Getting the most out of Orris
Orris was started in 2025 by a team of medicos who wanted better, deeper answers from medical literature — and built the tool they wished they had.
What's under the hood
Orris has access to a large body of medical texts — research papers, clinical guidelines, journals, and textbooks — along with a precisely curated corpus of medical images.
Unlike general-purpose AI tools that skim surface-level information, Orris uses specialised AI agents that read, scroll, and navigate medical texts the way a doctor would — page by page, context by context. This gives it significantly more depth and accuracy when answering clinical questions.
What you can do
Ask in plain language. Be specific about what you need — the more context you give, the better the answer.
Differential Diagnosis
Describe a clinical picture and get a structured differential with reasoning.
Understand Any Topic
Pathology, pathophysiology, physiology — across any subject, at any depth.
Compare Across Books
See how different textbooks cover the same topic, side by side.
Treatment Plans
Ask for treatment of a disease, a specific subgroup, or a patient with multiple comorbidities — it handles that level of complexity with proper reasoning.
Latest Guidelines
Fetch the most recent clinical guidelines and updates from any medical field.
Medical Images
Relevant clinical images are fetched and shown alongside answers when appropriate.
Compare Guidelines Head-to-Head
Ask Orris to lay two guidelines or sets of findings side by side — ADA vs. EASD, ACC vs. ESC, old vs. new — with the key differences surfaced clearly.
Weighted Responses
Tell Orris which source to prioritise — a specific guideline, a preferred textbook, or a level of evidence — and the answer will be weighted accordingly.
Case Discussion Prep
Feed in a case and get a structured presentation-ready summary: differentials, workup rationale, management approach — formatted for a ward round or teaching session.
What's Changed
Ask what has changed from the standard textbook position on a topic — recent trial data, updated cut-offs, revised classifications, new first-line agents.
Cross-Subject Perspectives
Pull how different disciplines view the same condition — how a cardiologist, a nephrologist, and a diabetologist each approach CKD with heart failure, for instance.
Drug Selection by Subgroup
Ask which agent is preferred for a specific patient profile — comorbidities, contraindications, age, organ function — with evidence-based reasoning for the choice.
Visual Explanations & Posters
Generate an infographic, explanatory poster, or illustrated summary of any topic — useful for teaching, presentations, or simply understanding complex mechanisms visually.
Flashcards
Turn any topic into a set of flashcards — with generated images where helpful — for rapid revision or spaced repetition practice.
Step-by-Step Procedures
Break down any clinical procedure into numbered steps with simplified illustrations — exportable as a Word document to keep as revision notes.
Exam Prep
Find high-yield topics for your next exam, solve MCQs with full reasoning, or ask for the same answer written at different levels — a short structured note, a detailed essay, or a one-liner.
Journal Club Prep
Find recent articles on a topic, get a structured critical appraisal of any paper — study design, bias, statistical validity, clinical applicability — ready for discussion.
Biostatistics & Evidence Evaluation
Solve biostatistics questions step by step with multiple approaches, or evaluate a research paper's inferences — NNT, confidence intervals, effect sizes, and whether the evidence is shifting.
Mnemonics & Memory Aids
Ask for a mnemonic, heuristic, or shortcut for any topic — framed however you want to remember it, including comic book characters, analogies, or visual stories.
Export & create
Once you have your answer, you can turn it into something you can take outside the tool and use directly.
Tips to get better answers
The single most important thing: be specific. The more precise your query, the more precise the output.
Instead of
“Tell me about diabetes treatment”Try
“Treatment of type 2 diabetes in a patient with CKD stage 3 and heart failure — latest ADA guidelines”Instead of
“What causes anemia?”Try
“Causes of microcytic anemia in a 25-year-old female with heavy menstrual bleeding — approach to workup”You can also give patient context — age, comorbidities, current medications — and the tool will reason through the complexity, just like a clinical discussion.
Examples in practice
These are the kinds of queries that unlock Orris properly. Copy them as starting points, or use them to calibrate how specific to be.
Guideline Comparison
“Compare ADA 2024 and EASD 2023 recommendations on initiating GLP-1 agonists in type 2 diabetes — where do they agree and where do they differ?”“ACC vs. ESC on anticoagulation in AF with moderate mitral stenosis — what does each recommend and what’s the evidence gap?”Weighted Response
“Management of septic shock — prioritise Surviving Sepsis Campaign 2021 guidelines, but flag where recent RCT data conflicts with the recommendations”“Approach to acute severe asthma in adults — answer primarily from BTS/SIGN guidelines, note where Harrison’s differs”Case Discussion Prep
“62M, HTN, CKD stage 3, presents with 3-week history of progressive exertional dyspnoea, orthopnoea, bilateral pitting oedema up to knees. BNP 840. Prepare a case discussion summary with differentials, workup rationale, and management plan — format for a cardiology ward round”“Create a teaching case presentation on a young woman with recurrent DVT, FHx of clotting, and a recent miscarriage — include the thrombophilia workup approach and pitfalls”What’s Changed
“What has changed in the classification and staging of CKD compared to the standard textbook position — any recent KDIGO updates or revised GFR cut-offs?”“How has the first-line treatment of H. pylori changed from what Harrison’s describes — current resistance patterns and revised regimens”Cross-Subject Perspectives
“How do cardiology, nephrology, and endocrinology each approach a T2DM patient with HFrEF and CKD stage 3 — where do their priorities align and where do they conflict?”“Anaemia of chronic disease — compare how haematology, rheumatology, and nephrology textbooks explain the pathophysiology and approach management differently”Drug Selection by Subgroup
“Best SGLT2 inhibitor choice in a patient with T2DM, HFpEF, eGFR 38, and recurrent UTIs — rank the options with reasoning”“Antihypertensive selection in a 70-year-old with isolated systolic hypertension, gout, and mild cognitive impairment — preferred agent and what to avoid, with evidence”Visual Explanations & Posters
“Generate a visual poster explaining the coagulation cascade — keep it clean, label the intrinsic and extrinsic pathways, and mark where common anticoagulants act”“Create a simplified infographic on the RAAS pathway — show where ACE inhibitors, ARBs, and aldosterone antagonists intervene, with a short explanation of each step”Flashcards
“Make flashcards for the major causes of nephrotic syndrome — one card per cause, with a generated image on the front and key distinguishing features on the back”“Flashcard set on cranial nerve palsies — clinical presentation, lesion site, and one image per nerve to anchor the memory”Step-by-Step Procedures
“Walk me through a lumbar puncture step by step — positioning, landmarks, needle technique, CSF interpretation — with illustrations at each stage. Export as a Word document I can use as notes”“Step-by-step approach to reading a chest X-ray systematically — annotated infographic showing what to look for at each zone, with common pathology examples”Exam Prep
“A 45-year-old presents with dyspnoea, pleuritic chest pain, and a positive D-dimer. The answer is PE — explain why each distractor is wrong, and what the question is really testing”“Write me an answer on the pathophysiology of hyponatraemia — give me three versions: a one-liner, a 5-mark structured answer, and a full essay-length response”“I have my internal medicine postgrad exam in 3 weeks. What are the highest-yield topics I should prioritise, and find me the best images to understand each one quickly”Journal Club Prep
“Find the most recent high-impact RCTs on SGLT2 inhibitors in heart failure published in the last 18 months — include journal, sample size, and key findings for each”“Critically appraise the DAPA-HF trial — study design, population, primary endpoint, risk of bias, statistical approach, and how applicable the findings are to real-world practice”Biostatistics & Evidence Evaluation
“Solve this: a new drug reduces MI risk from 8% to 5%. Calculate ARR, RRR, NNT — then explain what each number actually means for a clinician deciding whether to prescribe”“Based on trials published in the last 2 years on beta-blockers in acute MI — is the evidence base shifting? What are the key inferences and what should I flag at journal club?”Mnemonics & Memory Aids
“Give me a mnemonic for the causes of raised anion gap metabolic acidosis — make it memorable, then give me the fundamental reasoning behind why each cause produces it”“I can never remember the brachial plexus. Create a comic book character or visual story that maps onto the roots, trunks, divisions, cords, and branches — make it stick”Who is this for
From a first-year medical student trying to understand basic physiology, to a senior doctor looking up the latest treatment protocol for a rare subgroup — Orris scales to your level of question. It's a clinical co-pilot that meets you where you are.
Orris is actively developed with continuous input from practising doctors. You'll notice it getting better as you use it — new capabilities, sharper answers, deeper coverage. It's a tool that grows with the community.
— The Orris Team