A clean, professional 2.5-day Physical Pharmacy study plan schedule table/planner. The plan covers Day 04 (Saturday 26 June 2025), Day 05 (Sunday 27 June 2025), and Day 05.5 Half Day (Sunday evening/Monday 28 June 2025 morning). Each day has Morning Session, Afternoon Session, and Evening Session blocks. Color scheme: blue header bars, yellow morning blocks, purple/lavender afternoon blocks, green evening blocks. Include important topics like Solutions, Solubilization, Ionization, Colloids, Emulsions, Suspensions, Micromeritics, Rheology, Kinetics, Stability Testing. Add IMP labels on high-priority topics. Include study tips at the bottom of each day. Clean academic planner style with clear fonts and section dividers.

ls -la /home/daytona/workspace/ 2>/dev/null || echo "workspace empty or not foun…

mkdir -p /home/daytona/workspace/pharm-formula-guide

~/pharm-formula-guide/generate_guide.py

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.units import cm, mm
from reportlab.platypus import (
    SimpleDocTemplate, Paragraph, Spacer, Table, TableStyle,
    HRFlowable, KeepTogether
)
from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_JUSTIFY
from reportlab.pdfgen import canvas
from reportlab.platypus import BaseDocTemplate, PageTemplate, Frame

# ── Colour palette ─────────────────────────────────────────────────────────────
NAVY       = colors.HexColor("#1a3a5c")
BLUE       = colors.HexColor("#2563EB")
LIGHT_BLUE = colors.HexColor("#DBEAFE")
YELLOW     = colors.HexColor("#FEF9C3")
YELLOW_BDR = colors.HexColor("#F59E0B")
GREEN      = colors.HexColor("#D1FAE5")
GREEN_BDR  = colors.HexColor("#059669")
PURPLE     = colors.HexColor("#EDE9FE")
PURPLE_BDR = colors.HexColor("#7C3AED")
RED_LIGHT  = colors.HexColor("#FEE2E2")
RED_BDR    = colors.HexColor("#DC2626")
ORANGE     = colors.HexColor("#FFF7ED")
ORANGE_BDR = colors.HexColor("#EA580C")
WHITE      = colors.white
GRAY_LIGHT = colors.HexColor("#F1F5F9")
GRAY_MID   = colors.HexColor("#94A3B8")
DARK_TEXT  = colors.HexColor("#1E293B")

W, H = A4

# ── Page-number callback ────────────────────────────────────────────────────────
def add_page_number(canvas_obj, doc):
    canvas_obj.saveState()
    canvas_obj.setFont("Helvetica", 8)
    canvas_obj.setFillColor(GRAY_MID)
    canvas_obj.drawCentredString(W / 2, 18, f"Physical Pharmacy Quick Reference  |  Page {doc.page}")
    canvas_obj.setStrokeColor(GRAY_MID)
    canvas_obj.setLineWidth(0.5)
    canvas_obj.line(2*cm, 25, W - 2*cm, 25)
    canvas_obj.restoreState()

# ── Styles ──────────────────────────────────────────────────────────────────────
styles = getSampleStyleSheet()

def S(name, **kw):
    return ParagraphStyle(name, **kw)

title_style = S("Title2", fontSize=22, textColor=WHITE, alignment=TA_CENTER,
                fontName="Helvetica-Bold", spaceAfter=4, leading=28)
subtitle_style = S("Subtitle2", fontSize=11, textColor=colors.HexColor("#BFDBFE"),
                   alignment=TA_CENTER, fontName="Helvetica", spaceAfter=2, leading=14)
section_header = S("SecHdr", fontSize=13, textColor=WHITE, alignment=TA_LEFT,
                   fontName="Helvetica-Bold", leading=18, leftIndent=6)
subsection_header = S("SubSecHdr", fontSize=10, textColor=NAVY,
                       fontName="Helvetica-Bold", leading=14, spaceAfter=2)
body = S("Body2", fontSize=9, textColor=DARK_TEXT, fontName="Helvetica",
          leading=13, spaceAfter=2)
formula_style = S("Formula", fontSize=10, textColor=NAVY, fontName="Helvetica-Bold",
                   leading=14, spaceAfter=1)
mnemonic_style = S("Mnemonic", fontSize=9.5, textColor=colors.HexColor("#7C3AED"),
                    fontName="Helvetica-Bold", leading=13)
note_style = S("Note", fontSize=8.5, textColor=colors.HexColor("#374151"),
               fontName="Helvetica-Oblique", leading=12)
tip_style = S("Tip", fontSize=8.5, textColor=colors.HexColor("#065F46"),
              fontName="Helvetica-Bold", leading=12)
small_body = S("SmallBody", fontSize=8.5, textColor=DARK_TEXT, fontName="Helvetica",
               leading=12, spaceAfter=1)

# ── Helper builders ─────────────────────────────────────────────────────────────
def section_title(text, bg=NAVY):
    data = [[Paragraph(text, section_header)]]
    t = Table(data, colWidths=[W - 4*cm])
    t.setStyle(TableStyle([
        ("BACKGROUND", (0,0), (-1,-1), bg),
        ("ROUNDEDCORNERS", [6]),
        ("TOPPADDING",  (0,0), (-1,-1), 7),
        ("BOTTOMPADDING",(0,0),(-1,-1), 7),
        ("LEFTPADDING", (0,0), (-1,-1), 10),
    ]))
    return t

def formula_box(label, formula, notes="", bg=LIGHT_BLUE, border=BLUE):
    content = [
        [Paragraph(f"<b>{label}</b>", small_body),
         Paragraph(f"<b>{formula}</b>", formula_style)]
    ]
    if notes:
        content.append(["", Paragraph(notes, note_style)])
    t = Table(content, colWidths=[4.5*cm, W - 4*cm - 4.5*cm - 0.2*cm])
    t.setStyle(TableStyle([
        ("BACKGROUND",    (0,0), (-1,-1), bg),
        ("BOX",           (0,0), (-1,-1), 1.2, border),
        ("LEFTPADDING",   (0,0), (-1,-1), 8),
        ("RIGHTPADDING",  (0,0), (-1,-1), 8),
        ("TOPPADDING",    (0,0), (-1,-1), 5),
        ("BOTTOMPADDING", (0,0), (-1,-1), 5),
        ("VALIGN",        (0,0), (-1,-1), "MIDDLE"),
        ("SPAN",          (1,1), (1,-1)),
    ]))
    return t

def mnemonic_box(title_text, items, bg=PURPLE, border=PURPLE_BDR):
    rows = [[Paragraph(f"<b>{title_text}</b>", mnemonic_style), ""]]
    for letter, meaning in items:
        rows.append([
            Paragraph(f"<b>{letter}</b>", mnemonic_style),
            Paragraph(meaning, small_body)
        ])
    t = Table(rows, colWidths=[1.8*cm, W - 4*cm - 1.8*cm - 0.2*cm])
    t.setStyle(TableStyle([
        ("BACKGROUND",    (0,0), (-1,-1), bg),
        ("BOX",           (0,0), (-1,-1), 1.2, border),
        ("SPAN",          (0,0), (-1,0)),
        ("TOPPADDING",    (0,0), (-1,-1), 4),
        ("BOTTOMPADDING", (0,0), (-1,-1), 4),
        ("LEFTPADDING",   (0,0), (-1,-1), 8),
        ("RIGHTPADDING",  (0,0), (-1,-1), 8),
    ]))
    return t

def tip_box(text, bg=GREEN, border=GREEN_BDR):
    data = [[Paragraph(f"★  HIGH YIELD: {text}", tip_style)]]
    t = Table(data, colWidths=[W - 4*cm])
    t.setStyle(TableStyle([
        ("BACKGROUND",    (0,0), (-1,-1), bg),
        ("BOX",           (0,0), (-1,-1), 1, border),
        ("LEFTPADDING",   (0,0), (-1,-1), 10),
        ("TOPPADDING",    (0,0), (-1,-1), 5),
        ("BOTTOMPADDING", (0,0), (-1,-1), 5),
    ]))
    return t

def two_col_table(rows_data, headers=None, col_w=None):
    if col_w is None:
        half = (W - 4*cm) / 2
        col_w = [half, half]
    data = []
    if headers:
        data.append([Paragraph(f"<b>{h}</b>", small_body) for h in headers])
    for row in rows_data:
        data.append([Paragraph(str(c), small_body) for c in row])
    t = Table(data, colWidths=col_w)
    style = [
        ("GRID",          (0,0), (-1,-1), 0.5, GRAY_MID),
        ("TOPPADDING",    (0,0), (-1,-1), 4),
        ("BOTTOMPADDING", (0,0), (-1,-1), 4),
        ("LEFTPADDING",   (0,0), (-1,-1), 6),
        ("BACKGROUND",    (0,0), (-1,0), GRAY_LIGHT),
        ("FONTNAME",      (0,0), (-1,0), "Helvetica-Bold"),
        ("FONTSIZE",      (0,0), (-1,-1), 8.5),
    ]
    if headers:
        style.append(("BACKGROUND", (0,0), (-1,0), NAVY))
        style.append(("TEXTCOLOR",  (0,0), (-1,0), WHITE))
    t.setStyle(TableStyle(style))
    return t

SP = lambda n=6: Spacer(1, n)
HR = lambda: HRFlowable(width="100%", thickness=0.5, color=GRAY_MID, spaceAfter=4, spaceBefore=4)

# ══════════════════════════════════════════════════════════════════════════════
#  BUILD STORY
# ══════════════════════════════════════════════════════════════════════════════
story = []

# ─── COVER HEADER ──────────────────────────────────────────────────────────────
cover_data = [[
    Paragraph("Physical Pharmacy", title_style),
    Paragraph("Quick Reference Guide", title_style),
    Paragraph("All Formulas · Mnemonics · High-Yield Notes", subtitle_style),
    Paragraph("Exam Date: 28 June 2025  |  Compiled for 2.5-Day Study Sprint", subtitle_style),
]]
cover_t = Table([[
    Paragraph("Physical Pharmacy", title_style)],
    [Paragraph("Quick Reference Guide — Formulas &amp; Mnemonics", subtitle_style)],
    [Paragraph("Exam: 28 June 2025  |  2.5-Day Study Sprint", subtitle_style)],
], colWidths=[W - 4*cm])
cover_t.setStyle(TableStyle([
    ("BACKGROUND",    (0,0), (-1,-1), NAVY),
    ("TOPPADDING",    (0,0), (-1,-1), 10),
    ("BOTTOMPADDING", (0,0), (-1,-1), 10),
    ("LEFTPADDING",   (0,0), (-1,-1), 14),
]))
story.append(cover_t)
story.append(SP(12))

# ══════════════════════════════════════════════════════════════════════════════
# SECTION 1 — SOLUTIONS & COLLIGATIVE PROPERTIES
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_title("1.  SOLUTIONS & COLLIGATIVE PROPERTIES", NAVY))
story.append(SP(5))

story.append(formula_box("Raoult's Law",
    "P = Xsolvent × P°solvent",
    "P = vapour pressure of solution  |  X = mole fraction  |  P° = pure solvent VP"))
story.append(SP(4))

story.append(formula_box("Osmotic Pressure",
    "π = iMRT",
    "i = van't Hoff factor  |  M = molarity  |  R = 0.0821 L·atm/mol·K  |  T = Kelvin"))
story.append(SP(4))

story.append(formula_box("Molarity",
    "M = (mass / MW) / V(L)",
    "Most common concentration expression — practice calculations!"))
story.append(SP(4))

story.append(formula_box("% w/v",
    "% w/v = (g of solute / 100 mL solution) × 100",
    "Most common pharma concentration unit"))
story.append(SP(4))

story.append(mnemonic_box("Mnemonic: Colligative Properties — 'Very Bad Osmotic Force'",
    [("V", "Vapour pressure lowering"),
     ("B", "Boiling point elevation"),
     ("O", "Osmotic pressure"),
     ("F", "Freezing point depression")]))
story.append(SP(6))
story.append(tip_box("Raoult's law deviations: positive = stronger solute-solvent interaction breaks; negative = stronger mixed interactions."))
story.append(SP(10))

# ══════════════════════════════════════════════════════════════════════════════
# SECTION 2 — IONIZATION & BUFFERS
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_title("2.  IONIZATION, pH & BUFFER SYSTEMS", colors.HexColor("#1D4ED8")))
story.append(SP(5))

story.append(formula_box("Henderson-Hasselbalch (Acid)",
    "pH = pKa + log ( [A⁻] / [HA] )",
    "A⁻ = conjugate base  |  HA = weak acid  |  Buffer range: pKa ± 1"))
story.append(SP(4))

story.append(formula_box("Henderson-Hasselbalch (Base)",
    "pOH = pKb + log ( [BH⁺] / [B] )",
    "BH⁺ = conjugate acid  |  B = weak base"))
story.append(SP(4))

story.append(formula_box("pH from Strong Acid",
    "pH = -log[H⁺]",
    "e.g. 0.01 M HCl → pH = -log(0.01) = 2"))
story.append(SP(4))

story.append(formula_box("pKa Relation",
    "pH = pKa  →  50% ionized",
    "Weak acid: >50% ionized above pKa  |  Weak base: >50% ionized below pKa"))
story.append(SP(4))

story.append(formula_box("Buffer Capacity (β)",
    "β = ΔB / ΔpH",
    "Maximum buffer capacity when pH = pKa"))
story.append(SP(5))

story.append(mnemonic_box("Mnemonic: Ionization of Weak Acid — 'ABHA'",
    [("A", "Above pKa → more ionized (A⁻ form dominates)"),
     ("B", "Below pKa → less ionized (HA form dominates)"),
     ("H", "Henderson-Hasselbalch links pH, pKa, and ratio"),
     ("A", "At pKa → equal parts HA and A⁻")]))
story.append(SP(6))
story.append(tip_box("Most tested: Calculate pH when ratio [A⁻]/[HA] = 10 → pH = pKa + 1. Ratio = 0.1 → pH = pKa - 1."))
story.append(SP(10))

# ══════════════════════════════════════════════════════════════════════════════
# SECTION 3 — SOLUBILITY & SOLUBILIZATION
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_title("3.  SOLUBILITY & SOLUBILIZATION", colors.HexColor("#065F46")))
story.append(SP(5))

story.append(formula_box("log S = f(pH)",
    "log S = log S₀ + (pH - pKa)   [for weak acid]",
    "S₀ = intrinsic solubility (unionized form)  |  Solubility increases above pKa for acids"))
story.append(SP(4))

story.append(formula_box("Micellar Solubilization",
    "CMC: minimum concentration for micelle formation",
    "Below CMC: monomers only  |  Above CMC: micelles form, drug partitions inside"))
story.append(SP(4))

story.append(Paragraph("<b>Factors Affecting Solubility (IMP):</b>", subsection_header))
story.append(two_col_table([
    ["Temperature", "Endothermic solutes: ↑ temp → ↑ solubility"],
    ["Particle size", "↓ size → ↑ solubility (Noyes-Whitney)"],
    ["Cosolvency", "Polar + non-polar solvent blend (e.g. EtOH + water)"],
    ["Complexation", "Drug + ligand complex (e.g. cyclodextrins)"],
    ["Salting out", "Added electrolyte reduces organic solubility"],
    ["pH", "Ionization increases solubility of weak acids/bases"],
], headers=["Factor", "Effect"]))
story.append(SP(5))

story.append(mnemonic_box("Mnemonic: Solubilization Methods — 'CAMP'",
    [("C", "Cosolvency (EtOH, PEG, glycerol)"),
     ("A", "Acids/Alkalis (pH adjustment)"),
     ("M", "Micellization (surfactants, CMC)"),
     ("P", "Prodrugs + Complexation (cyclodextrins)")]))
story.append(SP(10))

# ══════════════════════════════════════════════════════════════════════════════
# SECTION 4 — MICROMERITICS & POWDER FLOW
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_title("4.  MICROMERITICS & POWDER FLOW", colors.HexColor("#92400E")))
story.append(SP(5))

story.append(formula_box("Carr's Compressibility Index",
    "CI = [(ρtap - ρbulk) / ρtap] × 100",
    "CI < 15% → good flow  |  CI 16-20% → fair  |  CI > 25% → poor (cohesive powder)"))
story.append(SP(4))

story.append(formula_box("Hausner Ratio",
    "HR = ρtap / ρbulk",
    "HR < 1.25 → good flow  |  HR > 1.5 → poor flow"))
story.append(SP(4))

story.append(formula_box("Angle of Repose",
    "tan θ = h / r   →   θ = arctan(h/r)",
    "θ < 25° → excellent flow  |  25-30° → good  |  30-40° → fair  |  >40° → very poor"))
story.append(SP(4))

story.append(formula_box("Specific Surface Area",
    "Sv = 6 / (ρ × d)   [for spherical particles]",
    "Sv = surface area per unit volume  |  Smaller d → larger Sv"))
story.append(SP(5))

story.append(mnemonic_box("Mnemonic: Powder Flow Tests — 'CASH'",
    [("C", "Carr's Index (compressibility)"),
     ("A", "Angle of Repose (static friction)"),
     ("S", "Shear cell testing"),
     ("H", "Hausner Ratio (tap/bulk density)")]))
story.append(SP(6))
story.append(tip_box("Sieve sizes: smaller mesh number = larger opening. USP sieves use mesh numbers. Know: 20 mesh = 850 µm, 60 mesh = 250 µm."))
story.append(SP(10))

# ══════════════════════════════════════════════════════════════════════════════
# SECTION 5 — DISPERSED SYSTEMS (Colloids, Emulsions, Suspensions)
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_title("5.  DISPERSED SYSTEMS", colors.HexColor("#4C1D95")))
story.append(SP(5))

story.append(formula_box("Stoke's Law (Sedimentation Rate)",
    "v = 2r²(ρ₁ - ρ₂)g / 9η",
    "v = velocity  |  r = particle radius  |  ρ₁/ρ₂ = densities  |  η = viscosity  |  g = gravity"))
story.append(SP(4))

story.append(formula_box("Zeta Potential",
    "ζ > ±30 mV → stable colloid",
    "High zeta potential = strong electrostatic repulsion = stable dispersion"))
story.append(SP(4))

story.append(formula_box("HLB Value (Griffin)",
    "HLB = 20 × (Mh / M)",
    "Mh = MW hydrophilic portion  |  M = total MW  |  HLB 8-18 → O/W  |  HLB 3-6 → W/O"))
story.append(SP(4))

story.append(formula_box("HLB (Davies Method)",
    "HLB = 7 + Σ(hydrophilic group nos.) - Σ(lipophilic group nos.)",
    "Commonly used for blending emulsifiers"))
story.append(SP(5))

story.append(Paragraph("<b>HLB Values Quick Reference (IMP):</b>", subsection_header))
story.append(two_col_table([
    ["3-6",   "W/O emulsifier (water-in-oil)"],
    ["7-9",   "Wetting / spreading agent"],
    ["8-18",  "O/W emulsifier (oil-in-water)"],
    ["13-15", "Detergent"],
    ["15-18", "Solubilizer / micellar"],
], headers=["HLB Range", "Application"], col_w=[3*cm, W - 4*cm - 3*cm - 0.2*cm]))
story.append(SP(5))

story.append(mnemonic_box("Mnemonic: Colloid Stability — 'ZEST'",
    [("Z", "Zeta potential (electrostatic repulsion)"),
     ("E", "Electrolyte concentration (reduces double layer)"),
     ("S", "Steric stabilization (polymer coating)"),
     ("T", "Temperature (kinetic energy affects flocculation)")]))
story.append(SP(5))

story.append(mnemonic_box("Mnemonic: Flocculated vs Deflocculated — 'FED vs DEC'",
    [("F", "Flocculated: Easy to redisperse, Dose uniform, caking absent"),
     ("D", "Deflocculated: Elegant appearance, Caking risk, slower sedimentation")]))
story.append(SP(6))
story.append(tip_box("Stoke's law exam trick: To slow sedimentation — decrease particle size, increase viscosity, or match densities (ρ₁ = ρ₂)."))
story.append(SP(10))

# ══════════════════════════════════════════════════════════════════════════════
# SECTION 6 — RHEOLOGY
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_title("6.  RHEOLOGY", colors.HexColor("#7C3AED")))
story.append(SP(5))

story.append(formula_box("Newton's Law of Viscosity",
    "τ = η × (dv/dr)   →   F/A = η × G",
    "τ = shear stress  |  η = viscosity (poise)  |  G = shear rate (s⁻¹)  |  F/A = force/area"))
story.append(SP(4))

story.append(formula_box("Fluidity",
    "φ = 1 / η",
    "Reciprocal of viscosity  |  Units: rhe (poise⁻¹)"))
story.append(SP(4))

story.append(formula_box("Kinematic Viscosity",
    "ν = η / ρ",
    "Units: Stokes (St) or cSt  |  ρ = density of fluid"))
story.append(SP(5))

story.append(Paragraph("<b>Flow Types Quick Reference (IMP):</b>", subsection_header))
story.append(two_col_table([
    ["Newtonian",       "Constant viscosity regardless of shear rate (water, dilute solutions)"],
    ["Plastic (Bingham)","Requires yield value before flow begins (tooth paste, concentrated suspensions)"],
    ["Pseudoplastic",   "Shear thinning — viscosity ↓ as shear ↑ (polymer solutions, most gels)"],
    ["Dilatant",        "Shear thickening — viscosity ↑ as shear ↑ (starch suspensions)"],
    ["Thixotropy",      "Time-dependent shear thinning — forms hysteresis loop on flow curve"],
], headers=["Flow Type", "Key Feature"], col_w=[3.5*cm, W - 4*cm - 3.5*cm - 0.2*cm]))
story.append(SP(5))

story.append(mnemonic_box("Mnemonic: Non-Newtonian Flow Types — 'PPD-T'",
    [("P", "Plastic — needs yield value (Bingham)"),
     ("P", "Pseudoplastic — shear thinning (most gels)"),
     ("D", "Dilatant — shear thickening (starch)"),
     ("-T", "Thixotropy — time-dependent, hysteresis loop")]))
story.append(SP(6))
story.append(tip_box("Draw the thixotropy curve: ascending curve (increasing shear) + descending curve (decreasing shear) = hysteresis loop. Area = degree of thixotropy."))
story.append(SP(10))

# ══════════════════════════════════════════════════════════════════════════════
# SECTION 7 — ADSORPTION
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_title("7.  ADSORPTION", colors.HexColor("#B45309")))
story.append(SP(5))

story.append(formula_box("Langmuir Isotherm",
    "x/m = abC / (1 + bC)",
    "x/m = amount adsorbed/g adsorbent  |  C = conc at equilibrium  |  a,b = Langmuir constants\nMonolayer adsorption, finite sites"))
story.append(SP(4))

story.append(formula_box("Freundlich Isotherm",
    "x/m = KC^(1/n)",
    "log(x/m) = log K + (1/n) log C  |  Plot: log(x/m) vs log C → straight line\nMultilayer, empirical, 1/n < 1 → favourable adsorption"))
story.append(SP(5))

story.append(mnemonic_box("Mnemonic: Langmuir vs Freundlich — 'LMF'",
    [("L", "Langmuir: Limited (monolayer), Linear at low conc, Saturation occurs"),
     ("M", "Monolayer maximum defined by constant 'a'"),
     ("F", "Freundlich: Free multilayer, Follows power law, No saturation plateau")]))
story.append(SP(6))
story.append(tip_box("Langmuir linearized: C/(x/m) = 1/(ab) + C/a → plot C/(x/m) vs C → slope = 1/a, intercept = 1/ab"))
story.append(SP(10))

# ══════════════════════════════════════════════════════════════════════════════
# SECTION 8 — CHEMICAL KINETICS & STABILITY
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_title("8.  CHEMICAL KINETICS & STABILITY TESTING", colors.HexColor("#B91C1C")))
story.append(SP(5))

story.append(Paragraph("<b>Rate Laws Summary (IMP):</b>", subsection_header))
story.append(two_col_table([
    ["Zero Order",  "-dC/dt = k₀",   "C = C₀ - k₀t",        "t½ = C₀/2k₀",    "Conc vs t → straight line"],
    ["First Order", "-dC/dt = k₁C",  "ln C = ln C₀ - k₁t",  "t½ = 0.693/k₁",  "ln Conc vs t → straight line"],
    ["Second Order","-dC/dt = k₂C²", "1/C = 1/C₀ + k₂t",    "t½ = 1/k₂C₀",   "1/Conc vs t → straight line"],
], headers=["Order", "Rate Eq", "Integrated Law", "Half-Life", "Graphical Test"],
   col_w=[2.2*cm, 2.8*cm, 3.5*cm, 2.5*cm, W - 4*cm - 11*cm - 0.2*cm]))
story.append(SP(5))

story.append(formula_box("Arrhenius Equation",
    "k = A · e^(-Ea / RT)",
    "A = frequency factor  |  Ea = activation energy (J/mol)  |  R = 8.314 J/mol·K  |  T = Kelvin"))
story.append(SP(4))

story.append(formula_box("Arrhenius (log form)",
    "log k = log A - Ea / (2.303 RT)",
    "Plot: log k vs 1/T → slope = -Ea/2.303R  |  Used to predict shelf life at different temps"))
story.append(SP(4))

story.append(formula_box("First-Order Half-Life",
    "t½ = 0.693 / k",
    "Independent of initial concentration — constant t½ is hallmark of first-order kinetics"))
story.append(SP(4))

story.append(formula_box("Shelf Life (t₉₀)",
    "t₉₀ = 0.105 / k   [first order]",
    "Time for drug to degrade to 90% of original potency  |  t₉₀ = 0.1 C₀/k₀ for zero order"))
story.append(SP(4))

story.append(formula_box("Q10 Rule (Temperature Coefficient)",
    "Q10 = k(T+10) / k(T)   ≈ 2-3 for most reactions",
    "For every 10°C rise, rate roughly doubles  |  Used in accelerated stability prediction"))
story.append(SP(5))

story.append(mnemonic_box("Mnemonic: Order of Reaction Identification — 'ZFL'",
    [("Z", "Zero: straight line on Conc vs Time plot"),
     ("F", "First: straight line on ln(Conc) vs Time plot"),
     ("L", "Log/Second: straight line on 1/Conc vs Time plot")]))
story.append(SP(5))

story.append(mnemonic_box("Mnemonic: Arrhenius Equation — 'A-E-RT'",
    [("A", "A = pre-exponential (Arrhenius) factor — collision frequency"),
     ("E", "Ea = activation energy — minimum energy for reaction"),
     ("R", "R = gas constant (8.314 J/mol·K)"),
     ("T", "T = absolute temperature in KELVIN (not °C!)")]))
story.append(SP(6))
story.append(tip_box("ICH Accelerated Stability: 40°C/75% RH for 6 months (Zone III/IV). Long-term: 25°C/60% RH for 12-24 months."))
story.append(SP(10))

# ══════════════════════════════════════════════════════════════════════════════
# SECTION 9 — MASTER FORMULA SHEET
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_title("9.  MASTER FORMULA SHEET — CUT & KEEP", colors.HexColor("#0F172A")))
story.append(SP(6))

master_data = [
    ["Henderson-Hasselbalch",   "pH = pKa + log([A⁻]/[HA])"],
    ["Stoke's Law",             "v = 2r²(ρ₁-ρ₂)g / 9η"],
    ["Arrhenius Equation",      "k = A·e^(-Ea/RT)"],
    ["1st Order Half-Life",     "t½ = 0.693 / k"],
    ["Zero Order Half-Life",    "t½ = C₀ / 2k₀"],
    ["2nd Order Half-Life",     "t½ = 1 / k₂C₀"],
    ["Shelf Life (t₉₀) 1st",   "t₉₀ = 0.105 / k"],
    ["Carr's Index",            "CI = [(ρtap - ρbulk)/ρtap] × 100"],
    ["Hausner Ratio",           "HR = ρtap / ρbulk"],
    ["Raoult's Law",            "P = Xsolvent × P°solvent"],
    ["Osmotic Pressure",        "π = iMRT"],
    ["Langmuir Isotherm",       "x/m = abC / (1 + bC)"],
    ["Freundlich Isotherm",     "x/m = KC^(1/n)  →  log(x/m) = logK + (1/n)logC"],
    ["Newton's Viscosity Law",  "τ = η × G   (F/A = η × dv/dr)"],
    ["HLB (Griffin)",           "HLB = 20 × Mh / M"],
    ["Zeta Potential (stable)", "ζ > ±30 mV"],
    ["Buffer Capacity",         "β = ΔB / ΔpH"],
    ["Q10 Rule",                "Q10 = k(T+10) / k(T)  ≈ 2-3"],
]

master_t = Table(
    [[Paragraph(f"<b>{r}</b>", small_body), Paragraph(f, formula_style)] for r, f in master_data],
    colWidths=[5*cm, W - 4*cm - 5*cm - 0.2*cm]
)
master_t.setStyle(TableStyle([
    ("GRID",          (0,0), (-1,-1), 0.5, colors.HexColor("#CBD5E1")),
    ("BACKGROUND",    (0,0), (0,-1),  GRAY_LIGHT),
    ("BACKGROUND",    (1,0), (1,-1),  YELLOW),
    ("TOPPADDING",    (0,0), (-1,-1), 5),
    ("BOTTOMPADDING", (0,0), (-1,-1), 5),
    ("LEFTPADDING",   (0,0), (-1,-1), 7),
    ("FONTSIZE",      (0,0), (-1,-1), 9),
    # Alternate rows
    *[("BACKGROUND", (0,i), (-1,i), colors.HexColor("#F8FAFC")) for i in range(1, len(master_data), 2)],
]))
story.append(master_t)
story.append(SP(10))

# ══════════════════════════════════════════════════════════════════════════════
# SECTION 10 — ALL MNEMONICS AT A GLANCE
# ══════════════════════════════════════════════════════════════════════════════
story.append(section_title("10.  ALL MNEMONICS AT A GLANCE", colors.HexColor("#5B21B6")))
story.append(SP(5))

mnemonics_summary = [
    ["VBOF", "Colligative Properties", "Vapour lowering · Boiling pt elevation · Osmotic pressure · Freezing pt depression"],
    ["ABHA", "Ionization of Weak Acid", "Above pKa = ionized · Below pKa = unionized · H-H equation · At pKa = 50:50"],
    ["CAMP", "Solubilization Methods",  "Cosolvency · Acids/Alkalis · Micellization · Prodrugs+Complexation"],
    ["CASH", "Powder Flow Tests",       "Carr's Index · Angle of repose · Shear cell · Hausner Ratio"],
    ["ZEST", "Colloid Stability",       "Zeta potential · Electrolyte · Steric stabilization · Temperature"],
    ["FED vs DEC","Floc vs Defloc",     "Floc: Easy redisperse, Dose uniform | Defloc: Elegant, Caking risk"],
    ["PPD-T","Non-Newtonian Flow",      "Plastic · Pseudoplastic · Dilatant · Thixotropy (time-dependent)"],
    ["LMF",  "Adsorption Isotherms",    "Langmuir=Limited monolayer · Freundlich=Free multilayer"],
    ["ZFL",  "Reaction Order ID",       "Zero=Conc vs t straight · First=lnC vs t · Second=1/C vs t"],
    ["AERT", "Arrhenius Equation",      "A=frequency factor · Ea=activation energy · R=8.314 · T=Kelvin"],
]

msum_t = Table(
    [[Paragraph(f"<b>{m}</b>", mnemonic_style),
      Paragraph(f"<b>{topic}</b>", small_body),
      Paragraph(meaning, small_body)]
     for m, topic, meaning in mnemonics_summary],
    colWidths=[2*cm, 3.5*cm, W - 4*cm - 5.7*cm]
)
msum_t.setStyle(TableStyle([
    ("GRID",          (0,0), (-1,-1), 0.5, colors.HexColor("#C4B5FD")),
    ("BACKGROUND",    (0,0), (-1,-1), PURPLE),
    ("TOPPADDING",    (0,0), (-1,-1), 5),
    ("BOTTOMPADDING", (0,0), (-1,-1), 5),
    ("LEFTPADDING",   (0,0), (-1,-1), 7),
    ("FONTSIZE",      (0,0), (-1,-1), 8.5),
    *[("BACKGROUND", (0,i), (-1,i), colors.HexColor("#EDE9FE")) for i in range(0, len(mnemonics_summary), 2)],
]))
story.append(msum_t)
story.append(SP(10))

# ══════════════════════════════════════════════════════════════════════════════
# FOOTER TIP BOX
# ══════════════════════════════════════════════════════════════════════════════
final_tip = Table([[Paragraph(
    "<b>EXAM DAY CHECKLIST:</b>  H-H equation ✓  |  Stoke's Law ✓  |  Arrhenius ✓  |  "
    "Rate laws (0, 1st, 2nd) ✓  |  HLB values ✓  |  Carr's Index thresholds ✓  |  "
    "Thixotropy curve ✓  |  Zeta potential ±30 mV ✓",
    tip_style)]],
    colWidths=[W - 4*cm])
final_tip.setStyle(TableStyle([
    ("BACKGROUND",    (0,0), (-1,-1), colors.HexColor("#FEF3C7")),
    ("BOX",           (0,0), (-1,-1), 2, YELLOW_BDR),
    ("LEFTPADDING",   (0,0), (-1,-1), 12),
    ("TOPPADDING",    (0,0), (-1,-1), 8),
    ("BOTTOMPADDING", (0,0), (-1,-1), 8),
]))
story.append(final_tip)

# ══════════════════════════════════════════════════════════════════════════════
# BUILD PDF
# ══════════════════════════════════════════════════════════════════════════════
output_path = "/home/daytona/workspace/pharm-formula-guide/Physical_Pharmacy_Quick_Reference.pdf"

doc = SimpleDocTemplate(
    output_path,
    pagesize=A4,
    leftMargin=2*cm,
    rightMargin=2*cm,
    topMargin=1.8*cm,
    bottomMargin=2*cm,
    title="Physical Pharmacy Quick Reference Guide",
    author="Study Sprint"
)

doc.build(story, onFirstPage=add_page_number, onLaterPages=add_page_number)
print(f"PDF generated: {output_path}")

cd /home/daytona/workspace/pharm-formula-guide && python generate_guide.py

ls -lh /home/daytona/workspace/pharm-formula-guide/Physical_Pharmacy_Quick_Refer…

A beautiful, colorful printable study timetable image for Physical Pharmacy exam preparation. 2.5 day study plan starting 26 June 2025 ending 28 June 2025 morning. Structured like a professional academic planner with: DAY 1 - Saturday 26 June 2025: - Morning Session (7:00 AM - 10:30 AM): Solutions (IMP), Solubilization (IMP), Ionization & Henderson-Hasselbalch - marked with red star IMP - Afternoon Session (12:00 PM - 3:00 PM): Colloids (IMP), Emulsions & HLB (IMP), Suspensions & Stokes Law (IMP) - Evening Session (5:00 PM - 7:00 PM): Hydrolysis + Adsorption, Micromeritics (IMP), Formula Review DAY 2 - Sunday 27 June 2025: - Morning Session (7:00 AM - 10:00 AM): Rheology (IMP), Kinetics - Rate & Order, Half-life calculations - Afternoon Session (12:00 PM - 3:00 PM): Arrhenius & Stability Testing (IMP), Physicochemical Processes, Miscellaneous Processes - Evening Session (5:00 PM - 7:30 PM): Full Revision Round, Past Paper MCQs (30-40 questions) DAY 2.5 - Monday 28 June 2025 (EXAM DAY): - Morning (7:00 AM - 10:00 AM): Weak areas revision, Formula Sheet review, Final MCQ round 20-25 questions, Last IMP skim Design: dark navy blue header, pastel yellow morning blocks, soft lavender afternoon blocks, mint green evening blocks, orange exam day block. Bold IMP tags in red. Clean sans-serif fonts. Motivational quote at bottom. Star ratings for priority topics. Professional academic planner aesthetic on white background with subtle grid lines.