("General Pharmacology: Pharmacodynamics — receptor theories & classification, regulation, drug-receptor interactions, signal transduction (G-protein, ion channels, enzyme-linked, JAK-STAT, transcription factors), dose-response relationship, therapeutic index, combined effects of drugs, factors modifying drug action; Adverse drug reactions; Drug interactions; Drug discovery & clinical evaluation, pharmacovigilance", { fill: "FFFFFF" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("III", { fill: "F3E5F5", bold: true, center: true }), cell("10", { fill: "F3E5F5", center: true }), cell("PNS Pharmacology: Organization & function of ANS; neurohumoral transmission, co-transmission, classification of neurotransmitters; Parasympathomimetics, parasympatholytics, sympathomimetics, sympatholytics; Neuromuscular blocking agents & skeletal muscle relaxants; Local anesthetic agents; Drugs in myasthenia gravis & glaucoma", { fill: "F3E5F5" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("IV", { fill: "FFFFFF", bold: true, center: true }), cell("8", { fill: "FFFFFF", center: true }), cell("CNS Pharmacology: Neurohumoral transmission in CNS — GABA, glutamate, glycine, serotonin, dopamine; General anesthetics & pre-anesthetics; Sedatives, hypnotics, centrally acting muscle relaxants; Anti-epileptics; Alcohols & disulfiram", { fill: "FFFFFF" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("V", { fill: "F3E5F5", bold: true, center: true }), cell("7", { fill: "F3E5F5", center: true }), cell("CNS Pharmacology: Psychopharmacological agents (antipsychotics, antidepressants, anti-anxiety, anti-manics, hallucinogens); Drugs in Parkinson's & Alzheimer's; CNS stimulants & nootropics; Opioid analgesics & antagonists; Drug addiction, abuse, tolerance & dependence", { fill: "F3E5F5" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
  ]
}));
children.push(spacer());

// BP405T
children.push(h2("BP405T — Pharmacognosy & Phytochemistry I  (45 Hrs)"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["Unit", "Hours", "Topics", "Done?"], "E65100"),
    new TableRow({ children: [cell("I", { fill: "FFF3E0", bold: true, center: true }), cell("10", { fill: "FFF3E0", center: true }), cell("Introduction: definition, history, scope & development; Sources of drugs (plants, animals, marine, tissue culture); Organized & unorganized drugs; Classification of drugs (alphabetical, morphological, taxonomical, chemical, pharmacological, chemo & serotaxonomical); Quality control: adulteration, evaluation methods (organoleptic, microscopic, physical, chemical, biological); Quantitative microscopy (lycopodium spore method, leaf constants, camera lucida)", { fill: "FFF3E0" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("II", { fill: "FFFFFF", bold: true, center: true }), cell("10", { fill: "FFFFFF", center: true }), cell("Cultivation, collection, processing & storage of drugs of natural origin; Factors influencing cultivation; Plant hormones & applications; Polyploidy, mutation & hybridization with reference to medicinal plants; Conservation of medicinal plants", { fill: "FFFFFF" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("III", { fill: "FFF3E0", bold: true, center: true }), cell("7", { fill: "FFF3E0", center: true }), cell("Plant tissue culture: historical development, types of cultures, nutritional requirements, growth & maintenance; Applications in pharmacognosy; Edible vaccines", { fill: "FFF3E0" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("IV", { fill: "FFFFFF", bold: true, center: true }), cell("10", { fill: "FFFFFF", center: true }), cell("Pharmacognosy in systems of medicine (Ayurveda, Unani, Siddha, Homeopathy, Chinese); Introduction to secondary metabolites: definition, classification, properties & tests for identification of Alkaloids, Glycosides, Flavonoids, Tannins, Volatile oils, Resins", { fill: "FFFFFF" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("V", { fill: "FFF3E0", bold: true, center: true }), cell("8", { fill: "FFF3E0", center: true }), cell("Biological source, chemical nature & uses of natural drugs: Plant products (Fibres — cotton, jute, hemp; Hallucinogens, teratogens, allergens); Primary metabolites: Carbohydrates (Acacia, Agar, Tragacanth, Honey); Proteins & Enzymes (Gelatin, papain, bromelain, streptokinase); Lipids (Castor oil, Chaulmoogra oil, Wool Fat, Bees Wax); Marine drugs", { fill: "FFF3E0" }), cell("[ ]", { fill: "FFFFFF", center: true })] }),
  ]
}));

// ─── PAGE 4+: 10-DAY TIMETABLE ───────────────────────────────
children.push(pgBreak());
children.push(h1("10-DAY DAILY TIMETABLE"));
children.push(infoBox("Key:", "Morning Session (5:30–7:30 AM) = New content  |  Evening Session (6:30–8:30 PM) = Revision + continuation  |  * = synthesis/structure to draw and memorize", "EBF3FB"));
children.push(spacer());

// TABLE
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    new TableRow({
      tableHeader: true,
      children: [
        new TableCell({ shading: { fill: "1F3864", type: ShadingType.CLEAR }, margins: { top: 100, bottom: 100, left: 100, right: 100 }, children: [new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: "DAY", bold: true, size: 22, color: "FFFFFF" })] })] }),
        new TableCell({ shading: { fill: "1F3864", type: ShadingType.CLEAR }, margins: { top: 100, bottom: 100, left: 100, right: 100 }, children: [new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: "Morning Preview\n(5:30–7:30 AM)", bold: true, size: 22, color: "FFFFFF" })] })] }),
        new TableCell({ shading: { fill: "1F3864", type: ShadingType.CLEAR }, margins: { top: 100, bottom: 100, left: 100, right: 100 }, children: [new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: "Evening Session A\n(6:30–7:30 PM)", bold: true, size: 22, color: "FFFFFF" })] })] }),
        new TableCell({ shading: { fill: "1F3864", type: ShadingType.CLEAR }, margins: { top: 100, bottom: 100, left: 100, right: 100 }, children: [new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: "Evening Session B\n(7:30–8:30 PM)", bold: true, size: 22, color: "FFFFFF" })] })] }),
        new TableCell({ shading: { fill: "1F3864", type: ShadingType.CLEAR }, margins: { top: 100, bottom: 100, left: 100, right: 100 }, children: [new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: "Target by End of Day", bold: true, size: 22, color: "FFFFFF" })] })] }),
      ]
    }),
    dailyRow("DAY 1\nSunday", "Day 1", "ORGANIC CHEM III\nUnit I: Stereoisomerism\nOptical isomerism, enantiomers, diastereomers, meso compounds, elements of symmetry", "ORGANIC CHEM III Unit I (continued)\nDL system, RS system (CIP rules step-by-step)", "ORGANIC CHEM III Unit II\nGeometrical isomerism (cis-trans, EZ, syn-anti), methods of configuration determination", "OC Unit I fully done\nOC Unit II first half done", "2E74B5"),
    dailyRow("DAY 2\nMonday", "Day 2", "ORGANIC CHEM III\nUnit II (finish): Conformational isomerism — ethane, n-butane, cyclohexane, atropisomerism", "ORGANIC CHEM III Unit III\nHeterocyclic: Nomenclature, Pyrrole/Furan/Thiophene — synthesis & reactions", "ORGANIC CHEM III Units IV & V\nPyrazole, Imidazole, Quinoline (Skraup), Beckmann & Schmidt rearrangement, reductions", "OC Units I–V complete", "2E74B5"),
    dailyRow("DAY 3\nTuesday", "Day 3", "MEDICINAL CHEM I\nUnit I: Introduction, physicochemical properties, drug metabolism Phase I & II", "MEDICINAL CHEM I Unit II\nAdrenergic drugs — SAR, sympathomimetics (Epinephrine, Dopamine, Salbutamol*)", "MEDICINAL CHEM I Unit II (finish)\nAdrenergic antagonists (Phentolamine, Prazosin), beta blockers SAR (Propranolol*, Atenolol)", "MC Units I–II complete", "C00000"),
    dailyRow("DAY 4\nWednesday", "Day 4", "MEDICINAL CHEM I\nUnit III: Cholinergic drugs — ACh biosynthesis, muscarinic/nicotinic, direct & indirect acting, Pralidoxime, cholinergic blockers", "MEDICINAL CHEM I Unit IV\nCNS: SAR benzodiazepines (Diazepam*, Alprazolam), SAR barbiturates (Phenobarbital*), Antipsychotics (Chlorpromazine*, Haloperidol, Risperidone)", "MEDICINAL CHEM I Unit V\nAnticonvulsants (Phenytoin*, Carbamazepine*); Analgesics (Morphine, Codeine, Methadone*); NSAIDs (Aspirin, Ibuprofen*, Diclofenac, Acetaminophen)", "MC Units I–V complete", "C00000"),
    dailyRow("DAY 5\nThursday", "Day 5", "PHYSICAL PHARMA II\nUnit I: Colloidal dispersions — classification, optical/kinetic/electrical properties, zeta potential, coacervation, peptization", "PHYSICAL PHARMA II Unit II\nRheology — Newtonian vs non-Newtonian, pseudoplastic, dilatant, thixotropy; viscometers; Heckel equation, elastic modulus", "PHYSICAL PHARMA II Unit III\nSuspensions — interfacial properties, flocculation/deflocculation; Emulsions — theories, HLB method, stability (formulae + numericals)", "PP Units I–III complete", "2E7D32"),
    dailyRow("DAY 6\nFriday", "Day 6", "PHYSICAL PHARMA II\nUnit IV: Micromeretics — particle size & distribution, all measurement methods, Stokes' law, Carr's index, Hausner ratio, flow properties (numericals)", "PHYSICAL PHARMA II Unit V\nDrug stability — reaction kinetics (zero/first/second order), half-life, Arrhenius equation, Accelerated stability testing, expiration dating (numericals)", "PHYSICAL PHARMA II — Full Revision\nRe-do all numericals from Units II, IV, V; check all formulas", "PP Units I–V complete\nAll numericals practiced", "2E7D32"),
    dailyRow("DAY 7\nSaturday", "Day 7", "PHARMACOLOGY I\nUnit I: General pharmacology — scope, routes of administration, pharmacokinetics (ADME), enzyme induction/inhibition, agonist/antagonist concepts", "PHARMACOLOGY I Unit II\nPharmacodynamics — receptor theories, G-protein/ion channel/enzyme-linked receptors, dose-response, therapeutic index, ADRs, drug interactions, pharmacovigilance", "PHARMACOLOGY I Unit III\nPNS pharmacology — ANS organization, neurohumoral transmission, sympathomimetics, parasympathomimetics, NMJ blockers, local anaesthetics, myasthenia gravis/glaucoma drugs", "Pharm Units I–III complete", "7B1FA2"),
    dailyRow("DAY 8\nSunday", "Day 8", "PHARMACOLOGY I\nUnit IV: CNS — GABA/glutamate/serotonin/dopamine, general anaesthetics, sedatives/hypnotics, anti-epileptics, alcohols & disulfiram", "PHARMACOLOGY I Unit V\nAntipsychotics, antidepressants, anti-anxiety; Parkinson's & Alzheimer's drugs; CNS stimulants; opioid analgesics; drug dependence/abuse", "PHARMACOLOGY I — Full Revision\nClassify all drug classes (table format), write mechanisms for 5 key drug categories", "Pharm Units I–V complete", "7B1FA2"),
    dailyRow("DAY 9\nMonday", "Day 9", "PHARMACOGNOSY I\nUnit I: Introduction, drug classification (all 6 types), quality control, adulteration, leaf constants, lycopodium spore method\nUnit II: Cultivation, collection, conservation, plant hormones, polyploidy", "PHARMACOGNOSY I\nUnit III: Plant tissue culture — types, nutritional requirements, applications, edible vaccines\nUnit IV: Secondary metabolites — alkaloids, glycosides, flavonoids, tannins, volatile oils, resins (definition, classification, tests)", "PHARMACOGNOSY I Unit V\nPrimary metabolites — Acacia, Agar, Tragacanth, Honey, Gelatin, papain, enzymes, Castor oil, Chaulmoogra oil; Marine drugs", "PCG Units I–V complete", "E65100"),
    dailyRow("DAY 10\nTuesday", "Day 10", "FULL REVISION — Morning\nOrganic Chem: re-read all named reactions one-liners\nMed Chem: re-read SAR tables for each class + 10 drug structures", "FULL REVISION — Evening A\nPhysical Pharma: all formulas on 1 page; attempt 2 numerical problems\nPharmacology: all classification tables; write receptor types from memory", "FULL REVISION — Evening B\nPharmacognosy: leaf constants, classification summary, secondary metabolites table\nAttempt 1 previous AU paper (50% questions only, timed)", "All 25 Units Revised\nPrevious paper attempted", "555555"),
  ]
}));

// ─── PAGE 5: DAILY STUDY TECHNIQUES ─────────────────────────
children.push(pgBreak());
children.push(h1("REVISION TIPS & STUDY TECHNIQUES"));
children.push(spacer());

children.push(h2("1. The 3-Read Method (for each Unit)"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["Read #", "When", "What to Do", "Time"]),
    new TableRow({ children: [cell("1st Read", { fill: "E3F2FD", bold: true }), cell("Morning session", { fill: "E3F2FD" }), cell("Read the full unit once WITHOUT stopping. Understand flow. Don't memorize.", { fill: "E3F2FD" }), cell("30–40 min", { fill: "E3F2FD", center: true })] }),
    new TableRow({ children: [cell("2nd Read", { fill: "FFFFFF", bold: true }), cell("Morning session", { fill: "FFFFFF" }), cell("Re-read and write key points in your own words. Draw diagrams. Write drug structures.", { fill: "FFFFFF" }), cell("40–50 min", { fill: "FFFFFF", center: true })] }),
    new TableRow({ children: [cell("3rd Read", { fill: "E3F2FD", bold: true }), cell("Evening session", { fill: "E3F2FD" }), cell("Read only your notes (not the textbook). Recall without looking. Fill in gaps.", { fill: "E3F2FD" }), cell("20–30 min", { fill: "E3F2FD", center: true })] }),
  ]
}));
children.push(spacer());

children.push(h2("2. Subject-Specific Techniques"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["Subject", "Best Study Method", "What to Avoid"]),
    new TableRow({ children: [cell("Organic Chemistry III", { fill: "E3F2FD", bold: true }), cell("Write each mechanism step-by-step by hand. Draw arrows for electron movement. Cover and re-draw. Use the PQRST method: Problem, Question, Reaction, Steps, Tips.", { fill: "E3F2FD" }), cell("Don't just read mechanisms — you MUST write them. Reading alone = forgetting.", { fill: "FDECEA" })] }),
    new TableRow({ children: [cell("Medicinal Chemistry I", { fill: "F3E5F5", bold: true }), cell("For each drug class: make a table — Class | SAR Key Points | Prototype Drug | Structure | Uses. Draw structures of starred (*) drugs daily.", { fill: "F3E5F5" }), cell("Don't try to memorize every drug name. Focus on prototype + SAR principles.", { fill: "FDECEA" })] }),
    new TableRow({ children: [cell("Physical Pharmaceutics II", { fill: "E8F5E9", bold: true }), cell("Write all formulas on a single A4 sheet. Solve at least 2 numericals per topic (particle size, kinetics, HLB). Use graphs for rheology curves.", { fill: "E8F5E9" }), cell("Don't skip numerical problems. AU definitely tests calculations.", { fill: "FDECEA" })] }),
    new TableRow({ children: [cell("Pharmacology I", { fill: "FFF3E0", bold: true }), cell("Use classification tables: for every drug class — Classify | Mechanism | Key drug | Dose/route | ADRs. Pharmacokinetics: draw ADME flowchart from memory.", { fill: "FFF3E0" }), cell("Don't memorize individual doses. Focus on mechanism and classification.", { fill: "FDECEA" })] }),
    new TableRow({ children: [cell("Pharmacognosy I", { fill: "FFF3E0", bold: true }), cell("Use mnemonics for classifications. Learn the 6 classification types with 1 example each. Memorize leaf constant numbers for 3–4 key drugs (Senna, Digitalis).", { fill: "FFF3E0" }), cell("Don't leave microscopy without learning 2–3 leaf constant values — it's direct marks.", { fill: "FDECEA" })] }),
  ]
}));
children.push(spacer());

children.push(h2("3. The 30-Minute College Break Trick"));
children.push(para("Every college break (10–15 min between classes, 30–45 min lunch) is study time. Here's how:"));
children.push(bullet("Make 10–15 flash cards every morning before leaving (index cards or phone notes)"));
children.push(bullet("During every college break, review 5 flash cards — don't study new topics"));
children.push(bullet("At lunch, spend 20 minutes re-reading your morning notes (not the textbook)"));
children.push(bullet("This adds ~1 effective hour of review daily without any extra evening effort"));
children.push(spacer());

children.push(h2("4. Memory Techniques for Pharmacy"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["Technique", "How to Use It", "Example"]),
    new TableRow({ children: [cell("Acronyms", { fill: "E3F2FD", bold: true }), cell("Create a word from the first letters of items in a list.", { fill: "E3F2FD" }), cell("ADME = Absorption, Distribution, Metabolism, Excretion", { fill: "E3F2FD" })] }),
    new TableRow({ children: [cell("Story Method", { fill: "FFFFFF", bold: true }), cell("Link drug names into a story or sentence.", { fill: "FFFFFF" }), cell("'Poor Peter Phenobarbital Always Amuses Beautiful People' = Barbiturate list", { fill: "FFFFFF" })] }),
    new TableRow({ children: [cell("Chunking", { fill: "E3F2FD", bold: true }), cell("Group similar items together and learn as a block.", { fill: "E3F2FD" }), cell("All benzodiazepines ending in -azepam: Diazepam, Oxazepam, Lorazepam", { fill: "E3F2FD" })] }),
    new TableRow({ children: [cell("Visual Mapping", { fill: "FFFFFF", bold: true }), cell("Draw a spider diagram with the main topic at center, branches for each subtopic.", { fill: "FFFFFF" }), cell("Cholinergic drugs map: Center = ACh, branches = Direct/Indirect/Blockers/Reactivators", { fill: "FFFFFF" })] }),
    new TableRow({ children: [cell("Teach-Back", { fill: "E3F2FD", bold: true }), cell("After studying a topic, explain it out loud as if teaching someone — reveals gaps immediately.", { fill: "E3F2FD" }), cell("Explain 'why phenytoin is used in epilepsy' out loud before sleeping", { fill: "E3F2FD" })] }),
  ]
}));
children.push(spacer());

children.push(h2("5. Exam Day Strategy (AU Pattern)"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["AU Exam Format", "Strategy"]),
    new TableRow({ children: [cell("Part A: Short answers (2 marks each)", { fill: "E3F2FD", bold: true }), cell("Attempt all. Write 3–4 lines each. Define → Example → One key fact. Do NOT write more than 5 lines.", { fill: "E3F2FD" })] }),
    new TableRow({ children: [cell("Part B: Medium answers (5–8 marks)", { fill: "FFFFFF", bold: true }), cell("Write with headings. Include a diagram or table wherever possible. One diagram = 1–2 extra marks.", { fill: "FFFFFF" })] }),
    new TableRow({ children: [cell("Part C: Long essays (16 marks)", { fill: "E3F2FD", bold: true }), cell("Use the IDEA format: Introduction | Detailed content (mechanism/classification) | Example with structure | Application/uses. Write a clear introduction first. Divide with subheadings.", { fill: "E3F2FD" })] }),
    new TableRow({ children: [cell("Time management (3-hour paper)", { fill: "FFFFFF", bold: true }), cell("First 10 min: read all questions, mark ones you know well. Start with long essays (35–40 min each). Leave 15 min at the end to review answers.", { fill: "FFFFFF" })] }),
    new TableRow({ children: [cell("Diagrams & structures", { fill: "E3F2FD", bold: true }), cell("Always label diagrams. Draw drug structures neatly — examiners award marks for neat structures even if mechanism is incomplete.", { fill: "E3F2FD" })] }),
  ]
}));
children.push(spacer());

children.push(h2("6. What NOT to Do in These 10 Days"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["Don't Do This", "Why", "Do This Instead"], "C00000"),
    new TableRow({ children: [cell("Start a new topic on Day 10", { fill: "FDECEA", bold: true }), cell("Unfinished topics cause panic and lower confidence for topics you already know.", { fill: "FDECEA" }), cell("Only revise covered topics on Day 10", { fill: "E8F5E9" })] }),
    new TableRow({ children: [cell("Study continuously for 4+ hours without break", { fill: "FDECEA", bold: true }), cell("Attention drops to ~20% after 90 minutes. You waste time but feel like you studied.", { fill: "FDECEA" }), cell("2 hours max per session with a 10-min break in the middle", { fill: "E8F5E9" })] }),
    new TableRow({ children: [cell("Sacrifice sleep to study late", { fill: "FDECEA", bold: true }), cell("Sleep consolidates memory. Sleeping less than 6 hours = significant memory loss next day.", { fill: "FDECEA" }), cell("Sleep by 10:30 PM. Study quality > quantity.", { fill: "E8F5E9" })] }),
    new TableRow({ children: [cell("Read without writing anything", { fill: "FDECEA", bold: true }), cell("Passive reading = forgetting within 24 hours for most pharmacy content.", { fill: "FDECEA" }), cell("Always have a pen — write key words, draw structures, make mini-notes", { fill: "E8F5E9" })] }),
    new TableRow({ children: [cell("Skip Physical Pharma numericals", { fill: "FDECEA", bold: true }), cell("AU regularly tests 5–8 marks of calculations. Skipping = guaranteed mark loss.", { fill: "FDECEA" }), cell("Practice at least 2 numericals per topic on Days 5–6", { fill: "E8F5E9" })] }),
  ]
}));
children.push(spacer());

children.push(h2("7. High-Yield Focus Topics (Greatest Marks for Least Time)"));
children.push(new Table({
  width: { size: 100, type: WidthType.PERCENTAGE },
  rows: [
    hdrRow(["Subject", "TOP 3 Must-Do Topics", "Expected Marks"]),
    new TableRow({ children: [cell("Organic Chemistry III", { fill: "E3F2FD", bold: true }), cell("1. Optical isomerism + RS nomenclature\n2. Synthesis of quinoline (Skraup) & indole (Fischer)\n3. Beckmann rearrangement mechanism", { fill: "E3F2FD" }), cell("~40–50 marks", { fill: "E3F2FD", center: true, bold: true })] }),
    new TableRow({ children: [cell("Medicinal Chemistry I", { fill: "F3E5F5", bold: true }), cell("1. SAR of benzodiazepines + structures of Diazepam, Alprazolam\n2. SAR of phenothiazines + Chlorpromazine structure\n3. SAR beta-blockers + Propranolol structure", { fill: "F3E5F5" }), cell("~45–55 marks", { fill: "F3E5F5", center: true, bold: true })] }),
    new TableRow({ children: [cell("Physical Pharma II", { fill: "E8F5E9", bold: true }), cell("1. Rheology — draw & label all 4 flow curves\n2. HLB calculation method + emulsion formulation\n3. First-order kinetics numerical + shelf-life calculation", { fill: "E8F5E9" }), cell("~40–45 marks", { fill: "E8F5E9", center: true, bold: true })] }),
    new TableRow({ children: [cell("Pharmacology I", { fill: "FFF3E0", bold: true }), cell("1. Pharmacokinetics (ADME) — full detail\n2. Receptor theories + classification (G-protein pathway diagram)\n3. ANS organization + neurotransmitter classification table", { fill: "FFF3E0" }), cell("~45–50 marks", { fill: "FFF3E0", center: true, bold: true })] }),
    new TableRow({ children: [cell("Pharmacognosy I", { fill: "FFF8E1", bold: true }), cell("1. Classification of crude drugs (all 6 types with examples)\n2. Secondary metabolites — Alkaloids, Glycosides, Flavonoids tests\n3. Lycopodium spore method + leaf constants (numbers)", { fill: "FFF8E1" }), cell("~40–45 marks", { fill: "FFF8E1", center: true, bold: true })] }),
  ]
}));
children.push(spacer());

// FINAL MOTIVATION
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      new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: "You have everything you need. 10 days, 4 hours a day, consistent effort.", bold: true, size: 26, color: "FFFFFF" })] }),
      new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: "Follow this plan, sleep well, stay hydrated, and trust the process.", size: 24, color: "BDD7EE", italics: true })] }),
      new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: "ALL THE BEST FOR YOUR EXAMS!", bold: true, size: 28, color: "FFD700" })] }),
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}));

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cd /home/daytona/workspace/bpharm-organic-chem && node generate_timetable.js 2>&…

python3 -c " import zipfile, os f = '/home/daytona/workspace/bpharm-organic-chem…