Chapter 10: Nutrition
LONG QUESTIONS
1. PEM (Protein-Energy Malnutrition)
Definition
Protein-Energy Malnutrition is a spectrum of nutritional disorders caused by inadequate intake of protein and/or energy (calories), resulting in impaired growth, body wasting, and immune dysfunction. It predominantly affects children under 5 years in developing countries.
Classification of PEM
WHO/Wellcome Classification (Clinical):
| Condition | Weight for Age | Oedema |
|---|
| Underweight (mild-moderate PEM) | 60-80% of expected | Absent |
| Marasmus | <60% of expected | Absent |
| Kwashiorkor | 60-80% of expected | Present |
| Marasmic-Kwashiorkor | <60% of expected | Present |
Gomez Classification (Weight for Age):
| Grade | % of Standard (Harvard) |
|---|
| Grade I (mild) | 75-90% |
| Grade II (moderate) | 60-75% |
| Grade III (severe) | <60% |
Waterlow Classification (uses Z-scores):
- Stunting (chronic malnutrition): Height for Age Z-score < -2 SD
- Wasting (acute malnutrition): Weight for Height Z-score < -2 SD
IAP Classification (India, based on % weight for age):
| Grade | % Expected Weight for Age |
|---|
| Normal | >80% |
| Grade I | 71-80% |
| Grade II | 61-70% |
| Grade III | 51-60% |
| Grade IV | <50% |
Marasmus
Definition: Severe energy deficiency with marked wasting of muscle and fat, but NO oedema.
Aetiology:
- Severe restriction of both calories and protein
- Early weaning from breast milk
- Repeated infections (diarrhoea, respiratory)
- Poverty, food insecurity
- Occurs commonly in infants under 1 year
Clinical Features:
- Severe wasting - "skin and bones" appearance
- Loss of subcutaneous fat (starting from buttocks, then abdomen, then face)
- "Old man face" (premature aging - loss of buccal fat pad, Bichat's fat pad)
- Muscle wasting - visible ribs, "baggy pants" (loss of gluteal fat)
- No oedema
- Weight severely reduced (<60% expected weight for age)
- Marked irritability and hunger (vs. kwashiorkor - apathy)
- Normal hair (unlike kwashiorkor)
- Skin: dry, wrinkled; no skin lesions (unlike kwashiorkor)
- Pot belly - due to weak abdominal muscles + gas
- Alert, hungry, irritable
Metabolic Changes:
- Low blood glucose, low insulin
- Elevated glucagon and cortisol
- Adipose tissue mobilized (lipolysis)
- Muscle protein catabolized (gluconeogenesis)
- Metabolic adaptation to starvation
Kwashiorkor
Definition: Predominantly protein deficiency with adequate or near-adequate caloric intake, resulting in OEDEMA and other characteristic features.
Etymology: Coined by Dr. Cicely Williams (1935); Ga language (Ghana) - "disease of the deposed child" (child displaced by next sibling from breast)
Aetiology:
- Predominantly protein-deficient diet (high carbohydrate, low protein)
- Common in weaned children 1-3 years given starchy weaning foods
- Precipitated by infections (measles, diarrhoea)
- Aflatoxin exposure (controversial role)
Clinical Features:
- Oedema (pitting) - hallmark; starts in legs, may become generalized (anasarca)
- Growth retardation - moderate weight deficit (60-80% expected)
- Psychomotor changes - apathy, misery, anorexia, "moon face"
- Skin changes:
- "Flaky paint" dermatosis / "Crazy pavement" dermatosis
- Areas of hyperpigmentation and hypopigmentation
- Desquamation (peeling)
- Ulceration in severe cases
- Hair changes:
- Reddish/brown discoloration (flag sign - bands of normal and abnormal hair)
- Thin, sparse, straight, silky, easily pluckable hair
- "Flag sign" (Bandera sign) - bands of depigmented hair
- Moon face - oedematous, rounded face
- Fatty liver - hepatomegaly (fat accumulation due to low apolipoprotein synthesis)
- Pot belly - hepatomegaly + weak muscles + gas
- Anaemia - pale conjunctivae
- Vitamin A deficiency - may coexist
Biochemical Changes:
- Low serum albumin (<3 g/dL; severe <2 g/dL) → oedema
- Low serum transferrin, retinol-binding protein, pre-albumin
- Low serum potassium, magnesium
- High serum ferritin (acute phase)
- Fatty liver → elevated liver enzymes
Marasmic-Kwashiorkor
- Features of BOTH: severe wasting + oedema
- Most severe form of PEM
- Weight <60% + oedema present
MUAC (Mid-Upper Arm Circumference) - Assessment Tool
| Age/Sex | SAM | MAM | Normal |
|---|
| Children 6-59 months | <11.5 cm | 11.5-12.5 cm | ≥12.5 cm |
| Pregnant women | <23 cm | 23-25 cm | ≥25 cm |
Global Burden
- India: ~35% of children under 5 are stunted (NFHS-5)
- ~19% are wasted; ~7.7% are severely wasted (SAM)
- ~32% are underweight
- "Double burden of malnutrition" - undernutrition + obesity coexist
Prevention of PEM
- Promotion of breastfeeding - exclusive breastfeeding for 6 months
- Complementary feeding from 6 months (appropriate, adequate, safe)
- Diet diversification - balanced diet
- ICDS programme - supplementary nutrition
- Deworming - biannual Albendazole (reduces parasite load competing for nutrients)
- Immunization - reduce infectious diseases
- ORS - treat diarrhoea promptly
- Vitamin A supplementation - reduces mortality
- WASH - safe water, sanitation, hygiene
- Women's education, empowerment - birth spacing, birth weight
- Poshan Abhiyan/Mission POSHAN 2.0 - national programme
Management
(SAM management: see Chapter 8 - NRC, WHO 10 steps, F-75/F-100)
2. Balanced Diet
Definition
A balanced diet is one that contains different kinds of foods in such quantities and proportions that the need for calories, proteins, minerals, vitamins, and other nutrients is adequately met and a small provision is made for extra nutrients to withstand short durations of leanness.
Nutrient Requirements (ICMR 2020 - Indian RDA)
Energy requirements:
| Group | Energy (kcal/day) |
|---|
| Sedentary adult male | 2110 |
| Moderate activity adult male | 2710 |
| Heavy activity adult male | 3470 |
| Sedentary adult female | 1660 |
| Moderate activity adult female | 2130 |
| Heavy activity adult female | 2720 |
| Pregnant woman (extra) | +350 (2nd trimester), +500 (3rd) |
| Lactating woman (extra) | +600 (0-6 months) |
Protein requirements (ICMR 2020):
- Adult male: 0.83 g/kg/day (sedentary ~54 g/day)
- Adult female: 0.83 g/kg/day (sedentary ~46 g/day)
- Pregnant: +23 g/day extra
- Lactating: +19 g/day extra (0-6 months)
- Children: higher per kg (1.0-1.5 g/kg/day depending on age)
Components of a Balanced Diet
Food Groups (Indian):
| Group | Foods | Main Nutrients |
|---|
| 1. Cereals/grains | Rice, wheat, jowar, bajra, maize | Carbohydrates, protein, B vitamins |
| 2. Pulses/legumes | Dal, beans, peas, soyabean | Protein, iron, fibre |
| 3. Milk and milk products | Milk, curd, paneer, cheese | Calcium, protein, riboflavin, Vit B12 |
| 4. Meat, fish, eggs | Chicken, fish, egg, liver | Protein, iron, Vit B12, zinc |
| 5. Vegetables (green leafy) | Spinach, methi, amaranth | Iron, calcium, folate, Vit A |
| 6. Other vegetables | Tomato, carrot, gourd, potato | Vitamins, minerals, fibre |
| 7. Fruits | Citrus, mango, banana, guava | Vitamin C, vitamin A, fibre |
| 8. Fats and oils | Mustard oil, groundnut oil, ghee | Energy, EFA, fat-soluble vitamins |
| 9. Sugar/jaggery | Sugar, gur | Energy |
Balanced Diet Plate (ICMR - "MyPlate India")
- Half plate: Vegetables + fruits
- Quarter plate: Cereals/grains
- Quarter plate: Protein (pulses + dairy/meat)
- Small portion: Fats
Nutritional Requirements - Key Points
- Energy distribution: Carbohydrates 50-60%, Fat 20-30%, Protein 10-15% of total calories
- Fats: At least 15g/day (minimum); essential fatty acids (linoleic acid, alpha-linolenic acid)
- Fibre: 25-40 g/day (dietary fibre - prevents constipation, diabetes, heart disease, colon cancer)
- Water: 2-2.5 litres/day
Cereals - Major Staple
- Provide 60-80% of calories in Indian diet
- Deficient in lysine (limiting amino acid) and tryptophan
- Rice milling removes B vitamins from outer layer → Thiamine deficiency (Beriberi)
- Wheat contains gluten (Coeliac disease in sensitive individuals)
- Millets (ragi, jowar, bajra): rich in calcium (ragi - highest), iron, fibre
Protein Quality
- Complete proteins (all essential amino acids): Animal sources - milk, egg, meat, fish
- Incomplete proteins: Plant sources - deficient in one or more essential AAs
- Complementary proteins: Combining plant proteins (cereal + pulse) improves amino acid profile (e.g., rice + dal = "protein complementation")
- NPU (Net Protein Utilization): See short notes
Special Diets
- Vegetarian diet: Adequate if includes dairy and variety of plants; may lack Vit B12, Vit D, zinc, iron, omega-3
- Vegan diet: Risk of B12, Vit D, calcium, iron, zinc, iodine deficiency
- Ketogenic diet: High fat, very low carbohydrate; used in epilepsy, obesity (medical supervision)
3. IDD (Iodine Deficiency Disorders)
(Detailed in Chapter 6 under NIDDCP)
Quick summary for this chapter:
Iodine in Nutrition
- RDA: 150 mcg/day (adults); 250 mcg/day (pregnancy and lactation)
- Sources: Seafood (best), iodized salt, seaweed, dairy
- Deficiency: Iodine-deficient areas - Himalayan foothills, Gangetic plain, inland areas
- Assessment: Urinary iodine excretion (UIE); median >100 mcg/L = adequate
Spectrum of IDD (across life cycle)
| Stage | Effects |
|---|
| Fetus | Abortion, stillbirth, congenital anomaly, cretinism, psychomotor defects |
| Neonate | Neonatal goitre, neonatal hypothyroidism, mental retardation |
| Child/Adolescent | Goitre, hypothyroidism, impaired mental function, retarded growth |
| Adult | Goitre, hypothyroidism, impaired mental function |
| All ages | Goitre |
Types of Goitre
- Grade 0: No goitre
- Grade 1: Palpable (not visible even with neck extended)
- Grade 2: Visible with neck in normal position
TGR (Total Goitre Rate): Grade 1 + Grade 2 goitres in school children 6-12 years; target <5% population
Cretinism
- Neurological cretinism (more common in India): Intellectual disability, deaf-mutism, spastic diplegia; due to maternal iodine deficiency (critical period: 8-12 weeks gestation)
- Myxoedematous cretinism: Hypothyroid features predominate; dwarfism, dry skin, myxoedema; less common in India
4. Iron Deficiency Anaemia
Definition
Anaemia due to depletion of iron stores, insufficient to support normal erythropoiesis.
WHO Definition of Anaemia (Hb levels):
| Group | Hb threshold |
|---|
| Adult males | <13 g/dL |
| Adult non-pregnant females | <12 g/dL |
| Pregnant women | <11 g/dL |
| Children 6-59 months | <11 g/dL |
| Children 5-11 years | <11.5 g/dL |
| Children 12-14 years | <12 g/dL |
Prevalence in India (NFHS-5)
- Children 6-59 months: 67.1% anaemic
- Women 15-49 years: 57% anaemic
- Pregnant women: 52.2% anaemic
- Men 15-49 years: 25% anaemic
Iron Metabolism
- Total body iron: 3-4 g (male), 2.5 g (female)
- Functional iron: Haemoglobin (~65%), myoglobin (~10%), tissue enzymes
- Storage iron: Ferritin, haemosiderin (in liver, spleen, bone marrow)
- Transport iron: Transferrin (bound to transferrin - normally 30% saturated)
- Recommended Daily Allowance (ICMR 2020): Male: 17 mg/day; Female: 21 mg/day (premenopausal); Pregnancy: 35 mg/day
Dietary Iron
- Haem iron (from animal sources - meat, fish, poultry): 15-35% bioavailability
- Non-haem iron (from plant sources - cereals, pulses, green vegetables): 1-10% bioavailability
- Enhancers of iron absorption: Vitamin C (most important), meat factor, acidic pH, ferrous > ferric
- Inhibitors of iron absorption: Phytates (cereals), oxalates (spinach), tannins (tea, coffee), calcium, antacids, polyphenols
Stages of Iron Deficiency
- Pre-latent (Storage depletion): Serum ferritin ↓; Hb normal; Transferrin saturation normal
- Latent (Transport depletion): Serum ferritin ↓↓; Serum iron ↓; TIBC ↑; Transferrin saturation ↓; Hb still normal
- Overt Iron Deficiency Anaemia: All above + Hb ↓; microcytic hypochromic RBCs; clinical symptoms
Clinical Features
- General: Pallor (conjunctiva, nail beds, palmar creases, tongue), fatigue, weakness, exertional dyspnoea
- Specific to iron deficiency:
- Koilonychia (spoon-shaped nails)
- Angular stomatitis, glossitis
- Dysphagia (Plummer-Vinson/Paterson-Brown-Kelly syndrome) - with oesophageal web
- PICA (pagophagia = ice eating; geophagia = dirt eating)
- Irritability, poor concentration, impaired cognitive function (in children)
- Restless leg syndrome
Diagnosis
- CBC: Low Hb, low MCV (<80 fL), low MCH (<27 pg), low MCHC (<32%)
- Peripheral smear: Microcytic hypochromic RBCs, anisocytosis, poikilocytosis, pencil cells, target cells
- Serum ferritin: Best single test to assess iron stores (low in IDA: <12-15 mcg/L); elevated in infection (acute phase reactant)
- Serum iron: Low (<60 mcg/dL)
- TIBC: High (>400 mcg/dL)
- Transferrin saturation: Low (<15%)
Treatment
- Therapeutic dose: Elemental iron 3-6 mg/kg/day in 2-3 divided doses (children); 100-200 mg/day (adults)
- Duration: Continue 3 months after Hb normalizes to replenish stores
- Form: Ferrous sulphate (cheapest, most common), ferrous gluconate, ferrous fumarate
- Parenteral iron (IV/IM): For malabsorption, intolerance, compliance issues, severe anaemia near surgery
- Iron sucrose (safest IV), Ferric carboxymaltose (FCM - single large dose)
- Blood transfusion: Hb <7 g/dL with symptoms; or emergency (Hb <6 in pregnancy)
- Treat underlying cause: Deworming (hookworm), treat bleeding disorders
Prevention (Programmes)
- WIFS: Weekly IFA for adolescents
- IFA in pregnancy: 100 mg iron + 500 mcg folic acid daily for 180 days
- IFA for children 6-59 months: 1 mg/kg/day liquid IFA daily
- ANAEMIA MUKT BHARAT (AMB): 6×6×6 strategy (see Chapter 6)
- Fortification: Iron-fortified salt, wheat flour, rice fortification (under FSSAI)
- Dietary diversification: Green leafy vegetables, Vitamin C-rich foods
- Deworming: Biannual Albendazole (reduces hookworm load)
5. Nutritional Assessment
Definition
Nutritional assessment is the comprehensive evaluation of nutritional status using multiple methods to identify nutritional disorders, their etiology, and severity.
Methods - "ABCD" of Nutritional Assessment
A - Anthropometric Assessment
- Weight: Most commonly used; weighed on calibrated scale, light clothing, no shoes
- Height/Length: Recumbent length (<2 years), standing height (>2 years)
- BMI (Body Mass Index): Weight (kg) / Height² (m²)
- WHO cut-offs: <18.5 = underweight; 18.5-24.9 = normal; 25-29.9 = overweight; ≥30 = obese
- Asian cut-offs (India/WHO Asia-Pacific): Overweight ≥23 kg/m²; Obese ≥27.5 kg/m²
- MUAC (Mid-Upper Arm Circumference): 6-59 months children, pregnant women
- Head circumference: Reflects brain growth; normal at birth ~34 cm; 1 year ~47 cm
- Chest circumference: Head > Chest at birth; Head = Chest at 1 year; Head < Chest after 1 year
- Skin fold thickness: Triceps, subscapular (reflects body fat); measured with Harpenden caliper
- Growth charts: Z-scores (WAZ, HAZ, WHZ) - plotted on WHO growth standards
B - Biochemical/Laboratory Assessment
- Serum proteins: Albumin (half-life 20 days - chronic status), Pre-albumin/Transthyretin (2 days - recent acute changes), Transferrin (8 days), Retinol-binding protein (12 hours)
- Haemoglobin: Anaemia assessment
- Serum iron, ferritin, TIBC: Iron status
- Serum vitamins: Retinol (Vit A), 25-OH Vitamin D, Vitamin C, B12, folate
- Urinary nitrogen: Nitrogen balance (positive = anabolism; negative = catabolism)
- Urinary creatinine-height index: Estimates muscle mass
- Urinary iodine excretion: Iodine status
C - Clinical Assessment
- Head-to-toe examination for signs of nutritional deficiencies:
- Hair: Flag sign (protein deficiency), alopecia (zinc, biotin)
- Eyes: Xerophthalmia (Vit A), Bitot's spots, angular palpebritis (riboflavin)
- Face: Moon face (kwashiorkor), pallor (anaemia)
- Mouth: Angular stomatitis (riboflavin, niacin, iron), cheilosis, glossitis, bleeding gums (Vit C - scurvy)
- Skin: Flaky paint dermatosis (kwashiorkor), pellagrous dermatitis (niacin), follicular hyperkeratosis (Vit A)
- Nails: Koilonychia (iron deficiency)
- Legs: Pitting oedema (kwashiorkor, Vit B1), Bitot's spots (Vit A), night blindness
D - Dietary Assessment
- 24-hour dietary recall: Most commonly used; person recalls all food/drink consumed in past 24 hours; single recall underestimates usual intake; 3-day recall more accurate
- Food frequency questionnaire (FFQ): Lists food items, frequency of consumption (daily/weekly/monthly); good for usual intake
- Diet history: Detailed interview about usual dietary patterns, food habits
- Food diary/record: Prospective recording for 3-7 days; most accurate but requires cooperation
- Household food balance sheet: Food available to household (production + purchase - wastage/storage)
- Duplicate food collection: Weighed analysis of duplicate portion; gold standard but impractical
PEM Grades - CIAF (Composite Index of Anthropometric Failure)
Uses all three indices (WAZ, HAZ, WHZ) combined - more comprehensive than single index
6. Nutrition Programmes
(Detailed in Chapter 6)
Quick summary:
| Programme | Launch | Target | Ministry |
|---|
| ICDS | 1975 | 0-6 years, P&L women | MWCD |
| Mid-Day Meal (PM POSHAN) | 1995/2021 | Classes 1-8 | Education |
| NNAPP / Anaemia Mukt Bharat | 1970/2018 | All age groups | Health |
| WIFS | 2012 | Adolescents 10-19 | Health |
| POSHAN Abhiyan/Mission POSHAN 2.0 | 2018/2021 | All | MWCD |
| NRC | Under NHM | SAM children | Health |
| PMMVY | 2017 | Pregnant women | MWCD |
| Vitamin A Programme | 1970 | 9 months-5 years | Health |
SHORT NOTES
Glycaemic Index (GI)
- Measures how quickly a carbohydrate-containing food raises blood glucose relative to a reference food (glucose or white bread)
- Formula: GI = (Area under blood glucose curve for test food / Area under blood glucose curve for reference) × 100
- Reference: Glucose = 100; White bread = 100
Classification:
| GI | Category |
|---|
| >70 | High GI |
| 56-69 | Medium GI |
| <55 | Low GI |
High GI foods: White rice, white bread, potatoes, watermelon, cornflakes
Low GI foods: Legumes, most fruits, non-starchy vegetables, barley, oats, nuts, whole wheat
Clinical relevance:
- Diabetics and insulin-resistant individuals benefit from low-GI diet
- Low GI → slower glucose absorption → less insulin spike → better glycaemic control
- Glycaemic Load (GL): GI × Carbohydrate content of serving / 100; better clinical predictor than GI alone
- Limitation: GI tested in isolated food; mixed meals change GI considerably
NPU (Net Protein Utilization)
- Measure of protein quality that accounts for both digestibility and biological value
- Formula: NPU = (Nitrogen retained / Nitrogen ingested) × 100
- Combines: Digestibility + Biological Value (BV)
- NPU = Digestibility × Biological Value (BV)
BV (Biological Value): Nitrogen retained / Nitrogen absorbed × 100 (reflects amino acid composition)
Comparison with other protein quality measures:
| Measure | Definition |
|---|
| PER (Protein Efficiency Ratio) | Weight gain / Protein consumed (in rats) |
| BV | N retained / N absorbed × 100 |
| NPU | N retained / N ingested × 100 = BV × Digestibility |
| PDCAAS | Amino acid score corrected for digestibility (WHO standard) |
| DIAAS | Digestible Indispensable Amino Acid Score (newer WHO standard) |
NPU values of common proteins:
- Egg (whole): NPU ~94% (reference/near perfect protein)
- Milk: NPU ~82%
- Meat/fish: NPU ~75-80%
- Soyabean: NPU ~61%
- Wheat: NPU ~40-60%
- Maize: NPU ~36%
- Rice: NPU ~57%
Xerophthalmia (Vitamin A Deficiency)
Definition: Pathological dryness of the conjunctiva and cornea due to Vitamin A deficiency.
WHO Classification (Sommer):
| Stage | Classification |
|---|
| XN | Night blindness (nyctalopia) - earliest symptom |
| X1A | Conjunctival xerosis (dryness/roughness) |
| X1B | Bitot's spots (foamy, cheesy white spots on temporal conjunctiva) - pathognomonic |
| X2 | Corneal xerosis (haziness) |
| X3A | Corneal ulceration < 1/3 cornea |
| X3B | Corneal ulceration ≥ 1/3 cornea / Keratomalacia (total corneal softening) → blindness |
| XS | Corneal scar |
| XF | Xerophthalmic fundus |
Night blindness (XN): Impaired dark adaptation due to insufficient rhodopsin (rod pigment containing Vit A/retinol)
Bitot's spots (X1B): Foamy-looking triangular white plaques on bulbar conjunctiva (temporal side); consist of keratinized epithelial cells with saprophytic bacilli (Corynebacterium xerosis)
Keratomalacia: Liquefactive necrosis of cornea → perforation → phthisis bulbi → permanent blindness; most severe stage
Vitamin A (Retinol) - Key facts:
- Fat-soluble vitamin (stored in liver)
- Sources: Liver, egg yolk, dairy, orange/yellow vegetables (beta-carotene - provitamin A)
- RDA: 600 mcg retinol equivalents (RE)/day for adult; 800 mcg/day pregnancy; 950 mcg/day lactation
- 1 mcg retinol = 6 mcg beta-carotene
- Deficiency effects: Night blindness, xerophthalmia, increased susceptibility to infections, impaired growth, anaemia
- Toxicity (hypervitaminosis A): Teratogenic (excess in pregnancy); raised ICP (pseudotumor cerebri); hepatotoxicity; hair loss, dry skin
Vitamin A Supplementation (National Programme):
- 9 months: 1 lakh IU with measles vaccine
- 18 months - 5 years: 2 lakh IU every 6 months
Treatment of Xerophthalmia:
- Day 1: Vit A 200,000 IU orally
- Day 2: Vit A 200,000 IU orally
- After 1-4 weeks: Vit A 200,000 IU orally
- Children <1 year or <8 kg: Half dose (100,000 IU each)
Food Pyramid
- Visual guide to recommended proportions of different food groups in daily diet
- Originally developed by USDA (USA) in 1992
- India: ICMR/NIN recommended food pyramid
USDA Food Pyramid (classic):
- Base (eat most): Grains/cereals
- Next level: Vegetables | Fruits
- Above: Dairy | Protein (meat/beans)
- Apex (eat least): Fats, oils, sweets
USDA MyPlate (2011 - replaced pyramid):
- Plate divided into 4 sections: Fruits, Vegetables, Grains, Protein
- Small circle (dairy) beside plate
- Half the plate = fruits and vegetables
Indian Food Pyramid (NIN):
- Base: Cereals, millets, pulses (eat most)
- 2nd level: Vegetables + Fruits
- 3rd level: Milk + Animal products
- Apex: Fats + Sugar (eat least)
My Plate
(See Food Pyramid notes - USDA MyPlate)
Key messages:
- Make half your plate fruits and vegetables
- Make at least half your grains whole grains
- Switch to fat-free or low-fat dairy
- Vary your protein routine
- Reduce sodium, saturated fat, added sugars
India equivalent: ICMR "Eat Right India" campaign and NIN food plate recommendations follow similar principles
Dietary Fibre
Definition: Non-digestible carbohydrates and lignin that are intrinsic and intact in plants; resistant to digestion and absorption in the human small intestine with complete or partial fermentation in the large intestine.
Types:
- Soluble fibre (fermentable): Pectin (fruits), guar gum, oat beta-glucan, psyllium; dissolves in water → gel; fermented by gut bacteria → SCFA
- Insoluble fibre (non-fermentable): Cellulose, hemicellulose, lignin (vegetables, whole grains, wheat bran); does not dissolve; adds bulk to stool
Recommended intake: 25-40 g/day (India: ~30 g/day)
Health benefits:
- Prevents constipation (increases stool bulk)
- Reduces serum cholesterol (soluble fibre - binds bile acids)
- Improves glycaemic control (slows glucose absorption - low GI)
- Reduces risk of colorectal cancer
- Promotes satiety, aids weight management
- Feeds gut microbiome (prebiotic effect)
Deficiency effects: Constipation, diverticular disease, increased colon cancer risk, obesity, diabetes, dyslipidaemia
Food Fortification
Definition: Addition of one or more nutrients to a food product to improve nutritional quality and public health benefit; the food vehicle carries the nutrient to the population.
Types:
- Mandatory fortification: Government mandated; e.g., iodized salt (mandatory in India)
- Voluntary/commercial fortification: By food industry; e.g., fortified cereals, energy drinks
- Market-driven fortification
- Targeted/complementary food fortification: For specific high-risk groups
Examples in India:
| Food Vehicle | Nutrient Added | Target Deficiency |
|---|
| Salt | Iodine (KIO₃) | IDD |
| Salt | Iodine + Iron ("Double fortified salt") | IDD + IDA |
| Wheat flour | Iron + Folic acid + Vit B12 | IDA, neural tube defects |
| Rice | Iron + Zinc + Vit B12 + Folic acid | Multiple deficiencies |
| Edible oil | Vitamin A + Vitamin D | VAD, rickets |
| Milk | Vitamin A + Vitamin D | VAD, rickets |
Advantages: Reaches large population, no behavior change needed, cost-effective, sustainable
Disadvantages: Not targeted to deficient individuals only, risk of excess in some groups, quality control
FSSAI (Food Safety and Standards Authority of India): Regulates food fortification; "+" logo on fortified foods
Food Adulteration
Definition: Intentional or unintentional addition of a substance to food that affects the quality, safety, or nutritive value of food in such a manner as to render it injurious to health or mislead the consumer.
Adulterants in Common Foods:
| Food | Common Adulterant | Detection |
|---|
| Milk | Water, urea, detergent, starch, skim milk powder | Lactometer (density), Starch test (iodine), Urea test |
| Ghee/Butter | Vanaspati (hydrogenated fat), animal fat | Butyro refractometer, Baudouin test (Vanaspati - reddish color with FeCl₃) |
| Pulses (Arhar dal) | Kesari dal (Lathyrus sativus) | Phloroglucinol test (yellow-green → orange in kesari) |
| Chilli powder | Brick powder, Sudan red dye | Water test (red color in water = brick; organic solvent for Sudan dye) |
| Turmeric | Metanil yellow, lead chromate | HCl test (pink = metanil yellow); water floats chalk |
| Honey | Sugar syrup, glucose | Fiehe's test (resorcinol + HCl = cherry red = HMF = heated/adulterated) |
| Tea leaves | Used tea leaves, iron filings | Magnet for iron filings |
| Mustard seeds | Argemone seeds | Nitric acid test (yellow = argemone - causes Epidemic Dropsy) |
| Sugar | Chalk powder, urea | Water solubility test |
| Pepper | Papaya seeds, light berries | Float in water (light berries float) |
| Atta/flour | Chalk, talc, sand | HCl dissolves chalk (effervescence) |
Laws:
- Prevention of Food Adulteration (PFA) Act, 1954 - repealed and replaced
- Food Safety and Standards Act (FSSA), 2006 - current; FSSAI (Food Safety and Standards Authority of India)
- FSSAI: Regulatory body for food safety standards in India
Health effects of adulteration:
- Metanil yellow (coal tar dye): Carcinogenic
- Sudan red: Carcinogenic
- Lead chromate: Lead poisoning
- Argemone seeds: Epidemic dropsy
- Kesari dal: Lathyrism
Lathyrism
Definition: A neurotoxic disorder caused by excessive consumption of the grass pea or chickling vetch, Lathyrus sativus (khesari dal/teura).
Neurotoxin: BOAA (Beta-N-Oxalyl-L-alpha,beta-Diaminopropionic Acid) / also called ODAP - affects motor neurons of spinal cord.
Epidemiology:
- Endemic in MP, Bihar, UP, Orissa (Indian states where khesari dal grown)
- Occurs in famines when Lathyrus consumed as staple
- Affects young males predominantly (protective effect of estrogens?)
Clinical Features:
- Irreversible spastic paraparesis (lower limb spasticity and weakness)
- Upper motor neuron signs: spasticity, hyperreflexia, extensor plantar
- "Scissors gait" due to spastic diplegia
- Sensory system preserved
- Bowel and bladder usually unaffected
- Once established, irreversible (no treatment)
Prevention:
- Avoid exclusive/excessive consumption of Lathyrus sativus
- Soak and boil discarding water (leaches BOAA)
- Blending with other grains (dilution)
- Ban on sale (under PFA Act) - but often ignored in famines
Epidemic Dropsy
Definition: Acute/sub-acute generalized oedema caused by argemone oil (from Argemone mexicana seeds, Mexican poppy) adulterating mustard oil.
Toxin: Sanguinarine (alkaloid in argemone oil) - inhibits pyruvate oxidase → blocks oxidative metabolism → increased capillary permeability → oedema.
Also contains: Dihydrosanguinarine
Epidemic setting:
- Outbreaks in India (most famously 1998 Delhi epidemic)
- Argemone seeds mixed with mustard seeds, pressed together for oil
- "Pungency test": Argemone oil is pungent (same as mustard), making adulteration difficult to detect by consumers
Clinical Features:
- Oedema - bilateral pitting oedema of legs, ascites (most prominent feature)
- Diarrhoea, abdominal pain, nausea
- Erythema of skin (brick-red discoloration)
- Glaucoma (raised intraocular pressure)
- Cardiovascular: tachycardia, CHF (cardiac failure)
- Anaemia
- Liver enlargement (hepatomegaly)
- Severe cases: death from cardiac failure
Detection of Argemone oil in mustard oil:
- Nitric acid test: A few drops nitric acid + oil → yellow color = argemone present (Burchfield's test)
Treatment:
- Stop adulterated oil
- Symptomatic: Diuretics for oedema, cardiac support
- No specific antidote
Endemic Ascites (Veno-occlusive Disease / Budd-Chiari)
Definition: Hepatic veno-occlusive disease (HVOD) - obstruction of hepatic venules leading to sinusoidal congestion, liver damage, and ascites.
Cause in India: Pyrrolizidine alkaloids (PA) in certain plants:
- Heliotropium (common in India - contaminating wheat and millet)
- Crotalaria
- Also: Senecio genus
Epidemiology:
- Rural areas; crops contaminated with PA-containing weeds
- India: Rajasthan, Gujarat, Maharashtra
- Also called "Bread poisoning" when cereal flour contaminated
Clinical Features:
- Hepatomegaly, tender
- Ascites (main feature - "endemic ascites")
- Jaundice
- Portal hypertension → variceal bleeding
- Liver failure in chronic cases
Histology: Obliteration of central hepatic venules, centrilobular hemorrhagic necrosis → fibrosis
Aflatoxicosis
Definition: Poisoning caused by aflatoxins - mycotoxins (fungal toxins) produced by Aspergillus flavus and Aspergillus parasiticus on stored food.
Susceptible foods: Groundnuts (peanuts) most common; also maize, wheat, rice, cottonseed, tree nuts, dried fruits, spices - when stored in warm, moist conditions.
Types of aflatoxins: B1, B2, G1, G2 (B = blue fluorescence, G = green); Aflatoxin B1 is most potent carcinogen known.
Clinical Features:
Acute aflatoxicosis:
- High-dose exposure
- Vomiting, abdominal pain, pulmonary oedema, cerebral oedema
- Acute liver failure (haemorrhagic necrosis)
- High mortality
- Example: India outbreak (Gujarat 1974 - 106 deaths from contaminated maize)
Chronic aflatoxicosis:
- Low-level prolonged exposure
- Hepatocellular carcinoma (HCC) - major consequence (aflatoxin B1 is Group 1A carcinogen - IARC)
- Synergistic with Hepatitis B → very high HCC risk
- Immunosuppression
- Growth retardation in children
Prevention:
- Proper storage (cool, dry, <13% moisture)
- Aflatoxin testing (TLC, ELISA, HPLC) in food
- FSSAI standards: Aflatoxin <15 ppb total (30 ppb B1) in food; <10 ppb in infant food
- Reject visually mouldy/damaged grains
Vitamin A Prophylaxis
(Also described under Xerophthalmia)
National Vitamin A Supplementation Programme:
| Age | Dose | Occasion |
|---|
| 9 months | 1,00,000 IU (1 lakh) | With measles-rubella (MR) vaccine |
| 18 months | 2,00,000 IU (2 lakh) | 2nd dose |
| 24 months | 2,00,000 IU | 3rd dose |
| 30 months | 2,00,000 IU | 4th dose |
| 36 months | 2,00,000 IU | 5th dose |
| 42 months | 2,00,000 IU | 6th dose |
| 48 months | 2,00,000 IU | 7th dose |
| 54 months | 2,00,000 IU | 8th dose |
| 60 months (5 years) | 2,00,000 IU | 9th dose |
- Total: 9 doses from 9 months to 5 years
- Delivered as biannual rounds (every 6 months) at AWC, immunization sessions
- Vitamin A given orally as oily solution (dark amber bottle)
Benefits beyond eye protection:
- Reduces all-cause child mortality by 24%
- Reduces diarrhoea mortality by 33%
- Reduces measles severity
- Reduces anaemia
ICDS (Integrated Child Development Services)
(Detailed in Chapter 6)
Quick recall for nutrition chapter:
- World's largest nutrition programme (launched 1975)
- Anganwadi Centre: serves 400-800 children, 150-200 pregnant/lactating women per AWC
- Supplementary Nutrition: Provided to children 6 months-6 years and pregnant/lactating women for 300 days/year (25 days/month)
- Children 6-72 months: 500 kcal + 12-15g protein
- Severely malnourished children: 800 kcal + 20-25g protein
- Pregnant and lactating women: 600 kcal + 18-20g protein
- Adolescent girls (in some states): 500 kcal + 25g protein
Poshan Abhiyan (Mission POSHAN 2.0)
POSHAN Abhiyan (Phase 1):
- Launched March 8, 2018 (International Women's Day)
- Prime Minister's Overarching Scheme for Holistic Nutrition
- Target: Reduce stunting, underweight, low birth weight, anaemia (by 2%, 2%, 2%, 3% annually respectively)
Mission POSHAN 2.0 (Phase 2 - 2021 onwards):
- Merged ICDS + PMMVY + National Crèche Scheme + several nutrition schemes
- Target beneficiaries: Children 0-6 years, Pregnant and Lactating women, Adolescent Girls
- Key features:
- POSHAN Tracker app (real-time monitoring of AWC services, beneficiary data)
- Convergence of ICDS, NHM, SBCC (Social and Behaviour Change Communication)
- Community-based nutrition management
- Poshan Maah: September = Nutrition Month (month-long activities)
- Poshan Pakhwada: Fortnight of nutrition activities (March)
- Focus on first 1000 days (conception to 2 years) as critical window
Mid-Day Meal (PM POSHAN)
(Detailed in Chapter 6 and Chapter 8)
Quick recall:
- Renamed PM POSHAN (Pradhan Mantri Poshan Shakti Nirman) in 2021
- Classes 1-8; government schools; free cooked meal
- Nutritional norms: Primary 450 kcal/12g protein; Upper Primary 700 kcal/20g protein
- Benefits: Reduces hunger, improves attendance, reduces dropout, reduces malnutrition
Anaemia in Pregnancy
Definition: Hb <11 g/dL in pregnancy (WHO)
Classification:
| Grade | Hb level |
|---|
| Mild | 10-10.9 g/dL |
| Moderate | 7-9.9 g/dL |
| Severe | 4-6.9 g/dL |
| Very severe | <4 g/dL |
Causes in India:
- Iron deficiency (most common - >70%)
- Folate deficiency
- Vitamin B12 deficiency
- Hookworm infestation
- Malaria (endemic areas)
- Haemoglobinopathies (sickle cell, thalassemia)
Maternal consequences:
- Increased maternal mortality (indirect cause of 20% maternal deaths in India)
- Heart failure (severe anaemia)
- Increased infection susceptibility
- PPH risk increased
- Poor wound healing
Fetal consequences:
- LBW, prematurity
- Perinatal mortality increased
- Fetal iron deficiency → poor neurodevelopment
Prevention and treatment:
- IFA supplementation: 100 mg elemental iron + 500 mcg folic acid daily for 180 days
- Treatment dose for moderate anaemia: 200 mg elemental iron/day
- IV iron (FCM - Ferric Carboxymaltose): For severe anaemia/non-responders
- Blood transfusion: Hb <7 with symptoms; Hb <6 anytime; any Hb <8 near term
- Treat underlying cause (deworming, malaria treatment)
Micronutrients
Definition: Nutrients required in small amounts (mg or mcg quantities) - includes vitamins and minerals (contrast: macronutrients = protein, fat, carbohydrate needed in grams).
Key micronutrients and deficiency diseases:
| Micronutrient | Deficiency Disease | Key sources |
|---|
| Vitamin A | Xerophthalmia, night blindness | Liver, egg, orange vegetables |
| Vitamin B1 (Thiamine) | Beriberi | Whole grains, legumes |
| Vitamin B2 (Riboflavin) | Angular stomatitis, cheilosis, glossitis | Milk, meat, eggs |
| Vitamin B3 (Niacin) | Pellagra (3 Ds: Dermatitis, Diarrhoea, Dementia) | Meat, nuts, whole grains |
| Vitamin B6 (Pyridoxine) | Peripheral neuropathy, dermatitis | Meat, fish, potatoes |
| Vitamin B9 (Folate) | Megaloblastic anaemia, NTDs | Green leafy vegetables, legumes |
| Vitamin B12 | Megaloblastic anaemia, subacute combined degeneration | Animal products only (meat, dairy, eggs) |
| Vitamin C (Ascorbic acid) | Scurvy (perifollicular haemorrhage, Scorbutic rosary, corkscrew hair, bleeding gums) | Citrus fruits, guava, amla |
| Vitamin D (Calciferol) | Rickets (children), Osteomalacia (adults) | Sunlight, fish liver oil, fortified foods |
| Vitamin K | Bleeding/Haemorrhagic disease of newborn | Green vegetables, liver |
| Iron | IDA, reduced immunity, poor cognitive development | Meat, green leafy vegetables |
| Iodine | IDD, goitre, cretinism | Seafood, iodized salt |
| Zinc | Growth retardation, hypogonadism, impaired immunity, diarrhoea | Meat, shellfish, legumes |
| Calcium | Rickets, osteoporosis, tetany | Milk, dairy, ragi |
| Fluoride | Dental caries (deficiency); Dental/Skeletal fluorosis (excess) | Fluoridated water, tea, seafood |
"Hidden hunger": Micronutrient deficiency without clinical signs of acute malnutrition - very common in India.
Marasmus and Kwashiorkor
(Detailed comprehensively under PEM section above)
Quick comparison table:
| Feature | Marasmus | Kwashiorkor |
|---|
| Age | <1 year | 1-3 years |
| Calorie deficit | Severe (both protein + energy) | Moderate (protein >> energy) |
| Weight | <60% expected | 60-80% expected |
| Oedema | Absent | Present (pathognomonic) |
| Subcutaneous fat | Absent (severe wasting) | Present |
| Appetite | Hungry, irritable | Anorexic, apathetic |
| Hair | Normal | Reddish, thin, flag sign |
| Skin | Dry, wrinkled | Flaky paint dermatosis |
| Face | "Old man face" | "Moon face" |
| Liver | Normal | Enlarged (fatty liver) |
| Serum albumin | Mildly low | Very low |
Iodized Salt
(Detailed in Chapter 6 under NIDDCP)
Key points for nutrition chapter:
- Universal Salt Iodization (USI): all edible salt
- Added as Potassium Iodate (KIO₃) - more stable than potassium iodide
- 30 ppm at production; 15 ppm at consumer level
- Storage: Cool, dry, dark (iodine volatilizes with heat, light, moisture)
- Use iodized salt AFTER cooking (heat reduces iodine content)
- Double Fortified Salt (DFS) = Iodine + Iron = addresses both IDD and IDA simultaneously
- Spot test kit: Starch-iodide test paper (turns blue with iodine)
Milk-Borne Diseases
Diseases transmitted through contaminated/raw/improperly handled milk:
| Disease | Pathogen | Source |
|---|
| Tuberculosis | Mycobacterium bovis | Infected cattle |
| Brucellosis (undulant fever) | Brucella abortus/melitensis | Cattle, goats |
| Typhoid | Salmonella typhi | Human fecal contamination |
| Diphtheria | Corynebacterium diphtheriae | Human (carrier milker) |
| Streptococcal sore throat/Scarlet fever | Group A Streptococcus | Human (carrier) |
| Staphylococcal food poisoning | Staphylococcus aureus (enterotoxin) | Human (carrier milker) |
| Campylobacter enteritis | Campylobacter jejuni | Cattle |
| Cryptosporidiosis | Cryptosporidium parvum | Cattle |
| Q fever | Coxiella burnetii | Cattle, sheep, goats |
| Listeriosis | Listeria monocytogenes | Environment contamination |
Prevention:
- Pasteurization (most effective and widely used):
- HTST (High Temperature Short Time): 72°C for 15 seconds
- LTLT (Low Temperature Long Time): 63°C for 30 minutes
- UHT (Ultra High Temperature): 135°C for 2 seconds
- Proper milking hygiene
- Cold chain maintenance
- Milk quality testing: MBR (Methylene Blue Reduction) test
This completes Chapter 10: Nutrition - covering all Long Questions (PEM, Balanced Diet, IDD, Iron Deficiency Anaemia, Nutritional Assessment, Nutrition Programmes) and all Short Notes (Glycaemic Index, NPU, Xerophthalmia, Food Pyramid, My Plate, Dietary Fibre, Food Fortification, Food Adulteration, Lathyrism, Epidemic Dropsy, Endemic Ascites, Aflatoxicosis, Vitamin A Prophylaxis, ICDS, Poshan Abhiyan, Mid-Day Meal, Anaemia in Pregnancy, Micronutrients, Marasmus, Kwashiorkor, Iodized Salt, Milk-borne Diseases).
Key numbers to remember: Marasmus = <60% weight, no oedema; Kwashiorkor = 60-80% weight + oedema; MUAC <11.5 cm = SAM; Anaemia in pregnancy = Hb <11 g/dL; IDA treatment = 100-200 mg elemental iron/day; Vitamin A at 9 months = 1 lakh IU; 18 months to 5 years = 2 lakh IU every 6 months (9 total doses); Egg NPU ~94% (near perfect protein); Aflatoxin B1 = most potent natural carcinogen; Lathyrism = Lathyrus sativus → BOAA → spastic paraparesis; Epidemic Dropsy = Argemone oil → Sanguinarine → oedema.