There is no fixed minimum dose or duration. Iron can darken stools even at routine prescribed doses, often within 1-2 days of starting, and may continue for as long as it is taken. The color usually settles within a few days after stopping.
Common adult iron-tablet strengths include:
- Ferrous sulfate 325 mg = about 65 mg elemental iron per tablet
- Ferrous fumarate 200 mg = about 65 mg elemental iron per tablet
- Ferrous gluconate 300-325 mg = about 35-36 mg elemental iron per tablet
A single daily tablet can be enough to cause dark greenish-black stool. It does not require a high dose or weeks of treatment. Older regimens used ferrous sulfate 325 mg 1-3 times daily, but the appropriate dose for an individual should be prescribed based on the hemoglobin, ferritin, cause of anemia, kidney status, and tolerance. The Washington Manual of Medical Therapeutics, p. 5, lists ferrous sulfate 325 mg as containing 65 mg elemental iron. Goldman-Cecil Medicine, p. 19, gives the same elemental-iron content.
Typical harmless iron-related stool: dark green or black, formed, not sticky, and the person otherwise feels well. Dark stool is a common iron effect.
NHS ferrous sulfate information
Do not assume it is iron if stool is black and tar-like/sticky, has a strong offensive odor, or there is dizziness, faintness, weakness, abdominal pain, vomiting blood/coffee-ground material, or falling hemoglobin. Those features need urgent assessment for gastrointestinal bleeding, even if she is taking iron. Iron can mask the appearance of melena, and it does not protect against bleeding. Rosen's Emergency Medicine, p. 21.