Reduced SHBG means your blood level of sex hormone-binding globulin is low. SHBG is a liver-made protein that carries testosterone and estrogen in the bloodstream.
When SHBG is low, a larger proportion of testosterone may be free (biologically active). It does not automatically mean your total testosterone is high or that you have a hormone disorder. Interpretation depends on your sex, symptoms, lab reference range, total testosterone or estradiol, albumin, and sometimes calculated free testosterone.
Common associations with low SHBG include:
- Overweight/obesity and insulin resistance or type 2 diabetes
- Hypothyroidism
- PCOS, in females
- Cushing syndrome
- Use of anabolic steroids or some steroid medicines
- Aging in some people
If you share the SHBG value, units, reference range, sex at birth, and related results such as total testosterone, free testosterone, TSH, glucose/HbA1c, I can help explain what the pattern may mean.