Do
not rely on the “halo/ring sign” on tissue paper or a urine glucose strip. These are unreliable. The best test to confirm that nasal fluid is CSF is
beta-2 transferrin (or beta-trace protein where available). After confirmation,
high-resolution CT of the skull base/PNS is usually the first study to identify the bony defect; MR cisternography can help if CT is unclear. This is supported by an
evidence-based diagnostic review and a more recent
diagnostic review.