Septic Arthritis - Orthopedic Notes
Definition
Septic arthritis is infection of a joint space, usually bacterial, causing acute synovial inflammation, purulent effusion, rapid cartilage destruction, and possible sepsis. It is an orthopedic emergency.
It is usually monoarticular and most often affects the knee, followed by the hip and shoulder. Delay in drainage and antibiotic treatment can cause irreversible articular cartilage loss, stiffness, secondary osteoarthritis, osteomyelitis, and death.
Rosen's Emergency Medicine, p. 2730.
Etiology and routes of infection
Routes
- Hematogenous spread - most common
- Direct inoculation - penetrating injury, intra-articular injection, arthroscopy, surgery
- Contiguous spread - osteomyelitis, cellulitis, abscess
Common organisms
| Clinical group | Common pathogen(s) |
|---|
| Most native-joint infections | Staphylococcus aureus |
| MRSA-prevalent settings / risk factors | MRSA |
| Older adult or immunocompromised patient | Gram-negative bacilli also considered |
| Injection drug use | S. aureus, Pseudomonas |
| Sexually active adolescent/young adult | Neisseria gonorrhoeae |
| Child 6 months to 4 years | S. aureus, Kingella kingae |
| Neonate | Group B streptococcus, S. aureus, Gram-negative organisms |
| Sickle-cell disease | Salmonella |
Risk factors
- Diabetes mellitus
- Rheumatoid arthritis, osteoarthritis, gout, or other pre-existing joint disease
- Immunosuppression, corticosteroid therapy, malignancy, HIV
- Chronic kidney or liver disease
- Intravenous drug use
- Recent joint injection, arthroscopy, trauma, or surgery
- Skin infection, infected wound, bacteremia
- Prosthetic joint
- Extremes of age
Clinical features
Symptoms
- Acute onset severe joint pain
- Pain markedly aggravated by both active and passive movement
- Swelling, warmth, erythema, and tenderness
- Restricted range of movement
- Fever, malaise, anorexia, or inability to bear weight
Important findings
- Knee: painful swollen joint with effusion, held in slight flexion
- Hip: painful limitation of all movements, especially internal rotation; patient may keep hip flexed, abducted, and externally rotated
- Children: refusal to walk or use limb, pseudoparalysis
- Fever may be absent, particularly in elderly or immunocompromised patients
Any acute atraumatic painful joint with marked restriction of passive movement should be treated as septic arthritis until excluded.
Investigations
1. Blood tests
- CBC: leukocytosis may be present but is non-specific
- CRP: useful baseline and for monitoring response
- ESR: supportive but rises and falls more slowly
- Blood culture: obtain at least two sets before antibiotics if this does not delay treatment
Normal inflammatory markers do not reliably exclude septic arthritis.
2. Joint aspiration - most important test
Perform urgent sterile arthrocentesis, preferably before antibiotics in a stable patient.
Send synovial fluid for:
- Gram stain
- Culture and sensitivity, including inoculation into blood-culture bottles if available
- White-cell count and differential
- Crystal analysis
Typical synovial-fluid features
| Feature | Suggestive of septic arthritis |
|---|
| Appearance | Turbid or purulent |
| WBC count | Often >50,000 cells/mm³ |
| Neutrophils | Usually >90% |
| Gram stain | May be positive, but a negative result does not exclude infection |
| Culture | Diagnostic when positive |
A synovial WBC count above 50,000/mm³ raises suspicion, but lower counts may occur in early infection, gonococcal infection, immunosuppression, or prior antibiotic exposure. Crystals do not rule out concurrent infection.
Current SANJO guidance recommends prioritizing synovial-fluid bacterial identification, followed by WBC count with PMN percentage and crystal analysis, as summarized in the
SANJO guideline.
3. Imaging
- Plain radiograph: baseline evaluation, excludes fracture, may show soft-tissue swelling or joint-space widening early; later joint-space loss, erosions, and subchondral destruction.
- Ultrasound: detects effusion and guides aspiration, particularly for hip, shoulder, and deep joints.
- MRI: detects adjacent osteomyelitis, pyomyositis, abscess, cartilage/bone involvement, or deep-joint infection.
- CT is useful when MRI is unavailable or for complex anatomy and surgical planning.
Differential diagnosis
- Crystal arthritis: gout or CPPD
- Hemarthrosis
- Acute flare of rheumatoid arthritis or osteoarthritis
- Reactive arthritis
- Transient synovitis of hip in children
- Cellulitis/bursitis
- Osteomyelitis
- Fracture or internal derangement
- Avascular necrosis
Management
Principles
Urgent aspiration + cultures + IV antibiotics + adequate joint drainage.
Initial approach
- Assess for sepsis or septic shock, begin resuscitation where needed.
- Obtain blood cultures.
- Aspirate the involved joint urgently.
- Start empiric IV antibiotics immediately after samples are obtained.
- Consult orthopedics early for drainage.
- Modify antibiotic regimen according to culture and susceptibility results.
- Monitor clinical status, CRP, WBC count, cultures, and range of movement.
If the patient is septic, unstable, or aspiration would cause harmful delay, do not delay antibiotics.
Empiric antibiotics
Choice must follow local antibiogram, age, allergy history, comorbidities, bacteremia risk, and Gram stain.
Typical principles:
- Cover S. aureus in all patients.
- Add MRSA coverage where prevalent or if patient-specific risk is high.
- Add Gram-negative coverage in elderly, immunocompromised patients, intravenous drug users, or when Gram-negative infection is suspected.
- Narrow therapy as soon as cultures are available.
Antibiotics should ideally start after joint aspiration and blood cultures in a stable patient. The
SANJO recommendations support this sequence and recommend culture-directed therapy.
Drainage options
| Method | Role |
|---|
| Repeated needle aspiration | May be appropriate in selected accessible joints, early disease, or some children, with close reassessment |
| Arthroscopic washout | Common preferred method for many large native joints, especially knee and shoulder |
| Open arthrotomy | Hip infection, difficult/advanced infection, loculations, extensive synovitis, failure of arthroscopy or aspiration, or associated osteomyelitis |
Hip septic arthritis requires urgent drainage, especially in children, because intracapsular pressure can compromise the femoral-head blood supply and risk avascular necrosis.
Surgery should not be delayed in a septic patient. In clinically stable native-joint infection, a short delay up to 24 hours may be considered only after aspiration/irrigation, initiation of antibiotics, and when timely surgery by an experienced team is assured, according to the
SANJO guideline.
Antibiotic duration
Duration depends on organism, joint, response, drainage adequacy, and associated osteomyelitis.
- Uncomplicated native-joint infection often requires approximately 2 to 4 weeks total therapy after adequate drainage, tailored to clinical and microbiological response.
- Longer treatment is needed with osteomyelitis, abscess, resistant organisms, immunosuppression, delayed control, or persistent infection.
- In uncomplicated pediatric native-joint infection responding promptly, SANJO suggests a minimum of 2-4 days IV treatment and 2-3 weeks total treatment, but local pediatric and infectious-disease protocols take priority.
Indications for repeat aspiration or repeat washout
- Persistent fever or systemic illness
- Ongoing severe pain/swelling
- Rising or non-falling CRP
- Persistent positive cultures/bacteremia
- Re-accumulation of effusion
- Failure to regain movement
- Inadequate initial drainage
- Associated osteomyelitis or abscess
Complications
- Articular cartilage destruction
- Joint stiffness and reduced range of movement
- Secondary osteoarthritis
- Osteomyelitis
- Growth-plate damage in children
- Avascular necrosis of femoral head, especially with hip involvement
- Pathological dislocation or subluxation
- Sepsis and death
Even with prompt management, septic arthritis can leave substantial functional impairment. Rosen's Emergency Medicine, p. 2730.
Exam-oriented summary
Acute hot swollen joint + pain on passive movement = septic arthritis until proved otherwise.
Gold-standard diagnostic step: urgent synovial-fluid aspiration for Gram stain, culture, cell count, and crystals.
Core treatment:
Aspiration and cultures → IV empirical antibiotics → urgent washout/drainage → culture-directed antibiotics → rehabilitation.
Most common organism: Staphylococcus aureus.