EPIDEMIOLOGY: Definition and Epidemiology of Tuberculosis (35 Marks)

PART I: DEFINITION OF EPIDEMIOLOGY

Etymology

• epi = among
• demos = people
• logos = study

Historical Definitions

1. Parkin (1873): "That branch of medical science which treats epidemics."
2. Frost (1927): "The science of the mass phenomena of infectious diseases."
3. Greenwood (1934): "The study of disease, any disease, as a mass phenomenon."
4. MacMahon (1960): "The study of the distribution and determinants of disease frequency in man."

Modern / Accepted Definition (IEA/Last)

"The study of the occurrence and distribution of health-related events, states, and processes in specified populations, including the study of the determinants influencing such processes, and the application of this knowledge to control relevant health problems."

• Study - includes surveillance, observation, screening, hypothesis testing, analytic research, experiments, and prediction.
• Distribution - refers to analysis by time, place, and population (descriptive epidemiology).
• Determinants - the geophysical, biological, behavioural, social, cultural, economic, and political factors that influence health (analytical epidemiology).
• Health-related events, states, and processes - includes outbreaks, diseases, disorders, causes of death, behaviours, environmental and socio-economic processes, effects of preventive programmes, and use of health and social services.
• Specified populations - those with common contexts and identifiable characteristics.
• Application to control - makes explicit the ultimate aim: to promote, protect, and restore health.

Three Core Components

1. Disease frequency - Measurement of how often disease occurs (rates, ratios such as incidence rate, prevalence rate, death rate).
2. Distribution of disease - Studying patterns by time, place, and person (who, when, where).
3. Determinants of disease - Identifying the underlying causes or risk factors (analytical epidemiology).

Aims of Epidemiology (IEA)

• (a) To describe the distribution and magnitude of health and disease problems in human populations.
• (b) To identify aetiological factors (risk factors) in the pathogenesis of disease.
• (c) To provide data essential for planning, implementation, and evaluation of services for prevention, control, and treatment of disease.

Epidemiology vs. Clinical Medicine

PART II: EPIDEMIOLOGY OF TUBERCULOSIS

Definition

1. PROBLEM STATEMENT (Global Burden)

• Approximately one-third of the world population is infected asymptomatically with M. tuberculosis, of whom 5-10% will develop clinical disease during their lifetime.
• The annual risk of TB infection in high-burden countries is estimated at 0.5-2%.
• Globally, 10 million people had TB in 2019.
• There were 1.2 million TB deaths among HIV-negative people plus an additional 208,000 deaths among HIV-positive people in 2019.
• One untreated patient with infectious pulmonary TB can infect 10-15 persons per year.
• In 2018, 86% of all TB cases were in the WHO regions of Southeast Asia (44%), Africa (24%), and the Western Pacific (18%).
• Most high-income countries have an incidence of less than 10 per 100,000 population.
• WHO has declared TB a global public health emergency and the WHO End TB Strategy (2014) aims to reduce TB deaths by 90% and new cases by 80% between 2015 and 2030.

2. BURDEN IN INDIA

• India accounts for 26% of the estimated global incident TB cases in 2019 - the highest TB burden country in the world in absolute numbers.
• Age distribution shows a predominance in adolescent and young adult age groups (15-30 years), indicating ongoing active disease transmission.
• Men (56%) account for the majority of cases; women 32%; children (<15 years) 12%.

3. NATURAL HISTORY OF TUBERCULOSIS

A. AGENT FACTORS

• Mycobacterium tuberculosis - a facultative intracellular parasite, readily ingested by phagocytes and resistant to intracellular killing.
• Two strains important to man: human strain (responsible for the vast majority of cases) and bovine strain (mainly affects cattle; transmitted via infected milk).
• Atypical mycobacteria (e.g., M. kansasii, M. scrofulaceum, M. intercellulare) can also cause TB-like disease.

• Human source (most common): An open case with sputum-positive TB. One infectious case can infect 10-15 people per year. Slow-multiplying bacilli can remain dormant for years and cause relapse.
• Bovine source: Infected milk. Less important in countries where milk is boiled before consumption.

• Patients are infective as long as they remain untreated. Effective antimicrobial treatment reduces infectivity by 90% within 48 hours.

B. HOST FACTORS

• TB affects all ages. In developing countries, infection rates rise sharply from childhood to adolescence. In India, infection rate rises from ~2% in the 0-14 year group to ~20% in the 15-24 year group. In developed countries, the disease is now more common in the elderly.

• More prevalent in males than in females.

• TB is not a hereditary disease. However, twin studies indicate that inherited susceptibility is an important risk factor.

• Malnutrition is widely believed to predispose to tuberculosis. It affects disease development, treatment outcome, and disease spread - and remains a major factor in developing countries.

• Man has no inherited immunity against TB. Immunity is acquired through natural infection or BCG vaccination. Cell-mediated immunity (delayed hypersensitivity) is the key immune mechanism; in most cases it limits further multiplication of bacilli.

• HIV/AIDS: People living with HIV are 20-30 times more likely to develop TB than those without HIV. TB causes one in three HIV deaths, with 70% of HIV-TB cases in Africa. In 2018, 8.6% of all TB cases were among persons with HIV infection.
• Diabetes mellitus: Triples the risk of TB and increases likelihood of poor treatment outcomes. Worldwide prevalence of diabetes among TB patients is approximately 15.3%.
• Poverty: Crowded and poorly ventilated living spaces, malnutrition, and lack of empowerment to act on health issues all increase TB risk and transmission.

C. ENVIRONMENTAL / SOCIAL FACTORS

• Overcrowding and poor housing - promote droplet transmission
• Poor ventilation - allows accumulation of droplet nuclei
• Malnutrition and undernutrition
• Poverty and low standard of living
• Smoking and alcohol abuse
• Lack of education and awareness
• Large families, early marriages, population explosion

D. MODE OF TRANSMISSION

• TB is transmitted mainly by droplet infection and droplet nuclei generated by sputum-positive patients with pulmonary TB.
• Droplet particles must be fresh enough to carry a viable organism.
• Coughing generates the largest number of droplets of all sizes.
• The frequency and vigour of cough and the ventilation of the environment influence transmission.
• TB is not transmitted by fomites (dishes, articles used by patients); sterilization of these articles is therefore of little value.
• Patients with extrapulmonary TB or smear-negative TB constitute a minimal hazard for transmission.

E. INCUBATION PERIOD

• Time from infection to development of a positive tuberculin test: 3 to 6 weeks.
• Thereafter, development of disease depends on: closeness of contact, extent of disease, sputum positivity of the source case (dose of infection), and host-parasite relationship.
• The incubation period may therefore range from weeks, months to years.

4. EPIDEMIOLOGICAL INDICES

5. DRUG-RESISTANT TUBERCULOSIS

• MDR-TB: Resistant to at least isoniazid and rifampicin (the two most effective first-line drugs).
• XDR-TB: MDR-TB also resistant to at least one fluoroquinolone and at least one injectable second-line agent.
• In 2018, an estimated 500,000 people developed rifampicin-resistant TB; 78% had MDR-TB.
• Nearly half of all rifampicin-resistant/MDR-TB cases were from India (24%), China (13%), and Russia (10%).
• XDR-TB was first reported in 2006 and has since been reported in 131 WHO member states (as of 2018).
• Cure rates for MDR-TB (56%) are far lower than drug-susceptible TB (85%).

6. TUBERCULOSIS AND HIV (THE DUAL EPIDEMIC)

• TB causes one in three HIV deaths globally.
• Most HIV-TB cases and deaths are in Africa (where 70% of the 37 million PLHIV live).
• Co-infection creates a vicious cycle: HIV-mediated immunosuppression accelerates TB progression, and TB accelerates HIV disease.

7. GLOBAL STRATEGY AND TARGETS

8. IMPACT OF COVID-19 ON TB

Summary Table: Epidemiological Triad for Tuberculosis

• Park's Textbook of Preventive and Social Medicine (Park K.), Chapter on Epidemiology and Tuberculosis
• Murray & Nadel's Textbook of Respiratory Medicine, Chapter 51 (Epidemiology of Tuberculosis)

EPIDEMIOLOGY OF CORONARY HEART DISEASE (35 Marks)

1. DEFINITION AND INTRODUCTION

"Impairment of heart function due to inadequate blood flow to the heart compared to its needs, caused by obstructive changes in the coronary circulation."

Clinical Presentations of CHD

• Angina pectoris of effort
• Myocardial infarction (MI) - specific to CHD
• Irregularities of the heart (arrhythmias)
• Cardiac failure
• Sudden death

2. MEASURING THE BURDEN OF DISEASE

3. GLOBAL BURDEN (PROBLEM STATEMENT)

• CHD caused 7.2 million deaths (with some estimates up to 9.4 million) globally in 2016.
• It accounts for 12.8-16.6% of all deaths worldwide - making it the single leading cause of death globally.

International Variations (Table: Mortality due to CHD, Global Estimates 2016)

• The highest coronary mortality is seen in the Western Pacific and European Regions.
• Rates in the Americas and Eastern Mediterranean are comparatively lower.

4. EPIDEMICITY (TRENDS OVER TIME)

• "Epidemics" of CHD began at different times in different countries:
  • USA: epidemic began in the early 1920s; a steady decline was evident from 1968 onwards; a 25% fall in mortality was recorded by 1980.
  • Britain: epidemic began in the 1930s.
  • European countries: still later.
  • Developing countries: now catching up.
• Substantial declines in CHD mortality have occurred in the USA, Australia, Canada, and New Zealand.
• The decline is attributed to:
  • Changes in lifestyle and related risk factors (diet, serum cholesterol, cigarette use, exercise habits)
  • Better control of hypertension
  • Improvements in medical care
• The WHO MONICA project ("Multinational Monitoring of Trends and Determinants in Cardiovascular Diseases") involving 41 centres in 26 countries was set up to study these changing trends.
• Historical social class shift: CHD was initially a disease of higher social classes in the most affluent societies. Today, there is a strong inverse relationship between social class and CHD in developed countries - the poor are now more affected.
• Even in countries showing a decline, CHD remains the most frequent single cause of death among men under 65.

5. CORONARY HEART DISEASE IN INDIA

• CHD is assuming serious dimensions in developing countries, including India.
• Considerable increase in the prevalence of CHD in urban areas over recent decades.
• Increase in rural areas too, but less steep - lifestyle changes have affected urban populations more.

• 25.1% of total deaths in urban areas are attributable to diseases of the circulatory system.
• In 2016, an estimated 16,08,700 people died of CHD in India - 10,00,800 men and 6,07,800 women.
• Crude death rate: 121.5 per 100,000 population.

6. DESCRIPTIVE EPIDEMIOLOGY: TIME, PLACE, PERSON

A. Time

• CHD was relatively rare in the early 20th century. It emerged as a major killer mid-century.
• Clear secular trends: rising mortality in mid-20th century, declining in developed nations since the 1970s-1980s.
• Seasonal variation: higher mortality in winter months (cold, increased blood viscosity, sympathetic activation).

B. Place

• Highest mortality: Finland, Russia, Eastern Europe, UK historically.
• Lowest: Japan, Mediterranean countries, sub-Saharan Africa.
• The Seven Countries Study (Ancel Keys) demonstrated marked geographic variation - Japanese had low fat diets, low serum cholesterol, and low CHD incidence; East Finns were at the other extreme.
• Urban > Rural prevalence in developing countries like India.

C. Person

• Risk increases progressively with age.
• Uncommon below 30 years; rises sharply after 40 in men and after menopause (~55) in women.

• Men are affected earlier and more frequently than women.
• Pre-menopausal women have relative protection (attributed to oestrogen's favourable effect on lipids).
• After menopause, women's risk approaches that of men.

• South Asians (Indians, Pakistanis) have disproportionately higher rates of CHD, often at a younger age.
• Black and Hispanic populations in the USA show different patterns and poorer outcomes.

• Originally higher in affluent classes; now higher in lower socioeconomic groups in developed countries.

7. RISK FACTORS FOR CHD

A. Non-Modifiable Risk Factors

B. Modifiable Risk Factors

1. Cigarette Smoking

• A major CHD risk factor with multiple mechanisms:
  • Carbon monoxide-induced atherogenesis
  • Nicotine stimulation of adrenergic drive (raises BP and myocardial O₂ demand)
  • Adverse lipid metabolism (fall in protective HDL)
• Responsible for 25% of CHD deaths under 65 years in men in countries with widespread smoking.
• Particularly important in causing sudden death from CHD in men under 50.
• Risk is directly proportional to number of cigarettes smoked per day.
• Effect is synergistic with hypertension and elevated serum cholesterol (more than additive).
• After cessation: risk declines substantially within 1 year; after 10-20 years it equals that of non-smokers.
• For those with prior MI, risk of fatal recurrence may be reduced by 50% after stopping smoking.

2. Hypertension

• The single most useful test for identifying individuals at high risk of CHD.
• Hypertension accelerates atherosclerosis, especially in the presence of hyperlipidaemia.
• Both systolic and diastolic blood pressure are significant risk factors; many investigators feel systolic BP is a better predictor of CHD.
• The risk role of "mild" hypertension is well accepted.

3. Serum Cholesterol and Lipoproteins

• Triangular relationship: habitual diet → blood cholesterol-lipoprotein levels → CHD.
• No population with a high CHD incidence has a mean cholesterol below 200 mg/dL.
• The Seven Countries Study (14-year data) showed cholesterol is an important risk factor, particularly at levels ≥220 mg/dL ("threshold level").
• LDL cholesterol: most directly associated with CHD.
• VLDL: associated with premature atherosclerosis and peripheral vascular disease.
• HDL cholesterol: protective - the higher the HDL, the lower the CHD incidence. HDL should be >40 mg/dL.
• Total cholesterol/HDL ratio: <3.5 recommended as clinical goal for CHD prevention.
• Apolipoproteins: ApoB (major LDL protein) and ApoA-I (major HDL protein) are better predictors than LDL/HDL cholesterol levels.

4. Other Risk Factors

• Risk of CHD is 2-3 times higher in diabetics compared to non-diabetics.
• Atherosclerosis is accelerated in diabetes due to hyperlipidaemia and endothelial dysfunction.

• Particularly central (abdominal) obesity (android pattern) is associated with dyslipidaemia, insulin resistance, hypertension, and CHD.
• Even moderate weight loss significantly reduces cardiovascular risk.

• Physical activity protects against CHD by: raising HDL, lowering BP, improving insulin sensitivity, reducing obesity.
• Physically active individuals have lower CHD incidence than sedentary individuals.

• Chronic stress elevates catecholamines, promotes hypertension and platelet aggregation.
• Type A behaviour (competitive drive, restlessness, hostility, sense of urgency/impatience) is associated with increased CHD risk compared to Type B individuals.

• High alcohol intake (≥75 g/day) is an independent risk factor for CHD, hypertension, and all cardiovascular diseases.

• Women using OCP have higher systolic and diastolic BP.
• Risk of MI is increased by OCP, especially when combined with smoking.

• Low dietary fibre intake, high sucrose intake, soft water consumption.
• Dyspnoea on exertion and low vital capacity cited as possible risk factors.

Risk Factor Interactions

8. NATURAL HISTORY AND PATHOGENESIS

• CHD begins with atherosclerosis of the coronary arteries - a chronic process starting in childhood.
• Key stages: endothelial injury → lipid deposition → foam cell formation → fibrous plaque → complicated plaque (rupture, thrombosis) → MI or sudden death.
• Positive tuberculin test analogy: just as in TB, CHD has a long subclinical phase followed by clinical disease.
• Disease may be latent for decades, with the first manifestation being MI or sudden death.

9. PREVENTION OF CHD

a. Population Strategy

• Address risk factors in whole populations (mass approach).
• Small changes in risk factor levels in the total population achieve the biggest reduction in mortality.
• Key interventions:
  • Dietary changes: Reduce total fat to 20-30% of energy intake; saturated fat <10%; dietary cholesterol <100 mg/1000 kcal/day; increase complex carbohydrates and dietary fibre; reduce salt and sugar.
  • Tobacco control: Reduce smoking prevalence.
  • Physical activity: Increase population activity levels.
  • Control of hypertension: Screen and treat.

b. High-Risk Strategy

• Identify and target individuals at high risk (through screening for risk factors).
• Drug therapy for hypertension, dyslipidaemia, diabetes.

c. Secondary Prevention

• For those who have already had a CHD event.
• Lifestyle modification + medications (statins, antiplatelets, beta-blockers, ACE inhibitors).
• Cardiac rehabilitation.

10. SUMMARY TABLE

• Park's Textbook of Preventive and Social Medicine (K. Park), Chapter on Coronary Heart Disease
• Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine
• WHO Global Health Estimates 2016

THE DEMOGRAPHIC CYCLE

CONCEPT

• They begin with high birth rates and high death rates (population stable).
• Death rates then fall due to improvements in sanitation, nutrition, and medicine.
• Birth rates eventually follow, falling due to education, urbanisation, and family planning.
• The endpoint is low birth rates and low death rates (population again stable, or declining).

THE FIVE STAGES

Stage 1 - HIGH STATIONARY

• High birth rates are maintained by the need for labour, absence of contraception, and high infant mortality.
• High death rates result from famine, epidemics, war, and lack of medical care.
• Population remains essentially stationary over generations.
• India was in this stage until 1920.

Stage 2 - EARLY EXPANDING

• The death rate starts to fall due to improvements in:
  • Sanitation and safe water supply
  • Nutrition and food security
  • Medical advances (vaccines, antibiotics)
  • Better maternal and child health care
• The birth rate remains unchanged or may even increase in some countries (improved health conditions, shortening of breast-feeding periods allowing shorter inter-birth intervals).
• The result is a widening gap between birth and death rates - population begins to expand rapidly.
• Many countries in South Asia and Africa are currently in this stage.

Stage 3 - LATE EXPANDING

• The death rate declines still further.
• The birth rate tends to fall as a result of:
  • Rising literacy and female education
  • Urbanisation (children become economic burden rather than asset)
  • Spread of family planning methods
  • Later age at marriage
  • Changing social values
• Population continues to grow because births still exceed deaths, but the rate of growth begins to slow.
• India has entered this phase.
• In a number of developing countries (e.g., China, Singapore), birth rates have declined rapidly in this stage.

Stage 4 - LOW STATIONARY

• Both birth rate and death rate are low and roughly equal.
• Population becomes stationary once again - but at a much larger total size than in Stage 1.
• Zero population growth has already been recorded in Austria (1980-85).
• Growth rates as low as 0.1% were recorded in UK, Denmark, Sweden, and Belgium during 1980-85.
• Most industrialized (developed) countries have undergone this demographic transition - shifting from high birth and high death rates to low birth and low death rates.

Stage 5 - DECLINING

• The birth rate falls below the death rate - population begins to decline.
• Caused by: increasing cost of child-rearing, high female workforce participation, social trends toward smaller families.
• Some East European countries, notably Germany and Hungary, are experiencing this stage.

DIAGRAMMATIC REPRESENTATION

Birth/Death  
   Rate
     |
High |----Birth Rate--------------------------------\
     |                                              \
     |----Death Rate-----------\                    \  Birth Rate
     |                          \                    \___________
     |                           \___Death Rate_________________
Low  |
     |_________________________________________________
          Stage 1   Stage 2   Stage 3   Stage 4   Stage 5
        (High Stat)(Early Exp)(Late Exp)(Low Stat)(Declining)

• The gap between birth rate and death rate in Stages 2 and 3 = population explosion
• Stages 1 and 4 = population stationary (but for different reasons)
• Stage 5 = population decline

SUMMARY TABLE

SIGNIFICANCE OF THE DEMOGRAPHIC CYCLE

1. Population explosion occurs in Stage 2-3: the gap between a falling death rate and a still-high birth rate is the engine of the world's rapid population growth.
2. It explains why developing countries face population pressure - they are in Stages 2 and 3.
3. It provides a framework for health policy: countries must accelerate the fertility transition (move from Stage 2 to 3) through education, family planning, and women's empowerment.
4. It predicts a future demographic dividend once birth rates fall - a large working-age population relative to dependents, as seen in India today.
5. Stage 4 and 5 countries face population ageing problems: shrinking workforce, pension burdens, and rising healthcare costs for the elderly.

INDIA'S POSITION IN THE DEMOGRAPHIC CYCLE

• Before 1920: Stage 1 - high birth rate (~49/1000) and high death rate (~48/1000).
• 1920-1947: Entry into Stage 2 - death rate began falling due to better control of plague, cholera, and other epidemics.
• Post-independence: Deep into Stage 2 - rapid fall in death rate while birth rate remained high → population explosion.
• Present: Stage 3 - birth rate declining (due to family planning programmes, improved literacy, urbanisation), death rate already low.
• Goal: To move quickly to Stage 4 through accelerated fertility decline via the National Family Planning Programme and related policies.

LEVELS OF HEALTH CARE

INTRODUCTION

LEVEL 1 - PRIMARY HEALTH CARE (PHC)

Definition

"Essential health care based on practical, scientifically sound and socially acceptable methods and technology made universally accessible to individuals and families in the community through their full participation and at a cost that the community and the country can afford to maintain at every stage of their development in the spirit of self-determination."

Key Features

• It is the first level of contact between the individual, family, community, and the national health system.
• It is the level closest to the people - where most health problems can be dealt with and resolved.
• A majority of prevailing health complaints can be satisfactorily managed at this level.
• Described as: "Health by the people" and "Placing people's health in people's hands."
• PHC was accepted as the key to achieving "Health for All by 2000 A.D." (HFA).

In the Indian Context

• Sub-centres (most peripheral unit)
• Primary Health Centres (PHCs)
• Community Health Centres (CHCs) (first referral unit at PHC level)
• Through the agency of: Multipurpose health workers, ANM (Auxiliary Nurse Midwife), ASHA (Accredited Social Health Activist), Anganwadi workers, village health guides, and trained dais

8 Essential Elements of PHC (Alma-Ata Declaration)

4 Principles of PHC

1. Equitable Distribution

• Health services must be shared equally by all people irrespective of their ability to pay.
• All - rich or poor, urban or rural - must have access to health services.
• Health services are currently concentrated in cities; PHC aims to shift the centre of gravity to rural areas (where three-quarters of the people live, but only one-quarter of the health budget is spent).
• Aims to redress the imbalance caused by inaccessibility - the major reason for failure to reach the majority.

2. Community Participation

• Involvement of individuals, families, and communities in promotion of their own health and welfare is an essential ingredient of PHC.
• Universal coverage cannot be achieved without community involvement.
• Requires community participation in planning, implementation, and maintenance of health services.
• India's approach: Use of village health guides, trained dais, ASHA workers, and Anganwadi workers - selected by and trained for the community they serve.
• Influenced by China's experience with "bare-foot doctors".

3. Intersectoral Coordination

• Components of PHC cannot be provided by the health sector alone.
• Requires coordination with: agriculture, animal husbandry, food, industry, education, housing, public works, communication, and other sectors.
• Requires political will, administrative reform, reallocation of resources, and legislation.
• Avoids unnecessary duplication of activities through joint planning.

4. Appropriate Technology

• Technology that is scientifically sound, adaptable to local needs, acceptable to users, and maintainable by the community with available resources.
• Avoids costly equipment and procedures when cheaper, valid alternatives exist (e.g., oral rehydration fluid, standpipes instead of house-to-house water connections).
• Opposes building large luxurious hospitals inappropriate to local needs that absorb the majority of the national health budget.

LEVEL 2 - SECONDARY HEALTH CARE

Definition and Features

• The second (intermediate) level of care in the health system.
• Deals with more complex problems that cannot be managed at the primary level.
• Comprises essentially curative services.
• Serves as the first referral level in the health system.
• Patients are referred here from the primary level.

In the Indian Context

• District Hospitals - serve the whole district population
• Community Health Centres (CHCs) - function as the first referral unit
• Sub-divisional/Taluka hospitals

Services at Secondary Level

• General medicine, surgery, obstetrics and gynaecology, paediatrics
• Basic diagnostic services (laboratory, X-ray, ECG, ultrasound)
• Emergency services and minor surgical procedures
• Blood bank services
• Specialist consultations not available at PHC level

LEVEL 3 - TERTIARY HEALTH CARE

Definition and Features

• The highest, most specialized level of health care.
• Deals with super-specialist care requiring specific highly specialized facilities and highly trained health workers.
• Provides both highly specialized care AND planning, managerial skills, and teaching for specialized staff.
• The tertiary level also supports and complements actions carried out at the primary level.
• Patient flow: referred from the secondary level.

In the Indian Context

• Medical College Hospitals (Government and private)
• All India Institutes (AIIMS, PGI Chandigarh, JIPMER, etc.)
• Regional Hospitals and Specialized Hospitals
• Apex Institutions (National Cancer Institute, National Institute of Mental Health, etc.)

Services at Tertiary Level

• Cardiology, neurosurgery, oncology, nephrology, organ transplantation
• Advanced diagnostic services (MRI, PET scan, genetic testing)
• Teaching and research
• National-level policy guidance and technical leadership

REFERRAL SYSTEM

• Patients referred upward from primary → secondary → tertiary for increasing complexity of care.
• Patients returned downward (back referral) to those who referred them for follow-up care.

• Continuity of care
• Appropriate use of specialized services
• Inspires confidence of the consumer in the system

SUMMARY TABLE

CHANGING CONCEPTS IN HEALTH CARE

1. Comprehensive Health Care

• Term first used by the Bhore Committee (1946).
• Provision of integrated preventive, curative, and promotive health services from "womb to tomb" to every individual in a defined geographic area.

2. Selective Health Care

• Focuses on specific high-priority interventions (e.g., immunization, ORS, breastfeeding promotion) rather than comprehensive services.
• Cost-effective but limited in scope.

3. Primary Health Care Approach (Post-Alma Ata 1978)

• A radical departure from conventional health systems.
• Integrates promotive, preventive, and curative services.
• An integral part of the country's socio-economic development plan.
• The deprofessionalization of medicine - laypersons (community health workers, ASHA, anganwadi workers) play a prominent role in health care delivery.

CONCLUSION

• Strengthening the primary level as the foundation (most services, most accessible, least cost)
• A functional referral and back-referral system
• Equitable distribution so that all populations, especially the rural poor, can access care
• Community participation and intersectoral coordination at the primary level