1. INTRODUCTION Migraine is one of the most prevalent neurological disorders worldwide, affecting approximately 1 billion individuals globally and ranking as the second leading cause of disability among all neurological conditions (Global Burden of Disease Study, 2019). It is characterised by recurrent attacks of unilateral, pulsating headache of moderate to severe intensity, lasting 4-72 hours, often associated with nausea, vomiting, photophobia, and phonophobia. Despite extensive modern biomedical research, the precise pathophysiology of migraine remains incompletely understood, and treatment strategies continue to be inadequate for a significant proportion of patients. Ayurveda, the ancient Indian system of medicine, offers a unique and individualistic approach to health and disease through the concept of Deha Prakriti (body constitution). The term 'Prakriti' literally means 'nature' or 'original form', and in the context of Ayurvedic medicine, it refers to the inherent psycho-somatic constitution of an individual determined at the time of conception. Deha Prakriti is governed by the relative predominance of the three biological humours - Vata, Pitta, and Kapha - collectively known as Tridoshas. According to classical Ayurvedic texts such as Charaka Samhita (Vimana Sthana 6/15) and Sushruta Samhita, an individual's Deha Prakriti determines their disease susceptibility, physiological responses, and prognosis. A person predominantly of Vataja Prakriti is considered more susceptible to disorders caused by Vata vitiation, while Pittaja Prakriti individuals are predisposed to Pitta-predominant conditions. Classical texts correlate migraine (Ardhavabhedaka) with Vata-Pitta or Tridoshaja pathogenesis. In Ayurvedic literature, migraine headache finds its closest correlation with 'Ardhavabhedaka' (half-sided headache). Acharya Charaka described it as Vata-Kaphaja Vyadhi, while Acharya Vagbhata considered it predominantly Vataja. Acharya Sushruta classified it as a Tridoshaja condition. The symptomatology described - namely paroxysmal attacks, unilateral location, pulsating nature, aggravation by movement, and association with nausea - closely parallels the modern International Classification of Headache Disorders (ICHD-3) diagnostic criteria for migraine. The concept that Deha Prakriti determines disease predisposition is well-established in Ayurveda. However, scientific validation of the association between specific Prakriti types and migraine through systematic cross-sectional studies remains sparse. Modern genomic and phenotypic studies have begun to validate the biological basis of Prakriti, demonstrating significant differences in gene expression, metabolic profiles, and immune parameters among the three Prakriti types. This opens a new avenue for integrating Ayurvedic constitutional medicine with contemporary neurology. The present cross-sectional observational study is therefore designed to systematically assess the Deha Prakriti of migraine patients using a validated Prakriti assessment tool and to identify any statistically significant association between specific Prakriti types and the occurrence, frequency, severity, and pattern of migraine. Such findings would contribute to personalised Ayurvedic management and provide a foundation for further interventional research.

1. INTRODUCTION Migraine is one of the most prevalent neurological disorders worldwide, affecting approximately 1 billion individuals globally and ranking as the second leading cause of disability among all neurological conditions (Global Burden of Disease Study, 2019). It is characterised by recurrent attacks of unilateral, pulsating headache of moderate to severe intensity, lasting 4-72 hours, often associated with nausea, vomiting, photophobia, and phonophobia. Despite extensive modern biomedical research, the precise pathophysiology of migraine remains incompletely understood, and treatment strategies continue to be inadequate for a significant proportion of patients. Ayurveda, the ancient Indian system of medicine, offers a unique and individualistic approach to health and disease through the concept of Deha Prakriti (body constitution). The term 'Prakriti' literally means 'nature' or 'original form', and in the context of Ayurvedic medicine, it refers to the inherent psycho-somatic constitution of an individual determined at the time of conception. Deha Prakriti is governed by the relative predominance of the three biological humours - Vata, Pitta, and Kapha - collectively known as Tridoshas. According to classical Ayurvedic texts such as Charaka Samhita (Vimana Sthana 6/15) and Sushruta Samhita, an individual's Deha Prakriti determines their disease susceptibility, physiological responses, and prognosis. A person predominantly of Vataja Prakriti is considered more susceptible to disorders caused by Vata vitiation, while Pittaja Prakriti individuals are predisposed to Pitta-predominant conditions. Classical texts correlate migraine (Ardhavabhedaka) with Vata-Pitta or Tridoshaja pathogenesis. In Ayurvedic literature, migraine headache finds its closest correlation with 'Ardhavabhedaka' (half-sided headache). Acharya Charaka described it as Vata-Kaphaja Vyadhi, while Acharya Vagbhata considered it predominantly Vataja. Acharya Sushruta classified it as a Tridoshaja condition. The symptomatology described - namely paroxysmal attacks, unilateral location, pulsating nature, aggravation by movement, and association with nausea - closely parallels the modern International Classification of Headache Disorders (ICHD-3) diagnostic criteria for migraine. The concept that Deha Prakriti determines disease predisposition is well-established in Ayurveda. However, scientific validation of the association between specific Prakriti types and migraine through systematic cross-sectional studies remains sparse. Modern genomic and phenotypic studies have begun to validate the biological basis of Prakriti, demonstrating significant differences in gene expression, metabolic profiles, and immune parameters among the three Prakriti types. This opens a new avenue for integrating Ayurvedic constitutional medicine with contemporary neurology. The present cross-sectional observational study is therefore designed to systematically assess the Deha Prakriti of migraine patients using a validated Prakriti assessment tool and to identify any statistically significant association between specific Prakriti types and the occurrence, frequency, severity, and pattern of migraine. Such findings would contribute to personalised Ayurvedic management and provide a foundation for further interventional research. i want only to the point and most needed information from introduction in 5-7 lines only to add into my ppt which i present in the scientific committee