const pptxgen = require("pptxgenjs");
const pres = new pptxgen();
pres.layout = "LAYOUT_WIDE";
pres.title = "Clinical Drug Reference Guide";

// ── THEME ──────────────────────────────────────────────────────────────────
const C = {
  navy:   "1A2E4A",
  teal:   "0E7C86",
  gold:   "F5A623",
  white:  "FFFFFF",
  light:  "EDF4F7",
  dark:   "1C1C1C",
  red:    "C0392B",
  green:  "1E8449",
  gray:   "5D6D7E",
  ltgray: "BDC3C7",
};

// ── HELPERS ────────────────────────────────────────────────────────────────
function titleSlide(title, subtitle) {
  const sl = pres.addSlide();
  sl.background = { color: C.navy };
  sl.addShape(pres.ShapeType.rect, { x: 0, y: 4.2, w: 13.3, h: 0.12, fill: { color: C.gold } });
  sl.addText(title, {
    x: 0.6, y: 1.2, w: 12, h: 2,
    fontSize: 38, bold: true, color: C.white,
    fontFace: "Calibri", align: "center", valign: "middle"
  });
  if (subtitle) {
    sl.addText(subtitle, {
      x: 0.6, y: 3.2, w: 12, h: 0.8,
      fontSize: 18, color: C.gold, fontFace: "Calibri", align: "center"
    });
  }
  sl.addText("Clinical Drug Reference Guide  |  2026", {
    x: 0.6, y: 6.8, w: 12, h: 0.4,
    fontSize: 11, color: C.ltgray, align: "center"
  });
}

function sectionDivider(label) {
  const sl = pres.addSlide();
  sl.background = { color: C.teal };
  sl.addText(label, {
    x: 1, y: 2.4, w: 11.3, h: 1.5,
    fontSize: 32, bold: true, color: C.white,
    fontFace: "Calibri", align: "center", valign: "middle"
  });
}

// Build a drug-info slide using a table layout
// rows: array of [label, value]  (label=bold col, value=detail col)
function drugSlide(heading, subheading, rows) {
  const sl = pres.addSlide();
  sl.background = { color: C.light };

  // Header bar
  sl.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 13.3, h: 1.1, fill: { color: C.navy } });
  sl.addText(heading, {
    x: 0.3, y: 0.05, w: 13, h: 0.65,
    fontSize: 20, bold: true, color: C.white, fontFace: "Calibri", valign: "middle"
  });
  if (subheading) {
    sl.addText(subheading, {
      x: 0.3, y: 0.68, w: 13, h: 0.38,
      fontSize: 12, color: C.gold, fontFace: "Calibri", valign: "middle"
    });
  }

  // Table
  const startY = 1.25;
  const rowH   = (7.5 - startY - 0.2) / rows.length;
  const labelW = 2.6;
  const valW   = 10.4;

  rows.forEach(([label, value], i) => {
    const y = startY + i * rowH;
    const bg = i % 2 === 0 ? C.white : "DDE8EE";

    sl.addShape(pres.ShapeType.rect, { x: 0.2, y, w: labelW, h: rowH - 0.04, fill: { color: C.navy }, line: { color: C.navy } });
    sl.addText(label, {
      x: 0.22, y: y + 0.02, w: labelW - 0.05, h: rowH - 0.08,
      fontSize: 10, bold: true, color: C.white, fontFace: "Calibri", valign: "middle", margin: 3
    });

    sl.addShape(pres.ShapeType.rect, { x: 0.2 + labelW, y, w: valW, h: rowH - 0.04, fill: { color: bg }, line: { color: C.ltgray } });
    sl.addText(value, {
      x: 0.22 + labelW, y: y + 0.02, w: valW - 0.1, h: rowH - 0.08,
      fontSize: 10, color: C.dark, fontFace: "Calibri", valign: "middle", margin: 3, wrap: true
    });
  });

  sl.addText("Clinical Drug Reference Guide  |  2026", {
    x: 0.3, y: 7.2, w: 12, h: 0.25,
    fontSize: 8, color: C.ltgray, align: "right"
  });
}

// ══════════════════════════════════════════════════════════════════════════
//  SLIDE CONTENT
// ══════════════════════════════════════════════════════════════════════════

titleSlide("Clinical Drug Reference Guide", "Dosing · Indications · Contraindications · Duration");

// ─────────────── SECTION 1 ───────────────
sectionDivider("Section 1 — NSAIDs + Paracetamol Combinations");

drugSlide("Aceclofenac 100mg + Paracetamol 325/500mg", "Anti-inflammatory & Analgesic Combination", [
  ["Diseases",       "Osteoarthritis, Rheumatoid arthritis, Dental pain, Dysmenorrhoea, Post-op pain, Muscle pain, Fever with pain"],
  ["Dose (Mild)",    "Aceclofenac 100mg + PCM 325mg — 1 tab twice daily"],
  ["Dose (Moderate)","Aceclofenac 100mg + PCM 500mg — 1 tab twice daily"],
  ["Dose (Severe)",  "Same; do NOT exceed 2 tabs/day — escalate to specialist care"],
  ["Frequency",      "Max 2 times daily (every 12 hrs)"],
  ["With Food",      "AFTER food (reduces GI irritation)"],
  ["Max Daily Dose", "Aceclofenac 200mg/day  |  Paracetamol 1000mg/day in combination"],
  ["Duration",       "Acute pain: 3–5 days  |  Arthritis: as prescribed, with regular review"],
  ["Avoid/Must Avoid","Peptic ulcer, severe renal/hepatic impairment, NSAID allergy, pregnancy (3rd trimester), children <18 yrs, anticoagulant use"],
]);

drugSlide("Diclofenac 50mg + Paracetamol 500mg", "Anti-inflammatory & Analgesic Combination", [
  ["Diseases",       "Arthritis (OA/RA), Back pain, Dental pain, Headache, Post-op pain, Dysmenorrhoea, Sports injuries"],
  ["Dose (Mild)",    "Diclofenac 50mg + PCM 500mg — 1 tab twice daily"],
  ["Dose (Moderate)","1 tab 2–3 times daily"],
  ["Dose (Severe)",  "1 tab 3 times daily (max); consider IV/IM form for severe cases"],
  ["Frequency",      "Max 3 times daily"],
  ["With Food",      "AFTER food or with milk"],
  ["Max Daily Dose", "Diclofenac 150mg/day  |  Paracetamol 1500mg/day in combination"],
  ["Duration",       "Acute: up to 7 days  |  Chronic: minimum effective dose, review monthly"],
  ["Avoid/Must Avoid","Active GI ulcer, severe heart failure, renal failure, 3rd trimester pregnancy, asthma triggered by NSAIDs, children"],
]);

drugSlide("Ibuprofen 400mg + Paracetamol 325mg", "Anti-inflammatory & Analgesic Combination", [
  ["Diseases",       "Fever, Headache, Toothache, Mild-moderate musculoskeletal pain, Common cold symptoms, Dysmenorrhoea"],
  ["Dose (Mild)",    "Ibuprofen 200mg + PCM 325mg — 1 tab 3 times daily"],
  ["Dose (Moderate)","Ibuprofen 400mg + PCM 325mg — 1 tab 3 times daily"],
  ["Dose (Severe)",  "Max dose per category; do NOT self-escalate"],
  ["Frequency",      "Max 3 times daily (every 8 hrs)"],
  ["With Food",      "AFTER food (mandatory to reduce GI risk)"],
  ["Max Daily Dose", "Ibuprofen 1200mg OTC / 2400mg Rx  |  Paracetamol 1000mg in combination"],
  ["Duration",       "Fever/pain: 3–5 days  |  Do not exceed 10 days without review"],
  ["Avoid/Must Avoid","Peptic ulcer, aspirin allergy, renal disease, pregnancy 3rd trimester, children <12 yrs, anticoagulants, liver disease"],
]);

drugSlide("Nimesulide 100mg + Paracetamol 325mg", "COX-2 Preferential NSAID + Analgesic", [
  ["Diseases",       "Acute pain, Osteoarthritis, Dysmenorrhoea, Post-op pain, ENT pain, Dental pain, Fever (short-term)"],
  ["Dose (Mild)",    "1 tab twice daily"],
  ["Dose (Moderate)","1 tab twice daily (same — do not increase)"],
  ["Dose (Severe)",  "Not recommended beyond twice daily; switch to stronger analgesic if needed"],
  ["Frequency",      "Max 2 times daily"],
  ["With Food",      "AFTER food"],
  ["Max Daily Dose", "Nimesulide 200mg/day  |  Paracetamol 650mg/day in this combination"],
  ["Duration",       "MAX 15 days (hepatotoxicity risk with prolonged use) — ideally 5–7 days"],
  ["Avoid/Must Avoid","Children <12 yrs (banned), hepatic disease, peptic ulcer, pregnancy, renal failure, alcohol use, asthma"],
]);

// ─────────────── SECTION 2 ───────────────
sectionDivider("Section 2 — Naproxen + Domperidone");

drugSlide("Naproxen 250/500mg + Domperidone 10mg", "NSAID + Prokinetic (Anti-nausea)", [
  ["Diseases",       "Migraine with nausea, Dysmenorrhoea, Arthritis pain with nausea, Post-op analgesia with GI symptoms"],
  ["Dose (Mild)",    "Naproxen 250mg + Domperidone 10mg — 1 tab twice daily"],
  ["Dose (Moderate)","Naproxen 500mg + Domperidone 10mg — 1 tab twice daily"],
  ["Dose (Severe)",  "Naproxen 500mg twice daily; Domperidone helps reduce NSAID-related nausea"],
  ["Frequency",      "Max 2 times daily"],
  ["With Food",      "BEFORE food (30 min before meals — Domperidone is most effective pre-meal)"],
  ["Max Daily Dose", "Naproxen 1000mg/day  |  Domperidone 30mg/day"],
  ["Duration",       "Acute migraine/pain: 2–5 days  |  Arthritis: review after 4 weeks"],
  ["Avoid/Must Avoid","GI bleed, cardiac arrhythmia (Domperidone prolongs QT), severe renal/hepatic disease, children, prolactinoma, pregnancy"],
]);

// ─────────────── SECTION 3 ───────────────
sectionDivider("Section 3 — Ophthalmic Antibiotics");

drugSlide("Ciprofloxacin 0.3% Eye Drops", "Fluoroquinolone Antibiotic — Topical Ophthalmic", [
  ["Diseases",       "Bacterial conjunctivitis, Corneal ulcer (bacterial), Blepharitis, Post-op eye infection prophylaxis"],
  ["Dose (Mild-Conjunctivitis)", "1–2 drops in affected eye(s) every 4 hrs while awake (Day 1–2: every 2 hrs)"],
  ["Dose (Corneal Ulcer)",       "Day 1: 2 drops every 15 min x 6 hrs, then every 30 min; Day 2: every hr; Day 3–14: every 4 hrs"],
  ["Frequency",      "4–6 times/day for conjunctivitis; more frequent for ulcers per protocol"],
  ["With Food",      "Not applicable (eye drops)"],
  ["Max Daily Dose", "Conjunctivitis: up to 8 instillations/day  |  Ulcer: as per protocol"],
  ["Duration",       "Conjunctivitis: 7 days  |  Corneal ulcer: up to 14 days"],
  ["Avoid/Must Avoid","Hypersensitivity to fluoroquinolones, do NOT use with contact lenses, viral/fungal eye infections, children <1 yr"],
]);

drugSlide("Moxifloxacin 0.5% Eye Drops", "4th-Gen Fluoroquinolone — Topical Ophthalmic", [
  ["Diseases",       "Bacterial conjunctivitis (first-line), Post-cataract surgery infection prophylaxis, Bacterial keratitis"],
  ["Dose",           "1 drop in affected eye(s) 3 times daily (every 8 hrs)"],
  ["Dose (Severe)",  "1 drop every 4 hrs on day 1–2, then 3 times daily"],
  ["Frequency",      "3 times daily (standard)"],
  ["With Food",      "Not applicable"],
  ["Max Daily Dose", "1 drop 3–4 times per day"],
  ["Duration",       "7 days (conjunctivitis)  |  Continue 2 days after symptoms clear"],
  ["Avoid/Must Avoid","Fluoroquinolone allergy, viral keratoconjunctivitis (herpes), fungal eye infection, contact lenses during treatment"],
]);

// ─────────────── SECTION 4 ───────────────
sectionDivider("Section 4 — Lubricant Eye Drops");

drugSlide("Carboxymethylcellulose (CMC) 0.5%/1% Eye Drops — Refresh Tears", "Ocular Lubricant / Artificial Tears", [
  ["Diseases",       "Dry Eye Syndrome, Computer Vision Syndrome, Post-LASIK dryness, Keratoconjunctivitis sicca, Eye fatigue"],
  ["Dose",           "1–2 drops in each eye as needed"],
  ["Frequency",      "As needed — typically 4–6 times/day; can use more frequently (preservative-free preferred if >4x/day)"],
  ["With Food",      "Not applicable"],
  ["Max Daily Dose", "No fixed maximum — use as required"],
  ["Duration",       "Ongoing for chronic dry eye  |  Acute dryness: use until resolved"],
  ["Avoid/Must Avoid","Hypersensitivity to CMC; avoid if wearing soft contact lenses (wait 15 min after instillation before inserting lenses)"],
]);

// ─────────────── SECTION 5 ───────────────
sectionDivider("Section 5 — Oral Cephalosporins");

drugSlide("Cefixime 200/400mg Tablet", "3rd-Generation Oral Cephalosporin", [
  ["Diseases",       "UTI, Otitis media, Pharyngitis/Tonsillitis, Typhoid fever, Gonorrhoea, Respiratory tract infections, Sinusitis"],
  ["Dose (Mild)",    "200mg once daily or 100mg twice daily"],
  ["Dose (Moderate)","200mg twice daily"],
  ["Dose (Severe)",  "400mg once daily or 200mg twice daily"],
  ["Frequency",      "Once or twice daily"],
  ["With Food",      "WITH or WITHOUT food (food reduces GI upset)"],
  ["Max Daily Dose", "400mg/day adults  |  Paediatric: 8mg/kg/day"],
  ["Duration",       "UTI: 3–7 days  |  Tonsillitis: 10 days  |  Typhoid: 7–14 days  |  Gonorrhoea: single 400mg dose"],
  ["Avoid/Must Avoid","Cephalosporin/penicillin allergy (cross-reactivity ~1–2%), severe renal impairment (reduce dose), pregnancy (use with caution)"],
]);

drugSlide("Cefpodoxime 100/200mg Tablet", "3rd-Generation Oral Cephalosporin", [
  ["Diseases",       "Community-acquired pneumonia, Acute exacerbation of chronic bronchitis, UTI, Skin & soft tissue infections, Otitis media, Sinusitis"],
  ["Dose (Mild)",    "100mg twice daily"],
  ["Dose (Moderate)","200mg twice daily"],
  ["Dose (Severe)",  "200mg twice daily (same; severe needs parenteral therapy)"],
  ["Frequency",      "Twice daily (every 12 hrs)"],
  ["With Food",      "WITH food (improves absorption significantly)"],
  ["Max Daily Dose", "400mg/day"],
  ["Duration",       "Pneumonia/bronchitis: 10–14 days  |  UTI: 7 days  |  Skin: 7–14 days  |  Otitis media: 5–10 days"],
  ["Avoid/Must Avoid","Cephalosporin allergy, renal impairment (adjust dose), avoid in known penicillin anaphylaxis"],
]);

// ─────────────── SECTION 6 ───────────────
sectionDivider("Section 6 — Cold/Flu Combinations & Antibiotics");

drugSlide("Paracetamol + Phenylephrine + Chlorpheniramine", "Antipyretic + Decongestant + Antihistamine (Cold/Flu Combo)", [
  ["Diseases",       "Common cold, Allergic rhinitis with fever, Sinusitis symptoms, Flu — nasal congestion + fever + runny nose"],
  ["Dose",           "1–2 tablets every 4–6 hrs as needed"],
  ["Frequency",      "Max 4 times daily"],
  ["With Food",      "AFTER food"],
  ["Max Daily Dose", "Paracetamol 4g/day  |  Phenylephrine 60mg/day  |  Chlorpheniramine 24mg/day"],
  ["Duration",       "3–5 days for cold symptoms; not for prolonged use"],
  ["Side Effects",   "Drowsiness (Chlorpheniramine), raised BP (Phenylephrine), urinary retention"],
  ["Avoid/Must Avoid","Hypertension, glaucoma, BPH, MAO inhibitor use, thyroid disease, severe hepatic disease, children <6 yrs, pregnancy"],
]);

drugSlide("Paracetamol + Phenylephrine + Pseudoephedrine", "Antipyretic + Dual Decongestant Combo", [
  ["Diseases",       "Nasal congestion, Sinusitis, Cold with fever, Eustachian tube dysfunction"],
  ["Dose",           "1 tab every 6 hrs"],
  ["Frequency",      "Max 4 times daily"],
  ["With Food",      "AFTER food"],
  ["Max Daily Dose", "PCM 4g/day  |  Pseudoephedrine 240mg/day"],
  ["Duration",       "Max 5–7 days"],
  ["Side Effects",   "Insomnia, palpitations, hypertension, anxiety (Pseudoephedrine is stimulant)"],
  ["Avoid/Must Avoid","Hypertension, heart disease, MAO inhibitor use, hyperthyroidism, angle-closure glaucoma, pregnancy, athletes (banned substance)"],
]);

drugSlide("Azithromycin 250/500mg Tablet", "Macrolide Antibiotic", [
  ["Diseases",       "Community-acquired pneumonia, Pharyngitis, Sinusitis, Skin infections, Chlamydia, Traveller's diarrhoea, Atypical pneumonia"],
  ["Dose (Mild)",    "250mg once daily x 5 days"],
  ["Dose (Moderate)","500mg once daily x 3 days (Z-pack) or 500mg on day 1 then 250mg x 4 days"],
  ["Dose (Severe)",  "500mg once daily x 5 days"],
  ["Frequency",      "Once daily"],
  ["With Food",      "WITHOUT food (tablet) — take 1 hr before or 2 hrs after meals for best absorption"],
  ["Max Daily Dose", "500mg/day"],
  ["Duration",       "3–5 days (most infections)  |  Chlamydia: single 1g dose"],
  ["Avoid/Must Avoid","QT-prolongation history, macrolide allergy, hepatic disease, concurrent QT-prolonging drugs (antiarrhythmics, antimalarials)"],
]);

// ─────────────── SECTION 7 ───────────────
sectionDivider("Section 7 — Cough Preparations");

drugSlide("Codeine + Chlorpheniramine — CODISTAR-DX (Hydrocodone/Codeine + CPM)", "Antitussive + Antihistamine Combination Syrup", [
  ["Diseases",       "Dry irritating cough, Allergic cough, Post-nasal drip cough, Upper respiratory tract congestion with cough"],
  ["Dose (Adults)",  "5–10 mL every 4–6 hrs as needed"],
  ["Dose (Children)","Use only if prescribed; dose per weight (pediatric formulation)"],
  ["Frequency",      "Max 4 times daily  |  Do NOT exceed prescribed dose"],
  ["With Food",      "WITH food to reduce nausea"],
  ["Max Daily Dose", "Codeine: 120mg/day  |  Chlorpheniramine: 24mg/day"],
  ["Duration",       "Short-term only: 3–5 days  |  NOT for chronic cough"],
  ["Avoid/Must Avoid","Children <12 yrs (codeine banned in many countries), post-tonsillectomy, respiratory depression, COPD, asthma, substance abuse history, pregnancy, breastfeeding, MAO inhibitors"],
]);

// ─────────────── SECTION 8 ───────────────
sectionDivider("Section 8 — Bronchodilator & Mucolytic Agents");

drugSlide("Terbutaline 2.5mg Tablet / Syrup", "Beta-2 Agonist Bronchodilator", [
  ["Diseases",       "Bronchial asthma, COPD, Bronchospasm, Acute wheeze, Chronic bronchitis with reversible airflow obstruction"],
  ["Dose (Mild)",    "2.5mg twice daily"],
  ["Dose (Moderate)","2.5mg 3 times daily"],
  ["Dose (Severe)",  "5mg 3 times daily (oral)  |  Subcutaneous: 0.25–0.5mg; repeat after 15 min if needed"],
  ["Frequency",      "Max 3 times daily (oral)"],
  ["With Food",      "WITH or WITHOUT food"],
  ["Max Daily Dose", "15mg/day (oral)"],
  ["Duration",       "As needed for acute bronchospasm; long-term for asthma under physician supervision"],
  ["Avoid/Must Avoid","Tachyarrhythmia, hyperthyroidism, hypokalemia risk (monitor), severe hypertension, 1st trimester pregnancy, concurrent beta-blockers"],
]);

drugSlide("Guaifenesin (Guaiphenesin) 100–200mg", "Expectorant / Mucolytic", [
  ["Diseases",       "Productive cough — URTI, LRTI, Bronchitis, Pneumonia (adjunct), Sinusitis — to loosen and thin mucus"],
  ["Dose (Adults)",  "200–400mg every 4 hrs"],
  ["Dose (Children 6–12 yrs)", "100–200mg every 4 hrs"],
  ["Frequency",      "Max 6 times daily"],
  ["With Food",      "WITH plenty of water (must hydrate well for mucolytic effect)"],
  ["Max Daily Dose", "2400mg/day (adult)"],
  ["Duration",       "7 days for acute infections; if no improvement, seek review"],
  ["Avoid/Must Avoid","Chronic/persistent cough from smoking, asthma, or emphysema without diagnosis, known allergy to guaifenesin"],
]);

drugSlide("Ambroxol 30mg Tablet / Syrup", "Mucoactive Expectorant (Secretolytic)", [
  ["Diseases",       "Acute/chronic bronchitis, Pneumonia (adjunct), COPD, Asthma (as mucolytic), Preterm lung maturity (neonatal)"],
  ["Dose (Adults)",  "30mg 3 times daily (first 2–3 days), then 30mg twice daily"],
  ["Dose (Children 5–12 yrs)", "15mg 2–3 times daily"],
  ["Frequency",      "Max 3 times daily initially; 2 times daily maintenance"],
  ["With Food",      "AFTER food with water"],
  ["Max Daily Dose", "90mg/day (adult, oral)"],
  ["Duration",       "Acute: 5–7 days  |  Chronic use: under medical supervision"],
  ["Avoid/Must Avoid","First trimester pregnancy, known hypersensitivity; caution in gastric ulcer (stimulates secretion), severe renal impairment"],
]);

// ─────────────── SECTION 9 ───────────────
sectionDivider("Section 9 — Vitamins, Probiotics & Topicals");

drugSlide("Becosules Capsule (B-Complex + Vit C)", "Multivitamin — B1, B2, B6, B12, Folic Acid, Niacinamide, Pantothenic Acid, Vit C", [
  ["Diseases/Uses",  "Vitamin B & C deficiency, Poor nutrition, Mouth ulcers, Fatigue, Peripheral neuropathy, Post-illness recovery, Pregnancy supplementation"],
  ["Dose",           "1 capsule once daily"],
  ["Frequency",      "Once daily"],
  ["With Food",      "AFTER food (prevents GI upset)"],
  ["Max Daily Dose", "1 capsule/day"],
  ["Duration",       "As advised; typically 1–3 months  |  Long-term in chronic deficiency"],
  ["Avoid/Must Avoid","Hypervitaminosis (do not double dose), allergy to any B vitamin; safe in pregnancy at standard doses"],
]);

drugSlide("Folic Acid 1mg / 5mg Tablet", "B9 Vitamin Supplement", [
  ["Diseases/Uses",  "Megaloblastic anaemia, Neural tube defect prevention (pregnancy), Folate deficiency, Methotrexate-induced folate depletion, Haemolytic anaemia"],
  ["Dose (Prevention/Pregnancy)", "0.4–1mg once daily"],
  ["Dose (Treatment/Deficiency)", "5mg once daily"],
  ["Frequency",      "Once daily"],
  ["With Food",      "WITH or WITHOUT food"],
  ["Max Daily Dose", "5mg/day (treatment dose)"],
  ["Duration",       "Prevention: preconception + first 12 weeks  |  Treatment: 4 months minimum; ongoing if cause persists"],
  ["Avoid/Must Avoid","Undiagnosed B12 deficiency (folic acid can mask neurological signs of B12 deficiency — always rule out B12 deficiency first)"],
]);

drugSlide("Sporlac Tablet (Lactobacillus acidophilus + Sporogenes)", "Probiotic / Gut Flora Restorer", [
  ["Diseases/Uses",  "Antibiotic-associated diarrhoea, IBS, Acute diarrhoea, Traveller's diarrhoea, Gut dysbiosis, Post-gastroenteritis recovery"],
  ["Dose",           "1–2 tablets 3 times daily"],
  ["Frequency",      "3 times daily"],
  ["With Food",      "WITH food (or just after meals — food protects organisms from gastric acid)"],
  ["Max Daily Dose", "6 tablets/day"],
  ["Duration",       "Diarrhoea: 5–7 days  |  With antibiotics: entire antibiotic course + 1 week after"],
  ["Avoid/Must Avoid","Immune-compromised patients (caution), known allergy to lactobacillus; give at least 2 hrs apart from antibiotics to prevent inactivation"],
]);

drugSlide("Dolo Gel (Diclofenac Diethylamine 1.16% Gel) — Topical", "Topical NSAID Gel", [
  ["Diseases/Uses",  "Localized muscle pain, Joint pain, Sports injuries (sprains/strains), Backache, Knee OA, Tendinitis, Neck pain"],
  ["Dose",           "Apply 1–2g (pea-sized to cherry-sized amount) to affected area"],
  ["Frequency",      "3–4 times daily  |  Gently rub in until absorbed"],
  ["With Food",      "Not applicable — topical"],
  ["Max Daily Dose", "4 applications per day; max 32g/day on large areas"],
  ["Duration",       "Acute injury: 7–14 days  |  OA: up to 3 months"],
  ["Avoid/Must Avoid","Open wounds, broken skin, mucous membranes, eyes; NSAID allergy (aspirin-sensitive asthma), pregnancy (3rd trimester); do NOT use with occlusive dressings"],
]);

// ─────────────── SECTION 10 ───────────────
sectionDivider("Section 10 — Ketorolac");

drugSlide("Ketorolac 10mg DT Tablet (Ketorol DT)", "Potent Oral NSAID — Short-Term Use Only", [
  ["Diseases",       "Moderate-to-severe acute pain — post-op, renal colic, dental pain, musculoskeletal pain, headache/migraine"],
  ["Dose",           "10mg every 4–6 hrs as needed"],
  ["Frequency",      "Max 4 times daily (40mg/day)"],
  ["With Food",      "AFTER food or with glass of milk (high GI risk)"],
  ["Max Daily Dose", "40mg/day (oral)"],
  ["Duration",       "STRICTLY max 5 days (oral)  |  Do not use for chronic pain — serious GI/renal/cardiovascular risk"],
  ["Important Note", "Dissolve in water before taking (DT = dispersible tablet). Not for chronic/prophylactic analgesia."],
  ["Avoid/Must Avoid","Active/history of GI ulcer, renal impairment, cerebrovascular bleed, anticoagulant therapy, children <16 yrs, pregnancy, breastfeeding, elderly (high risk)"],
]);

// ─────────────── SECTION 11 ───────────────
sectionDivider("Section 11 — Oral/Dental Infections");

drugSlide("Azithromycin 500mg Tablet", "Macrolide Antibiotic — Higher Dose", [
  ["Diseases",       "Severe community-acquired pneumonia, Dental abscess, Skin infections, Typhoid carrier, STIs, Severe ENT infections"],
  ["Dose",           "500mg once daily"],
  ["Frequency",      "Once daily"],
  ["With Food",      "WITHOUT food (1 hr before or 2 hrs after meals for best absorption — tablet form)"],
  ["Max Daily Dose", "500mg/day"],
  ["Duration",       "3 days (Z-pack for RTI)  |  5 days for severe infection  |  Single 1g dose for Chlamydia"],
  ["Avoid/Must Avoid","QT-prolongation, macrolide allergy, severe hepatic failure, concurrent ergotamine, QT-prolonging drugs (haloperidol, amiodarone)"],
]);

drugSlide("Chlorhexidine 0.2% Mouthwash", "Broad-Spectrum Antiseptic Oral Rinse", [
  ["Diseases/Uses",  "Gingivitis, Periodontal disease, Post-tooth extraction wound care, Oral ulcers, Post-dental surgery, Plaque control"],
  ["Dose",           "10–15 mL undiluted, rinse for 30–60 seconds, then spit"],
  ["Frequency",      "Twice daily (morning and night) after brushing"],
  ["With Food",      "Use AFTER meals; do NOT rinse with water or eat for 30 min after use"],
  ["Max Daily Dose", "2 rinses/day"],
  ["Duration",       "Post-surgery: 1–2 weeks  |  Gingivitis/plaque: up to 4 weeks  |  Not for long-term continuous use (stains teeth)"],
  ["Avoid/Must Avoid","Do NOT swallow, children <6 yrs, allergy to chlorhexidine; long-term use causes tooth/tongue staining and taste alteration"],
]);

drugSlide("Betadine (Povidone-Iodine 1%) Gargle/Mouthwash", "Antiseptic Gargle", [
  ["Diseases/Uses",  "Sore throat (pharyngitis), Tonsillitis, Oral candidiasis, Post-tonsillectomy care, Oral ulcers, COVID-19 symptom support (adjunct)"],
  ["Dose",           "Dilute 1:1 with warm water — gargle 5–10 mL for 30 seconds, spit"],
  ["Frequency",      "3–4 times daily"],
  ["With Food",      "After meals"],
  ["Max Daily Dose", "4 gargle sessions/day"],
  ["Duration",       "5–7 days for acute sore throat"],
  ["Avoid/Must Avoid","Thyroid disease (absorbed iodine), pregnancy/breastfeeding, children <6 yrs, iodine allergy, NOT for children <2 yrs, do NOT swallow"],
]);

// ─────────────── SECTION 12 ───────────────
sectionDivider("Section 12 — GI Protectors & Antacids");

drugSlide("Aspirin 325mg / Painkiller (Chest Pain Context)", "Antiplatelet / Analgesic — Chest Pain Use", [
  ["Diseases",       "Chest pain — Acute MI (emergency use), Stable angina, Post-MI secondary prevention, Ischaemic stroke prevention"],
  ["Dose (Acute MI)","300–325mg (chew immediately, not swallow) — EMERGENCY"],
  ["Dose (Prevention)","75–100mg once daily"],
  ["Frequency",      "Once daily (prevention)  |  Single loading dose (acute MI)"],
  ["With Food",      "AFTER food for daily use; CHEW immediately in emergency"],
  ["Max Daily Dose", "Prevention: 100mg/day  |  Analgesic use: 4g/day (avoid for MI use)"],
  ["Duration",       "Secondary prevention: indefinite  |  Acute MI: followed by cardiologist"],
  ["Avoid/Must Avoid","Active GI bleed, haemophilia, severe asthma (aspirin-sensitive), children <16 yrs (Reye's syndrome), pregnancy 3rd trimester, dengue fever (bleeding risk)"],
]);

drugSlide("Pantoprazole 20mg / 40mg Tablet", "Proton Pump Inhibitor (PPI)", [
  ["Diseases",       "GERD, Peptic ulcer (H. pylori eradication), NSAID-induced gastropathy, Zollinger-Ellison syndrome, Oesophagitis, Stress ulcer prophylaxis"],
  ["Dose (Mild/GERD)","20mg once daily"],
  ["Dose (Ulcer/Severe)","40mg once daily or twice daily"],
  ["Frequency",      "Once daily (usually); twice daily for severe cases"],
  ["With Food",      "BEFORE breakfast (30–60 min before first meal — acid suppression is meal-triggered)"],
  ["Max Daily Dose", "80mg/day"],
  ["Duration",       "GERD: 4–8 weeks  |  Ulcer healing: 4–8 weeks  |  H. pylori: 14 days (triple therapy)  |  NSAID cover: as long as NSAID is used"],
  ["Avoid/Must Avoid","Allergy to PPIs; long-term use risk: B12/Mg deficiency, C. difficile, osteoporosis (bone loss); avoid in HIV antiretroviral regimens (atazanavir)"],
]);

drugSlide("Digene Syrup (Magnesium Hydroxide + Simethicone + Activated Dimethicone)", "Antacid + Anti-flatulent", [
  ["Diseases",       "Heartburn, Acid indigestion, GERD symptoms, Bloating, Flatulence, Hiatus hernia symptoms, Post-meal discomfort"],
  ["Dose (Adults)",  "10–15 mL (2–3 tsp) after meals and at bedtime"],
  ["Frequency",      "3–4 times daily (after each meal + bedtime)"],
  ["With Food",      "AFTER food (1–3 hrs after meal or at onset of symptoms)"],
  ["Max Daily Dose", "60 mL/day"],
  ["Duration",       "Symptom relief use — not for long-term >2 weeks without investigation"],
  ["Avoid/Must Avoid","Renal failure (magnesium accumulation), appendicitis/intestinal obstruction, allergy; do NOT take within 2 hrs of other medications (impairs absorption)"],
]);

// ─────────────── SECTION 13 ───────────────
sectionDivider("Section 13 — Antispasmodics");

drugSlide("Dicyclomine (Dicycloverine) 10–20mg Tablet", "Anticholinergic Antispasmodic", [
  ["Diseases",       "IBS, Intestinal colic, Renal colic (adjunct), Biliary colic, Dysmenorrhoea, Bladder spasm, Peptic ulcer (adjunct)"],
  ["Dose (Adults)",  "20mg 3–4 times daily before meals"],
  ["Dose (Mild)",    "10mg 3 times daily"],
  ["Frequency",      "3–4 times daily"],
  ["With Food",      "BEFORE food (30 min before meals for GI spasm)"],
  ["Max Daily Dose", "80mg/day"],
  ["Duration",       "Acute spasm: 2–5 days  |  IBS: short courses as needed"],
  ["Avoid/Must Avoid","Glaucoma, BPH, myasthenia gravis, tachycardia, ulcerative colitis, obstructive uropathy, INFANTS <6 months (apnoea risk), pregnancy"],
]);

drugSlide("Drotaverine 40mg Tablet", "Smooth Muscle Relaxant (PDE-4 Inhibitor) — No Anticholinergic Side Effects", [
  ["Diseases",       "Renal/ureteric colic, Biliary colic, Intestinal colic, Dysmenorrhoea, IBS cramping, Labour pain (obstetric — cervical relaxation)"],
  ["Dose (Adults)",  "40–80mg 3 times daily"],
  ["Dose (Severe colic)", "80mg 3 times daily or IV/IM 40–80mg"],
  ["Frequency",      "3 times daily"],
  ["With Food",      "WITH or WITHOUT food"],
  ["Max Daily Dose", "240mg/day (oral)"],
  ["Duration",       "Acute colic: 2–5 days  |  Dysmenorrhoea: during menstrual period only"],
  ["Avoid/Must Avoid","Severe renal/hepatic/cardiac failure, hypersensitivity; preferred over dicyclomine when anticholinergic effects need to be avoided"],
]);

// ─────────────── SECTION 14 ───────────────
sectionDivider("Section 14 — Proton Pump Inhibitors & H2-Blockers");

drugSlide("Omeprazole 20/40mg Capsule", "PPI — First-Generation", [
  ["Diseases",       "GERD, Peptic ulcer, H. pylori eradication (triple therapy), NSAID-induced gastropathy, Oesophagitis, Dyspepsia"],
  ["Dose",           "20mg once daily (standard)  |  40mg once daily (severe/erosive oesophagitis)"],
  ["Frequency",      "Once daily (before breakfast)"],
  ["With Food",      "BEFORE meals (30–60 min before food)"],
  ["Max Daily Dose", "80mg/day"],
  ["Duration",       "GERD maintenance: 4–8 weeks  |  Ulcer: 4–8 weeks  |  H. pylori: 10–14 days (with antibiotics)"],
  ["Avoid/Must Avoid","Clopidogrel co-use (reduces antiplatelet effect via CYP2C19), allergy to PPIs; long-term risk: hypomagnesaemia, B12 deficiency"],
]);

drugSlide("Rabeprazole 10/20mg Tablet", "PPI — Less CYP2C19 Interaction", [
  ["Diseases",       "GERD, Peptic ulcer disease, H. pylori eradication, Dyspepsia, Zollinger-Ellison syndrome, NSAID-induced gastritis"],
  ["Dose",           "10–20mg once daily"],
  ["Frequency",      "Once daily"],
  ["With Food",      "BEFORE breakfast"],
  ["Max Daily Dose", "40mg/day (ZES: up to 120mg)"],
  ["Duration",       "GERD: 4–8 weeks  |  Ulcer: 4–6 weeks"],
  ["Advantage",      "Less drug interaction via CYP2C19 compared to omeprazole — preferred with clopidogrel"],
  ["Avoid/Must Avoid","PPI hypersensitivity; same long-term cautions as all PPIs (fracture, C. difficile, B12, Mg)"],
]);

drugSlide("Ranitidine 150/300mg Tablet — (H2-Blocker, largely replaced by PPIs)", "H2-Receptor Antagonist (Note: Ranitidine withdrawn in many countries due to NDMA contamination)", [
  ["Diseases",       "GERD, Duodenal/gastric ulcer, Zollinger-Ellison syndrome, NSAID-induced ulcer, Prevention of stress ulcer"],
  ["Dose (Adults)",  "150mg twice daily OR 300mg at bedtime"],
  ["Frequency",      "Twice daily or once at night"],
  ["With Food",      "WITH or WITHOUT food (take evening dose at bedtime)"],
  ["Max Daily Dose", "300mg/day standard  |  1200mg/day for ZES"],
  ["Duration",       "Ulcer: 4–8 weeks  |  GERD maintenance: as needed"],
  ["Regulatory Note","Withdrawn by USFDA/EMA in 2020 due to NDMA impurity. Many countries still have reformulated versions. Confirm local availability."],
  ["Avoid/Must Avoid","Allergy to H2-blockers, renal/hepatic impairment (dose reduce), porphyria; inferior to PPIs for acid suppression"],
]);

// ─────────────── SECTION 15 ───────────────
sectionDivider("Section 15 — Antiemetics");

drugSlide("Domperidone 10mg Tablet", "Dopamine Antagonist — Prokinetic / Antiemetic", [
  ["Diseases",       "Nausea & vomiting (various causes), Gastroparesis, Functional dyspepsia, GERD (prokinetic), Nausea from chemotherapy/drugs"],
  ["Dose",           "10mg 3 times daily"],
  ["Frequency",      "3 times daily (before meals)"],
  ["With Food",      "15–30 min BEFORE meals (prokinetic effect is meal-triggered)"],
  ["Max Daily Dose", "30mg/day  |  Max 10mg per dose"],
  ["Duration",       "Acute nausea: 3–5 days  |  Gastroparesis: up to 4 weeks at lowest dose"],
  ["Avoid/Must Avoid","Cardiac arrhythmia (prolongs QT), hepatic impairment, prolactinoma, GI haemorrhage/obstruction/perforation, concurrent CYP3A4 inhibitors (ketoconazole, erythromycin), elderly (high arrhythmia risk)"],
]);

drugSlide("Ondansetron 4/8mg Tablet", "5-HT3 Antagonist — Potent Antiemetic", [
  ["Diseases",       "Chemotherapy-induced nausea/vomiting (CINV), Post-operative nausea, Severe vomiting in pregnancy (hyperemesis), Radiation-induced nausea, Gastroenteritis"],
  ["Dose (Adults)",  "4–8mg every 8 hrs as needed"],
  ["Dose (Severe CINV)", "8mg before chemo, then 8mg every 8 hrs for 1–2 days"],
  ["Frequency",      "Max 3 times daily (every 8 hrs)"],
  ["With Food",      "WITH or WITHOUT food"],
  ["Max Daily Dose", "32mg/day (standard)  |  24mg/day IV"],
  ["Duration",       "As needed for acute episodes; CINV cover: 1–2 days post-chemo"],
  ["Avoid/Must Avoid","Congenital QT prolongation, concurrent apomorphine, allergy to 5-HT3 antagonists; caution with serotonergic drugs (serotonin syndrome risk)"],
]);

// ─────────────── SECTION 16 ───────────────
sectionDivider("Section 16 — Digestive Enzymes & Appetite Stimulants");

drugSlide("Aristozyme Syrup (Fungal Diastase + Pepsin)", "Digestive Enzyme Supplement", [
  ["Diseases/Uses",  "Indigestion, Dyspepsia, Bloating, Flatulence, Poor appetite, Enzyme deficiency states, Post-illness digestive weakness"],
  ["Dose (Adults)",  "10 mL after each meal (3 times daily)"],
  ["Dose (Children)","5 mL after meals"],
  ["Frequency",      "3 times daily after meals"],
  ["With Food",      "AFTER food (enzymes work in GI tract with food)"],
  ["Max Daily Dose", "30 mL/day"],
  ["Duration",       "2–4 weeks; longer under supervision"],
  ["Avoid/Must Avoid","Allergy to fungal/porcine enzymes, acute pancreatitis; no major contraindications at standard doses"],
]);

drugSlide("Cyproheptadine 2mg/5mL Syrup", "Antihistamine + Appetite Stimulant (5-HT antagonist)", [
  ["Diseases/Uses",  "Poor appetite / weight gain in children, Allergic rhinitis, Urticaria, Migraine prophylaxis, Serotonin syndrome (adjunct)"],
  ["Dose (Children 2–6 yrs)", "2mg (5mL) 2–3 times daily"],
  ["Dose (Children 7–14 yrs)", "4mg (10mL) 2–3 times daily"],
  ["Dose (Adults)",  "4mg 3 times daily"],
  ["Frequency",      "2–3 times daily"],
  ["With Food",      "WITH food or milk"],
  ["Max Daily Dose", "Children: 12mg/day  |  Adults: 32mg/day"],
  ["Duration",       "Appetite stimulant: 4–8 weeks; allergic conditions: as needed"],
  ["Avoid/Must Avoid","Newborns/premature infants, elderly (falls, confusion), glaucoma, BPH, asthma, MAO inhibitors, driving/operating machinery (sedating)"],
]);

// ─────────────── SECTION 17 ───────────────
sectionDivider("Section 17 — Back Pain & Musculoskeletal");

drugSlide("Lower Back Pain Painkillers (Etoricoxib 60mg / Aceclofenac 100mg)", "COX-2 Inhibitor / NSAID for Back Pain", [
  ["Diseases",       "Acute lower back pain, Lumbar spondylosis, Sciatica, Muscle spasm, Disc prolapse (conservative management)"],
  ["Etoricoxib Dose","60mg once daily (mild-mod)  |  90mg once daily (severe, short-term)"],
  ["Aceclofenac Dose","100mg twice daily"],
  ["Frequency",      "Once or twice daily depending on drug"],
  ["With Food",      "AFTER food"],
  ["Max Daily Dose", "Etoricoxib: 90mg/day  |  Aceclofenac: 200mg/day"],
  ["Duration",       "Acute: 5–7 days  |  Chronic: minimum effective dose with regular review"],
  ["Avoid/Must Avoid","Active GI ulcer, cardiovascular disease (etoricoxib increases CV risk — avoid in hypertension/IHD), renal failure, pregnancy, aspirin allergy"],
]);

drugSlide("Diclofenac Diethylamine 1.16% Gel (Topical)", "Topical NSAID for Musculoskeletal Pain", [
  ["Diseases",       "Lower back pain, Knee/hip OA, Tendinitis, Shoulder pain, Sports injuries, Soft tissue inflammation"],
  ["Dose",           "2–4g gel to affected area 3–4 times daily; gently rub in until absorbed"],
  ["Frequency",      "3–4 times daily"],
  ["With Food",      "Not applicable"],
  ["Max Daily Dose", "32g/day over large area (avoid systemic absorption)"],
  ["Duration",       "Acute: 7–14 days  |  OA (knee): up to 3 months"],
  ["Avoid/Must Avoid","Open wounds, broken skin, eyes/mucosa, NSAID allergy, aspirin-induced asthma, do NOT cover with airtight dressing, avoid in pregnancy 3rd trimester"],
]);

drugSlide("Calcium Tablets (Calcium Carbonate 500mg + Vit D3 250IU)", "Calcium & Vitamin D Supplement", [
  ["Diseases/Uses",  "Osteoporosis, Osteomalacia, Hypocalcaemia, Rickets, Post-menopausal bone loss, Fracture prevention, During pregnancy & lactation, Chronic steroid therapy"],
  ["Dose",           "1–2 tablets daily"],
  ["Frequency",      "Once or twice daily (divide doses — max 500mg elemental Ca per dose for absorption)"],
  ["With Food",      "WITH food (calcium carbonate requires acid for absorption — best after meals)"],
  ["Max Daily Dose", "Total calcium (diet + supplement) should not exceed 2500mg/day  |  Supplement: 1000–1200mg/day elemental Ca"],
  ["Duration",       "Long-term (months-years) for osteoporosis prevention"],
  ["Avoid/Must Avoid","Hypercalcaemia, hypercalciuria, renal stones (calcium oxalate), severe renal failure, thiazide diuretics (risk of hypercalcaemia), excess Vit D toxicity"],
]);

// ─────────────── SECTION 18 ───────────────
sectionDivider("Section 18 — Injectable Analgesics");

drugSlide("Diclofenac 75mg Injection (IM)", "NSAID Injection — For Moderate-Severe Acute Pain", [
  ["Diseases",       "Renal colic, Post-op pain, Severe musculoskeletal pain, Migraine (acute), Biliary colic"],
  ["Dose",           "75mg deep IM injection; may repeat after 30 min if needed (max 2 injections/day)"],
  ["Frequency",      "Max 2 injections/day (150mg/day)"],
  ["Route",          "Deep IM only into upper-outer quadrant of gluteal muscle; NOT IV"],
  ["Max Daily Dose", "150mg/day (IM)"],
  ["Duration",       "Maximum 2 days IM use; switch to oral/topical if continuing"],
  ["Avoid/Must Avoid","IV administration, dehydration (renal colic paradox — ensure hydration), GI ulcer, renal/hepatic failure, bleeding disorders, pregnancy 3rd trimester, anticoagulants, heart failure"],
]);

drugSlide("Tramadol 50/100mg Injection (IM/IV)", "Centrally Acting Opioid Analgesic", [
  ["Diseases",       "Moderate-to-severe acute pain, Post-op pain, Cancer pain (adjunct), Renal colic, Trauma pain"],
  ["Dose (Adults)",  "50–100mg IM/IV every 4–6 hrs as needed"],
  ["Dose (IV)",      "100mg diluted in 250–500 mL saline, infuse over 20–30 min"],
  ["Frequency",      "Max 4–6 times/day (every 4 hrs)"],
  ["With Food",      "Not applicable (injection)"],
  ["Max Daily Dose", "400mg/day"],
  ["Duration",       "Short-term acute pain only; avoid prolonged opioid use without specialist oversight"],
  ["Avoid/Must Avoid","Respiratory depression, seizure disorder (lowers seizure threshold), MAO inhibitors, serotonin syndrome risk (SSRIs + tramadol), substance abuse, children <12 yrs, pregnancy/breastfeeding, severe hepatic/renal impairment"],
]);

// ─────────────── SECTION 19 ───────────────
sectionDivider("Section 19 — Laxatives & Bowel Preparations");

drugSlide("Bisacodyl 5mg Tablet / 10mg Suppository", "Stimulant Laxative", [
  ["Diseases",       "Constipation (short-term), Pre-operative bowel preparation, Post-operative constipation, Drug-induced constipation"],
  ["Dose (Adults)",  "5–10mg at bedtime (oral)  |  10mg suppository (rectal)"],
  ["Dose (Children 6–12)","5mg at bedtime"],
  ["Frequency",      "Once daily (at night)"],
  ["With Food",      "Do NOT take within 1 hr of milk/antacids (destroys enteric coating; causes stomach cramps)"],
  ["Max Daily Dose", "10mg/day (oral)"],
  ["Duration",       "Max 7–10 days  |  Not for chronic constipation — investigate cause"],
  ["Avoid/Must Avoid","Intestinal obstruction, acute abdominal pain, IBD (Crohn's/UC), dehydration, appendicitis suspicion, children <6 yrs, pregnancy (1st trimester)"],
]);

drugSlide("Lactulose 3.35g/5mL Solution", "Osmotic Laxative / Ammonia Reducer", [
  ["Diseases",       "Constipation (incl. chronic), Hepatic encephalopathy (reduce ammonia), Drug-induced constipation, Constipation in pregnancy (safe)"],
  ["Dose (Constipation Adults)", "15–30 mL once daily; adjust to produce 2 soft stools/day"],
  ["Dose (Hepatic Encephalopathy)", "30–45 mL 3–4 times daily (titrate to 2–3 soft stools/day)"],
  ["Frequency",      "Once or twice daily (constipation)  |  3–4 times daily (encephalopathy)"],
  ["With Food",      "Can be taken WITH food or diluted in water/juice"],
  ["Max Daily Dose", "Constipation: ~45 mL/day  |  Encephalopathy: 180 mL/day (divided)"],
  ["Duration",       "Constipation: 2–4 weeks initially; safe for long-term  |  Encephalopathy: ongoing"],
  ["Avoid/Must Avoid","Galactosaemia, lactose intolerance (contains small amounts), intestinal obstruction, galactose-free diet; causes flatulence initially"],
]);

drugSlide("Smuth / Cremaffin / MOM Plus — Combination Laxatives", "Antacid-Laxative / Osmotic Combinations", [
  ["Smuth (Simethicone + Magnesium Hydroxide)","Bloating + constipation; 10–20 mL after meals; 3 times daily; AFTER food"],
  ["Cremaffin (Liquid Paraffin + Magnesium Hydroxide)","Constipation; 10–20 mL at bedtime; once at night; WITH or AFTER food"],
  ["MOM Plus (Milk of Magnesia + Liquid Paraffin)","Constipation; 15–30 mL once daily at bedtime; AFTER food"],
  ["Max Duration",   "Smuth: 2 weeks  |  Cremaffin: 1–2 weeks  |  MOM Plus: short-term (7–10 days)"],
  ["Common Max Dose","Cremaffin: 30 mL/night  |  MOM: 30 mL/day"],
  ["Avoid",          "Renal failure (Mg accumulation), intestinal obstruction, abdominal pain of unknown cause, appendicitis, prolonged liquid paraffin use (fat-soluble vitamin malabsorption, aspiration risk in elderly)"],
]);

// ─────────────── SECTION 20 ───────────────
sectionDivider("Section 20 — Antidiarrhoeals & Probiotics");

drugSlide("Loperamide 2mg Tablet", "Opioid Receptor Agonist — Antidiarrhoeal (does not cross BBB)", [
  ["Diseases",       "Acute non-specific diarrhoea, Traveller's diarrhoea, Chronic diarrhoea (IBS-D), Diarrhoea associated with IBD (short-term)"],
  ["Dose (Adults)",  "4mg initially (2 tabs), then 2mg after each loose stool"],
  ["Dose (Children 6–12 yrs)", "1mg after each loose stool; max 3mg/day"],
  ["Frequency",      "As needed after each loose stool; not more than 3 times/day typically"],
  ["With Food",      "WITH or WITHOUT food"],
  ["Max Daily Dose", "Adults: 16mg/day (acute)  |  8mg/day (chronic self-medication)"],
  ["Duration",       "Acute: max 2 days OTC  |  If no improvement in 48 hrs — seek medical advice"],
  ["Avoid/Must Avoid","Bloody diarrhoea/dysentery, bacterial enterocolitis (E. coli O157, Shigella — traps toxins), pseudomembranous colitis, children <6 yrs, ulcerative colitis (risk of toxic megacolon), fever >38.5°C with diarrhoea"],
]);

// ─────────────── SECTION 21 ───────────────
sectionDivider("Section 21 — Diarrhoea / GI Infection Treatment");

drugSlide("Ofloxacin 200mg + Ornidazole 500mg Tablet", "Fluoroquinolone + Nitroimidazole Antibiotic Combination", [
  ["Diseases",       "Infective diarrhoea, Giardiasis, Amoebic dysentery, Traveller's diarrhoea, Pelvic inflammatory disease (adjunct), H. pylori (adjunct), Mixed aerobic-anaerobic infections"],
  ["Dose",           "1 tablet twice daily (Ofloxacin 200mg + Ornidazole 500mg)"],
  ["Frequency",      "Twice daily (every 12 hrs)"],
  ["With Food",      "AFTER food (reduces GI side effects)"],
  ["Max Daily Dose", "Ofloxacin 400mg/day  |  Ornidazole 1000mg/day"],
  ["Duration",       "Acute diarrhoea: 3–5 days  |  Amoebic dysentery: 5–7 days  |  PID: 7–14 days"],
  ["Avoid/Must Avoid","Children (fluoroquinolone tendon risk), pregnancy, epilepsy (Ornidazole lowers seizure threshold), QT-prolongation, alcohol (Ornidazole = disulfiram-like reaction)"],
]);

drugSlide("ORS (Oral Rehydration Salts) — WHO Formula", "Electrolyte Replacement for Diarrhoea", [
  ["Diseases",       "All types of diarrhoea with dehydration — cholera, rotavirus, secretory diarrhoea, traveller's diarrhoea"],
  ["Dose (Mild Dehydration)","50 mL/kg over 4 hrs + ongoing replacement (10 mL/kg after each loose stool)"],
  ["Dose (Moderate)","100 mL/kg over 4 hrs (under supervision)"],
  ["Frequency",      "Sip frequently — small amounts every few minutes to avoid vomiting"],
  ["With Food",      "Continue breastfeeding/feeding — ORS does NOT replace food/milk; food should continue"],
  ["Max",            "No maximum — replace ongoing losses"],
  ["Duration",       "Until diarrhoea stops and dehydration is corrected"],
  ["Avoid/Must Avoid","Severe dehydration with shock — requires IV rehydration. Avoid plain water only (no electrolytes). Avoid sugary drinks (worsen diarrhoea). Severe vomiting — may need NG tube or IV."],
]);

// ─────────────── SECTION 22 ───────────────
sectionDivider("Section 22 — Methylcobalamin (Nerve Vitamin)");

drugSlide("Methylcobalamin 1500mcg Tablet", "Active Form of Vitamin B12 — Neuroprotective", [
  ["Diseases/Uses",  "Peripheral neuropathy, Diabetic neuropathy, Vitamin B12 deficiency, Megaloblastic anaemia, Subacute combined degeneration of spinal cord, Carpal tunnel syndrome, Restless leg syndrome"],
  ["Dose",           "1500mcg once daily OR 500mcg 3 times daily"],
  ["Frequency",      "Once daily (1500mcg) or 3 times daily (500mcg)"],
  ["With Food",      "WITH or WITHOUT food (better absorbed with food)"],
  ["Max Daily Dose", "1500mcg/day for neuropathy  |  Higher doses (IV/IM) for severe deficiency"],
  ["Duration",       "Neuropathy/deficiency: minimum 3 months; often 6–12 months or ongoing  |  Pernicious anaemia: lifelong"],
  ["Avoid/Must Avoid","Hypersensitivity to cobalamin; benign — very safe; excess excreted in urine; caution if polycythaemia; do NOT stop early in neuropathy (slow nerve repair)"],
]);

// ─────────────── SECTION 23 ───────────────
sectionDivider("Section 23 — Amoxicillin-Clavulanate");

drugSlide("Amoxicillin-Clavulanate (Co-amoxiclav) 625mg / 1g Tablet", "Beta-Lactam + Beta-Lactamase Inhibitor Antibiotic", [
  ["Diseases",       "Respiratory tract infections (sinusitis, pneumonia, bronchitis), UTI, Skin/soft tissue infections, Dental infections, Otitis media, Bite wounds, Pelvic infections"],
  ["Dose (Mild/Mod)","625mg (500mg Amox + 125mg Clav) twice daily"],
  ["Dose (Severe)",  "1g (875mg + 125mg) twice daily OR 625mg 3 times daily"],
  ["Frequency",      "Twice or 3 times daily"],
  ["With Food",      "AT THE START of a meal (reduces GI side effects, improves absorption of clavulanate)"],
  ["Max Daily Dose", "3g/day (3 x 625mg)  |  4g/day (2 x 1g tabs) for severe"],
  ["Duration",       "RTI/sinusitis: 5–7 days  |  UTI: 3–7 days  |  Pneumonia: 7–10 days  |  Dental: 5 days  |  Bite wound: 5–7 days"],
  ["Avoid/Must Avoid","Penicillin allergy (anaphylaxis), amoxicillin-associated cholestatic jaundice history, mononucleosis (causes rash), severe renal impairment (dose adjust); GI upset very common — always with food"],
]);

// ─────────────── SECTION 24 ───────────────
sectionDivider("Section 24 — Topical Antibiotics (Skin)");

drugSlide("Fusidic Acid 2% Cream", "Topical Antibiotic — Staphylococcal Infections", [
  ["Diseases",       "Impetigo, Infected eczema, Infected wounds, Folliculitis, Boils (furunculosis), Surgical wound infections (surface)"],
  ["Dose",           "Apply thin layer to affected area"],
  ["Frequency",      "3 times daily (every 8 hrs)"],
  ["With Food",      "Not applicable"],
  ["Max Daily Dose", "Apply to affected area only; not over large body surface area"],
  ["Duration",       "7–14 days; do NOT exceed 2 weeks (resistance risk)"],
  ["Avoid/Must Avoid","Eyes/mucous membranes, large surface area application (systemic absorption risk), known allergy; do NOT use as monotherapy for MRSA"],
]);

drugSlide("Mupirocin 2% Cream / Ointment", "Topical Antibiotic — Pseudomonic Acid", [
  ["Diseases",       "Impetigo (first-line), Secondary skin infections, MRSA decolonisation (nasal — 2% nasal ointment), Infected minor wounds"],
  ["Dose",           "Apply small amount 3 times daily; cover with dressing if needed"],
  ["Frequency",      "3 times daily"],
  ["With Food",      "Not applicable"],
  ["Max Daily Dose", "Affected area only; nasal decolonisation: apply to nostrils twice daily x 5 days"],
  ["Duration",       "Skin: 7–10 days (max 10 days)  |  MRSA nasal decolonisation: 5 days"],
  ["Avoid/Must Avoid","Eye application, polyethylene glycol-containing ointment base caution in renal failure (if used over large areas), allergy to mupirocin; emerging resistance — do NOT overuse"],
]);

// ─────────────── SECTION 25 ───────────────
sectionDivider("Section 25 — Emergency / Acute Injections");

drugSlide("Avil (Pheniramine Maleate) 45.5mg Injection", "Antihistamine Injection — Allergic Emergencies", [
  ["Diseases",       "Anaphylaxis (adjunct), Acute allergic reactions, Urticaria, Angioedema, Drug hypersensitivity reactions, Transfusion reactions, Insect bite anaphylaxis"],
  ["Dose",           "45.5mg (1 ampule) IM or slow IV"],
  ["Dose (Children)","0.5mg/kg IM"],
  ["Frequency",      "Every 4–6 hrs if needed  |  Max 3 doses/day in acute setting"],
  ["Route",          "IM preferred; slow IV (undiluted causes hypotension — dilute if IV use)"],
  ["Max Daily Dose", "135mg/day"],
  ["Duration",       "Acute reactions: as needed until allergic response controlled"],
  ["Avoid/Must Avoid","Rapid IV bolus (hypotension, arrhythmia), neonates, MAO inhibitors, epilepsy; causes sedation — warn patient; NEVER substitute for epinephrine in anaphylaxis — Epinephrine (Adrenaline) is FIRST-LINE"],
]);

drugSlide("Dexamethasone (Dexona) 4mg Injection", "Potent Corticosteroid — Anti-inflammatory / Immunosuppressive", [
  ["Diseases",       "Severe allergic reactions, Anaphylaxis (adjunct), Cerebral oedema, Septic shock (adjunct), Severe asthma, COPD exacerbation, Anti-emetic (chemo), COVID-19 (severe), Inflammatory conditions"],
  ["Dose (Allergy)", "4–8mg IM/IV stat"],
  ["Dose (Cerebral Oedema)", "10mg IV stat, then 4mg every 6 hrs"],
  ["Dose (Severe Asthma)","4–8mg IM/IV once"],
  ["Frequency",      "Variable — depends on indication; acute: stat dose to 4-6 hourly"],
  ["With Food",      "Not applicable (injection)"],
  ["Max Daily Dose", "Variable by indication; typical acute: 8–40mg/day"],
  ["Duration",       "Shortest course possible; taper if >5–7 days use"],
  ["Avoid/Must Avoid","Active infection without antimicrobial cover, live vaccines, systemic fungal infection; long-term risks: hyperglycaemia, immunosuppression, osteoporosis, Cushing's syndrome; do NOT stop suddenly after prolonged use (adrenal suppression)"],
]);

// ─────────────── SECTION 26 ───────────────
sectionDivider("Section 26 — Antihistamines");

drugSlide("Cetirizine 10mg Tablet", "2nd-Generation Antihistamine (H1-blocker)", [
  ["Diseases",       "Allergic rhinitis (hay fever), Chronic urticaria, Allergic conjunctivitis, Food allergy (mild), Insect bite reactions, Atopic dermatitis (itch relief)"],
  ["Dose (Adults)",  "10mg once daily"],
  ["Dose (Children 6–12 yrs)", "5mg twice daily or 10mg once daily"],
  ["Frequency",      "Once daily (or twice daily in children)"],
  ["With Food",      "WITH or WITHOUT food"],
  ["Max Daily Dose", "10mg/day adults  |  5–10mg/day children 6–12 yrs"],
  ["Duration",       "Seasonal allergy: during season  |  Urticaria: until resolved (weeks-months)  |  Acute: 5–7 days"],
  ["Avoid/Must Avoid","Severe renal impairment (reduce dose), allergy to hydroxyzine (related drug), driving if drowsy (mild sedation in some), concurrent CNS depressants/alcohol"],
]);

drugSlide("Levocetirizine 5mg Tablet", "Active Enantiomer of Cetirizine — Less Sedating", [
  ["Diseases",       "Allergic rhinitis, Chronic idiopathic urticaria, Atopic dermatitis, Allergic conjunctivitis"],
  ["Dose (Adults)",  "5mg once daily (evening)"],
  ["Dose (Children 6–12)","2.5mg once daily"],
  ["Frequency",      "Once daily"],
  ["With Food",      "WITH or WITHOUT food"],
  ["Max Daily Dose", "5mg/day adults  |  2.5mg/day children 6–12 yrs"],
  ["Duration",       "As clinically indicated  |  Urticaria: reassess after 6 months"],
  ["Avoid/Must Avoid","Severe renal impairment (CrCl <10 mL/min — contraindicated), children <6 yrs for 5mg tablet; minimal sedation but still warn about driving"],
]);

drugSlide("Hydroxyzine 10/25mg Tablet", "1st-Generation Antihistamine — Anxiolytic + Sedating", [
  ["Diseases",       "Anxiety (short-term), Pruritus (itch — urticaria, atopic dermatitis, contact dermatitis), Pre-operative sedation, Alcohol withdrawal (adjunct), Nausea"],
  ["Dose (Anxiety)", "50–100mg 4 times daily"],
  ["Dose (Itch)",    "25mg 3–4 times daily"],
  ["Dose (Pre-op)",  "50–100mg IM 1 hr before procedure"],
  ["Frequency",      "3–4 times daily"],
  ["With Food",      "WITH food (reduces GI upset)"],
  ["Max Daily Dose", "600mg/day (anxiety)  |  100mg single dose"],
  ["Duration",       "Anxiety: weeks (not for long-term use — not a BZD substitute)  |  Itch: as needed"],
  ["Avoid/Must Avoid","QT-prolongation, elderly (high fall risk — sedating, anticholinergic), pregnancy (1st trimester), children <6 months, MAO inhibitors, alcohol, concurrent CNS depressants — causes significant sedation — do not drive"],
]);

// ── FINAL SUMMARY SLIDE ───────────────────────────────────────────────────
const sum = pres.addSlide();
sum.background = { color: C.navy };
sum.addShape(pres.ShapeType.rect, { x: 0, y: 2.0, w: 13.3, h: 0.08, fill: { color: C.gold } });
sum.addShape(pres.ShapeType.rect, { x: 0, y: 5.2, w: 13.3, h: 0.08, fill: { color: C.gold } });
sum.addText("Clinical Drug Reference Guide", {
  x: 0.5, y: 0.4, w: 12.3, h: 1.4,
  fontSize: 30, bold: true, color: C.white,
  fontFace: "Calibri", align: "center", valign: "middle"
});
sum.addText([
  { text: "26 Drug Groups Covered", options: { breakLine: true, bold: true } },
  { text: "NSAIDs  |  Antibiotics  |  Eye Drops  |  GI Agents  |  Analgesics  |  Antihistamines", options: { breakLine: true } },
  { text: "Antispasmodics  |  Laxatives  |  Vitamins  |  Antiemetics  |  Emergency Injections", options: { breakLine: true } },
  { text: "Each drug: Indication · Dose by Severity · Frequency · Food Timing · Max Daily Dose · Duration · Contraindications", options: {} }
], {
  x: 0.8, y: 2.3, w: 11.7, h: 2.8,
  fontSize: 14, color: C.white, fontFace: "Calibri",
  align: "center", valign: "middle", lineSpacingMultiple: 1.5
});
sum.addText("For educational purposes only — always verify doses with current prescribing information", {
  x: 0.5, y: 5.5, w: 12.3, h: 0.8,
  fontSize: 11, color: C.ltgray, align: "center", italic: true
});

// ── WRITE FILE ─────────────────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/pharma-ppt/Clinical_Drug_Reference_Guide.pptx" })
  .then(() => console.log("DONE: /home/daytona/workspace/pharma-ppt/Clinical_Drug_Reference_Guide.pptx"))
  .catch(e => { console.error("ERROR:", e); process.exit(1); });