from reportlab.lib import colors
from reportlab.lib.enums import TA_CENTER, TA_LEFT
from reportlab.lib.pagesizes import A4
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.units import cm
from reportlab.platypus import SimpleDocTemplate, Paragraph, Spacer, KeepTogether
from reportlab.pdfbase.ttfonts import TTFont
from reportlab.pdfbase import pdfmetrics

OUT = '/tmp/workspace/anemia-questions-pdf/output/Anemia_Questions.pdf'

styles = getSampleStyleSheet()
styles.add(ParagraphStyle(name='DocTitle', parent=styles['Title'], fontName='Helvetica-Bold', fontSize=18, leading=23, alignment=TA_CENTER, textColor=colors.HexColor('#17365D'), spaceAfter=8))
styles.add(ParagraphStyle(name='Subtitle', parent=styles['Normal'], fontName='Helvetica', fontSize=10, leading=13, alignment=TA_CENTER, textColor=colors.HexColor('#555555'), spaceAfter=18))
styles.add(ParagraphStyle(name='Question', parent=styles['Heading2'], fontName='Helvetica-Bold', fontSize=13, leading=17, textColor=colors.HexColor('#17365D'), spaceBefore=12, spaceAfter=7))
styles.add(ParagraphStyle(name='Body', parent=styles['BodyText'], fontName='Helvetica', fontSize=10.5, leading=15, spaceAfter=6))
styles.add(ParagraphStyle(name='Part', parent=styles['BodyText'], fontName='Helvetica', fontSize=10.5, leading=15, leftIndent=13, firstLineIndent=-13, spaceAfter=4))
styles.add(ParagraphStyle(name='AnswerHead', parent=styles['Heading2'], fontName='Helvetica-Bold', fontSize=13, leading=17, textColor=colors.HexColor('#2F6B3E'), spaceBefore=13, spaceAfter=7))
styles.add(ParagraphStyle(name='Answer', parent=styles['BodyText'], fontName='Helvetica', fontSize=10.5, leading=15, leftIndent=13, firstLineIndent=-13, spaceAfter=6))


def p(txt, style='Body'):
    return Paragraph(txt, styles[style])

story = [
    p('Anemia: Clinical Case Questions', 'DocTitle'),
    p('Hematology - Question Set', 'Subtitle'),
]

# Q1
story += [
    p('Question 1', 'Question'),
    p('A 35-year-old female had come to a medical outpatient department with complaints of weakness, giddiness and loss of appetite. On examination she was pale. On investigation RBC count: 3.5 million/mm³, Hb: 9 g%. Peripheral smear showed microcytes with hypochromia.', 'Body'),
    p('<b>a.</b> Identify the condition.', 'Part'),
    p('<b>b.</b> Discuss the physiological basis for the above condition and its management.', 'Part'),
    p('<b>c.</b> Discuss the stages of erythropoiesis.', 'Part'),
    p('<b>d.</b> Describe the various factors which regulate erythropoiesis.', 'Part'),
]

# Q2
story += [
    p('Question 2', 'Question'),
    p('A 30-year-old lady comes to hospital with complaints of fatigue for many months. On physical examination she had pale conjunctiva and spooning of nails. Her haemoglobin is 8 g%, PCV 20% and MCV 60 fL. Stools are negative for occult blood.', 'Body'),
    p('<b>a.</b> Name the clinical condition.', 'Part'),
    p('<b>b.</b> Describe the blood picture.', 'Part'),
    p('<b>c.</b> What other investigations you would like to do in this setting?', 'Part'),
    p('<b>d.</b> What are the dietary options for better treatment?', 'Part'),
]

# Q3
story += [
    p('Question 3', 'Question'),
    p('A 25-year-old young man came with a history of tiredness, mouth ulcers and numbness and tingling sensation over his hand and feet. Haematological investigation revealed RBC count is 3.2 million/cuu mm. Haemoglobin - 9.1 gm%, MCV was 121.6 fL. MCHC was 34 g/dL. MCH - 30 pg. Peripheral smear showed the presence of hyper-segmented neutrophils and megakaryocytes.', 'Body'),
    p('<b>a.</b> What is the most probable diagnosis?', 'Part'),
    p('<b>b.</b> What is the physiological basis for megakaryocytes?', 'Part'),
    p('<b>c.</b> What is the treatment given?', 'Part'),
    p('Answer', 'AnswerHead'),
    p('<b>a.</b> Megaloblastic anemia (from the symptoms &amp; investigation)', 'Answer'),
    p('<b>b.</b> Vitamin B12 is required for DNA synthesis, and maturation of RBC, from the proerythroblast stage to mature RBC. In the deficiency of B12, large RBCs (megaloblasts) are seen.', 'Answer'),
    p('<b>c.</b> Vit B12 - Intramuscular route. Also supplement with the animal source of B12 - meat, liver, fish.', 'Answer'),
]

def footer(canvas, doc):
    canvas.saveState()
    canvas.setStrokeColor(colors.HexColor('#D9E2F3'))
    canvas.line(doc.leftMargin, 1.3*cm, A4[0]-doc.rightMargin, 1.3*cm)
    canvas.setFont('Helvetica', 8)
    canvas.setFillColor(colors.HexColor('#666666'))
    canvas.drawString(doc.leftMargin, 0.85*cm, 'Anemia: Clinical Case Questions')
    canvas.drawRightString(A4[0]-doc.rightMargin, 0.85*cm, f'Page {doc.page}')
    canvas.restoreState()

doc = SimpleDocTemplate(OUT, pagesize=A4, rightMargin=2*cm, leftMargin=2*cm, topMargin=1.7*cm, bottomMargin=1.8*cm, title='Anemia Questions')
doc.build(story, onFirstPage=footer, onLaterPages=footer)
print(OUT)