Migraine
Migraine is a common recurrent primary headache disorder. It is characterized by attacks of moderate to severe, usually unilateral, pulsating headache associated with nausea, vomiting, and sensitivity to light and sound. It is more common in females and may have a family history.
Types
- Migraine without aura: Headache occurs without preceding neurologic symptoms.
- Migraine with aura: Headache is preceded or accompanied by reversible neurologic symptoms, most often visual disturbances such as flashing lights, zig-zag lines, or blind spots. Sensory or speech symptoms can also occur.
- Chronic migraine: Headache on 15 or more days per month for over 3 months, with migraine features on at least 8 days per month.
Causes and triggers
The exact cause is not fully understood. Migraine involves altered brain pain pathways and activation of the trigeminal nerve system. Common triggers include:
- Stress or anxiety
- Lack of sleep or excessive sleep
- Skipping meals and dehydration
- Bright lights, loud sounds, or strong smells
- Menstruation or hormonal changes
- Alcohol, excess caffeine, and some foods
- Certain medicines
Clinical features
A migraine attack may have four stages:
- Prodrome: Tiredness, yawning, irritability, food cravings, and poor concentration.
- Aura: Visual symptoms, tingling, dizziness, or speech disturbance.
- Headache phase: Throbbing headache, often one-sided, worsened by routine activity. Nausea, vomiting, photophobia, and phonophobia are common.
- Postdrome: Fatigue, weakness, and difficulty concentrating after the headache resolves.
Diagnosis
Diagnosis is mainly clinical, based on the pattern of recurrent headaches and associated symptoms. A headache diary helps identify triggers and frequency. Brain imaging is not routinely needed unless there are warning signs or abnormal neurological findings.
Treatment
Acute treatment
- Rest in a quiet, dark room and maintain hydration.
- Paracetamol/acetaminophen or an NSAID such as ibuprofen may help in mild attacks, if safe for the patient.
- Antiemetics such as metoclopramide may be used for nausea and vomiting.
- Triptans such as sumatriptan are used for moderate to severe attacks or when simple analgesics fail.
- Opioids/narcotics should generally be avoided.
Preventive treatment
Preventive therapy is considered when attacks are frequent, prolonged, or disabling. Options include:
- Beta-blockers, for example propranolol
- Antiepileptic drugs, for example topiramate
- Antidepressants, for example amitriptyline
- CGRP-targeting medicines in selected patients
- Regular sleep, meals, exercise, stress management, and avoiding identified triggers
Overuse of painkillers can cause medication-overuse headache. The
NHS migraine guidance advises avoiding painkillers on more than 2 days per week where possible.
Red-flag symptoms
Urgent medical assessment is required for a sudden severe "worst-ever" headache, headache after injury, fever with neck stiffness, seizures, fainting, weakness, persistent speech difficulty, or a major change in the usual headache pattern.
Conclusion
Migraine is a recurrent disabling headache disorder that may occur with or without aura. Early treatment of attacks, avoidance of triggers, and preventive treatment for frequent attacks can greatly reduce symptoms and improve quality of life.