Dosage of udiliv
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Udiliv ursodeoxycholic acid dosage indications
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Here is a complete dosage reference for Udiliv (Ursodeoxycholic Acid / UDCA) - manufactured by Abbott India:
Udiliv - Dosage by Indication
| Indication | Dose | Frequency |
|---|---|---|
| Primary Biliary Cholangitis (PBC) | 13-15 mg/kg/day | 2-4 divided doses with food |
| Gallstone Dissolution (radiolucent cholesterol stones) | 8-10 mg/kg/day | 2-3 divided doses |
| Intrahepatic Cholestasis of Pregnancy | 10-15 mg/kg/day | 2-3 divided doses |
| Non-alcoholic Fatty Liver Disease (NAFLD) | 10-15 mg/kg/day | 2-3 divided doses |
| Primary Sclerosing Cholangitis (PSC) | 13-15 mg/kg/day | 2-4 divided doses |
| Cystic Fibrosis-related liver disease | 20-30 mg/kg/day | 2-3 divided doses |
| Pediatric cholestasis | 10-20 mg/kg/day | Divided doses |
Available Strengths
- Udiliv 150 mg tablets
- Udiliv 300 mg tablets
Key Notes
- Take with food to improve absorption and reduce GI side effects
- Gallstone dissolution may require 6-24 months of therapy; stones recur in ~50% within 5 years of stopping
- Contraindicated in: calcified/radiopaque gallstones, acute cholecystitis, cholangitis, biliary obstruction, biliary-GI fistula
- Renal dose adjustment: Not required (dose as in normal renal function)
- No dose adjustment needed for hepatic impairment in standard use, but use with caution in decompensated cirrhosis
Common Side Effects
Diarrhea, abdominal pain/discomfort, nausea, flatulence, rash, hair thinning, and headache.
Drug Interactions
- Bile acid sequestrants (cholestyramine, colestipol) - reduce absorption; administer 2 hours apart
- Aluminum-containing antacids - reduce absorption
- Fibrates/estrogens/oral contraceptives - may counteract efficacy by increasing cholesterol secretion
The FDA prescribing information for ursodiol confirms the standard 13-15 mg/kg/day dosing for PBC, supported by a multicenter RCT. The PubMed dose-response study (PMID 10524634) found the optimum dose is approximately 900 mg/day (≈13.5 mg/kg/day) for PBC patients.
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